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Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,243) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 18,265 0 9
Proteins 16,953 0 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000001049Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.00000000000001147Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0486Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.1674Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1913Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.4308Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.4662Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6605Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.005757Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2968Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.00007609InformativeDirect
Worm Phenotype (WP)oxygen response variant0.001631InformativeInherited
Worm Phenotype (WP)early larval arrest0.003432InformativeInherited
Worm Phenotype (WP)fat content variant0.008429InformativeInherited
Worm Phenotype (WP)RNA expression variant0.05578InformativeInherited
Worm Phenotype (WP)fat content increased0.00009396Highly InformativeDirect
Worm Phenotype (WP)mRNA levels increased0.0002378Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000001186Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001319Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000000000000005852Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.00000005733InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.0000000003839Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000001537Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9811Least InformativeInherited
Biological processUbl conjugation pathway0.00000000006518Moderately InformativeDirect
Biological processProtein transport0.00002227Moderately InformativeDirect
Biological processmRNA processing0.0001837InformativeDirect
Biological processTranslation regulation0.0007562InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus0.0000002102Least InformativeDirect
Cellular componentMembrane0.000001023Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000004613Moderately InformativeDirect
Cellular componentCell projection0.00003722Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm0.000003301InformativeDirect
Coding sequence diversityAlternative splicing0.0004164Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium0.0000000001513Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.00686Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.0000000000003574InformativeDirect
Post-translational modificationPalmitate9.745e-16Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.00003252InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]