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Galactose oxidase, central domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Galactose oxidase, central domain [ 50965]
Families:   Galactose oxidase, central domain [ 50966]


Superfamily statistics
Genomes (748) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,334 29,859 6
Proteins 6,953 28,459 6


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5278 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5485 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.3233 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6848 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8893 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.7459 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4034 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0004436 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00265 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3123 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6346 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06243 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2905 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3125 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3978 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2832 Moderately Informative Inherited
Biological Process (BP) growth 0.00001477 Informative Direct
Biological Process (BP) cell activation 0.0004317 Informative Direct
Biological Process (BP) hemopoiesis 0.0007229 Informative Direct
Biological Process (BP) proteolysis 0.04068 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1833 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.007312 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1365 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02619 Informative Inherited
Biological Process (BP) cell growth 0.0000000001082 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000003251 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.000001229 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000001886 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000002769 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00007208 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0002904 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0005028 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.001039 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.07342 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.03534 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.000009364 Informative Direct
Molecular Function (MF) zinc ion binding 0.00003748 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.02278 Informative Inherited
Molecular Function (MF) phosphatidylinositol phosphate binding 0.00000001745 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00001184 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.002072 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000003085 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0006215 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDNA recombination0.0001283InformativeDirect
Cellular componentNucleus0.000298Least InformativeDirect
Cellular componentCell projection0.00001488Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationChromatin regulator0.00000009696InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011043 SSF50965 Protein matches
Abstract

This entry represents a beta-propeller domain found in galactose oxidase and in Kelch repeat-containing proteins.

The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [PubMed7593276]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [PubMed8126718].

Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde [PubMed11698678]. The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation [PubMed12418174]. Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich, the central domain forms a seven 4-bladed beta-propeller, and the C-terminal domain has an immunoglobulin-like fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose oxidase, central domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Galactose oxidase, central domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]