Single hybrid motif superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	Barrel-sandwich hybrid [ 51229] (4)
Superfamily:	Single hybrid motif [ 51230]
Families:	Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)

Superfamily statistics

	Genomes (2,442)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	18,218	47,910	16
Proteins	16,852	42,797	16

Functional annotation

General category	Metabolism
Detailed category	Coenzyme metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	biosynthetic process	0.0006173	Least Informative	Direct
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	nitrogen compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	cofactor metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	4.692e-10	Moderately Informative	Direct
Biological Process (BP)	lipid biosynthetic process	5.931e-08	Moderately Informative	Direct
Biological Process (BP)	cellular amino acid metabolic process	5.963e-07	Moderately Informative	Direct
Biological Process (BP)	monocarboxylic acid metabolic process	8.031e-05	Moderately Informative	Direct
Biological Process (BP)	cellular component biogenesis	0.4159	Moderately Informative	Inherited
Biological Process (BP)	macromolecular complex subunit organization	0.1861	Moderately Informative	Inherited
Biological Process (BP)	carbohydrate metabolic process	0.4655	Moderately Informative	Inherited
Biological Process (BP)	small molecule biosynthetic process	0.1105	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.01934	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.01649	Moderately Informative	Inherited
Biological Process (BP)	oxidation-reduction process	0.4649	Moderately Informative	Inherited
Biological Process (BP)	organonitrogen compound catabolic process	1.706e-08	Informative	Direct
Biological Process (BP)	fatty acid metabolic process	2.332e-06	Informative	Direct
Biological Process (BP)	hexose metabolic process	5.096e-05	Informative	Direct
Biological Process (BP)	carboxylic acid catabolic process	0.000184	Informative	Direct
Biological Process (BP)	monocarboxylic acid biosynthetic process	0.0002773	Informative	Direct
Biological Process (BP)	coenzyme biosynthetic process	0.1414	Informative	Inherited
Biological Process (BP)	protein oligomerization	0.03329	Informative	Inherited
Biological Process (BP)	carbohydrate biosynthetic process	0.06562	Informative	Inherited
Biological Process (BP)	energy derivation by oxidation of organic compounds	0.01089	Informative	Inherited
Biological Process (BP)	acyl-CoA metabolic process	0	Highly Informative	Direct
Biological Process (BP)	thioester biosynthetic process	0	Highly Informative	Direct
Biological Process (BP)	aerobic respiration	9.013e-07	Highly Informative	Direct
Biological Process (BP)	protein tetramerization	3.346e-06	Highly Informative	Direct
Biological Process (BP)	branched-chain amino acid metabolic process	9.892e-05	Highly Informative	Direct
Biological Process (BP)	protein homooligomerization	0.0001032	Highly Informative	Direct
Biological Process (BP)	monosaccharide biosynthetic process	0.0005505	Highly Informative	Direct
Biological Process (BP)	serine family amino acid metabolic process	0.005566	Highly Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	transferase activity	0.892	Least Informative	Inherited
Molecular Function (MF)	heterocyclic compound binding	0.04949	Moderately Informative	Inherited
Molecular Function (MF)	organic cyclic compound binding	0.05777	Moderately Informative	Inherited
Molecular Function (MF)	anion binding	0.02414	Moderately Informative	Inherited
Molecular Function (MF)	transferase activity, transferring acyl groups	6.021e-15	Informative	Direct
Molecular Function (MF)	carboxylic acid binding	4.008e-14	Informative	Direct
Molecular Function (MF)	nucleotide binding	1	Informative	Inherited
Molecular Function (MF)	sulfur compound binding	0	Highly Informative	Direct
Molecular Function (MF)	monocarboxylic acid binding	0	Highly Informative	Direct
Molecular Function (MF)	ATP binding	6.759e-06	Highly Informative	Direct
Molecular Function (MF)	acetyltransferase activity	0.1922	Highly Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0	Least Informative	Direct
Cellular Component (CC)	protein complex	0.2366	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	0.9327	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.04014	Least Informative	Inherited
Cellular Component (CC)	membrane	0.9985	Least Informative	Inherited
Cellular Component (CC)	mitochondrial part	7.483e-10	Moderately Informative	Direct
Cellular Component (CC)	organelle envelope	0.0003954	Moderately Informative	Direct
Cellular Component (CC)	intracellular organelle lumen	0.7193	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.03762	Moderately Informative	Inherited
Cellular Component (CC)	plastid	0.002728	Informative	Inherited
Cellular Component (CC)	lipid particle	5.357e-05	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Ligases	1.568e-12	Least Informative	Direct
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0.1167	Moderately Informative	Inherited
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0	Informative	Direct
Enzyme Commission (EC)	Ligases that form carbon-carbon bonds	1	Informative	Inherited
Enzyme Commission (EC)	Biotin carboxylase	0	Highly Informative	Direct
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Pyruvate carboxylase	4.713e-16	Highly Informative	Direct
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)tra	5.21e-11	Highly Informative	Direct
Enzyme Commission (EC)	Methylcrotonoyl-CoA carboxylase	1.983e-06	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of metabolism	0.0004885	Moderately Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.03751	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0.0996	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.000191	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of movement	0.0005802	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Cognitive impairment	0.01976	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of muscle physiology	0.399	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Acidosis	1.471e-05	Informative	Direct
Phenotypic Abnormality (PA)	Muscular hypotonia	0.0003416	Informative	Direct
Phenotypic Abnormality (PA)	Intellectual disability	0.0003885	Informative	Direct
Phenotypic Abnormality (PA)	Lethargy	0.0004219	Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of carboxylic acid metabolism	0.001743	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of serum amino acid levels	6.845e-08	Highly Informative	Direct

