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PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (915) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,241 80,177 146
Proteins 65,279 71,522 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.73490Least InformativeInherited
Molecular Function (MF)anion binding0.015410Moderately InformativeInherited
Molecular Function (MF)phospholipid binding0.0000028160InformativeDirect
Molecular Function (MF)phosphatidylinositol bisphosphate binding0.00000000096981Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001085 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000000000003886 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000000009307 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000000001547 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000000001634 Moderately Informative Direct
Biological Process (BP) immune system process 0.000000000225 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000007543 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000008521 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000925 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000004592 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00002967 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00007077 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0006014 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0158 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.6266 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3699 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01008 Moderately Informative Inherited
Biological Process (BP) system development 0.5272 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1204 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.4143 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.315 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.09852 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000002868 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000000000208 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000000007407 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000000000004626 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000000009418 Informative Direct
Biological Process (BP) behavior 0.000000000000968 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000001591 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003582 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000000001025 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000002014 Informative Direct
Biological Process (BP) epithelium development 0.0000000007867 Informative Direct
Biological Process (BP) generation of neurons 0.000000004941 Informative Direct
Biological Process (BP) regulation of growth 0.000000007791 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000008189 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000972 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000003406 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00003532 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00004055 Informative Direct
Biological Process (BP) post-embryonic development 0.00007517 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00007871 Informative Direct
Biological Process (BP) cell development 0.0001047 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0001469 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0001613 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0004293 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0006681 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0007028 Informative Direct
Biological Process (BP) positive regulation of transport 0.01492 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.9724 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1441 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.439 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2702 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.3699 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.00168 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2725 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.7903 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.8887 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1994 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.2129 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.02722 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3188 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8142 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phosphorylation 0.01566 Informative Inherited
Biological Process (BP) growth 0.1045 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3714 Informative Inherited
Biological Process (BP) pigment metabolic process 0.004022 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) cell adhesion 0.9361 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.0221 Informative Inherited
Biological Process (BP) embryo development 0.02685 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0799 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1528 Informative Inherited
Biological Process (BP) central nervous system development 0.8921 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2699 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.03745 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.06891 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0949 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8763 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001224 Informative Inherited
Biological Process (BP) ion homeostasis 0.7349 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) cell cycle process 0.005218 Informative Inherited
Biological Process (BP) secretion 0.6424 Informative Inherited
Biological Process (BP) lipid localization 0.4823 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0000000000000208 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.00000000000003886 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00000000000004369 Highly Informative Direct
Biological Process (BP) cell division 0.0000000000001465 Highly Informative Direct
Biological Process (BP) metamorphosis 0.0000000000006819 Highly Informative Direct
Biological Process (BP) hemopoiesis 0.0000000000008824 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000001366 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000002013 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000007482 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000001135 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000000002621 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000006348 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000001147 Highly Informative Direct
Biological Process (BP) endosomal transport 0.00000001362 Highly Informative Direct
Biological Process (BP) appendage development 0.000000151 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0000003084 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000005497 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000004218 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.000007494 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000008471 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.00001301 Highly Informative Direct
Biological Process (BP) coagulation 0.00002128 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.00002656 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00003169 Highly Informative Direct
Biological Process (BP) lipid modification 0.00004156 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00004645 Highly Informative Direct
Biological Process (BP) neuron development 0.00007539 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0001257 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0001291 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0002198 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0002406 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0003339 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.0004135 Highly Informative Direct
Biological Process (BP) wound healing 0.000765 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0007818 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0008339 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.0009781 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.001335 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.2427 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.03808 Highly Informative Inherited
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.06434 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.06827 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.00116 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.05602 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.0884 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.2672 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.2912 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.09499 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2741 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.03378 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1705 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.8836 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.2773 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.02157 Highly Informative Inherited
Biological Process (BP) regulation of actin filament polymerization 0.02165 Highly Informative Inherited
Biological Process (BP) negative regulation of protein polymerization 0.9925 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.5551 Highly Informative Inherited
Biological Process (BP) pigmentation 0.2529 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1368 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.361 Highly Informative Inherited
Biological Process (BP) endocytosis 0.7197 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01317 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.9316 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.4089 Highly Informative Inherited
Biological Process (BP) amide transport 0.007713 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6199 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.8717 Highly Informative Inherited
Biological Process (BP) innate immune response 0.04663 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002111 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.3482 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.7327 Highly Informative Inherited
Biological Process (BP) gliogenesis 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.3188 Highly Informative Inherited
Biological Process (BP) brain development 0.9355 Highly Informative Inherited
Biological Process (BP) cell migration 0.05078 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) synaptic signaling 0.009793 Highly Informative Inherited
Biological Process (BP) signal release 0.1749 Highly Informative Inherited
Biological Process (BP) regulated exocytosis 0.7434 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.04248 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.8051 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002037 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.007483 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.2241 Highly Informative Inherited
Biological Process (BP) germ cell development 0.6266 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.577 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.4422 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.6419 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3868 Highly Informative Inherited
