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Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,236) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 18,050 41,196 9
Proteins 16,753 38,727 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.63890.7843Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.092390.03145Least InformativeInherited
Biological Process (BP)cellular localization0.00037430.0121Moderately InformativeInherited
Biological Process (BP)organelle organization0.10850.006863Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00072530.000004496InformativeDirect
Biological Process (BP)vesicle-mediated transport0.021480.02783InformativeInherited
Biological Process (BP)Golgi vesicle transport0.00016680.0001799Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.000081590.0003525Highly InformativeDirect
Biological Process (BP)vesicle localization0.00000071110.001421Highly InformativeInherited
Biological Process (BP)cell projection organization0.0022150.2797Highly InformativeInherited
Cellular Component (CC)membrane0.95431Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.27420.000001535Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.081770.003861Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.03050.0000003092Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.012480.1158Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.001110.008034Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00010280.00002515InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0013130.00000000001272InformativeInherited
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.0000033620.000000000001118Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 0.7304 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7843 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.09845 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5243 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3806 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.03145 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5104 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3242 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0.0002239 Moderately Informative Direct
Biological Process (BP) organelle organization 0.006863 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.04578 Moderately Informative Inherited
Biological Process (BP) gene expression 0.001779 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0121 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5426 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.401 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7989 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.4032 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2224 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2079 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3267 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.571 Moderately Informative Inherited
Biological Process (BP) response to stress 0.0141 Moderately Informative Inherited
Biological Process (BP) cell communication 0.04001 Moderately Informative Inherited
Biological Process (BP) signaling 0.1933 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9066 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5006 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.938 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.9078 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.000004496 Informative Direct
Biological Process (BP) cell cycle process 0.0007458 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.00006035 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000744 Informative Direct
Biological Process (BP) organelle assembly 0.02795 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02011 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02783 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.005508 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.09219 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.07058 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.6052 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.7674 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.4803 Informative Inherited
Biological Process (BP) phosphorylation 0.004933 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.1305 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.08426 Informative Inherited
Biological Process (BP) ncRNA processing 0.0778 Informative Inherited
Biological Process (BP) rRNA metabolic process 0.0000000005523 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000002585 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001799 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0003525 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0008293 Highly Informative Direct
Biological Process (BP) cell projection organization 0.2797 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.3974 Highly Informative Inherited
Biological Process (BP) mRNA metabolic process 0.1894 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.001421 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.003791 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.0471 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.7036 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.07115 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.2063 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.2368 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.00007423 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.007905 Informative Inherited
Molecular Function (MF) kinase activity 0.05877 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02465 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00007012 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00396 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.001667 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.000001535 Least Informative Direct
Cellular Component (CC) protein complex 0.003376 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.003861 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0000003092 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.03526 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.09965 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1158 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.008034 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000000001272 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00002515 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.001189 Informative Inherited
Cellular Component (CC) spindle 0.00000002593 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.000000000001118 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000001049Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.00000000000001147Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3324Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.004535Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.03681Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1517Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.4412Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.4749Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6632Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2372Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0001809InformativeDirect
Worm Phenotype (WP)fat content variant0.00797InformativeInherited
Worm Phenotype (WP)fat content increased0.00008987Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.003085Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0.8367Moderately InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.005063InformativeInherited
Zebrafish Anatomy (ZA)coelom0.1854InformativeInherited
Zebrafish Anatomy (ZA)pancreas0.0003435Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000002572Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000007623Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000000000001654Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.00000004627InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.000000000265Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0.0000000000304Moderately InformativeDirect
Biological processProtein transport0.0004132Moderately InformativeDirect
Biological processmRNA processing0.0001297InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0.000000338Least InformativeDirect
Cellular componentMembrane0.0000009658Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000009137Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm0.00001374InformativeDirect
Coding sequence diversityAlternative splicing0.0006786Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium0.000000002377Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.005192Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000000000002189InformativeDirect
Post-translational modificationPalmitate4.811e-16Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000009609Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]