SUPERFAMILY 1.75 HMM library and genome assignments server


Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,233) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,982 41,196 9
Proteins 16,686 38,727 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.83740.1327Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.6940.4331Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.70070.4049Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.93290.9778Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.80360.6329Least InformativeInherited
Biological Process (BP)regulation of cellular process0.014750.9782Least InformativeInherited
Biological Process (BP)single-organism cellular process0.14190.4668Least InformativeInherited
Biological Process (BP)developmental process0.21581Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.3460.4665Least InformativeInherited
Biological Process (BP)response to stimulus0.76011Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0214.088e-05Moderately InformativeInherited
Biological Process (BP)signal transduction0.057450.001434Moderately InformativeInherited
Biological Process (BP)organelle organization0.50180.2243Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.02961Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.087640.001056Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.09280.8057Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.067431.882e-05Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.11720.004702Moderately InformativeInherited
Biological Process (BP)response to organic substance0.27310.1535Moderately InformativeInherited
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.0025741.037e-05InformativeInherited
Biological Process (BP)apoptotic process0.0070580.0004277InformativeInherited
Biological Process (BP)intracellular signal transduction2.809e-050.08529InformativeInherited
Biological Process (BP)cell projection organization0.0015580.5364InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0028510.8287InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.018440.745InformativeInherited
Biological Process (BP)organelle assembly0.00092980.02491InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway6.252e-050Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.00023180Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein9.887e-050Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic1.157e-050.000593Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.018893.148e-06Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis0.00042260.01496Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00066450.003362Highly InformativeInherited
Biological Process (BP)cilium organization0.001280.0001214Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.00010060.1808Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.86921Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.15430.05998Moderately InformativeInherited
Molecular Function (MF)nuclease activity0.00057381.266e-07InformativeDirect
Molecular Function (MF)endoribonuclease activity5.387e-060.0001052Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.81391Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.50480.0002463Least InformativeInherited
Cellular Component (CC)membrane0.65821Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0017425.706e-08Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.0068426.393e-09Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.085240.0004075Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.00012155.392e-13InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.4331 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9782 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4668 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4665 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.4049 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9778 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6329 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1327 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3066 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) RNA metabolic process 4.088e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.882e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.001056 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8057 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2243 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.004702 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001434 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4712 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9167 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9251 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1378 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2856 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9376 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7806 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1094 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7608 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1326 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6397 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1535 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4253 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3801 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.917 Moderately Informative Inherited
Biological Process (BP) organ development 0.2935 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) apoptotic process 0.0004277 Informative Direct
Biological Process (BP) phosphorylation 0.0005721 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.0002939 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1.037e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 0.08529 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1609 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8287 Informative Inherited
Biological Process (BP) cell projection organization 0.5364 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.745 Informative Inherited
Biological Process (BP) organelle assembly 0.02491 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7545 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9523 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9164 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9958 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02515 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04358 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3113 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.02988 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1533 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.2003 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.08346 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3253 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01236 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1093 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.07307 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.07178 Informative Inherited
Biological Process (BP) ossification 0.0001894 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.057e-05 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) cilium organization 0.0001214 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0.000593 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.148e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.02392 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1808 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01496 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003362 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.8177 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.03876 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006311 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.002225 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01055 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.00122 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.05382 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001828 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1268 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.05998 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 1.266e-07 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.006709 Informative Inherited
Molecular Function (MF) kinase activity 0.03851 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01536 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.0001052 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0009891 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.002926 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0002463 Least Informative Direct
Cellular Component (CC) protein complex 0.08219 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0189 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 5.706e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 6.393e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0004075 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.1028 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5123 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.009922 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 5.392e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 3.162e-06 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.001045 Informative Inherited
Cellular Component (CC) integral to membrane 0.4888 Informative Inherited
Cellular Component (CC) spindle 6.301e-09 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 8.091e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0001815 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1.049e-06Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor1.147e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0136Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02876Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.3949Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6469Least InformativeInherited
Worm Phenotype (WP)growth variant0.9682Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05863Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1991Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0001013InformativeDirect
Worm Phenotype (WP)activity level variant0.001129InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.09966InformativeInherited
Worm Phenotype (WP)fat content increased0.0005572Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.0007819Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases2.962e-09Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups9.624e-06Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1.803e-12Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters5.252e-08InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease3.002e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0.0008693Moderately InformativeDirect
Biological processUbl conjugation pathway6.144e-10InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus1.635e-07Least InformativeDirect
Cellular componentMembrane3.885e-07Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.208e-09Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm7.749e-06InformativeDirect
Coding sequence diversityAlternative splicing0.0001581Least InformativeDirect
DomainRepeat3.104e-16Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium1.183e-05Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.002828Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase5.29e-14InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationADP-ribosylation7.217e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]