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ADC-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double psi beta-barrel [ 50684] (2)
Superfamily:   ADC-like [ 50692] (3)
Families:   Pyruvoyl dependent aspartate decarboxylase, ADC [ 50693]
  Formate dehydrogenase/DMSO reductase, C-terminal domain [ 50696] (10)
  Cdc48 N-terminal domain-like [ 50708] (4)


Superfamily statistics
Genomes (2,536) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,256 85,394 42
Proteins 13,251 85,389 42


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000004446 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000004108 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02953 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7226 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6277 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.9747 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0007657 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000192 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000000000002221 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001661 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.2865 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.004145 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3004 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01862 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1424 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.07002 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.01484 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1803 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1109 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1328 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.004047 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0000001239 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000425 Informative Direct
Biological Process (BP) electron transport chain 0.00006712 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000008546 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0005455 Informative Direct
Biological Process (BP) cellular respiration 0 Informative Direct
Biological Process (BP) DNA metabolic process 0.02164 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01319 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002858 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1634 Informative Inherited
Biological Process (BP) autophagy 0.00000000001351 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00001451 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.00000000001356 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0006277 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000001163 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00003684 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0000005736 Highly Informative Direct
Biological Process (BP) pigmentation 0.00004391 Highly Informative Direct
Biological Process (BP) single-organism membrane fusion 0.00004284 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0008732 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0000000000002845 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.004246 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.001322 Highly Informative Inherited
Molecular Function (MF) binding 0.09704 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.3238 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.00000000001679 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000000000001475 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.1034 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.0006754 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0.000000001988 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.2709 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1205 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05719 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5927 Least Informative Inherited
Cellular Component (CC) vacuole 0.0006014 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004871 Informative Direct
Cellular Component (CC) microbody 0.00005169 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) chromosome 0.004171 Informative Inherited
Cellular Component (CC) lytic vacuole 0.04805 Informative Inherited
Cellular Component (CC) periplasmic space 0.000005305 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.5931Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.2132Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.8366Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0.00001206InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.7643InformativeInherited
Enzyme Commission (EC)Nitrate reductase0Highly InformativeDirect
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Thymidine phosphorylase0.00000000005855Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase (quinone)0.000002852Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.3666Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the inner ear0InformativeDirect
Phenotypic Abnormality (PA)Hearing abnormality0InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0InformativeDirect
Phenotypic Abnormality (PA)Neurological speech impairment0InformativeDirect
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0InformativeDirect
Phenotypic Abnormality (PA)Sensorineural hearing impairment0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality, complete penetrance0.0008598Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00198Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004447Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.006974Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02519Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00007645Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00008695Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0001436Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0001683Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0001821Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0002332Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0003769Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0004564Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.0007536Moderately InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.000001683InformativeDirect
Worm Phenotype (WP)gonad development variant0.00000755InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.00000000008665Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0000001865Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0000005823Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)eye0InformativeDirect

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.3242InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.6414InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.7197InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.8991InformativeInherited
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000000801Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase (quinone)0.00000162Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.1756Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processAutophagy0.0002117InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Cellular componentCytoplasm0.0000000000005647Least InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Coding sequence diversitySelenocysteine0.000000008156InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0.7236Least InformativeInherited
Molecular functionIron0Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular function2Fe-2S0.0000000000000112InformativeDirect
Molecular functionPyruvate0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)nitrogen metabolism0.1437Moderately InformativeInherited
UniPathway (UP)energy metabolism0.6802Moderately InformativeInherited
UniPathway (UP)one-carbon metabolism0.8002Moderately InformativeInherited
UniPathway (UP)nitrate reduction0.00001303InformativeDirect
UniPathway (UP)methanogenesis0.007227InformativeInherited
UniPathway (UP)(R)-pantothenate biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from CO(2)0.0003438Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009010 SSF50692 Protein matches
Abstract

Beta barrels are commonly observed in protein structures. They are classified in terms of two integral parameters: the number of strands in the sheet, n, and the shear number, S, a measure of the stagger of the strands in the beta-sheet. These two parameters have been shown to determine the major geometrical features of beta-barrels. Six-stranded beta-barrels with a pseudo-twofold axis are found in several proteins. One involving parallel strands forming two psi structures is known as the double-psi barrel. The first psi structure consists of the loop connecting strands beta1 and beta2 (a 'psi loop') and the strand beta5, whereas the second psi structure consists of the loop connecting strands beta4 and beta5 and the strand beta2. All the psi structures in double-psi barrels have a unique handedness, in that beta1 (beta4), beta2 (beta5) and the loop following beta5 (beta2) form a right-handed helix. The unique handedness may be related to the fact that the twisting angle between the parallel pair of strands is always larger than that between the antiparallel pair [PubMed10368289].

In many cases, including aspartate decarboxylase and aspartic proteinases, strands 1 and 4 are each bent and consist of two sections. The two sections normally make a right angle; sometimes their hydrogen-bond patterns are disrupted at the corner by a bulge or even by a large insertion. In these cases, the barrel can also be viewed as a pair of orthogonally packed sheets, each with four strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADC-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the ADC-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]