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Sialidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Sialidases [ 50939] (2)
Families:   Sialidases (neuraminidases) [ 50940] (9)
  Endo-alpha-sialidase [ 117276]


Superfamily statistics
Genomes (1,244) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,788 104,598 43
Proteins 3,369 102,737 43


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.00000000057230.0000002841Least InformativeDirect
Biological Process (BP)primary metabolic process0.00000014040.00003362Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000006330.0004771Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00089250.002868Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.014030.001002Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000000000020160.00000000000501Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000000000033070.000000000005383Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.000011570.0000007779Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.000011760.0000002942Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.000024650.00001274Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.011620.008214Moderately InformativeInherited
Biological Process (BP)liposaccharide metabolic process00InformativeDirect
Biological Process (BP)membrane lipid metabolic process00InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.00000064240.000000001487InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000013590.000000684InformativeDirect
Biological Process (BP)lipid catabolic process0.000079710.000004164InformativeDirect
Biological Process (BP)glycosphingolipid metabolic process00Highly InformativeDirect
Biological Process (BP)oligosaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process00Highly InformativeDirect
Molecular Function (MF)hydrolase activity00.0000000002119Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00053830.01361Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.092910.7587Least InformativeInherited
Cellular Component (CC)vacuole0.00096670.00002147Moderately InformativeDirect
Cellular Component (CC)lytic vacuole0.0000053950.0000005988InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0000002841 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00003362 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0004771 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9224 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002868 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.001002 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.00000000000501 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000000005383 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0000007779 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000002942 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00001274 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.1697 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2514 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2544 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4684 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1648 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2061 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.008214 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1204 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3847 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06639 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3294 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6381 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2684 Moderately Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000001487 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.000000684 Informative Direct
Biological Process (BP) lipid catabolic process 0.000004164 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000634 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0009332 Informative Direct
Biological Process (BP) generation of neurons 0.00933 Informative Inherited
Biological Process (BP) cell development 0.09233 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.0207 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01189 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.009604 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.002863 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.003071 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.009326 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.01856 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.2565 Informative Inherited
Biological Process (BP) localization of cell 0.09699 Informative Inherited
Biological Process (BP) central nervous system development 0.006566 Informative Inherited
Biological Process (BP) phosphorylation 0.01463 Informative Inherited
Biological Process (BP) locomotion 0.01282 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.005746 Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0 Highly Informative Direct
Biological Process (BP) forebrain development 0.00001235 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00003531 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0005571 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.003916 Highly Informative Inherited
Biological Process (BP) neuron development 0.002583 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000002119 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01361 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7587 Least Informative Inherited
Cellular Component (CC) vacuole 0.00002147 Moderately Informative Direct
Cellular Component (CC) lytic vacuole 0.0000005988 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8292Least InformativeInherited
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processProtein transport0.0000000006959Moderately InformativeDirect
Biological processCarbohydrate metabolism0.0000004718Moderately InformativeDirect
Biological processLipid metabolism0.001736Moderately InformativeInherited
Biological processVirus entry into host cell0InformativeDirect
Biological processLipid degradation0.000000000000179InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000002281Moderately InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentLysosome0.0001675InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationReceptor0.0000001815Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011040 SSF50939 Protein matches
Abstract

Neuraminidases (sialidases) hydrolyse the non-reducing, terminal sialic acid linkage in various natural substrates, such as glycoproteins, glycolipids, gangliosides, and polysaccharides [PubMed12374200]. In mammals, neuraminidases occur in the lysosome, the cytosol, and associated with the plasma membrane. Neuraminidases have also been implicated in the pathogenesis of many diseases. For example, in viruses neuraminidases enable the transport of the virus through mucin, the eruption of the virus from the infected host cell, and the prevention of self-aggregation of virus particles through the destruction of the host cell receptor recognised by the virus [PubMed14561719]. Eukaryotic, bacterial and viral neuraminidases share highly conserved regions of beta-sheet motifs. Bacterial neuraminidases often possess domains in addition to the catalytic neuraminidase domain, for instance the neuraminidase from Micromonospora viridifaciens contains three domains, of which the catalytic domain described here is the N-terminal domain [PubMed8591030]. Similarly, leech neuraminidase is a multidomain protein, where the catalytic domain is the C-terminal domain [PubMed9878409]. In several paramyxoviruses, neuraminidase forms part of the multi-functional haemagglutinin-neuraminidase glycoprotein found on the viral envelope [PubMed14729348].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sialidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Sialidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]