SUPERFAMILY 1.75 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (913) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,136 80,177 146
Proteins 65,156 71,522 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00021010Least InformativeDirect
Biological Process (BP)developmental process1.906e-050Least InformativeDirect
Biological Process (BP)single-organism cellular process2.457e-070Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.478e-050Least InformativeDirect
Biological Process (BP)response to stimulus0.01560Least InformativeInherited
Biological Process (BP)localization0.11340Least InformativeInherited
Biological Process (BP)regulation of cellular process0.01171.722e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.76641Least InformativeInherited
Biological Process (BP)protein metabolic process0.40031Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.5581Least InformativeInherited
Biological Process (BP)macromolecule localization0.00024280.0002106Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00061551.297e-06Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00062950Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.59980.7436Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.79240.9393Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00069510.281Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.47070Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.13840Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.087250.1102Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.1250.128Moderately InformativeInherited
Biological Process (BP)response to organic substance0.35640.005209Moderately InformativeInherited
Biological Process (BP)cellular localization0.0075391.604e-14Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.93530.005405Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0041240Moderately InformativeInherited
Biological Process (BP)cell differentiation4.633e-061Moderately InformativeInherited
Biological Process (BP)system process0.058430.000141Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.045881.98e-11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.046730.00011Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.32091Moderately InformativeInherited
Biological Process (BP)organelle organization0.53515.839e-08Moderately InformativeInherited
Biological Process (BP)regulation of localization0.018042.795e-05Moderately InformativeInherited
Biological Process (BP)nervous system development0.021371.703e-07Moderately InformativeInherited
Biological Process (BP)signal transduction0.059520Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.037920.01051Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.052323.741e-15Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.00034950InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00042851.257e-07InformativeDirect
Biological Process (BP)cellular membrane organization0.00034712.147e-05InformativeDirect
Biological Process (BP)cell projection organization0.00010330InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.00089760.000159InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00048860InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.23e-053.206e-07InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0027370.02359InformativeInherited
Biological Process (BP)response to hormone stimulus0.0024870.2395InformativeInherited
Biological Process (BP)regulation of organelle organization0.13770InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.044280InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.019110InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.17490InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.033020InformativeInherited
Biological Process (BP)positive regulation of developmental process0.058480.3709InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.25520InformativeInherited
Biological Process (BP)cytoskeleton organization0.021810InformativeInherited
Biological Process (BP)actin filament-based process0.0094980InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0025580InformativeInherited
Biological Process (BP)phosphorylation0.0021310.03933InformativeInherited
Biological Process (BP)protein phosphorylation4.787e-050Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.187e-061.971e-12Highly InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity6.23e-073.049e-09Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.745e-052.457e-07Highly InformativeDirect
Biological Process (BP)cell junction organization2.075e-063.926e-10Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus5.443e-060Highly InformativeDirect
Biological Process (BP)neural precursor cell proliferation2.594e-089.124e-06Highly InformativeDirect
Biological Process (BP)stem cell proliferation2.227e-086.069e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus1.255e-060.0001786Highly InformativeDirect
Biological Process (BP)cellular response to peptide4.474e-070Highly InformativeDirect
Biological Process (BP)regulation of glucose import1.143e-080.009915Highly InformativeInherited
Biological Process (BP)positive regulation of organelle organization0.019324.675e-13Highly InformativeInherited
Biological Process (BP)glial cell differentiation5.614e-050.805Highly InformativeInherited
Biological Process (BP)regulation of membrane potential8.01e-051Highly InformativeInherited
Biological Process (BP)regulation of protein complex assembly0.00044990.001034Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.00028051Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis0.00020871Highly InformativeInherited
Molecular Function (MF)binding0.0001590Least InformativeDirect
Molecular Function (MF)transferase activity0.39111Least InformativeInherited
Molecular Function (MF)anion binding0.017360Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0051068.273e-09Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00032721.805e-12InformativeDirect
Molecular Function (MF)lipid binding0.0031560InformativeInherited
Molecular Function (MF)kinase activity0.0017137.097e-14InformativeInherited
Molecular Function (MF)protein kinase activity5.573e-054.601e-10Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding5.599e-091.017e-10Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.47481Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0027070Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.74949.331e-05Least InformativeInherited
Cellular Component (CC)membrane0.030840Least InformativeInherited
Cellular Component (CC)cell projection0.00013260Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.005280Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.0099630Moderately InformativeInherited
Cellular Component (CC)cell cortex3.385e-060InformativeDirect
Cellular Component (CC)cell leading edge1.229e-050InformativeDirect
Cellular Component (CC)actin cytoskeleton0.20481.423e-13InformativeInherited
Cellular Component (CC)apical plasma membrane5.054e-051.317e-10Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane8.541e-053.524e-10Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton1.925e-051.713e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.722e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 2.513e-08 Moderately Informative Direct
Biological Process (BP) system process 0.000141 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.741e-15 Moderately Informative Direct
Biological Process (BP) organelle organization 5.839e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.703e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 7.713e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.795e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002106 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.297e-06 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00011 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1.604e-14 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1.98e-11 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7436 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9393 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.008136 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.02941 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3704 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005209 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1102 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.128 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.005405 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.281 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2855 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01051 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 5.959e-12 Informative Direct
Biological Process (BP) cellular component movement 2.284e-14 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) synaptic transmission 1.2e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) response to wounding 0.0001428 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.257e-07 Informative Direct
Biological Process (BP) protein transport 0.0006995 Informative Direct
Biological Process (BP) cellular membrane organization 2.147e-05 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) dephosphorylation 1.587e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) biological adhesion 1.121e-07 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.45e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 2.471e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0.0002173 Informative Direct
Biological Process (BP) positive regulation of transport 2.723e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.13e-07 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 4.966e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of cell development 6.379e-14 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 2.863e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.000159 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.206e-07 Informative Direct
Biological Process (BP) regulation of ion transport 0.7813 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.2591 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02359 Informative Inherited
Biological Process (BP) apoptotic process 0.02703 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.8184 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5369 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.382 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001546 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.02276 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.2395 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5285 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6788 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.726 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3654 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.9225 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4839 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6797 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2874 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1429 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01387 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9728 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002625 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) growth 0.2447 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.07326 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.1135 Informative Inherited
Biological Process (BP) immune response 0.6329 Informative Inherited
Biological Process (BP) immune effector process 0.1832 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) lipid localization 0.953 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3709 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.04621 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.4037 Informative Inherited
