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Galactose oxidase, central domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Galactose oxidase, central domain [ 50965]
Families:   Galactose oxidase, central domain [ 50966]


Superfamily statistics
Genomes (741) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,105 16,214 6
Proteins 6,763 15,735 6


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.9643 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7895 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7007 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7176 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6488 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8478 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6673 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0002199 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.002466 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1911 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.8834 Moderately Informative Inherited
Biological Process (BP) system development 0.7245 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2592 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3404 Moderately Informative Inherited
Biological Process (BP) cell adhesion 0.000002301 Informative Direct
Biological Process (BP) growth 0.00002008 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.1745 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.08816 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01208 Informative Inherited
Biological Process (BP) DNA recombination 0.000001665 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.0000003024 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0007773 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000003968 Highly Informative Direct
Biological Process (BP) hemopoiesis 0.0003768 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00008819 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000002311 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00005834 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.02543 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.05647 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.5638 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.000006275 Informative Direct
Molecular Function (MF) zinc ion binding 0.00002272 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0007063 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.01823 Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.0000000002008 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.004103 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000002366 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0003637 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0109Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.8546Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.0000002056Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.00002543Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.0004101InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.003971InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.00000000001048Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDNA recombination0.0001406InformativeDirect
Cellular componentNucleus0.0008014Least InformativeDirect
Cellular componentCell projection0.00001036Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationChromatin regulator0.0000001057InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)tRNA modification0.0000004654InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011043 SSF50965 Protein matches
Abstract

This entry represents a beta-propeller domain found in galactose oxidase and in Kelch repeat-containing proteins.

The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [PubMed7593276]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [PubMed8126718].

Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde [PubMed11698678]. The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation [PubMed12418174]. Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich, the central domain forms a seven 4-bladed beta-propeller, and the C-terminal domain has an immunoglobulin-like fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose oxidase, central domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Galactose oxidase, central domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]