SUPERFAMILY 1.75 HMM library and genome assignments server

Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,235) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 18,038 41,196 9
Proteins 16,739 38,727 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.74020.6278Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.95661Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.85430.1908Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.73410.6602Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.83810.8437Least InformativeInherited
Biological Process (BP)regulation of cellular process0.021771Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.35820.5511Least InformativeInherited
Biological Process (BP)developmental process0.21811Least InformativeInherited
Biological Process (BP)response to stimulus0.76241Least InformativeInherited
Biological Process (BP)single-organism cellular process0.84761Least InformativeInherited
Biological Process (BP)RNA metabolic process0.022150.0001201Moderately InformativeInherited
Biological Process (BP)signal transduction0.04880.003036Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.13920.4168Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.029891Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.093980.001441Moderately InformativeInherited
Biological Process (BP)response to organic substance0.28430.1681Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.071740.00002541Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.12530.006214Moderately InformativeInherited
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.002550.00002221InformativeInherited
Biological Process (BP)apoptotic process0.0073080.0004748InformativeInherited
Biological Process (BP)intracellular signal transduction0.00003710.09803InformativeInherited
Biological Process (BP)cell projection organization0.0011610.5201InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0031610.8452InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.018980.7702InformativeInherited
Biological Process (BP)organelle assembly0.0010810.02589InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.000062940Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.00023410Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.00010380Highly InformativeDirect
Biological Process (BP)cilium organization0.000022070.0002172Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.017380.000002021Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis0.00022470.01803Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00072280.003401Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.00012090.1906Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.8821Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.16760.06973Moderately InformativeInherited
Molecular Function (MF)nuclease activity0.00069520.0000002199InformativeDirect
Molecular Function (MF)endoribonuclease activity0.0000057330.00005755Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.91731Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.50830.0001828Least InformativeInherited
Cellular Component (CC)membrane0.70011Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.001940.00000006771Moderately InformativeInherited
Cellular Component (CC)membrane region0.0039910.00001093Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.012710.0003548Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.00013620.0000000000005982InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.6278 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1908 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6602 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5511 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8437 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2906 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0.0001201 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00002541 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.4168 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1681 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.006214 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9716 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8116 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003036 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9726 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.904 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2762 Moderately Informative Inherited
Biological Process (BP) organ development 0.3617 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.001441 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8231 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3719 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6788 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1476 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1537 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1892 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.743 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3378 Moderately Informative Inherited
Biological Process (BP) immune system process 0.909 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) apoptotic process 0.0004748 Informative Direct
Biological Process (BP) phosphorylation 0.0005425 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.000293 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.00002221 Informative Direct
Biological Process (BP) intracellular signal transduction 0.09803 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1669 Informative Inherited
Biological Process (BP) cell projection organization 0.5201 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8452 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7702 Informative Inherited
Biological Process (BP) organelle assembly 0.02589 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7923 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9745 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.671 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.643 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02066 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.06678 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3527 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.03131 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0495 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.1578 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.07981 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2239 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01057 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2029 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2317 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.07356 Informative Inherited
Biological Process (BP) ossification 0.0001941 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00002246 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) cilium organization 0.0002172 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.000002021 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0249 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1906 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01803 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003401 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.856 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.033 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.005547 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.002251 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01197 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001268 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.05489 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.002009 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.131 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.06973 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.0000002199 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.007063 Informative Inherited
Molecular Function (MF) protein complex binding 0.004853 Informative Inherited
Molecular Function (MF) kinase activity 0.03924 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01599 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.00005755 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.002879 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.001008 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0001828 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1618 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.04757 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000006771 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0003548 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00001093 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.5739 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.1031 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.2136 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.006722 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0000000000005982 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000001703 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.001587 Informative Inherited
Cellular Component (CC) integral component of membrane 0.5625 Informative Inherited
Cellular Component (CC) spindle 0.000000002522 Highly Informative Direct
Cellular Component (CC) integral component of organelle membrane 0.000003288 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000001049Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.00000000000001147Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0136Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02876Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.3949Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6469Least InformativeInherited
Worm Phenotype (WP)growth variant0.9682Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05863Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1991Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0001013InformativeDirect
Worm Phenotype (WP)activity level variant0.001129InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.09966InformativeInherited
Worm Phenotype (WP)fat content increased0.0005572Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.0007819Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000003215Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.000009405Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000000000001622Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.00000005211InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.0000000002979Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0.0008704Moderately InformativeDirect
Biological processUbl conjugation pathway0.0000000006207InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0.0000001702Least InformativeDirect
Cellular componentMembrane0.0000004072Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000001364Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm0.000007919InformativeDirect
Coding sequence diversityAlternative splicing0.0004572Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium0.0000135Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.002842Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.00000000000005339InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000007148InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism6.774e-16Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]