Biological Process (BP) gastrulation 0.0946 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.01004 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.04194 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.05974 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.03194 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.02624 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00003526 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000755 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000000001399 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000002705 Informative Direct
Molecular Function (MF) kinase activity 0.0000000008242 Informative Direct
Molecular Function (MF) receptor binding 0.0007729 Informative Direct
Molecular Function (MF) amide binding 0.3357 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.003981 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0000000008415 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000000401 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000001865 Highly Informative Direct
Molecular Function (MF) steroid binding 0.0003366 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol bisphosphate binding 1 Highly Informative Inherited
Molecular Function (MF) carbohydrate derivative transporter activity 0.1704 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.8149 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1767 Highly Informative Inherited
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000001279 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00002438 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.00939 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.2841 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.8877 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.8845 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.589 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) site of polarized growth 0.000000000000008925 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000000000001513 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000003378 Informative Direct
Cellular Component (CC) nuclear envelope 0.0003332 Informative Direct
Cellular Component (CC) endosome 0.0003826 Informative Direct
Cellular Component (CC) side of membrane 0.008907 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) organelle subcompartment 0.0019 Informative Inherited
Cellular Component (CC) neuron projection 0.3337 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.002762 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.01108 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.1803 Informative Inherited
Cellular Component (CC) transport vesicle 1 Informative Inherited
Cellular Component (CC) membrane region 0.02221 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.6528 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.4675 Informative Inherited
Cellular Component (CC) vacuolar part 0.5451 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000000000001413 Highly Informative Direct
Cellular Component (CC) cell division site 0.000000000002663 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.000000000009463 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000005729 Highly Informative Direct
Cellular Component (CC) nuclear pore 0.00001001 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0003124 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0003506 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0004988 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum subcompartment 0.001706 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) myofibril 0.6758 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.3178 Highly Informative Inherited
Cellular Component (CC) vesicle membrane 0.4039 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 1 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.5033 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.362 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.001012 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.00204 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.06946 Highly Informative Inherited
Cellular Component (CC) tethering complex 0.001085 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.8646InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.8311Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2101Moderately InformativeInherited
Phenotypic Abnormality (PA)Juvenile myelomonocytic leukemia0.0006365Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.09889Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.227Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3582Least InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.7965Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1284InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.4177InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.00000946Highly InformativeDirect
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.0008478Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.9216Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000000004548Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000008029Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00003558Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00007474Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00009213Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002035Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0003544Least InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000001531Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000007098Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.1583Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1699Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2735Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.43Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4952Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.6385Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7675Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.00000047InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000007411InformativeDirect
Worm Phenotype (WP)growth rate variant0.000001861InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00003616InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0003203InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00335InformativeInherited
Worm Phenotype (WP)tail morphology variant0.004827InformativeInherited
Worm Phenotype (WP)defecation variant0.03325InformativeInherited
Worm Phenotype (WP)cell stress response variant0.1238InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1554InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.1918InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.2596InformativeInherited
Worm Phenotype (WP)metal response variant0.3503InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.3745InformativeInherited
Worm Phenotype (WP)cell number increased0.4999InformativeInherited
Worm Phenotype (WP)protein modification variant0.5218InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.599InformativeInherited
Worm Phenotype (WP)endocytic transport defect1InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant0.000000007383Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.000001396Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.000008585Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00001097Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00001284Highly InformativeDirect
Worm Phenotype (WP)antimicrobial gene expression variant0.00002026Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.000081Highly InformativeDirect
Worm Phenotype (WP)coelomocyte uptake defective0.0001385Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.00021Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0002476Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0002995Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.0003389Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0005682Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0006043Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.003719Highly InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.07305Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.1201Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.1202Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1613Highly InformativeInherited
Worm Phenotype (WP)cell differentiation variant0.166Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02768Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.3783InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003822Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03623Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6563Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00001534InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00004503Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000000000008871Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000549Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.03839Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000000000039InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00001846InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellular movement0.00000000000002064Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000002638Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.000003043Least InformativeDirect
Drugbank ATC_code (DB)immunosuppressants0.1628Moderately InformativeInherited
Drugbank ATC_code (DB)tofacitinib0.00008201InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00001811Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processImmunity4.822e-16Moderately InformativeDirect
Biological processCell cycle0.1556Moderately InformativeInherited
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.000000000001394InformativeDirect
Biological processMitosis0.000001648InformativeDirect
Biological processCell adhesion0.000004578InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processPhagocytosis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.0000000000001695Highly InformativeDirect
Biological processAdaptive immunity0.000000003263Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.00000001099Highly InformativeDirect
Biological processmRNA transport0.00000001234Highly InformativeDirect
Biological processSterol biosynthesis0.00007547Highly InformativeDirect
Biological processGlucose metabolism0.00009144Highly InformativeDirect
Biological processTranslocation1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000001503Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentMicrotubule0.00000000003113InformativeDirect
Cellular componentLysosome0.00009442InformativeDirect
Cellular componentCoated pit0.0006995Highly InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DiseaseTumor suppressor0.000009232Moderately InformativeDirect
DiseaseProto-oncogene0.0007423Moderately InformativeDirect
DiseaseNeuropathy0.0003889Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionZinc0.00000002076Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000000000005868Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0.00000000000001358Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000000005304Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.0001107Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001364Least InformativeDirect
Post-translational modificationMyristate0.000709InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0.0000005019Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 94 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 94 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]