SUPERFAMILY 1.75 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (864) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 65,732 59,677 146
Proteins 58,694 53,151 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00019130Least InformativeDirect
Biological Process (BP)developmental process1.724e-050Least InformativeDirect
Biological Process (BP)single-organism cellular process1.031e-070Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.144e-050Least InformativeDirect
Biological Process (BP)response to stimulus0.013440Least InformativeInherited
Biological Process (BP)localization0.11460Least InformativeInherited
Biological Process (BP)regulation of cellular process0.014331.795e-07Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.80171Least InformativeInherited
Biological Process (BP)protein metabolic process0.3811Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.53081Least InformativeInherited
Biological Process (BP)macromolecule localization0.00020110.0002726Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00060141.146e-05Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00073750Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.002090.6004Moderately InformativeInherited
Biological Process (BP)regulation of localization0.037480.0001099Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.60740.5116Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.80491Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.12190.04412Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0890.06125Moderately InformativeInherited
Biological Process (BP)response to organic substance0.34960.002963Moderately InformativeInherited
Biological Process (BP)cellular localization0.0066311.947e-14Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.94250.01501Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.001270Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.20810.002377Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.47161Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.50710Moderately InformativeInherited
Biological Process (BP)organelle organization0.53131.099e-08Moderately InformativeInherited
Biological Process (BP)cell differentiation2.352e-061Moderately InformativeInherited
Biological Process (BP)nervous system development0.063833.816e-07Moderately InformativeInherited
Biological Process (BP)system process0.053537.52e-05Moderately InformativeInherited
Biological Process (BP)signal transduction0.06720Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.035670.005098Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.045031.932e-15Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.00032720InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00040977.883e-09InformativeDirect
Biological Process (BP)cell projection organization8.715e-050InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.0008040.0002225InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00045190InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.076e-057.487e-09InformativeDirect
Biological Process (BP)positive regulation of transport0.061361.487e-06InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0023550.002548InformativeInherited
Biological Process (BP)response to hormone stimulus0.0020160.09792InformativeInherited
Biological Process (BP)regulation of organelle organization0.1532.51e-12InformativeInherited
Biological Process (BP)regulation of nucleotide catabolic process0.039640InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.037060InformativeInherited
Biological Process (BP)positive regulation of developmental process0.14180.7753InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.079020InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.023111.017e-13InformativeInherited
Biological Process (BP)cytoskeleton organization0.023170InformativeInherited
Biological Process (BP)actin filament-based process0.010030InformativeInherited
Biological Process (BP)membrane organization0.0031850.003406InformativeInherited
Biological Process (BP)transmission of nerve impulse0.0010452.171e-08InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0027570InformativeInherited
Biological Process (BP)phosphorylation0.002120.02712InformativeInherited
Biological Process (BP)protein phosphorylation4.532e-050Highly InformativeDirect
Biological Process (BP)plasma membrane organization0.00013915.381e-05Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.273e-061.625e-11Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity1.521e-063.113e-13Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.568e-054.718e-05Highly InformativeDirect
Biological Process (BP)cell junction organization1.567e-061.931e-09Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus5.039e-060Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus6.376e-070.000156Highly InformativeDirect
Biological Process (BP)cellular response to peptide4.847e-070Highly InformativeDirect
Biological Process (BP)positive regulation of glucose import1.213e-090.178Highly InformativeInherited
Biological Process (BP)cell proliferation0.0077711Highly InformativeInherited
Biological Process (BP)regulation of protein complex assembly0.00045430.008052Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.027510.1675Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation5.73e-051Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis8.602e-051Highly InformativeInherited
Biological Process (BP)glial cell differentiation6.918e-050.597Highly InformativeInherited
Biological Process (BP)regulation of membrane potential3.368e-051Highly InformativeInherited
Molecular Function (MF)binding0.00014320Least InformativeDirect
Molecular Function (MF)anion binding0.013970Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0039885.637e-10Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00025824.563e-12InformativeDirect
Molecular Function (MF)lipid binding0.0037560InformativeInherited
Molecular Function (MF)kinase activity0.0013263.05e-15InformativeInherited
Molecular Function (MF)protein kinase activity4.665e-057.008e-10Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding4.826e-099.747e-11Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.48181Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0043290Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.59634.652e-07Least InformativeInherited
Cellular Component (CC)membrane0.010480Least InformativeInherited
Cellular Component (CC)cell projection0.00047470Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.006170Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.021790.0004005Moderately InformativeInherited
Cellular Component (CC)cell cortex4.181e-060InformativeDirect
Cellular Component (CC)cell leading edge1.125e-050InformativeDirect
Cellular Component (CC)actin cytoskeleton0.14956.446e-12InformativeInherited
Cellular Component (CC)apical plasma membrane8.759e-066.544e-11Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane9.131e-051.136e-10Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton1.318e-054.328e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.795e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 6.889e-09 Moderately Informative Direct
Biological Process (BP) system process 7.52e-05 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.932e-15 Moderately Informative Direct
Biological Process (BP) organelle organization 1.099e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 3.816e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.747e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001099 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002726 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.146e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1.947e-14 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.5116 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.5671 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01113 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.04539 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4175 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.002963 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.06125 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04412 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002377 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01501 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6004 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2939 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.005098 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 5.244e-10 Informative Direct
Biological Process (BP) cellular component movement 5.887e-14 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) response to wounding 6.764e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 7.883e-09 Informative Direct
