SUPERFAMILY 1.75 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (732) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 64,608 59,677 146
Proteins 57,710 53,151 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process1.754e-060Least InformativeDirect
Biological Process (BP)developmental process1.941e-050Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis2.398e-050Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00024510Least InformativeDirect
Biological Process (BP)response to stimulus0.020410Least InformativeInherited
Biological Process (BP)localization0.14470Least InformativeInherited
Biological Process (BP)regulation of cellular process0.016879.557e-08Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.84231Least InformativeInherited
Biological Process (BP)protein metabolic process0.3881Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.56031Least InformativeInherited
Biological Process (BP)regulation of signaling2.042e-050Moderately InformativeDirect
Biological Process (BP)regulation of cell communication9.602e-050Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00018165.75e-05Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00042322.103e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.00052111Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0038287.659e-12Moderately InformativeInherited
Biological Process (BP)regulation of localization0.043334.345e-06Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.52370.7335Moderately InformativeInherited
Biological Process (BP)tissue development0.10351Moderately InformativeInherited
Biological Process (BP)organ development0.29481Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.079020.0444Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.11460.201Moderately InformativeInherited
Biological Process (BP)response to organic substance0.31650.0002512Moderately InformativeInherited
Biological Process (BP)cellular localization0.0058477.609e-12Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.73471Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.65661Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.022860Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.26764.861e-05Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.54571Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.50880Moderately InformativeInherited
Biological Process (BP)organelle organization0.52641.054e-08Moderately InformativeInherited
Biological Process (BP)cell differentiation6.11e-061Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.48971Moderately InformativeInherited
Biological Process (BP)nervous system development0.068245.535e-09Moderately InformativeInherited
Biological Process (BP)system process0.05355.918e-06Moderately InformativeInherited
Biological Process (BP)homeostatic process0.22881Moderately InformativeInherited
Biological Process (BP)signal transduction0.042960Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.02536.635e-14Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.033630.02914Moderately InformativeInherited
Biological Process (BP)negative regulation of signaling1.814e-071.337e-05InformativeDirect
Biological Process (BP)negative regulation of cell communication7.87e-073.621e-05InformativeDirect
Biological Process (BP)cellular response to nitrogen compound3.157e-055.438e-10InformativeDirect
Biological Process (BP)protein phosphorylation3.866e-050InformativeDirect
Biological Process (BP)cell projection organization0.00010060InformativeDirect
Biological Process (BP)response to organic nitrogen0.00066532.699e-07InformativeDirect
Biological Process (BP)positive regulation of transport0.049724.212e-09InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0030910.0002866InformativeInherited
Biological Process (BP)cellular membrane organization0.0012340.0005928InformativeInherited
Biological Process (BP)cell proliferation0.0093821InformativeInherited
Biological Process (BP)tube development0.054081InformativeInherited
Biological Process (BP)epithelium development0.5920.9425InformativeInherited
Biological Process (BP)regulation of organelle organization0.024321InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.017220.1116InformativeInherited
Biological Process (BP)response to hormone stimulus0.0035550.1625InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.83341.77e-07InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0042510InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0012493.563e-05InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.040670InformativeInherited
Biological Process (BP)positive regulation of developmental process0.10820.4583InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.019540InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.02245.395e-13InformativeInherited
Biological Process (BP)actin filament-based process0.0097610InformativeInherited
Biological Process (BP)cytoskeleton organization0.025970InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0038480InformativeInherited
Biological Process (BP)stem cell proliferation5.205e-086.344e-05Highly InformativeDirect
Biological Process (BP)neural precursor cell proliferation6.062e-089.035e-06Highly InformativeDirect
Biological Process (BP)cellular response to peptide hormone stimulus7.101e-070Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway2.842e-062.518e-10Highly InformativeDirect
Biological Process (BP)plasma membrane organization6.516e-061.452e-07Highly InformativeDirect
Biological Process (BP)protein localization to membrane8.491e-068.585e-05Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.749e-050.0001678Highly InformativeDirect
Biological Process (BP)regulation of purine nucleotide catabolic process2.398e-054.008e-15Highly InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process5.063e-050Highly InformativeDirect
Biological Process (BP)lung development0.001151Highly InformativeInherited
Biological Process (BP)protein complex localization9.637e-050.2711Highly InformativeInherited
Biological Process (BP)regulation of Ras protein signal transduction7.025e-061Highly InformativeInherited
Biological Process (BP)regulation of protein complex assembly0.00050280.005386Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.023040.03704Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation1.566e-050.9497Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis5.209e-051Highly InformativeInherited
Biological Process (BP)regulation of cellular component size0.0015230Highly InformativeInherited
Biological Process (BP)glial cell differentiation0.00010460.5591Highly InformativeInherited
Biological Process (BP)regulation of membrane potential5.43e-080.003408Highly InformativeInherited
Molecular Function (MF)transferase activity0.42430.7695Least InformativeInherited
Molecular Function (MF)binding0.0011360Least InformativeInherited
Molecular Function (MF)protein binding0.0130Moderately InformativeInherited
Molecular Function (MF)anion binding0.032650Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0082361.706e-10Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00065652.919e-13InformativeDirect
Molecular Function (MF)lipid binding0.0028320InformativeInherited
Molecular Function (MF)kinase activity0.0027530InformativeInherited
Molecular Function (MF)phosphatidylinositol binding9.873e-099.557e-10Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.00012913.656e-06Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.62231Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0074410Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.8010.003457Least InformativeInherited
Cellular Component (CC)membrane0.09150Least InformativeInherited
Cellular Component (CC)cell projection6.186e-080Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0016180Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.021290Moderately InformativeInherited
Cellular Component (CC)cell leading edge2.152e-120InformativeDirect
Cellular Component (CC)cell cortex4.025e-060InformativeDirect
Cellular Component (CC)actin cytoskeleton0.22769.13e-15InformativeInherited
Cellular Component (CC)lamellipodium3.22e-080Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane6.026e-060.000741Highly InformativeDirect
Cellular Component (CC)apical plasma membrane1.104e-051.52e-10Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton2.687e-054.881e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 9.557e-08 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 5.75e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.103e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 7.659e-12 Moderately Informative Direct
