SUPERFAMILY 1.75 HMM library and genome assignments server

PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (914) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,206 80,177 146
Proteins 65,221 71,522 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00041720Least InformativeDirect
Biological Process (BP)developmental process0.00006780Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.00023180Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.000017840Least InformativeDirect
Biological Process (BP)regulation of cellular process0.02270.000003778Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.83391Least InformativeInherited
Biological Process (BP)localization0.13660Least InformativeInherited
Biological Process (BP)single-organism cellular process0.01540Least InformativeInherited
Biological Process (BP)response to stimulus0.0075870Least InformativeInherited
Biological Process (BP)protein metabolic process0.43091Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.5781Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.00017930Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00017280.000004346Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000033250Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00038160Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.00026140Moderately InformativeDirect
Biological Process (BP)cellular localization0.000036720Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.091830.139Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.93171Moderately InformativeInherited
Biological Process (BP)response to organic substance0.37030.006137Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.15280.1067Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.79520.0006678Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.54070Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.68130.7638Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.570.000000002025Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.12840Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.49750Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.050310.00006343Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.25611Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000030011Moderately InformativeInherited
Biological Process (BP)regulation of localization0.02120.0001239Moderately InformativeInherited
Biological Process (BP)nervous system development0.013030.00000009868Moderately InformativeInherited
Biological Process (BP)signal transduction0.021310Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.040950.01421Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.071840Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00072870InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.0002720InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00045510.0000001505InformativeDirect
Biological Process (BP)cell projection organization0.0000096280InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.00010740.00002251InformativeDirect
Biological Process (BP)single-organism membrane organization0.000054460.00001709InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00044960InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.00002460.0000005361InformativeDirect
Biological Process (BP)single-organism cellular localization0.00000000098370.00006725InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0031030.02471InformativeInherited
Biological Process (BP)cell proliferation0.0022820.3538InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.085230.00000000008846InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.035370InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.15050InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.01450InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.036310InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.0046710.000000000000003707InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.0027760InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.25220InformativeInherited
Biological Process (BP)positive regulation of developmental process0.11441InformativeInherited
Biological Process (BP)regulation of organelle organization0.15090InformativeInherited
Biological Process (BP)phosphorylation0.0043970.03208InformativeInherited
Biological Process (BP)protein phosphorylation0.000052230Highly InformativeDirect
Biological Process (BP)plasma membrane organization0.000028280.000003643Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.000000056740.0000000000003378Highly InformativeDirect
Biological Process (BP)ensheathment of neurons0.00000000034670.000003807Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity0.0000011390.000000000000007248Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization0.000018290.0000001015Highly InformativeDirect
Biological Process (BP)cell junction organization0.00000030440.000000000001443Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00032880.0006841Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.0000059350Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity0.000020920Highly InformativeDirect
Biological Process (BP)neural precursor cell proliferation0.000000027330.00008242Highly InformativeDirect
Biological Process (BP)stem cell proliferation0.000000023490.0003932Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus0.0000013140.0003268Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.00000049630Highly InformativeDirect
Biological Process (BP)regulation of glucose import0.000000012080.01229Highly InformativeInherited
Biological Process (BP)positive regulation of organelle organization0.038460.000000002668Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.00037371Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis0.00018771Highly InformativeInherited
Biological Process (BP)glial cell differentiation0.000030090.7663Highly InformativeInherited
Molecular Function (MF)binding0.00017920Least InformativeDirect
Molecular Function (MF)transferase activity0.46211Least InformativeInherited
Molecular Function (MF)anion binding0.018420Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0055690.00000001064Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00036830.000000000001823InformativeDirect
Molecular Function (MF)lipid binding0.0031180InformativeInherited
Molecular Function (MF)kinase activity0.0018260.00000000000008087InformativeInherited
Molecular Function (MF)protein kinase activity0.000060210.0000000003718Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding0.0000000059790.00000000005543Highly InformativeDirect
Molecular Function (MF)cell adhesion molecule binding0.0000006330.0000001532Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.47821Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.0065790Least InformativeInherited
Cellular Component (CC)membrane0.038790Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.7580.0007168Least InformativeInherited
Cellular Component (CC)cell projection0.00083840Moderately InformativeDirect
Cellular Component (CC)membrane region0.0041260.7324Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.0038310Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.028520.000001585Moderately InformativeInherited
Cellular Component (CC)cell cortex0.0000034780InformativeDirect
Cellular Component (CC)cell leading edge0.000011810InformativeDirect
Cellular Component (CC)plasma membrane region0.000039870.0000005267InformativeDirect
Cellular Component (CC)actin cytoskeleton0.19440.0000000001643InformativeInherited
Cellular Component (CC)apical plasma membrane0.0000090680.0000000002587Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.000017350.0000000004431Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000003778 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.00000000289 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000009868 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001716 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0006678 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001239 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000004346 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00006343 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000002025 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000000004707 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.139 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006137 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.02289 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1067 Moderately Informative Inherited
Biological Process (BP) defense response 0.05123 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.1722 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5804 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.08748 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5457 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01421 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7638 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.000964 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00000000002208 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) synaptic transmission 0.0001049 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000001505 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) dephosphorylation 0.00002596 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0006512 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) biological adhesion 0.000000005907 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002251 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0006552 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000001198 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) single-organism behavior 0.0002911 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00001709 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0003477 Informative Direct
Biological Process (BP) generation of neurons 0.0002811 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000001877 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000008846 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 0.000000000005181 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of cell development 0.00000000006132 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000001174 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000000000003707 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0000005361 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00006725 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0000000001024 Informative Direct
Biological Process (BP) regulation of ion transport 0.8208 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02471 Informative Inherited
Biological Process (BP) apoptotic process 0.008039 Informative Inherited
Biological Process (BP) growth 0.5188 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5565 Informative Inherited
Biological Process (BP) response to cytokine 0.559 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6674 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6656 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001411 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.08322 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2341 Informative Inherited
Biological Process (BP) muscle structure development 0.9502 Informative Inherited
Biological Process (BP) organelle localization 0.00688 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.03079 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.7891 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.02496 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.6882 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.06365 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2527 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.0257 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) immune effector process 0.1992 Informative Inherited
Biological Process (BP) immune response 0.5993 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) cell cycle process 0.768 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05111 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0176 Informative Inherited
Biological Process (BP) cell proliferation 0.3538 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.2803 Informative Inherited
