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Peptidase/esterase 'gauge' domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Processes_IC |
| Detailed category | Proteases |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR004106 SSF50993 Protein matches |
| Abstract | This unusual 7-stranded beta-propeller found as a N-terminal domain protects the catalytic triad of oligopeptidase B and prolyl oligopeptidase (see ) with which it is almost always associated, excluding larger peptides and proteins from proteolysis in the cytosol.
Oligopeptidase B and prolyl oligopeptidase are serine peptidases belong to MEROPS peptidase family S9 (clan SC), subfamily S9A. The protein fold of the peptidase domain for members of this family resembles that of serine carboxypeptidase D, the type example of clan SC.
The prolyl oligopeptidase family [ 1953688, 1515061, 1355343] consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolution. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 2 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Peptidase/esterase 'gauge' domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 2 hidden Markov models representing the Peptidase/esterase 'gauge' domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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