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Galactose oxidase, central domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Galactose oxidase, central domain [ 50965]
Families:   Galactose oxidase, central domain [ 50966]


Superfamily statistics
Genomes (746) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,315 29,859 6
Proteins 6,938 28,459 6


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.3075 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8773 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.7406 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5224 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.679 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5439 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4194 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0003179 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001991 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05722 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2737 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3098 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4001 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2471 Moderately Informative Inherited
Biological Process (BP) system development 0.6002 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.6385 Moderately Informative Inherited
Biological Process (BP) cell activation 0.0004092 Informative Direct
Biological Process (BP) growth 0.00002615 Informative Direct
Biological Process (BP) proteolysis 0.04329 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1725 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.00715 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1345 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02802 Informative Inherited
Biological Process (BP) leukocyte differentiation 0.000001178 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000002085 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0002952 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000006211 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000003018 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0004948 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000286 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00006384 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.000712 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.07081 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.03217 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.00000766 Informative Direct
Molecular Function (MF) zinc ion binding 0.00003146 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.01945 Informative Inherited
Molecular Function (MF) chromatin binding 0.00001063 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.000000000211 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.9982 Least Informative Inherited
Cellular Component (CC) transferase complex 0.002977 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000003202 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0004907 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01047Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.8351Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.0000005474Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.00002145Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.0003956InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.003829InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.00000000001011Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDNA recombination0.0001393InformativeDirect
Cellular componentNucleus0.0008927Least InformativeDirect
Cellular componentCell projection0.00001492Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationChromatin regulator0.0000001057InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)tRNA modification0.000000439InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011043 SSF50965 Protein matches
Abstract

This entry represents a beta-propeller domain found in galactose oxidase and in Kelch repeat-containing proteins.

The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [PubMed7593276]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [PubMed8126718].

Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde [PubMed11698678]. The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation [PubMed12418174]. Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich, the central domain forms a seven 4-bladed beta-propeller, and the C-terminal domain has an immunoglobulin-like fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose oxidase, central domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Galactose oxidase, central domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]