Biological Process (BP) protein transport 0.0005879 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) dephosphorylation 0.000274 Informative Direct
Biological Process (BP) transmission of nerve impulse 2.171e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) biological adhesion 3.08e-06 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.303e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 2.51e-12 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 5.127e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 4.268e-14 Informative Direct
Biological Process (BP) generation of neurons 0.0006201 Informative Direct
Biological Process (BP) positive regulation of transport 1.487e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.368e-07 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.99e-10 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.519e-06 Informative Direct
Biological Process (BP) localization of cell 8.513e-11 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0002225 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.017e-13 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 7.487e-09 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.002548 Informative Inherited
Biological Process (BP) cell death 0.3607 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9504 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6919 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6903 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4582 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 1 Informative Inherited
Biological Process (BP) membrane organization 0.003406 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01489 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.09792 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5315 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6194 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.5562 Informative Inherited
Biological Process (BP) cell-cell signaling 0.4938 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4344 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3993 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3555 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.08438 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03954 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9576 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001248 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) growth 0.02344 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.05642 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) defense response 0.132 Informative Inherited
Biological Process (BP) immune response 0.616 Informative Inherited
Biological Process (BP) immune effector process 0.3763 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) lipid localization 0.9018 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7753 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.00845 Informative Inherited
Biological Process (BP) phosphorylation 0.02712 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) organelle localization 0.005163 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) secretion by cell 0.06222 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.2745 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of system process 0.8637 Informative Inherited
Biological Process (BP) regulation of growth 0.02853 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.07155 Informative Inherited
Biological Process (BP) muscle structure development 0.9875 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.05111 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2623 Informative Inherited
Biological Process (BP) cell activation 0.125 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01796 Informative Inherited
Biological Process (BP) sexual reproduction 0.05807 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7833 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2295 Informative Inherited
Biological Process (BP) epithelium development 0.9651 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1056 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 7.57e-10 Highly Informative Direct
Biological Process (BP) phagocytosis 2.268e-07 Highly Informative Direct
Biological Process (BP) chemotaxis 1.359e-12 Highly Informative Direct
Biological Process (BP) plasma membrane organization 5.381e-05 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001504 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 5.044e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.625e-11 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) hemostasis 2.435e-12 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 3.381e-07 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 9.895e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 7.785e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0001436 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 8.535e-12 Highly Informative Direct
Biological Process (BP) cell projection assembly 5.521e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 6.864e-10 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 3.113e-13 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 4.718e-05 Highly Informative Direct
Biological Process (BP) cell junction organization 1.931e-09 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0003138 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) wound healing 6.833e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 1.265e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 2.708e-05 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 9.433e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0002858 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0002874 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.569e-05 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.753e-08 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0004069 Highly Informative Direct
Biological Process (BP) coagulation 1.048e-05 Highly Informative Direct
Biological Process (BP) leukocyte migration 3.299e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0004467 Highly Informative Direct
Biological Process (BP) cell division 0.0001102 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 4.708e-09 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 3.749e-15 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.000156 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 2.847e-08 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 8.008e-05 Highly Informative Direct
Biological Process (BP) positive regulation of glucose import 0.178 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.1681 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04336 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.2745 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.08054 Highly Informative Inherited
Biological Process (BP) cell growth 0.6156 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.004317 Highly Informative Inherited
Biological Process (BP) cell proliferation 1 Highly Informative Inherited
Biological Process (BP) placenta development 0.8505 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.5425 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02395 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.008052 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.06601 Highly Informative Inherited
Biological Process (BP) hair follicle development 0.5614 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.02327 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02467 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03498 Highly Informative Inherited
Biological Process (BP) lipid modification 0.01011 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.4946 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4397 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001375 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9367 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5409 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.8935 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.2262 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.001794 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of transmission of nerve impulse 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1675 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.9159 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.007759 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.5284 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.009351 Highly Informative Inherited
Biological Process (BP) exocytosis 0.02822 Highly Informative Inherited
