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cAMP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Families:   CO-sensing protein CooA, N-terminal domain [ 51207]
  Listeriolysin regulatory protein PrfA, N-terminal domain [ 89419]
  cAMP-binding domain [ 51210] (12)


Superfamily statistics
Genomes (2,678) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 29,253 158,938 34
Proteins 23,953 141,881 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000634Moderately InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3174Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5273Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0.116Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2548Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.7133Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.00837InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.09509InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.1037InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.2423InformativeInherited
Phenotypic Abnormality (PA)Abnormality of retinal pigmentation0.0002679Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal electroretinogram0.0003017Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of color vision0.01259Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1051Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1605Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0003029InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb layer morphology0.01563Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart atrium morphology0.07999Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.004284Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01363Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03154Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.06628Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2183Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00004936Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001025Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.01358Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.04345Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2758Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3009Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0000006005InformativeDirect
Worm Phenotype (WP)drug resistant0.0002606InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003445InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0004226InformativeDirect
Worm Phenotype (WP)body length variant0.005638InformativeInherited
Worm Phenotype (WP)body width variant0.007745InformativeInherited
Worm Phenotype (WP)localized movement variant0.007934InformativeInherited
Worm Phenotype (WP)body posture variant0.008992InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.03441InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.07312InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.1357InformativeInherited
Worm Phenotype (WP)egg laying variant0.1393InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.000000003669Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.0000000456Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000008331Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.0000002948Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0000003301Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000001121Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0001051Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0001217Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.0001638Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0001717Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001723Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0001841Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0002015Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0002061Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0.0003316Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0003789Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0004153Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0007951Highly InformativeDirect
Worm Phenotype (WP)egg retention0.006275Highly InformativeInherited
Worm Phenotype (WP)aqueous positive chemotaxis defective0.123Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.0005138InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.0347Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.1106InformativeInherited
Xenopus DEvelopment stage (XDE)early tailbud stage0.05801Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.05856Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000006881Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR000595 SSF51206 Protein matches
Abstract Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [PubMed14638413, PubMed10550204, PubMed1710853]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain, three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal transduction.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the cAMP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]