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Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,241) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 18,164 80,735 9
Proteins 16,860 73,996 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.77031Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.038590.04068Least InformativeInherited
Biological Process (BP)cellular localization0.00022470.02885Moderately InformativeInherited
Biological Process (BP)organelle organization0.094450.02891Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00056240.000000242InformativeDirect
Biological Process (BP)organelle localization0.0097330.02173InformativeInherited
Biological Process (BP)vesicle-mediated transport0.014660.02302InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0000094370.0002684Highly InformativeDirect
Biological Process (BP)vesicle localization0.00000082130.001603Highly InformativeInherited
Biological Process (BP)plasma membrane bounded cell projection organization0.0019780.9384Highly InformativeInherited
Cellular Component (CC)intracellular organelle part0.4620.000003414Least InformativeInherited
Cellular Component (CC)membrane0.95161Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.16860.0005065Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.033060.000001529Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.013040.163Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.0049320.02307Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00049740.0001325InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0013130.00000000007135InformativeInherited
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.0000031770.0000000000001269Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 0.7325 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2443 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9762 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2877 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.07136 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.04068 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4324 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.422 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0.00007618 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000001177 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.1232 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02891 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02885 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5207 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2774 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7042 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3906 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3605 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3832 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.303 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1165 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) system development 0.4505 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1349 Moderately Informative Inherited
Biological Process (BP) cell communication 0.009425 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.9243 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04179 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.732 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9982 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.001849 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.000000242 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000109 Informative Direct
Biological Process (BP) organelle assembly 0.07222 Informative Inherited
Biological Process (BP) cell cycle process 0.004014 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.322 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5547 Informative Inherited
Biological Process (BP) organelle localization 0.02173 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.00579 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.003674 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02302 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.06683 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.04561 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.02854 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5796 Informative Inherited
Biological Process (BP) proteolysis 0.06712 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.01219 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.4607 Informative Inherited
Biological Process (BP) phosphorylation 0.005898 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.08185 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.04991 Informative Inherited
Biological Process (BP) ncRNA processing 0.1158 Informative Inherited
Biological Process (BP) ribosome biogenesis 0.1121 Informative Inherited
Biological Process (BP) rRNA metabolic process 0.000000003251 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.000003097 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000000263 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0002684 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001992 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.01227 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1691 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.7821 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.001603 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001655 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.9384 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.5963 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.01277 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.00224 Highly Informative Inherited
Biological Process (BP) seed development 0.003526 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.0118 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.3081 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.03891 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.2349 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.102 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.000003878 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.009965 Informative Inherited
Molecular Function (MF) kinase activity 0.071 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0302 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.000226 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002305 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.003893 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.002091 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0005065 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000003414 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.05687 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000001529 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.163 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.1357 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1189 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.02307 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1584 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.07783 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000000007135 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0001325 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.001617 Informative Inherited
Cellular Component (CC) spindle 0.00000002001 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0000000000001269 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000001049Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.00000000000001147Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.04719Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.1204Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1743Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.4417Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.4756Least InformativeInherited
Worm Phenotype (WP)larval development variant0.661Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2703Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.00007182InformativeDirect
Worm Phenotype (WP)oxygen response variant0.002206InformativeInherited
Worm Phenotype (WP)early larval arrest0.003454InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.02625InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0553InformativeInherited
Worm Phenotype (WP)fat content increased0.00009306Highly InformativeDirect
Worm Phenotype (WP)mRNA levels increased0.0002354Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)digestive system0.01678InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000003715Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00000961Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000000000001553Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.00000005122InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.0000000003224Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0.0000000000395Moderately InformativeDirect
Biological processProtein transport0.0004389Moderately InformativeDirect
Biological processmRNA processing0.0001439InformativeDirect
Biological processTranslation regulation0.0002931InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0.0000003853Least InformativeDirect
Cellular componentMembrane0.000001637Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000001868Moderately InformativeDirect
Cellular componentCell projection0.00006244Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm0.00001716InformativeDirect
Coding sequence diversityAlternative splicing0.0006904Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium0.000000003049Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.005697Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000000000002742InformativeDirect
Post-translational modificationPalmitate4.818e-16Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.0000191InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]