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cAMP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Families:   CO-sensing protein CooA, N-terminal domain [ 51207]
  Listeriolysin regulatory protein PrfA, N-terminal domain [ 89419]
  cAMP-binding domain [ 51210] (12)


Superfamily statistics
Genomes (2,671) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,902 77,338 34
Proteins 23,709 70,666 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000007178 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.04455 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00139 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) signaling 0.00000003033 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000598 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000685 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002457 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003062 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0015 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1165 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9953 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5095 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03251 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.05091 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8772 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5203 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8039 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.9418 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9663 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9415 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.372 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3293 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1352 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1178 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5277 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.665 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4004 Moderately Informative Inherited
Biological Process (BP) behavior 0.00000000000006772 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000001185 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000002565 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000000004957 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000002206 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000002289 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0000001014 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000000161 Informative Direct
Biological Process (BP) regulation of system process 0.0000002088 Informative Direct
Biological Process (BP) protein oligomerization 0.000001982 Informative Direct
Biological Process (BP) system process 0.000005907 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000009222 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00004593 Informative Direct
Biological Process (BP) cell development 0.00006212 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00008435 Informative Direct
Biological Process (BP) circulatory system development 0.0001321 Informative Direct
Biological Process (BP) response to radiation 0.0002205 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0002575 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0007534 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.3886 Informative Inherited
Biological Process (BP) generation of neurons 0.05267 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.8249 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0326 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01202 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8353 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.4044 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6442 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.6051 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.8551 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9757 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.9202 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.183 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.6106 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4693 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.8429 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.003826 Informative Inherited
Biological Process (BP) metal ion transport 0.7122 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.00651 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1476 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6401 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.03066 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.06535 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.0646 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03533 Informative Inherited
Biological Process (BP) cell death 0.006116 Informative Inherited
Biological Process (BP) cell adhesion 0.009903 Informative Inherited
Biological Process (BP) central nervous system development 0.00637 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7174 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1191 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.007296 Informative Inherited
Biological Process (BP) phosphorylation 0.6411 Informative Inherited
Biological Process (BP) locomotion 0.1205 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.4283 Informative Inherited
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000000000001571 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00000000003428 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0000000002216 Highly Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.000000006199 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000003206 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000555 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00001427 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00004088 Highly Informative Direct
Biological Process (BP) aging 0.00007121 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.00007726 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0001544 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0002247 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.03586 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.3767 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.8028 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.4736 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.03674 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.08214 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.1786 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.689 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.1389 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.7271 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.003063 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.4418 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.2595 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.01149 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.09513 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.3539 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.08587 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5125 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.2569 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.4284 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.03493 Highly Informative Inherited
Biological Process (BP) neuron development 0.5439 Highly Informative Inherited
Biological Process (BP) brain development 0.004369 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.6039 Highly Informative Inherited
Biological Process (BP) sensory perception 0.08869 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.04686 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.2013 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.1937 Highly Informative Inherited
Biological Process (BP) cell migration 0.4312 Highly Informative Inherited
Molecular Function (MF) binding 0.09831 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.1113 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3487 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.001271 Moderately Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000005001 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.000002936 Informative Direct
Molecular Function (MF) enzyme binding 0.00003538 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0002505 Informative Direct
Molecular Function (MF) phospholipid binding 0.8919 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.7107 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.05566 Informative Inherited