Biological Process (BP) cellular localization 7.609e-12 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 6.635e-14 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.345e-06 Moderately Informative Direct
Biological Process (BP) system process 5.918e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 5.535e-09 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.264e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.861e-05 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002512 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1.054e-08 Moderately Informative Direct
Biological Process (BP) immune system process 6.302e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7335 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08387 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8327 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0444 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.201 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.06929 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.09995 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.22 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1369 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02914 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of signaling 1.337e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 3.621e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 5.438e-10 Informative Direct
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) response to organic nitrogen 2.699e-07 Informative Direct
Biological Process (BP) cellular membrane organization 0.0005928 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 3.563e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002866 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0003324 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 5.395e-13 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.334e-07 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 5.184e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) positive regulation of transport 4.212e-09 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of hydrolase activity 1.77e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.003e-13 Informative Direct
Biological Process (BP) regulation of cell development 6.875e-11 Informative Direct
Biological Process (BP) phospholipid metabolic process 5.947e-10 Informative Direct
Biological Process (BP) regulation of locomotion 2.775e-09 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 3.629e-09 Informative Direct
Biological Process (BP) cellular component movement 3.933e-07 Informative Direct
Biological Process (BP) dephosphorylation 5.014e-06 Informative Direct
Biological Process (BP) synaptic transmission 2.122e-05 Informative Direct
Biological Process (BP) localization of cell 2.917e-05 Informative Direct
Biological Process (BP) biological adhesion 5.813e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0001805 Informative Direct
Biological Process (BP) apoptotic process 0.2264 Informative Inherited
Biological Process (BP) regulation of protein localization 0.774 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2461 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7395 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.02322 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.1583 Informative Inherited
Biological Process (BP) cell proliferation 1 Informative Inherited
Biological Process (BP) chordate embryonic development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.6736 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.7182 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2895 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.003367 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.02412 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.1633 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4879 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.9488 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.7635 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003066 Informative Inherited
Biological Process (BP) protein transport 0.00516 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.3672 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1116 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1625 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.5888 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.243 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1495 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.0685 Informative Inherited
Biological Process (BP) growth 0.1421 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.05411 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to wounding 0.007667 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.1835 Informative Inherited
Biological Process (BP) immune response 0.4758 Informative Inherited
Biological Process (BP) immune effector process 0.219 Informative Inherited
Biological Process (BP) lipid transport 0.007201 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4583 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.05923 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.08604 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) secretion 0.01436 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.4114 Informative Inherited
Biological Process (BP) regulation of ion transport 0.875 Informative Inherited
Biological Process (BP) regulation of system process 0.9921 Informative Inherited
Biological Process (BP) regulation of growth 0.01002 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.3045 Informative Inherited
Biological Process (BP) muscle structure development 0.9539 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.08085 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.07898 Informative Inherited
Biological Process (BP) cell activation 0.1982 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.004705 Informative Inherited
Biological Process (BP) sexual reproduction 0.002777 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6394 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1631 Informative Inherited
Biological Process (BP) epithelium development 0.9425 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.7859 Informative Inherited
Biological Process (BP) stem cell proliferation 6.344e-05 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 9.035e-06 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 2.518e-10 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.452e-07 Highly Informative Direct
Biological Process (BP) protein localization to membrane 8.585e-05 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0001678 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 4.008e-15 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 5.192e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0009967 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 0.0001407 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 6.291e-14 Highly Informative Direct
Biological Process (BP) endosomal transport 3.115e-13 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.465e-12 Highly Informative Direct
Biological Process (BP) polyol metabolic process 3.242e-09 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.662e-08 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 2.278e-08 Highly Informative Direct
Biological Process (BP) hemostasis 4.213e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 1.19e-07 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.343e-07 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.634e-07 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 4.342e-07 Highly Informative Direct
Biological Process (BP) phagocytosis 1.108e-06 Highly Informative Direct
Biological Process (BP) synaptic vesicle transport 1.481e-06 Highly Informative Direct
Biological Process (BP) wound healing 4.401e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 6.138e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 8.717e-05 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0001411 Highly Informative Direct
Biological Process (BP) cell division 0.0001536 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0002269 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0004567 Highly Informative Direct
Biological Process (BP) coagulation 0.0006204 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0007132 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1093 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.7104 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.2337 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1531 Highly Informative Inherited
