SUPERFAMILY 1.75 HMM library and genome assignments server


WD40 repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   WD40 repeat-like [ 50978] (2)
Families:   WD40-repeat [ 50979] (10)
  Cell cycle arrest protein BUB3 [ 110289]


Superfamily statistics
Genomes (1,123) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 114,549 128,176 21
Proteins 104,616 117,222 19


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.00025621.357e-08Least InformativeDirect
Biological Process (BP)single-organism cellular process4.283e-148.709e-08Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0016680.7953Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.44581.089e-06Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.1257Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.36271.762e-07Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.73180.000338Least InformativeInherited
Biological Process (BP)localization0.023320.06077Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process1.456e-051Least InformativeInherited
Biological Process (BP)developmental process5.086e-050.6151Least InformativeInherited
Biological Process (BP)protein metabolic process0.065541Least InformativeInherited
Biological Process (BP)biosynthetic process0.14731Least InformativeInherited
Biological Process (BP)response to stimulus0.00013961Least InformativeInherited
Biological Process (BP)organelle organization9.39e-120Moderately InformativeDirect
Biological Process (BP)gene expression4.894e-061.091e-14Moderately InformativeDirect
Biological Process (BP)macromolecule localization7.712e-090Moderately InformativeDirect
Biological Process (BP)cellular localization0.00028720Moderately InformativeDirect
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.33450.09867Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)homeostatic process0.87841Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.85410.01391Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.0021861Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.14951Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10721Moderately InformativeInherited
Biological Process (BP)signal transduction0.22961Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.11241Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0022480.0002588Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.81050.962Moderately InformativeInherited
Biological Process (BP)reproduction0.0022120.04434Moderately InformativeInherited
Biological Process (BP)organ development0.50311Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.93390.6747Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.80070.0004842Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization10.8937Moderately InformativeInherited
Biological Process (BP)organic substance transport0.022981Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.74194.792e-14Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.58010.001108Moderately InformativeInherited
Biological Process (BP)microtubule-based process3.266e-060InformativeDirect
Biological Process (BP)cell cycle process2.013e-081.269e-14InformativeDirect
Biological Process (BP)regulation of organelle organization1.409e-053.278e-08InformativeDirect
Biological Process (BP)positive regulation of protein modification process0.08820.002203InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.049650.006343InformativeInherited
Biological Process (BP)regulation of cell cycle process7.404e-050.001055InformativeInherited
Biological Process (BP)regulation of ion transport0.44671InformativeInherited
Biological Process (BP)negative regulation of transport0.63831InformativeInherited
Biological Process (BP)cytoskeleton organization0.73011InformativeInherited
Biological Process (BP)embryonic morphogenesis0.016930.6148InformativeInherited
Biological Process (BP)cellular component movement0.55720.4365InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter1.189e-050.325InformativeInherited
Biological Process (BP)cell projection organization0.74575.303e-05InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.65321InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.1971InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.020141InformativeInherited
Biological Process (BP)intracellular signal transduction11InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.30082.524e-05InformativeInherited
Biological Process (BP)reproductive system development0.0071320.001155InformativeInherited
Biological Process (BP)cellular membrane organization0.81890.217InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.00064280.9631InformativeInherited
Biological Process (BP)protein transport0.012153.493e-07InformativeInherited
Biological Process (BP)chromosome organization9.837e-070.5887InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.0016770.2427InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.0014350.3364InformativeInherited
Biological Process (BP)mitotic cell cycle0.0047960.09254InformativeInherited
Biological Process (BP)organelle localization0.024220.3112InformativeInherited
Biological Process (BP)nitrogen compound transport0.43411InformativeInherited
Biological Process (BP)cytoplasmic transport0.0011350.09332InformativeInherited
Biological Process (BP)response to nutrient levels3.654e-070.0104InformativeInherited
Biological Process (BP)organelle assembly0.96371.482e-12InformativeInherited
Biological Process (BP)protein methylation3.029e-050.0001752Highly InformativeDirect
Biological Process (BP)autophagy2.28e-080Highly InformativeDirect
Biological Process (BP)chromosome segregation2.654e-070.0001038Highly InformativeDirect
Biological Process (BP)cellular response to starvation1.123e-055.93e-08Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.00055860.0001942Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport0.00059228.554e-05Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly02.125e-14Highly InformativeDirect
Biological Process (BP)histone modification03.843e-07Highly InformativeDirect
Biological Process (BP)protein import1.033e-061.118e-07Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification1.041e-076.541e-05Highly InformativeDirect
Biological Process (BP)spindle checkpoint1.689e-060.0003277Highly InformativeDirect
Biological Process (BP)establishment of RNA localization3.374e-063.87e-06Highly InformativeDirect
Biological Process (BP)regulation of reproductive process1.046e-061.839e-06Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.47580.9951Highly InformativeInherited
Biological Process (BP)regulation of calcium ion transport0.07891Highly InformativeInherited
Biological Process (BP)regulation of transporter activity0.024220.5848Highly InformativeInherited
Biological Process (BP)maintenance of location1.368e-070.152Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.35150.1089Highly InformativeInherited
Biological Process (BP)nucleus organization2.1e-050.006142Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.004040.06556Highly InformativeInherited
Biological Process (BP)limb morphogenesis0.026070.4311Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.64940Highly InformativeInherited
Biological Process (BP)cilium organization0.071440Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle0.00017180.1238Highly InformativeInherited
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.089871Highly InformativeInherited
