SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (922) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 75,120 183,983 146
Proteins 66,982 165,564 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.91220Least InformativeInherited
Molecular Function (MF)anion binding0.00520Moderately InformativeInherited
Molecular Function (MF)phospholipid binding0.00000013170InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000007478 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001959 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000833 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000000000001864 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000000001726 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000000001994 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000000006395 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000004401 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00001422 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00005412 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00005779 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0002345 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0003734 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0005925 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1811 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8046 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3651 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.8805 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.9709 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.006575 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04662 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.883 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000004227 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) hemopoiesis 0.000000000000001925 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000000003429 Informative Direct
Biological Process (BP) behavior 0.0000000000005384 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000000001599 Informative Direct
Biological Process (BP) regulation of locomotion 0.00000000001341 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.00000000005584 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000003412 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000000491 Informative Direct
Biological Process (BP) intracellular transport 0.00000000178 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000501 Informative Direct
Biological Process (BP) regulation of growth 0.00000001047 Informative Direct
Biological Process (BP) epithelium development 0.00000003753 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000001271 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000001955 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000001956 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000006211 Informative Direct
Biological Process (BP) response to wounding 0.00007158 Informative Direct
Biological Process (BP) generation of neurons 0.0001086 Informative Direct
Biological Process (BP) cell development 0.0001226 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0001467 Informative Direct
Biological Process (BP) microtubule-based process 0.0001788 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0003424 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0006024 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006478 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0008778 Informative Direct
Biological Process (BP) positive regulation of transport 0.0358 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.9158 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1684 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1363 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) growth 0.05597 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001273 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1558 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.9626 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.001476 Informative Inherited
Biological Process (BP) post-embryonic development 0.002618 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001832 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.141 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1699 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.01767 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3147 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) phosphorylation 0.1163 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) lipid localization 0.6339 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) organelle localization 0.787 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05736 Informative Inherited
Biological Process (BP) immune response 0.9375 Informative Inherited
Biological Process (BP) pigment metabolic process 0.008486 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) cell cycle process 0.01674 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0551 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01562 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1211 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.09117 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) localization of cell 0.002184 Informative Inherited
Biological Process (BP) embryo development 0.01033 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2117 Informative Inherited
Biological Process (BP) cell activation 0.006399 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.4207 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.6695 Informative Inherited
Biological Process (BP) cation homeostasis 0.7112 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.69 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4707 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) immune effector process 0.01788 Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000000000000003734 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000000002769 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000000000002033 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000000001311 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000007066 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000001992 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.000000002395 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000004572 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000000008575 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00000003423 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.00000003976 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000004273 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000007948 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00000008392 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00000008871 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0000001215 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.000001625 Highly Informative Direct
Biological Process (BP) neuron development 0.000002348 Highly Informative Direct
Biological Process (BP) response to growth factor 0.000006476 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000008848 Highly Informative Direct
Biological Process (BP) appendage development 0.000009031 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.000009762 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00003744 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00006012 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001068 Highly Informative Direct
Biological Process (BP) coagulation 0.0001319 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0001425 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0002218 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0003176 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0004846 Highly Informative Direct
Biological Process (BP) wound healing 0.0007613 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0007652 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0009908 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.2785 Highly Informative Inherited
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.06499 Highly Informative Inherited
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.00239 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.6368 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.5037 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001196 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.639 Highly Informative Inherited
Biological Process (BP) autophagy 0.02021 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01815 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.002552 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1079 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.0961 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.7451 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.04888 Highly Informative Inherited
