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PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (922) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 75,120 226,141 146
Proteins 66,982 203,244 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.8904InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Gonosomal inheritance0.01924InformativeInherited
Mode of Inheritance (MI)X-linked recessive inheritance0.0006086Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3134Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.8309Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8545Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.9957Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.05007InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.5145InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.5297InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral myelination0.0008697Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.3571Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1611Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2748Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4539Least InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.6193Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1355InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.00001034Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.4781Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.9275Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000001308Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000000003124Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000000003912Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00001377Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00004339Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00007571Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.002093Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0000001334Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000002015Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000006202Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.000406Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.08139Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.09129Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2339Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4603Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.6054Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6552Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.8767Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000000006223InformativeDirect
Worm Phenotype (WP)brood size variant0.0000006392InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0000009289InformativeDirect
Worm Phenotype (WP)growth rate variant0.000002109InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000234InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00003954InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0003067InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0004586InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0009309InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.003652InformativeInherited
Worm Phenotype (WP)tail morphology variant0.006545InformativeInherited
Worm Phenotype (WP)defecation variant0.03059InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.05059InformativeInherited
Worm Phenotype (WP)neurite morphology variant0.1918InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.1939InformativeInherited
Worm Phenotype (WP)cell number increased0.2573InformativeInherited
Worm Phenotype (WP)cell stress response variant0.3133InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.3268InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.6881InformativeInherited
Worm Phenotype (WP)protein modification variant0.7186InformativeInherited
Worm Phenotype (WP)endocytic transport defect1InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant0.000000006798Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.000001068Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.000002438Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00001088Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.00003349Highly InformativeDirect
Worm Phenotype (WP)coelomocyte uptake defective0.00008444Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00009215Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00009775Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0002212Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0003804Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0005747Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0007807Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.06619Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.1186Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.1236Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1626Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.4153Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02775Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.3799InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)acellular anatomical structure0.005511Moderately InformativeInherited
Fly Anatomy (FA)procuticle0.001555InformativeInherited
Fly Anatomy (FA)prepupa0.02947InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.05339Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2804Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4577Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.00005877Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003822Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03623Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6563Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00001534InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00004503Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000000000204Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0003568Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.03309Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000000000000105InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00001059InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 129 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]