SUPERFAMILY 1.75 HMM library and genome assignments server


Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,189) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 17,113 24,466 9
Proteins 15,870 22,610 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.84370.1548Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.69410.4145Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.70250.3873Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.93350.9604Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.80380.6117Least InformativeInherited
Biological Process (BP)regulation of cellular process0.030381Least InformativeInherited
Biological Process (BP)single-organism cellular process0.22060.9526Least InformativeInherited
Biological Process (BP)developmental process0.35741Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.32950.7373Least InformativeInherited
Biological Process (BP)response to stimulus0.7461Least InformativeInherited
Biological Process (BP)RNA metabolic process0.021043.91e-05Moderately InformativeInherited
Biological Process (BP)signal transduction0.03760.001455Moderately InformativeInherited
Biological Process (BP)organelle organization0.44080.608Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.024251Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.087980.003022Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.1611Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.068771.453e-05Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.12050.004173Moderately InformativeInherited
Biological Process (BP)response to organic substance0.27080.1483Moderately InformativeInherited
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.0026891.343e-05InformativeInherited
Biological Process (BP)cell death0.019980.003091InformativeInherited
Biological Process (BP)intracellular signal transduction3.275e-050.08613InformativeInherited
Biological Process (BP)cell projection organization0.0010610.4544InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0027070.7953InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.011140.7181InformativeInherited
Biological Process (BP)organelle assembly0.00079470.01181InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway7.233e-050Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.00026230Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.0001110Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic1.037e-050.0005635Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.018833.155e-06Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis0.00019270.0127Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00066770.002189Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.00014350.1741Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.87351Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.15690.05666Moderately InformativeInherited
Molecular Function (MF)nuclease activity0.00053991.018e-07InformativeDirect
Molecular Function (MF)endoribonuclease activity4.739e-060.0001023Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.74251Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.46710.001846Least InformativeInherited
Cellular Component (CC)membrane0.57561Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0015883.416e-08Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.0071352.498e-09Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.082940.0006704Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.00011443.48e-13InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.4145 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9526 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7373 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3873 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9604 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6117 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1548 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3535 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) RNA metabolic process 3.91e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.453e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.003022 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.608 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.004173 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001455 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4365 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9304 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9797 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1387 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9828 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9982 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.09833 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7178 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.06672 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6292 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1483 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4136 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4684 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0.0005922 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.0001466 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1.343e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 0.08613 Informative Inherited
Biological Process (BP) cell death 0.003091 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1562 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7953 Informative Inherited
Biological Process (BP) cell projection organization 0.4544 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7181 Informative Inherited
Biological Process (BP) organelle assembly 0.01181 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7251 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9323 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.8862 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9775 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2829 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.02702 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1415 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.1769 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.009818 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3219 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1107 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.07336 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.06202 Informative Inherited
Biological Process (BP) ossification 0.0001359 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.102e-05 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0.0005635 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.155e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.02522 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1741 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0127 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.002189 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.789 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.002051 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01085 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001143 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.04758 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001506 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1162 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.05666 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 1.018e-07 Informative Direct
Molecular Function (MF) kinase activity 0.03545 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01434 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.0001023 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0008716 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.001846 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1248 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.05705 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.416e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.498e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0006704 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.09823 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.6047 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.02858 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0002124 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 3.48e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.965e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.2572 Informative Inherited
Cellular Component (CC) spindle 0.0001366 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 3.968e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 2.964e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1.049e-06Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor1.147e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0136Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02876Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.3949Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6469Least InformativeInherited
Worm Phenotype (WP)growth variant0.9682Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05863Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1991Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0001013InformativeDirect
Worm Phenotype (WP)activity level variant0.001129InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.09966InformativeInherited
Worm Phenotype (WP)fat content increased0.0005572Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.0007819Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1.273e-09Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups2.075e-05Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors2.164e-12Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters2.783e-06InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease4.53e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway5.071e-10InformativeDirect
Biological processTranslation regulation0.0009924InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus1.231e-07Least InformativeDirect
Cellular componentMembrane3.42e-07Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum8.615e-10Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm7.703e-06InformativeDirect
Coding sequence diversityAlternative splicing9.526e-05Least InformativeDirect
DomainRepeat3.106e-16Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium8.82e-06Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.005219Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase4.203e-13InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationADP-ribosylation6.837e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]