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.002624 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.07745 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.2229 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.5857 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.8904 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.00314 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.03954 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.6869 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.03184 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.2036 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.6717 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.6781 Highly Informative Inherited
Biological Process (BP) nervous system process 0.9393 Highly Informative Inherited
Biological Process (BP) pigmentation 0.3369 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) lipid modification 0.002196 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.07509 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.993 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.672 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.6968 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.006736 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.228 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.3524 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3531 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002207 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1058 Highly Informative Inherited
Biological Process (BP) regulation of oxidoreductase activity 0.01797 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.07629 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.6227 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01325 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.03075 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.2872 Highly Informative Inherited
Biological Process (BP) forebrain development 1 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.8759 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001846 Highly Informative Inherited
Biological Process (BP) germ cell development 0.9088 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.4784 Highly Informative Inherited
Biological Process (BP) gastrulation 0.04057 Highly Informative Inherited
Biological Process (BP) fertilization 0.0345 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.1736 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.8856 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.05684 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.3488 Highly Informative Inherited
Biological Process (BP) steroid biosynthetic process 0.4443 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02018 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.004654 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.89 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.02803 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.04883 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.2971 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.05178 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.004936 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.01122 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0001247 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.002324 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000000000001615 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000001435 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000001804 Informative Direct
Molecular Function (MF) kinase activity 0.000000003578 Informative Direct
Molecular Function (MF) receptor binding 0.0002359 Informative Direct
Molecular Function (MF) amide binding 0.5041 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000000003188 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.00000000000006311 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0000000003784 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000000004125 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000001526 Highly Informative Direct
Molecular Function (MF) steroid binding 0.0004321 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.208 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.5848 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1121 Highly Informative Inherited
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000000000008837 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000003026 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1008 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000135 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0002795 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.5641 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.9283 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.9856 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000000000006594 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000000009426 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.000000000004693 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0000000002333 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00003198 Informative Direct
Cellular Component (CC) side of membrane 0.00004537 Informative Direct
Cellular Component (CC) cell surface 0.9859 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.807 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.08247 Informative Inherited
Cellular Component (CC) membrane region 0.01229 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002444 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.08198 Informative Inherited
Cellular Component (CC) endosome 0.003438 Informative Inherited
Cellular Component (CC) vacuolar part 0.9917 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000000000003495 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00000000002222 Highly Informative Direct
Cellular Component (CC) contractile ring 0.000001746 Highly Informative Direct
Cellular Component (CC) nuclear pore 0.000002846 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.000004406 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000007461 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.00003596 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0004881 Highly Informative Direct
Cellular Component (CC) presynapse 1 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) main axon 0.00113 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.4891 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.3686 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 1 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.6062 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.8361 Highly Informative Inherited
Cellular Component (CC) membrane coat 0.03728 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.6948 Highly Informative Inherited
Cellular Component (CC) RNA polymerase II transcription factor complex 0.4054 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.1677 Highly Informative Inherited
Cellular Component (CC) tethering complex 0.002821 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000004554Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0.000000000000003332Moderately InformativeDirect
Biological processCell cycle0.01315Moderately InformativeInherited
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processAutophagy0InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processSteroid metabolism0.000000000002431InformativeDirect
Biological processMitosis0.00000000003146InformativeDirect
Biological processCell adhesion0.000005131InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processPhagocytosis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processGrowth regulation0.0000000000002908Highly InformativeDirect
Biological processmRNA transport0.000000006966Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.00000002156Highly InformativeDirect
Biological processAdaptive immunity0.00000007539Highly InformativeDirect
Biological processSterol biosynthesis0.00005059Highly InformativeDirect
Biological processGlucose metabolism0.0001368Highly InformativeDirect
Biological processTranslocation1Highly InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000003291Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentMicrotubule0.0000000000122InformativeDirect
Cellular componentLysosome0.0002069InformativeDirect
Cellular componentCoated pit0.0006833Highly InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DiseaseTumor suppressor0.00001519Moderately InformativeDirect
DiseaseNeuropathy0.0005929Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
Molecular functionZinc0.000000005417Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000000000009614Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0.000000000000009071Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000000005135Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.0001374Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00001775Least InformativeDirect
Post-translational modificationNitration0.0005514InformativeDirect
Post-translational modificationMyristate0.0007624InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 94 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 94 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]