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WD40 repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   WD40 repeat-like [ 50978] (2)
Families:   WD40-repeat [ 50979] (10)
  Cell cycle arrest protein BUB3 [ 110289]


Superfamily statistics
Genomes (1,131) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 116,205 295,342 21
Proteins 106,129 268,874 19


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000150.00000000002755Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation0.000000000000066720.3141Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.055891Least InformativeInherited
Biological Process (BP)response to stimulus0.87781Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process10.0002725Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.96340.01106Least InformativeInherited
Biological Process (BP)heterocycle metabolic process10.00012Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process10.01288Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)gene expression0.00000002740Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00006350.0000000000001311Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.00000072970.0000001857Moderately InformativeDirect
Biological Process (BP)cellular localization0.00000000022880Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.74840.6325Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.34821Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.74410.0000004339Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.25650.1835Moderately InformativeInherited
Biological Process (BP)single-organism transport11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis10.536Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.63330.9723Moderately InformativeInherited
Biological Process (BP)organic substance transport0.049871Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.0040320.05358Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.085791Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.024191Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.16731Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.071171Moderately InformativeInherited
Biological Process (BP)cell communication0.064151Moderately InformativeInherited
Biological Process (BP)system development0.38121Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.4671Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.6170.5647Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.60410.4537Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.68790.9182Moderately InformativeInherited
Biological Process (BP)organelle organization0.12250Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000000045760.5324Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.000020941Moderately InformativeInherited
Biological Process (BP)reproduction0.00036640.003436Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.068290.598Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.012830.0009413Moderately InformativeInherited
Biological Process (BP)single organism signaling0.012211Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.18941Moderately InformativeInherited
Biological Process (BP)cellular component assembly10.001336Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle0.00003410.0003395InformativeDirect
Biological Process (BP)cell cycle process0.0000000000012980InformativeDirect
Biological Process (BP)regulation of organelle organization0.000036850.0000005043InformativeDirect
Biological Process (BP)regulation of cell cycle0.0000000081080InformativeDirect
Biological Process (BP)single-organism intracellular transport0.0001250.0000000000005448InformativeDirect
Biological Process (BP)negative regulation of transport0.5950.8925InformativeInherited
Biological Process (BP)regulation of protein modification process0.24850.5273InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.059861InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.037010.03837InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.0067130.09738InformativeInherited
Biological Process (BP)negative regulation of molecular function0.59771InformativeInherited
Biological Process (BP)regulation of ion transport0.21841InformativeInherited
Biological Process (BP)protein localization to organelle0.91841InformativeInherited
Biological Process (BP)intracellular protein transport0.00004590.268InformativeInherited
Biological Process (BP)organelle localization0.043770.9056InformativeInherited
Biological Process (BP)chromosome organization0.00000000023860.6792InformativeInherited
Biological Process (BP)tissue development0.94230.9098InformativeInherited
Biological Process (BP)post-embryonic development0.0016530.0008264InformativeInherited
Biological Process (BP)pigment metabolic process0.039940.4441InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.002490.2154InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.083110.8425InformativeInherited
Biological Process (BP)positive regulation of gene expression0.54591InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00043240.7618InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.55951InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.011080.8833InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.30050.4947InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.010590.00006042InformativeInherited
Biological Process (BP)reproductive system development0.013130.0085InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.87591InformativeInherited
Biological Process (BP)negative regulation of cell communication0.19050.8928InformativeInherited
Biological Process (BP)negative regulation of signaling0.21170.865InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.000000020730.07202InformativeInherited
Biological Process (BP)single organism reproductive process0.0019340.002625InformativeInherited
Biological Process (BP)cellular component morphogenesis11InformativeInherited
Biological Process (BP)cell development0.56220.0173InformativeInherited
Biological Process (BP)response to extracellular stimulus0.0020310.0000000006446InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.000000037550.963InformativeInherited
Biological Process (BP)DNA metabolic process0.86161InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.97651InformativeInherited
Biological Process (BP)multi-organism reproductive process0.064530.01092InformativeInherited
Biological Process (BP)organelle assembly10.00000000004983InformativeInherited
Biological Process (BP)cell cycle checkpoint0.000000000095320.0000004102Highly InformativeDirect
Biological Process (BP)autophagy0.0000000086990Highly InformativeDirect
Biological Process (BP)protein alkylation00.00000001142Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly00Highly InformativeDirect
Biological Process (BP)histone modification00.0000001477Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification00.0000000761Highly InformativeDirect
Biological Process (BP)response to nutrient levels0.00033080.00004583Highly InformativeDirect
Biological Process (BP)cellular response to extracellular stimulus0.00032420.00000000000001439Highly InformativeDirect
Biological Process (BP)regulation of microtubule-based process0.00000043360.000000114Highly InformativeDirect
Biological Process (BP)macromolecule methylation0.000000000069810.00001599Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00000005480.00001317Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.0000051490.00002771Highly InformativeDirect
Biological Process (BP)regulation of chromosome organization0.0013940.4414Highly InformativeInherited
Biological Process (BP)regulation of cell division0.0016210.007805Highly InformativeInherited
Biological Process (BP)positive regulation of cellular component biogenesis0.000012260.5251Highly InformativeInherited
Biological Process (BP)negative regulation of ion transmembrane transport0.00062050.0453Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0043360.8278Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.013660.9712Highly InformativeInherited
Biological Process (BP)regulation of calcium ion transport0.0094650.7071Highly InformativeInherited
Biological Process (BP)nucleobase-containing compound transport0.0000014230.02526Highly InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.012770.03841Highly InformativeInherited
Biological Process (BP)nuclear export0.0000000005990.009671Highly InformativeInherited
Biological Process (BP)ribonucleoprotein complex localization0.0000005040.1027Highly InformativeInherited
