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cAMP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Families:   CO-sensing protein CooA, N-terminal domain [ 51207]
  Listeriolysin regulatory protein PrfA, N-terminal domain [ 89419]
  cAMP-binding domain [ 51210] (12)


Superfamily statistics
Genomes (2,676) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 29,099 123,563 34
Proteins 23,852 109,266 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000002944 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1587 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.003177 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000001101 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000173 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00005839 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001127 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002243 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0005211 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07938 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8182 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2937 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8861 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4143 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7703 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.01946 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3141 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.241 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1256 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.0649 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6385 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4016 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.04138 Moderately Informative Inherited
Biological Process (BP) protein oligomerization 0.000000002098 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000002894 Informative Direct
Biological Process (BP) transmembrane transport 0.000000003519 Informative Direct
Biological Process (BP) behavior 0.000000006247 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000009465 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.00000001006 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000001278 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000002747 Informative Direct
Biological Process (BP) system process 0.00000003334 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00000009752 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0000002102 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00001381 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00002069 Informative Direct
Biological Process (BP) cell development 0.00006551 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000728 Informative Direct
Biological Process (BP) circulatory system development 0.0001611 Informative Direct
Biological Process (BP) regulation of system process 0.0002141 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000454 Informative Direct
Biological Process (BP) response to radiation 0.0004941 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0009697 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.3812 Informative Inherited
Biological Process (BP) generation of neurons 0.3306 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7023 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.865 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9832 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.879 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2163 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.512 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.6868 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1721 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9182 Informative Inherited
Biological Process (BP) metal ion transport 0.6626 Informative Inherited
Biological Process (BP) tissue development 0.03113 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01243 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.9745 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) cell death 0.004244 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03776 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2222 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6933 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.589 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.05745 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.06172 Informative Inherited
Biological Process (BP) regulation of locomotion 0.00763 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.05744 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) central nervous system development 0.008064 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7336 Informative Inherited
Biological Process (BP) regulation of secretion 0.0518 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.01109 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.4668 Informative Inherited
Biological Process (BP) phosphorylation 0.6047 Informative Inherited
Biological Process (BP) locomotion 0.1737 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.3545 Informative Inherited
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000000000000003764 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000000000002178 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00000000005595 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0000000001157 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.000000000195 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000007188 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00002411 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00006642 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00007808 Highly Informative Direct
Biological Process (BP) aging 0.0001092 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0001187 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0371 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.3982 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7653 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.8814 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.03292 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.07681 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.1761 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6933 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.1589 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.6772 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01903 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.008552 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.06472 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.01361 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.1825 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.004659 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.373 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.007703 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.2887 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4443 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.1736 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.2671 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.4954 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.04143 Highly Informative Inherited
Biological Process (BP) neuron development 0.6258 Highly Informative Inherited
Biological Process (BP) brain development 0.005363 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.09942 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.6677 Highly Informative Inherited
Biological Process (BP) neurological system process 0.1265 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.0232 Least Informative Inherited
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.001859 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3874 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.000000003144 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000004029 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000002163 Informative Direct
Molecular Function (MF) enzyme binding 0.00001465 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001819 Informative Direct
Molecular Function (MF) DNA binding 0.0002808 Informative Direct
Molecular Function (MF) phospholipid binding 0.8684 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.7134 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.06689 Informative Inherited
Molecular Function (MF) kinase activity 0.1417 Informative Inherited
Molecular Function (MF) receptor binding 0.9187 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0000000000005679 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.00000000000111 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000003291 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000006744 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00002197 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00005106 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.00005218 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.000131 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0007033 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.006669 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.03502 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.00167 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.005817 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.00000000006405 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000000007855 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00008005 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.000919 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.1875 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) protein-DNA complex 0.0000000002077 Informative Direct
Cellular Component (CC) synapse 0.0000008395 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000063 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0005158 Informative Direct
Cellular Component (CC) membrane region 0.0425 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.4844 Informative Inherited
Cellular Component (CC) neuron projection 0.06494 Informative Inherited
Cellular Component (CC) receptor complex 0.00000000234 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000109 Highly Informative Direct
Cellular Component (CC) photoreceptor cell cilium 0.000009115 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0001936 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.000285 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.000318 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.2016 Highly Informative Inherited
Cellular Component (CC) dendrite 0.7369 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000634Moderately InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.03561Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1122Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.00588Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.04293Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.0696Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.08126Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.09121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.2256InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.3968InformativeInherited
Phenotypic Abnormality (PA)Abnormal electroretinogram0.00007939Highly InformativeDirect
Phenotypic Abnormality (PA)Progressive visual loss0.00007939Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0001821Highly InformativeDirect
Phenotypic Abnormality (PA)Yellow/white lesions of the retina0.01185Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.04057Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the macula0.09029Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1065Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1607Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.533Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0003042InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb layer morphology0.01566Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart atrium morphology0.07939Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.004049Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.008094Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0291Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.06361Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00004618Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0009677Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.04381Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2797Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2839Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0000005804InformativeDirect
Worm Phenotype (WP)drug resistant0.0002555InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003288InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0004193InformativeDirect
Worm Phenotype (WP)growth rate variant0.0007681InformativeDirect
Worm Phenotype (WP)sexually dimorphic behavior variant0.003538InformativeInherited
Worm Phenotype (WP)body length variant0.005524InformativeInherited
Worm Phenotype (WP)body width variant0.007566InformativeInherited
Worm Phenotype (WP)localized movement variant0.007744InformativeInherited
Worm Phenotype (WP)body posture variant0.009128InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.03333InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.0724InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.1356InformativeInherited
Worm Phenotype (WP)egg laying variant0.1362InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.000000003654Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.00000004527Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000008244Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000000293Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0000003278Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000001065Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0001206Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.0001623Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0001702Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001713Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0001824Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0001998Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0002043Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.00029Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0.0003288Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0003759Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0004042Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.1222Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.000424InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.2746Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.3484Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 250.0004207Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.06034Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000006135Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processTranscription regulation0.000000000000005206Moderately InformativeDirect
Biological processVirulence0.0005099Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processCell adhesion0.00002534InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.0000001179Highly InformativeDirect
Biological processVision0.00004449Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0.00000000007905Moderately InformativeDirect
Cellular componentEndosome0.0001142Moderately InformativeDirect
Cellular componentTight junction0.0000002615Highly InformativeDirect
DiseaseDisease mutation0.0002052Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.00009063Least InformativeDirect
DomainANK repeat0.00002024InformativeDirect
Molecular functionNucleotide-binding0.000000000000005141Least InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncGMP-binding0Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein6.593e-16Moderately InformativeDirect
Post-translational modificationDNA-binding0.0000000001298Moderately InformativeDirect
Post-translational modificationRepressor0.00002466Moderately InformativeDirect
Post-translational modificationKinase0.5904Moderately InformativeInherited
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000387InformativeDirect
Post-translational modificationGTPase activation0.000008306InformativeDirect
Post-translational modificationLigand-gated ion channel0.00000000000002974Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000001138Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000001171Least InformativeDirect
Post-translational modificationGlycoprotein0.000000003852Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000595 SSF51206 Protein matches
Abstract Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [PubMed14638413, PubMed10550204, PubMed1710853]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the cAMP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]