SUPERFAMILY 1.75 HMM library and genome assignments server

cAMP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Families:   CO-sensing protein CooA, N-terminal domain [ 51207]
  Listeriolysin regulatory protein PrfA, N-terminal domain [ 89419]
  cAMP-binding domain [ 51210] (12)


Superfamily statistics
Genomes (2,671) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,902 77,338 34
Proteins 23,709 70,666 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.00000000000007043 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000002026 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000002674 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.4497 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.06562 Least Informative Inherited
Biological Process (BP) developmental process 0.006295 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1769 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9145 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) system process 0.000003139 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000005143 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000005517 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001864 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0006734 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0007766 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7922 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5543 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01854 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5241 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02523 Moderately Informative Inherited
Biological Process (BP) tissue development 0.08412 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1292 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1412 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01545 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01294 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001008 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.6402 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8422 Moderately Informative Inherited
Biological Process (BP) organ development 0.1935 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9478 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04352 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1003 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2827 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.03887 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of kinase activity 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000000000005907 Informative Direct
Biological Process (BP) transmembrane transport 0.000000000001801 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000000000005133 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000000002965 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.00000006356 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000008817 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000001185 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0000003703 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0000003885 Informative Direct
Biological Process (BP) regulation of system process 0.0000008562 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000003881 Informative Direct
Biological Process (BP) regulation of secretion 0.00002976 Informative Direct
Biological Process (BP) response to nutrient levels 0.00003686 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0001357 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0001574 Informative Direct
Biological Process (BP) protein oligomerization 0.0003899 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0004528 Informative Direct
Biological Process (BP) regulation of ion transport 0.0006243 Informative Direct
Biological Process (BP) phosphorylation 0.0006379 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0006733 Informative Direct
Biological Process (BP) cardiovascular system development 0.0008184 Informative Direct
Biological Process (BP) regulation of locomotion 0.01015 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02015 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3638 Informative Inherited
Biological Process (BP) generation of neurons 0.2247 Informative Inherited
Biological Process (BP) regulation of cell development 0.2704 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3387 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.5667 Informative Inherited
Biological Process (BP) biological adhesion 0.01466 Informative Inherited
Biological Process (BP) metal ion transport 0.7201 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.08753 Informative Inherited
Biological Process (BP) epithelium development 0.7468 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2547 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2606 Informative Inherited
Biological Process (BP) muscle tissue development 0.005618 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2983 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.002045 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.07389 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.07916 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) growth 0.01368 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02262 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2479 Informative Inherited
Biological Process (BP) muscle structure development 0.01242 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07926 Informative Inherited
Biological Process (BP) organelle assembly 0.02188 Informative Inherited
Biological Process (BP) actin filament-based process 0.214 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.3633 Informative Inherited
Biological Process (BP) single-organism behavior 0.6531 Informative Inherited
Biological Process (BP) central nervous system development 0.2882 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2848 Informative Inherited
Biological Process (BP) response to light stimulus 0.1161 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03824 Informative Inherited
Biological Process (BP) response to wounding 0.1662 Informative Inherited
Biological Process (BP) locomotion 0.4313 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4602 Informative Inherited
Biological Process (BP) response to purine-containing compound 0.000000000000007347 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000000001364 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.000000000003375 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.00000000001871 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0000000001975 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0.0000000003445 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000000001466 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.000000003397 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000004537 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0000003164 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0000007706 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000002368 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.00000774 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.0002385 Highly Informative Direct
Biological Process (BP) aging 0.0008819 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.03912 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.06794 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.08031 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.05073 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.0554 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.003731 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.03105 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.0523 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0566 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1061 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.4267 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.01028 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.4969 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.9032 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.1009 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.259 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.03219 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.8022 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001128 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001218 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.1237 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.5354 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.005528 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3362 Highly Informative Inherited
Biological Process (BP) wound healing 0.003638 Highly Informative Inherited
Biological Process (BP) coagulation 0.004778 Highly Informative Inherited
Biological Process (BP) hemostasis 0.02441 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.0419 Highly Informative Inherited
Molecular Function (MF) binding 0.7634 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.9814 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.001084 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3382 Moderately Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.00001531 Informative Direct
Molecular Function (MF) receptor binding 0.8704 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.7561 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.07286 Informative Inherited
Molecular Function (MF) kinase activity 0.1451 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.0000000000001251 Highly Informative Direct
Molecular Function (MF) lipase activity 0.0000000008338 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0000212 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.003871 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.008808 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3766 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.008386 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01418 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0000000000004198 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0002203 Moderately Informative Direct
Cellular Component (CC) cell projection 0.002395 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.09136 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.002403 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.00783 Moderately Informative Inherited
Cellular Component (CC) cell junction 0.000005242 Informative Direct
Cellular Component (CC) integral to membrane 0.6056 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.7944 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) cell body 0.000008297 Highly Informative Direct
Cellular Component (CC) cilium part 0.001577 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.1947 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000634Moderately InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1507Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.006219InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.05432InformativeInherited
Phenotypic Abnormality (PA)Monochromacy0.00000007307Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0003867Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.201Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.08009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0001709InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.01154Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart atrium morphology0.1018Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.007523Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00007082Moderately InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.000004175InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.00000003001Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000002447Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000007776Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000015Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.3576Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.0003656InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.07041Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000004391Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0Least InformativeDirect
Drugbank ATC_code (DB)antiinfectives for systemic use0Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0Least InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0Moderately InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0Moderately InformativeDirect
Drugbank ATC_code (DB)antifungals for topical use1Moderately InformativeInherited
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)imidazole derivatives0InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0InformativeDirect
Drugbank ATC_code (DB)antiadrenergic agents, peripherally acting0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)alpha-adrenoreceptor antagonists0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)miconazole0InformativeDirect
Drugbank ATC_code (DB)ibutilide0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0.0000000000002182Moderately InformativeDirect
Biological processLipid metabolism0.0000000391Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processCell adhesion0.00001192InformativeDirect
Biological processVirulence0.0001526InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.00000005804Highly InformativeDirect
Biological processVision0.00004388Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0.00000002415Moderately InformativeDirect
Cellular componentTight junction0.00000001655Highly InformativeDirect
DiseaseDisease mutation0.000004592Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.00001994Least InformativeDirect
DomainANK repeat0.00001834InformativeDirect
Molecular functionNucleotide-binding0.000000000000001834Least InformativeDirect
Molecular functionDNA-binding0.0000004126Least InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncAMP-binding0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0.00003844Moderately InformativeDirect
Post-translational modificationKinase0.6263Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000163InformativeDirect
Post-translational modificationGTPase activation0.000004266InformativeDirect
Post-translational modificationLigand-gated ion channel0.0000000000002148Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000003482Highly InformativeDirect
Post-translational modificationGlycoprotein0.00000002064Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000685Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000595 SSF51206 Protein matches
Abstract Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [PubMed14638413, PubMed10550204, PubMed1710853]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the cAMP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]