SUPERFAMILY 1.75 HMM library and genome assignments server

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PK beta-barrel domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PK beta-barrel domain-like [ 50799]
Superfamily:   PK beta-barrel domain-like [ 50800] (2)
Families:   Pyruvate kinase beta-barrel domain [ 50801]
  MOSC (MOCO sulphurase C-terminal) domain [ 101844] (2)


Superfamily statistics
Genomes (2,974) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,311 41,100 18
Proteins 8,277 41,030 18


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000009419 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000002078 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000002136 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000001967 Least Informative Direct
Biological Process (BP) primary metabolic process 0.08848 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4221 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1372 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000003359 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000000212 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0006352 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000002479 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00000000000002273 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000001578 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0003739 Moderately Informative Direct
Biological Process (BP) animal organ development 0.6794 Moderately Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0.00009373 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.29 Informative Inherited
Biological Process (BP) phosphorylation 0.8971 Informative Inherited
Biological Process (BP) glycolytic process 0.00000000006323 Highly Informative Direct
Molecular Function (MF) transferase activity 0.003544 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000000001615 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Pyruvate kinase0Highly InformativeDirect
Enzyme Commission (EC)Molybdenum cofactor sulfurtransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentMitochondrion0.002441Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.000000000001208InformativeDirect
Cellular componentPeroxisome0.000001109InformativeDirect
DomainTransit peptide0.000001858Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0.00000000000005123Least InformativeDirect
Molecular functionMetal-binding0.00000000002674Least InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionMolybdenum0.000000000005291InformativeDirect
Molecular functionPyruvate0Highly InformativeDirect
Molecular functionPyridoxal phosphate0.00000000002933Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.000004059Least InformativeDirect
Post-translational modificationIsopeptide bond0.000001706Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00007621Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011037 SSF50800 Protein matches
Abstract

This entry represents the beta-barrel domain (note: it does not include the beta/alpha-barrel it is inserted into). This domain has a similar topology to the beta-strand-rich C-terminal domain of molybdenum cofactor (MOCO) sulphurase (MOSC domain). MOSC domains are found alone in bacterial YiiM proteins, or fused to other domains, such as a NifS-like catalytic domain in MOCO sulphurase. The MOSC domain is predicted to be a sulphur-carrier domain that receives sulphur abstracted from pyridoxal phosphate-dependent NifS-like enzymes, using it for the formation of diverse sulphur-metal clusters [PubMed11886751].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PK beta-barrel domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PK beta-barrel domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]