Biological Process (BP) signal release 0.3966 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.03646 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4103 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.597 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.03674 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.8776 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8693 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.4988 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9519 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.005147 Highly Informative Inherited
Biological Process (BP) fertilization 0.07874 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.168 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01713 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.00183 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein import 0.1944 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01229 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) mitosis 0.9091 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.009403 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.04747 Highly Informative Inherited
Biological Process (BP) B cell activation 0.7174 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2967 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.246 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.8032 Highly Informative Inherited
Biological Process (BP) neural tube development 0.9887 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.08779 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.2977 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.09651 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.9821 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 5.637e-10 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 3.21e-13 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 3.05e-15 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 4.563e-12 Informative Direct
Molecular Function (MF) enzyme binding 1.609e-12 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.001272 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) amide binding 0.9433 Informative Inherited
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 7.008e-10 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 1.081e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 1.271e-05 Highly Informative Direct
Molecular Function (MF) steroid binding 7.687e-05 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 4.982e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.159e-05 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 9.747e-11 Highly Informative Direct
Molecular Function (MF) alcohol binding 4.315e-11 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.029 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.9421 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.0435 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 4.652e-07 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 3.953e-10 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0004005 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) endosome 1.432e-09 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 6.446e-12 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001765 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.994 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.01779 Informative Inherited
Cellular Component (CC) vacuolar part 0.27 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) actin filament 3.267e-05 Highly Informative Direct
Cellular Component (CC) coated pit 4.497e-07 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0002307 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 3.891e-09 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 6.544e-11 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.136e-10 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 2.347e-07 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.0006067 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 4.328e-11 Highly Informative Direct
Cellular Component (CC) cell projection membrane 1.072e-05 Highly Informative Direct
Cellular Component (CC) leading edge membrane 2.804e-05 Highly Informative Direct
Cellular Component (CC) cell division site part 1.555e-14 Highly Informative Direct
Cellular Component (CC) cell body 1.247e-12 Highly Informative Direct
Cellular Component (CC) pore complex 0.0001559 Highly Informative Direct
Cellular Component (CC) contractile ring 1.047e-05 Highly Informative Direct
Cellular Component (CC) axon part 1 Highly Informative Inherited
Cellular Component (CC) dendrite 0.1767 Highly Informative Inherited
Cellular Component (CC) neuron spine 0.04454 Highly Informative Inherited
Cellular Component (CC) microvillus 0.009223 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.8562 Highly Informative Inherited
Cellular Component (CC) centrosome 1 Highly Informative Inherited
Cellular Component (CC) spindle 0.9984 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.229 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.65 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.674 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.09048 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.7182 Highly Informative Inherited
Cellular Component (CC) Golgi membrane 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.4026 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.02901 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase4.532e-08InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula1.873e-14Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C3.652e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)musculoskeletal system disease1Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.8158InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.9177Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.7169InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06949Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.05643Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.9012Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.8408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.002192InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.3723InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology8.635e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.0001238Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0.000957Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.648Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.6879Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.362e-08Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant4.283e-06Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0009567Least InformativeDirect
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organ system development variant7.006e-08Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001114Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.04673Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.4867Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.7249Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.9653Moderately InformativeInherited
Worm Phenotype (WP)endocytic transport defect1Moderately InformativeInherited
Worm Phenotype (WP)brood size variant8.564e-06InformativeDirect
Worm Phenotype (WP)cell migration variant4.001e-05InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0001942InformativeDirect
Worm Phenotype (WP)protein expression variant0.00042InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0006791InformativeDirect
Worm Phenotype (WP)cell stress response variant0.1242InformativeInherited
Worm Phenotype (WP)metal response variant0.1519InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.5478InformativeInherited
Worm Phenotype (WP)copulation variant0.6665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant1.048e-08Highly InformativeDirect
Worm Phenotype (WP)growth rate variant8.053e-07Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.121e-06Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes9.107e-06Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant1.083e-05Highly InformativeDirect
Worm Phenotype (WP)response to injury variant3.822e-05Highly InformativeDirect
Worm Phenotype (WP)coelomocyte uptake defective8.757e-05Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0004568Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0009288Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0009716Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.002843Highly InformativeInherited
Worm Phenotype (WP)defecation contraction variant0.00888Highly InformativeInherited
Worm Phenotype (WP)post hermaphrodite contact variant0.03239Highly InformativeInherited
Worm Phenotype (WP)male mating defective0.03511Highly InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.1285Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.01747Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.3028InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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