Biological Process (BP) phosphorylation 0.03208 Informative Inherited
Biological Process (BP) central nervous system development 0.7373 Informative Inherited
Biological Process (BP) secretion by cell 0.002905 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) regulation of growth 0.02274 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4067 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.08557 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1766 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01358 Informative Inherited
Biological Process (BP) epithelium development 0.1238 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.3539 Informative Inherited
Biological Process (BP) sexual reproduction 0.3689 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell division 0.2149 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3481 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.07481 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01536 Informative Inherited
Biological Process (BP) leukocyte activation 0.7903 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2538 Informative Inherited
Biological Process (BP) cytokinesis 0.00000000007318 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.000003112 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0000000004833 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000001031 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000005694 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.000003643 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00001266 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000000005833 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000000003378 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0.000003807 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000000006969 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000000002668 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0007846 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0003407 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00001603 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000003397 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000000001689 Highly Informative Direct
Biological Process (BP) lipid modification 0.00005291 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000412 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.000000000000007248 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0000001015 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000000001443 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) wound healing 0.00008742 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.0009783 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0006841 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0.00000000004401 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000000000000001913 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000002021 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000007809 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.00001983 Highly Informative Direct
Biological Process (BP) coagulation 0.000003615 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.00003456 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0005969 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0001358 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.00000006155 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.00008242 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0003932 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0003268 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0003606 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.01229 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.9122 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.0632 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.1489 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.563 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.001327 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.2986 Highly Informative Inherited
Biological Process (BP) cell growth 0.3626 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.2904 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) placenta development 0.7799 Highly Informative Inherited
Biological Process (BP) in utero embryonic development 0.04105 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.9542 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.576 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.004481 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.03946 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.009236 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.007436 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.04698 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.00547 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01882 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.007442 Highly Informative Inherited
Biological Process (BP) circadian rhythm 1 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.4589 Highly Informative Inherited
Biological Process (BP) positive regulation of behavior 0.9665 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.5105 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.8177 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7526 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.887 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.4156 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9551 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.002222 Highly Informative Inherited
Biological Process (BP) innate immune response 0.003322 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.3789 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.1537 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.05846 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.4401 Highly Informative Inherited
Biological Process (BP) signal release 0.6657 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.002736 Highly Informative Inherited
Biological Process (BP) exocytosis 0.01216 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.7663 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.08036 Highly Informative Inherited
Biological Process (BP) regulation of alcohol biosynthetic process 0.01665 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02015 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.9837 Highly Informative Inherited
Biological Process (BP) cell recognition 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.007194 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.007843 Highly Informative Inherited
Biological Process (BP) germ cell development 0.9116 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.373 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.816 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.3569 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein import 0.2032 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.2724 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.3874 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 1 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 1 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.9736 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02733 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.1272 Highly Informative Inherited
Biological Process (BP) B cell activation 0.7896 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2931 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.8588 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7898 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000001064 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00000000000003802 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.00000000003757 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 0.00000000000008087 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000001823 Informative Direct
Molecular Function (MF) enzyme binding 0.00000000000483 Informative Direct
Molecular Function (MF) protein complex binding 0.000004115 Informative Direct
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.00117 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000003718 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.00000000002932 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.00003354 Highly Informative Direct
Molecular Function (MF) steroid binding 0.00008352 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.000001575 Highly Informative Direct
Molecular Function (MF) lipase activity 0.00000000000001653 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00000000005543 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0000000002817 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000001532 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.1769 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.9507 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.1435 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0007168 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0000000007956 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000000000008301 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000001585 Moderately Informative Direct
Cellular Component (CC) membrane region 0.7324 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.1606 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0.00000002263 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000001643 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000005267 Informative Direct
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.001461 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.1963 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) transporter complex 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.963 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.03319 Informative Inherited
Cellular Component (CC) vacuolar part 0.2932 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000000002587 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0000000004431 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000000000751 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0002347 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) cell body 0.000000000001213 Highly Informative Direct
Cellular Component (CC) pore complex 0.0002892 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0572 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.937 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.2749 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.1961 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.4925 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.4225 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.8797 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1306 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.005957 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease1Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.9189Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.8282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.7084InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06891Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.05211Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1809Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5732Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.9153Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.09399Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1623Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.8213Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.002228InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.08213InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.1442InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.000009565Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.0002173Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0.0008373Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.6332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.8816Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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