Molecular Function (MF) kinase activity 0.1202 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0000000000003987 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.000000000001091 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0000006374 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00001869 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00004009 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.00004543 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.0006695 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001443 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.004688 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8034 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000000000434 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00006092 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0003516 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.8901 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.001099 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.145 Moderately Informative Inherited
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) cilium 0.000000000000001578 Informative Direct
Cellular Component (CC) cell projection part 0.000000000000003057 Informative Direct
Cellular Component (CC) synapse 0.0000002506 Informative Direct
Cellular Component (CC) cell junction 0.000004966 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001054 Informative Direct
Cellular Component (CC) membrane region 0.03501 Informative Inherited
Cellular Component (CC) neuron projection 0.4518 Informative Inherited
Cellular Component (CC) receptor complex 0.000000000002204 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000006262 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0002382 Highly Informative Direct
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.3132 Highly Informative Inherited
Cellular Component (CC) dendrite 0.3212 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.231 Highly Informative Inherited
Cellular Component (CC) 9+2 non-motile cilium 0.3647 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000634Moderately InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.03535Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1347Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.693Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.00581Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.03818Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.06953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.08187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.1001Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.2295InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.4035InformativeInherited
Phenotypic Abnormality (PA)Progressive visual loss0.0000835Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal electroretinogram0.00008427Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.000197Highly InformativeDirect
Phenotypic Abnormality (PA)Yellow/white lesions of the retina0.01187Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.04057Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the macula0.09081Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1553Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1676Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.03987Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0002374InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.004492InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb layer morphology0.01155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart atrium morphology0.09044Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.003786Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.006212Least InformativeInherited
Worm Phenotype (WP)cell development variant0.02875Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.0511Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05196Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00003713Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0009363Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.04268Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2501Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2863Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0000004941InformativeDirect
Worm Phenotype (WP)drug resistant0.0002252InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0003324InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0006881InformativeDirect
Worm Phenotype (WP)growth rate variant0.0007033InformativeDirect
Worm Phenotype (WP)sexually dimorphic behavior variant0.003191InformativeInherited
Worm Phenotype (WP)body length variant0.005383InformativeInherited
Worm Phenotype (WP)body width variant0.00749InformativeInherited
Worm Phenotype (WP)muscle system morphology variant0.007708InformativeInherited
Worm Phenotype (WP)localized movement variant0.007732InformativeInherited
Worm Phenotype (WP)body posture variant0.009059InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.03257InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.07245InformativeInherited
Worm Phenotype (WP)egg laying variant0.1395InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.1395InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.000000003346Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.00000004451Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000008122Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0000002724Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.0000002885Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.0000009197Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0001163Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.000157Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0001647Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001694Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0001766Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0001934Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0001978Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0002802Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0003654Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0003928Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.118Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.000237InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.2755Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.346Least InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.02291InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 250.0004457Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.06419Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000006294Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0Least InformativeDirect
Drugbank ATC_code (DB)antiinfectives for systemic use0Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0Least InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0Moderately InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0Moderately InformativeDirect
Drugbank ATC_code (DB)dermatologicals0Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0Moderately InformativeDirect
Drugbank ATC_code (DB)otologicals0Moderately InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)imidazole derivatives0InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0InformativeDirect
Drugbank ATC_code (DB)antiadrenergic agents, peripherally acting0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)alpha-adrenoreceptor antagonists0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)ibutilide0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processTranscription regulation0.00000000000000379Moderately InformativeDirect
Biological processVirulence0.0004833Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processCell adhesion0.00002466InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.00000008886Highly InformativeDirect
Biological processVision0.00004308Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0.00000000006305Moderately InformativeDirect
Cellular componentEndosome0.00009429Moderately InformativeDirect
Cellular componentTight junction0.0000002975Highly InformativeDirect
DiseaseDisease mutation0.0001572Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.00005228Least InformativeDirect
DomainANK repeat0.00001794InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionDNA-binding0.00000008372Least InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein4.502e-16Moderately InformativeDirect
Post-translational modificationRepressor0.0000228Moderately InformativeDirect
Post-translational modificationKinase0.5857Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000003603InformativeDirect
Post-translational modificationGTPase activation0.000008277InformativeDirect
Post-translational modificationLigand-gated ion channel0.00000000000001725Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000001495Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000005056Least InformativeDirect
Post-translational modificationGlycoprotein0.000000005331Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000595 SSF51206 Protein matches
Abstract Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [PubMed14638413, PubMed10550204, PubMed1710853]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the cAMP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]