SUPERFAMILY 1.75 HMM library and genome assignments server

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WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 16,207 49,108 31
Proteins 10,466 31,173 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000014Least InformativeDirect
Enzyme Commission (EC)Isomerases0.00004689Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000005085Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000007733Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009564InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.07286Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5249Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal nasal morphology0.04387Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.05287Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1355Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.01653Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.2087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4382Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.62Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6643Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.8729Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2594InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.3577InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension0.0001632Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.01515Highly InformativeInherited
Mammalian Phenotype (MP)bundle branch block1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)maintenance of gene silencing variant0.0003121InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.8432Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.14Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.7337Moderately InformativeInherited
Zebrafish Anatomy (ZA)musculature system0.01065InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.01825Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.02238Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1529Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.000006486InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000002306Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]