Biological Process (BP)regulation of mitosis0.0021350.02396Highly InformativeInherited
Biological Process (BP)mitosis0.00032530.01137Highly InformativeInherited
Biological Process (BP)nuclear export0.011020.1252Highly InformativeInherited
Molecular Function (MF)binding0.00033031Least InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding0.0092371Moderately InformativeInherited
Molecular Function (MF)lipid binding0.61080.7985InformativeInherited
Molecular Function (MF)RNA binding0.00040590.4639InformativeInherited
Molecular Function (MF)amide binding0.0016471InformativeInherited
Molecular Function (MF)phosphatidylinositol binding6.242e-050.0004105Highly InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding3.461e-070.009443Highly InformativeInherited
Molecular Function (MF)peptide binding0.00025491Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle7.321e-090Least InformativeDirect
Cellular Component (CC)protein complex2.347e-078.857e-12Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.248e-080Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.86070.1285Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)membrane0.28661Least InformativeInherited
Cellular Component (CC)cytosol0.00011310.0005139Moderately InformativeDirect
Cellular Component (CC)endomembrane system1.345e-090.0001469Moderately InformativeDirect
Cellular Component (CC)nuclear part00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0035831Moderately InformativeInherited
Cellular Component (CC)cell projection0.4178.015e-06Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.059220.06039Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0035361Moderately InformativeInherited
Cellular Component (CC)vesicle11Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.24031.521e-06Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nuclear envelope1.965e-120.0007732InformativeDirect
Cellular Component (CC)integral to membrane1.659e-071InformativeInherited
Cellular Component (CC)coated vesicle0.060687.968e-06InformativeInherited
Cellular Component (CC)nucleoplasm part0.11160.4116InformativeInherited
Cellular Component (CC)nuclear DNA-directed RNA polymerase complex0.47230.9225InformativeInherited
Cellular Component (CC)actin cytoskeleton0.062791InformativeInherited
Cellular Component (CC)chromosome8.852e-101InformativeInherited
Cellular Component (CC)kinetochore1.606e-121.358e-07Highly InformativeDirect
Cellular Component (CC)Arp2/3 protein complex7.503e-091.51e-08Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.273e-136.275e-05Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex00Highly InformativeDirect
Cellular Component (CC)pore complex07.647e-13Highly InformativeDirect
Cellular Component (CC)chromatin10.68Highly InformativeInherited
Cellular Component (CC)intraflagellar transport particle0.022312.627e-10Highly InformativeInherited
Cellular Component (CC)transport vesicle0.0037950.0002911Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 1.089e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.357e-08 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.709e-08 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.762e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000338 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.7953 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.6151 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.06077 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1257 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) gene expression 1.091e-14 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0004842 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 4.792e-14 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002588 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01391 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.5305 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.09867 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8879 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.962 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01388 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8937 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7675 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5963 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6747 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001108 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04434 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 2.524e-05 Informative Direct
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) proteolysis 5.892e-05 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 3.493e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 5.134e-07 Informative Direct
Biological Process (BP) cell cycle process 1.269e-14 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 3.91e-12 Informative Direct
Biological Process (BP) cell projection organization 5.303e-05 Informative Direct
Biological Process (BP) protein catabolic process 1.109e-11 Informative Direct
Biological Process (BP) regulation of organelle organization 3.278e-08 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 4.47e-06 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0004714 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 9.912e-07 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 7.916e-09 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 1.016e-10 Informative Direct
Biological Process (BP) organelle assembly 1.482e-12 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.001055 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.8162 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02006 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 0.8341 Informative Inherited
Biological Process (BP) sensory organ development 0.2782 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.09332 Informative Inherited
Biological Process (BP) positive regulation of transport 0.998 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.006343 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3877 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1804 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2016 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1288 Informative Inherited
Biological Process (BP) tube development 0.6743 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.299 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.325 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.3285 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.6776 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.01452 Informative Inherited
Biological Process (BP) chromosome organization 0.5887 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1996 Informative Inherited
Biological Process (BP) cellular membrane organization 0.217 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.04029 Informative Inherited
Biological Process (BP) cellular component movement 0.4365 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 0.4269 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9631 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.9316 Informative Inherited
Biological Process (BP) secretion by cell 0.3588 Informative Inherited
Biological Process (BP) reproductive system development 0.001155 Informative Inherited
Biological Proce