Biological Process (BP) phosphorylation 0.03933 Informative Inherited
Biological Process (BP) central nervous system development 0.7236 Informative Inherited
Biological Process (BP) organelle localization 0.006089 Informative Inherited
Biological Process (BP) secretion by cell 0.04194 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.3729 Informative Inherited
Biological Process (BP) regulation of system process 0.5401 Informative Inherited
Biological Process (BP) regulation of growth 0.0373 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.09178 Informative Inherited
Biological Process (BP) muscle structure development 0.9411 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.06595 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4071 Informative Inherited
Biological Process (BP) epithelium development 0.7105 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.006494 Informative Inherited
Biological Process (BP) sexual reproduction 0.0207 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5761 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08191 Informative Inherited
Biological Process (BP) pigment metabolic process 0.07155 Informative Inherited
Biological Process (BP) leukocyte activation 0.7965 Informative Inherited
Biological Process (BP) response to nutrient levels 0.09236 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 4.876e-10 Highly Informative Direct
Biological Process (BP) phagocytosis 1.863e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 6.744e-13 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001816 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.582e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.971e-12 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) hemostasis 6.997e-12 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 4.675e-13 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00058 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0002405 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 2.675e-06 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 1.688e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 2.525e-11 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0009623 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.137e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.44e-09 Highly Informative Direct
Biological Process (BP) lipid modification 5.11e-05 Highly Informative Direct
Biological Process (BP) adult behavior 0.0005363 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 3.049e-09 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 2.457e-07 Highly Informative Direct
Biological Process (BP) cell junction organization 3.926e-10 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0002661 Highly Informative Direct
Biological Process (BP) wound healing 7.474e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 2.095e-07 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0001219 Highly Informative Direct
Biological Process (BP) innate immune response 0.0008415 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0002967 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.976e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 2.026e-09 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.166e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 2.114e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.608e-05 Highly Informative Direct
Biological Process (BP) leukocyte migration 2.241e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 6.984e-05 Highly Informative Direct
Biological Process (BP) cell division 0.0001104 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 9.124e-06 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) stem cell proliferation 6.069e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0001786 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 4.061e-07 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.009915 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.1597 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.9671 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.8373 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1176 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04849 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1607 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.103 Highly Informative Inherited
Biological Process (BP) cell growth 0.7239 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.007326 Highly Informative Inherited
Biological Process (BP) placenta development 0.901 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.6295 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.03968 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.001034 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.001036 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.007192 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) hair follicle development 0.5592 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01181 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02235 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) circadian rhythm 1 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.4603 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4467 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.002001 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9779 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.6046 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.466 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.897 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.2584 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.967 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.805 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.1243 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.4486 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.003191 Highly Informative Inherited
Biological Process (BP) exocytosis 0.01521 Highly Informative Inherited
Biological Process (BP) signal release 0.2908 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.02719 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2893 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1083 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9342 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1864 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9478 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.008162 Highly Informative Inherited
Biological Process (BP) fertilization 0.1158 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.04169 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.003123 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.001643 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein import 0.2077 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01223 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) mitosis 0.9917 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) B cell activation 0.7352 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.277 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2275 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.8257 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.1687 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.05274 Highly Informative Inherited
Biological Process (BP) organelle fusion 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 8.273e-09 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.756e-14 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.0007009 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 7.097e-14 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.805e-12 Informative Direct
Molecular Function (MF) enzyme binding 1.24e-12 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) protein kinase activity 4.601e-10 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 4.114e-06 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 2.682e-05 Highly Informative Direct
Molecular Function (MF) steroid binding 6.032e-05 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 8.257e-07 Highly Informative Direct
Molecular Function (MF) lipase activity 2.325e-14 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.745e-06 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 1.017e-10 Highly Informative Direct
Molecular Function (MF) alcohol binding 8.133e-11 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.03486 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.955 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.128 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 9.331e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 1.83e-09 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.387e-12 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) endosome 8.696e-09 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 1.423e-13 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0005747 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.7203 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.03167 Informative Inherited
Cellular Component (CC) vacuolar part 0.3056 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.317e-10 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 3.524e-10 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.0003534 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.713e-11 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0001046 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) cell body 4.547e-13 Highly Informative Direct
Cellular Component (CC) pore complex 0.0001892 Highly Informative Direct
Cellular Component (CC) cilium part 0.02286 Highly Informative Inherited
Cellular Component (CC) centrosome 1 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.9369 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.2555 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.6258 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.8209 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1023 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.8004 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.9131 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.2664 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.03728 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase4.532e-08InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula1.873e-14Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C3.652e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease1Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.9188Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.8284Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.7082InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06906Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0617Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1531Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5242Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8892Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.09401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1504Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.8001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.001919InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.07977InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.4398InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology9.028e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.0001639Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0.000956Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.6492Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.8798Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.362e-08Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant4.283e-06Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009567Least InformativeDirect
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organ system development variant7.006e-08Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001114Moderately Informat