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Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,241) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 18,164 80,735 9
Proteins 16,860 73,996 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular localization0.00022690.00387Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00061830.00000002172InformativeDirect
Biological Process (BP)organelle localization0.0098570.01507InformativeInherited
Biological Process (BP)vesicle-mediated transport0.014670.003462InformativeInherited
Biological Process (BP)Golgi vesicle transport0.000010530.0003142Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.000056740.00004566Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.45420.000005798Least InformativeInherited
Cellular Component (CC)membrane0.97841Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.18740.002395Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.013350.1415Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.32620.0002202Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.0058020.04094Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00056040.0001461InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0013610.0000000001008InformativeInherited
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.0000032450.0000000000001466Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5072 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3485 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7319 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8947 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.06587 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.03571 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4959 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.000001154 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000171 Moderately Informative Direct
Biological Process (BP) organelle organization 0.03937 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7611 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.9732 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.00387 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1391 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2036 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4158 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2263 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9581 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1563 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.05306 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.4908 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4883 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.01241 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.06906 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3517 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8524 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.003778 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.00000002172 Informative Direct
Biological Process (BP) intracellular transport 0.000042 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001762 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0009329 Informative Direct
Biological Process (BP) mitotic cell cycle 0.3293 Informative Inherited
Biological Process (BP) organelle localization 0.01507 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003462 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.001085 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.03317 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.05015 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.01956 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.284 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.02002 Informative Inherited
Biological Process (BP) proteolysis 0.08832 Informative Inherited
Biological Process (BP) post-embryonic development 0.01632 Informative Inherited
Biological Process (BP) reproductive system development 0.5729 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) cell cycle process 0.005348 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.03043 Informative Inherited
Biological Process (BP) phosphorylation 0.001592 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.0556 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.09052 Informative Inherited
Biological Process (BP) ribosome biogenesis 0.08488 Informative Inherited
Biological Process (BP) ncRNA processing 0.1063 Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.0003142 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.00004566 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000004796 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0.000000004993 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.0000008114 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.000174 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002567 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0003038 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0006431 Highly Informative Direct
Biological Process (BP) RNA splicing 0.3267 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.7939 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.02524 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.5821 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.001047 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.008539 Highly Informative Inherited
Biological Process (BP) seed development 0.003727 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.3442 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.01263 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1303 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.1241 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.000004357 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.005962 Informative Inherited
Molecular Function (MF) kinase activity 0.02873 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0103 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00002269 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0004452 Highly Informative Direct
Molecular Function (MF) endoribonuclease activity 0.0004562 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.008799 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.000005798 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01293 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.002395 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0002202 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.1415 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.1572 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1349 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.04094 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2113 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1115 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0001461 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0000000001008 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.001631 Informative Inherited
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0000000000001466 Highly Informative Direct
Cellular Component (CC) spindle 0.00000001203 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000001049Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.00000000000001147Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0.00000000004798Moderately InformativeDirect
Biological processProtein transport0.00003266Moderately InformativeDirect
Biological processmRNA processing0.0001551InformativeDirect
Biological processTranslation regulation0.0003159InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0.0000002674Least InformativeDirect
Cellular componentMembrane0.0000008873Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000002389Moderately InformativeDirect
Cellular componentCell projection0.00001321Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm0.00001939InformativeDirect
Coding sequence diversityAlternative splicing0.0004964Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium0.000000003977Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.006463Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000000000003531InformativeDirect
Post-translational modificationPalmitate9.538e-16Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.00002132InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]