Biological Process (BP)nuclear division0.0000000000093180.3565Highly InformativeInherited
Biological Process (BP)nuclear chromosome segregation0.000034420.3462Highly InformativeInherited
Biological Process (BP)establishment of RNA localization0.0000000037250.007024Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle phase transition0.016331Highly InformativeInherited
Biological Process (BP)negative regulation of mitotic cell cycle0.38391Highly InformativeInherited
Biological Process (BP)regulation of nuclear division0.11480.0006087Highly InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.000091580.4543Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-templated0.0059560.6054Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0068461Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.00069961Highly InformativeInherited
Biological Process (BP)seed development0.089180.00001578Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.35121Highly InformativeInherited
Biological Process (BP)trichome differentiation0.0079380.02886Highly InformativeInherited
Biological Process (BP)flavonoid biosynthetic process0.000005190.002731Highly InformativeInherited
Biological Process (BP)nucleus organization0.00000070180.07329Highly InformativeInherited
Molecular Function (MF)binding0.00020031Least InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.097480.9777Moderately InformativeInherited
Molecular Function (MF)small molecule binding11Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding0.000013391Moderately InformativeInherited
Molecular Function (MF)phospholipid binding0.0058510.137InformativeInherited
Molecular Function (MF)DNA binding0.91441InformativeInherited
Molecular Function (MF)enzyme binding0.56090.6014InformativeInherited
Molecular Function (MF)amide binding0.011971InformativeInherited
Molecular Function (MF)RNA binding0.19840.1418InformativeInherited
Molecular Function (MF)phosphatidylinositol bisphosphate binding0.0000042290.0001789Highly InformativeDirect
Molecular Function (MF)sequence-specific DNA binding0.11361Highly InformativeInherited
Molecular Function (MF)kinase binding0.025460.2823Highly InformativeInherited
Molecular Function (MF)translation factor activity, RNA binding0.0000000034990.006065Highly InformativeInherited
Molecular Function (MF)peptide binding0.0010761Highly InformativeInherited
Cellular Component (CC)macromolecular complex00Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.00000040360Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000000000011290Least InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.32061Least InformativeInherited
Cellular Component (CC)nuclear part00Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.000000002680Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.00000056540.0000000000001771Moderately InformativeDirect
Cellular Component (CC)whole membrane0.000000066420.0000000000006671Moderately InformativeDirect
Cellular Component (CC)transferase complex0.00000000037640Moderately InformativeDirect
Cellular Component (CC)cytosolic part0.03680.9499Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)membrane protein complex11Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.00071721Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.82170.00001936Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.0000000000000052140InformativeDirect
Cellular Component (CC)lytic vacuole0.00089030.0000367InformativeDirect
Cellular Component (CC)nuclear envelope00.00001104InformativeDirect
Cellular Component (CC)extrinsic component of membrane0.000000044260.000000251InformativeDirect
Cellular Component (CC)vacuolar part0.000073150.00000003211InformativeDirect
Cellular Component (CC)chromosome0.000000000000010281InformativeInherited
Cellular Component (CC)nucleoplasm part0.24290.4334InformativeInherited
Cellular Component (CC)transferase complex, transferring phosphorus-containing groups11InformativeInherited
Cellular Component (CC)actin cytoskeleton0.41861InformativeInherited
Cellular Component (CC)side of membrane0.0000000052540.5683InformativeInherited
Cellular Component (CC)plasma membrane protein complex0.00000062710.4137InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.33350.0000000002257InformativeInherited
Cellular Component (CC)kinetochore0.0000000000000013540.0000000005784Highly InformativeDirect
Cellular Component (CC)nuclear pore00.00000000000002638Highly InformativeDirect
Cellular Component (CC)lysosomal membrane0.000000000097280.000000009832Highly InformativeDirect
Cellular Component (CC)Arp2/3 protein complex0.000028780.0001542Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00000000049730.0002876Highly InformativeDirect
Cellular Component (CC)methylosome0.0000001850.00002697Highly InformativeDirect
Cellular Component (CC)SMN-Sm protein complex0.0000021510.00001252Highly InformativeDirect
Cellular Component (CC)germ cell nucleus0.00099680.0005309Highly InformativeDirect
Cellular Component (CC)chromatin11Highly InformativeInherited
Cellular Component (CC)transcription elongation factor complex0.0000055480.1949Highly InformativeInherited
Cellular Component (CC)GTPase complex0.000000045950.001818Highly InformativeInherited
Cellular Component (CC)spindle0.0013240.000002061Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0002725 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000002755 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00012 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.3141 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01288 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.01106 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000000000007367 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000000000001311 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0009413 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000004339 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000001857 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6325 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5647 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4738 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003436 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4537 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8951 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1835 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.05358 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.598 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.001336 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9182 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.5324 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9723 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.536 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0003395 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00006042 Informative Direct
Biological Process (BP) proteolysis 0.000000006736 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0005776 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) embryo development 0.00002921 Informative Direct
Biological Process (BP) post-embryonic development 0.0008264 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00001483 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0000000006446 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000000003764 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000005043 Informative Direct
Biological Process (BP) ncRNA processing 0.00000003026 Informative Direct
Biological Process (BP) ribosome biogenesis 0.0001778 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000003435 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) organelle assembly 0.00000000004983 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0000000000005448 Informative Direct
Biological Process (BP) negative regulation of transport 0.8925 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.5273 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.2939 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.03837 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.09738 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4417 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9958 Informative Inherited
Biological Process (BP) secretion by cell 0.9188 Informative Inherited
Biological Process (BP) intracellular protein transport 0.268 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.2802 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) sensory organ development 0.009433 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.8595 Informative Inherited