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PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (920) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 74,117 183,983 146
Proteins 66,077 165,564 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.84390Least InformativeInherited
Molecular Function (MF)anion binding0.0046140Moderately InformativeInherited
Molecular Function (MF)phospholipid binding0.00000011490InformativeDirect
Molecular Function (MF)phosphatidylinositol bisphosphate binding0.41411Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000006465 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000308 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000000009312 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000000001529 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000000003827 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000000009057 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000000004383 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000002072 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00002327 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00004697 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00006949 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00009815 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000146 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01538 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2295 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.002877 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.1671 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1563 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02722 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7935 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000000668 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000000001267 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000000009312 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003038 Informative Direct
Biological Process (BP) behavior 0.000000000004114 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000000303 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000003928 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000000004358 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000001281 Informative Direct
Biological Process (BP) regulation of growth 0.000000001921 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000005931 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000004833 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000001025 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00001212 Informative Direct
Biological Process (BP) cell development 0.00001522 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000715 Informative Direct
Biological Process (BP) generation of neurons 0.0001658 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001704 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0005849 Informative Direct
Biological Process (BP) dephosphorylation 0.0007661 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0007886 Informative Direct
Biological Process (BP) microtubule-based process 0.0008422 Informative Direct
Biological Process (BP) response to cytokine 0.1257 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.8675 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01751 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1434 Informative Inherited
Biological Process (BP) secretion by cell 0.1215 Informative Inherited
Biological Process (BP) ion homeostasis 0.7506 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) growth 0.1645 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.07104 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002042 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.002419 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.6983 Informative Inherited
Biological Process (BP) organelle localization 0.8993 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.004741 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.987 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) membrane organization 0.1409 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1158 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.01305 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5551 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9347 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of immune response 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) lipid localization 0.4631 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.0049 Informative Inherited
Biological Process (BP) immune effector process 0.00924 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3892 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.001077 Informative Inherited
Biological Process (BP) cell activation 0.004891 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01313 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.04759 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1666 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2529 Informative Inherited
Biological Process (BP) phosphorylation 0.1055 Informative Inherited
Biological Process (BP) sensory organ development 0.8155 Informative Inherited
Biological Process (BP) cell-cell signaling 0.6651 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1226 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) embryo development 0.05018 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3518 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.399 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001671 Informative Inherited
Biological Process (BP) cell cycle process 0.009383 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.6 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) immune response 0.9181 Informative Inherited
Biological Process (BP) post-embryonic development 0.002364 Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000000007709 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000000000002163 Highly Informative Direct
Biological Process (BP) cell division 0.00000000001978 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000006206 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000000001394 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000004206 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000004912 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000003107 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000000411 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00000001141 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00000002024 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000002907 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000003556 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000433 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.00000005181 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000006791 Highly Informative Direct
Biological Process (BP) neuron development 0.0000001597 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.000003011 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.000003961 Highly Informative Direct
Biological Process (BP) appendage development 0.000008287 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00001524 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.00001762 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00002079 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0.0000302 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00003897 Highly Informative Direct
Biological Process (BP) coagulation 0.00004025 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00009722 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0001473 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0001812 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0002481 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0002632 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0004007 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0007789 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0007792 Highly Informative Direct
Biological Process (BP) wound healing 0.0008457 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00365 Highly Informative Inherited
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.05247 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.2882 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01613 Highly Informative Inherited
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.001087 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.002016 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.5109 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.2162 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.9724 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00249 Highly Informative Inherited
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.02103 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1085 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.1802 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3802 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.9554 Highly Informative Inherited
Biological Process (BP) divalent metal ion transport 0.3785 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.002357 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.03821 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.8555 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.2907 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.7292 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.8391 Highly Informative Inherited
Biological Process (BP) regulation of oxidoreductase activity 0.01851 Highly Informative Inherited
Biological Process (BP) neurological system process 0.8444 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.5916 Highly Informative Inherited
Biological Process (BP) pigmentation 0.3229 Highly Informative Inherited
Biological Process (BP) lipid modification 0.001871 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1603 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.9254 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.5355 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.004138 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.2658 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4785 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6528 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001414 Highly Informative Inherited
Biological Process (BP) innate immune response 0.05681 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.8792 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.05652 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.009423 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.01365 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01108 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.2494 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.02547 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.05108 Highly Informative Inherited
Biological Process (BP) signal release 0.1176 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9041 Highly Informative Inherited
Biological Process (BP) germ cell development 0.7705 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8081 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.7287 Highly Informative Inherited
Biological Process (BP) gastrulation 0.1225 Highly Informative Inherited
Biological Process (BP) fertilization 0.0266 Highly Informative Inherited