Biological Process (BP) cell growth 0.4653 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.5099 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.006609 Highly Informative Inherited
Biological Process (BP) embryonic placenta development 0.197 Highly Informative Inherited
Biological Process (BP) lung development 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.6709 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.06111 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.3186 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.005386 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.9772 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) hair cycle process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.03444 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03312 Highly Informative Inherited
Biological Process (BP) organelle localization 0.01103 Highly Informative Inherited
Biological Process (BP) lipid modification 0.003347 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.7476 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.8506 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.02574 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7121 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) peptidyl-tyrosine phosphorylation 0.001646 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.63 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) epidermis development 1 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.519 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.1017 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.001744 Highly Informative Inherited
Biological Process (BP) protein complex localization 0.2711 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.003408 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.5381 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.07208 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.03704 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.9497 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.8586 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.4315 Highly Informative Inherited
Biological Process (BP) signal release 0.006476 Highly Informative Inherited
Biological Process (BP) exocytosis 0.006606 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.405 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.002817 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2683 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5591 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.001243 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.006571 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002528 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.3664 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.922 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.001471 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.001289 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.306 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.2679 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.004101 Highly Informative Inherited
Biological Process (BP) gastrulation 0.003553 Highly Informative Inherited
Biological Process (BP) fertilization 0.07361 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6094 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.00191 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.296 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.01235 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.005218 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.377 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.0368 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.2218 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2768 Highly Informative Inherited
Biological Process (BP) lymphocyte differentiation 0.05701 Highly Informative Inherited
Biological Process (BP) T cell activation 0.5953 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.3731 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.9038 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.956 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.7695 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1.706e-10 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 2.367e-10 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.919e-13 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme binding 1.029e-12 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.002042 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 9.557e-10 Highly Informative Direct
Molecular Function (MF) protein kinase activity 3.656e-06 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 3.051e-07 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 2.302e-06 Highly Informative Direct
Molecular Function (MF) steroid binding 8.148e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.313e-05 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 3.664e-05 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 6.434e-05 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.03262 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.003457 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytosol 9.346e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 7.216e-11 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) endosome 1.233e-09 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 9.13e-15 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001014 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.8999 Informative Inherited
Cellular Component (CC) coated vesicle 0.9828 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) vacuole 0.06528 Informative Inherited
Cellular Component (CC) nuclear envelope 0.1232 Informative Inherited
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000741 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.52e-10 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 4.881e-11 Highly Informative Direct
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell body 3.162e-13 Highly Informative Direct
Cellular Component (CC) cell division site part 3.713e-13 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 1.846e-10 Highly Informative Direct
Cellular Component (CC) coated pit 3.47e-07 Highly Informative Direct
Cellular Component (CC) cell projection membrane 1.396e-06 Highly Informative Direct
Cellular Component (CC) actin filament 3.482e-05 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.0002006 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0002044 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0.0003541 Highly Informative Direct
Cellular Component (CC) pore complex 0.0007175 Highly Informative Direct
Cellular Component (CC) axon part 1 Highly Informative Inherited
Cellular Component (CC) dendrite 0.06723 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.8568 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.4106 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.126 Highly Informative Inherited
Cellular Component (CC) vesicle membrane 0.05431 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.00318 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.8101 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.08485 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.4811 Highly Informative Inherited
Cellular Component (CC) Golgi membrane 0.9027 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.4885 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) vacuolar membrane 0.005043 Highly Informative Inherited
Cellular Component (CC) lysosome 0.1713 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.315 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase4.532e-08InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula1.873e-14Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C3.652e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.8847Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7689Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.6707InformativeInherited
Phenotypic Abnormality (PA)Inflammation of the large intestine0.0002492Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.08242Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.9018Least InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.6292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9509Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.9881InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology7.411e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung epithelium morphology0.3938Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)