Biological Process (BP) nuclear division 0.1672 Highly Informative Inherited
Biological Process (BP) steroid biosynthetic process 0.3628 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0157 Highly Informative Inherited
Biological Process (BP) renal system process 0.9654 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.2462 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.03122 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.05559 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.05811 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.03679 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00003525 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.001014 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000000002221 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000002563 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000005617 Informative Direct
Molecular Function (MF) kinase activity 0.0000000008887 Informative Direct
Molecular Function (MF) receptor binding 0.0002843 Informative Direct
Molecular Function (MF) amide binding 0.3607 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.000000000000006357 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00000000000001697 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00000000004518 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.000000000198 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000001133 Highly Informative Direct
Molecular Function (MF) steroid binding 0.0003104 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol bisphosphate binding 1 Highly Informative Inherited
Molecular Function (MF) carbohydrate derivative transporter activity 0.1817 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.59 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.0929 Highly Informative Inherited
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000000004905 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000001063 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.002816 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.8681 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.538 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9423 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000000006155 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000000004916 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000000000007713 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000000009934 Informative Direct
Cellular Component (CC) side of membrane 0.000143 Informative Direct
Cellular Component (CC) endosome 0.0005143 Informative Direct
Cellular Component (CC) nuclear envelope 0.0007214 Informative Direct
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.9285 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.05003 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.05617 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.006755 Informative Inherited
Cellular Component (CC) membrane region 0.006973 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.8319 Informative Inherited
Cellular Component (CC) vacuolar part 0.9203 Informative Inherited
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000000000002241 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0000000004348 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.0000000401 Highly Informative Direct
Cellular Component (CC) nuclear pore 0.000002066 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0003669 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) contractile fiber part 0.003075 Highly Informative Inherited
Cellular Component (CC) myofibril 0.7594 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.3268 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.5706 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.7851 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.3602 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.4869 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.08224 Highly Informative Inherited
Cellular Component (CC) tethering complex 0.001513 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.8896InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.08433Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.7748Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01888Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2085Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.9991Moderately InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.4632InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.6466InformativeInherited
Phenotypic Abnormality (PA)Juvenile myelomonocytic leukemia0.0007291Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.136Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2772Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.1839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.6161Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.7959InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.0000103Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.4758Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.9307Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000000001186Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000000001059Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00000003382Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00002384Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00003357Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000354Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0008754Least InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000001477Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000002391Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000006481Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.08905Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1446Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2444Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2585Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.4828Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.6487Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.9973Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000000001528InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000008622InformativeDirect
Worm Phenotype (WP)brood size variant0.000001916InformativeDirect
Worm Phenotype (WP)growth rate variant0.000002176InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002314InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00004283InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0004855InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0009818InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.004886InformativeInherited
Worm Phenotype (WP)tail morphology variant0.005484InformativeInherited
Worm Phenotype (WP)defecation variant0.0361InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1631InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.2103InformativeInherited
Worm Phenotype (WP)cell stress response variant0.2181InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.3971InformativeInherited
Worm Phenotype (WP)cell number increased0.466InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.6907InformativeInherited
Worm Phenotype (WP)protein modification variant0.7171InformativeInherited
Worm Phenotype (WP)endocytic transport defect1InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant0.000000007099Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.0000009237Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.000002511Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00001285Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00001605Highly InformativeDirect
Worm Phenotype (WP)antimicrobial gene expression variant0.00001971Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.000034Highly InformativeDirect
Worm Phenotype (WP)coelomocyte uptake defective0.0001425Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0002168Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0003241Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.0003259Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0003946Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.000593Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0007637Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.003723Highly InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.06588Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.1104Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.1254Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.1594Highly InformativeInherited
Worm Phenotype (WP)cell differentiation variant0.1848Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02775Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.3798InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003822Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03623Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6563Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00001534InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00004503Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000000000004081Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0005692Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.07279Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000000000002376InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00001848InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000007913Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processImmunity9.633e-16Moderately InformativeDirect
Biological processCell cycle0.1606Moderately InformativeInherited
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.000000000001881InformativeDirect
Biological processMitosis0.000001913InformativeDirect
Biological processCell adhesion0.000004873InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processPhagocytosis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.0000000000002715Highly InformativeDirect
Biological processmRNA transport0.00000000393Highly InformativeDirect
Biological processAdaptive immunity0.000000005001Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.00000002193Highly InformativeDirect
Biological processSterol biosynthesis0.00006299Highly InformativeDirect
Biological processGlucose metabolism0.00009213Highly InformativeDirect
Biological processTranslocation1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000003162Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentMicrotubule0.00000000001206InformativeDirect
Cellular componentLysosome0.0001943InformativeDirect
Cellular componentCoated pit0.0007143Highly InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DiseaseTumor suppressor0.00001456Moderately InformativeDirect
DiseaseProto-oncogene0.0009511Moderately InformativeDirect
DiseaseNeuropathy0.0005774Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionZinc0.00000001166Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000000000008172Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0.000000000000009051Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000000005264Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.0001344Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001815Least InformativeDirect
Post-translational modificationMyristate0.0007515InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0.0000004835Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 94 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 94 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]