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct
Fly Anatomy (FA)	organ system subdivision	0	Least Informative	Direct

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)

	ZA term	FDR (all)	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	nervous system	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	head	0	Least Informative	Direct

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	male genitalia	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	central nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	viscus	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	portion of tissue	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	ovary	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	heart	0.0006645	Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot apex	0	Least Informative	Direct
Plant ANatomical entity (PAN)	plant embryo	0	Least Informative	Direct
Plant ANatomical entity (PAN)	seed	0	Least Informative	Direct
Plant ANatomical entity (PAN)	vascular leaf	0	Least Informative	Direct
Plant ANatomical entity (PAN)	megasporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sepal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	petal	0	Least Informative	Direct
Plant ANatomical entity (PAN)	pedicel	0	Least Informative	Direct
Plant ANatomical entity (PAN)	gynoecium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	collective leaf structure	0	Least Informative	Direct
Plant ANatomical entity (PAN)	stalk	0.000565	Least Informative	Direct
Plant ANatomical entity (PAN)	sporangium	0.001808	Least Informative	Inherited
Plant ANatomical entity (PAN)	microgametophyte	0.01842	Least Informative	Inherited
Plant ANatomical entity (PAN)	leaf lamina	0.0695	Least Informative	Inherited
Plant ANatomical entity (PAN)	plant cell	0.6074	Least Informative	Inherited
Plant ANatomical entity (PAN)	microsporophyll	0.7048	Least Informative	Inherited
Plant ANatomical entity (PAN)	guard cell	1.328e-05	Moderately Informative	Direct
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	C globular stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	seed development stage	0.0007341	Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases	3.819e-12	Moderately Informative	Direct
Enzyme Commission (EC)	Carbon-carbon lyases	0.6322	Moderately Informative	Inherited
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0	Informative	Direct
Enzyme Commission (EC)	Carboxy-lyases	0.2914	Informative	Inherited
Enzyme Commission (EC)	Biotin carboxylase	0	Highly Informative	Direct
Enzyme Commission (EC)	Urea carboxylase	1.938e-08	Highly Informative	Direct
Enzyme Commission (EC)	Ligases that form carbon-carbon bonds	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)

	DB term	FDR (all)	SDDB level	Annotation (direct or inherited)
Drugbank ATC_code (DB)	vitamins	4.695e-06	Least Informative	Direct
Drugbank ATC_code (DB)	other plain vitamin preparations	1	Moderately Informative	Inherited

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	1	Least Informative	Inherited
Biological process	Lipid metabolism	5.958e-11	Moderately Informative	Direct
Biological process	Ion transport	1	Moderately Informative	Inherited
Biological process	Glycolysis	0	Informative	Direct
Biological process	Tricarboxylic acid cycle	0	Informative	Direct
Biological process	Lipid biosynthesis	2.053e-15	Informative	Direct
Biological process	Fatty acid metabolism	8.826e-14	Informative	Direct
Biological process	Gluconeogenesis	2.909e-09	Highly Informative	Direct
Biological process	Sodium transport	1.047e-06	Highly Informative	Direct
Cellular component	Mitochondrion	0	Moderately Informative	Direct
Domain	Transit peptide	1.73e-11	Moderately Informative	Direct
Molecular function	Sodium	0.0001578	Informative	Direct
Molecular function	Biotin	0	Highly Informative	Direct
Molecular function	Pyruvate	7.748e-09	Highly Informative	Direct
Post-translational modification	Transferase	1	Least Informative	Inherited
Post-translational modification	Acyltransferase	0	Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	1.638e-11	Least Informative	Direct
UniPathway (UP)	amino-acid metabolism	2.251e-05	Least Informative	Direct
UniPathway (UP)	carbohydrate metabolism	0.3953	Least Informative	Inherited
UniPathway (UP)	fatty acid metabolism	0	Moderately Informative	Direct
UniPathway (UP)	amino-acid degradation	0	Moderately Informative	Direct
UniPathway (UP)	lipid biosynthesis	2.207e-15	Moderately Informative	Direct
UniPathway (UP)	carbohydrate biosynthesis	6.989e-11	Moderately Informative	Direct
UniPathway (UP)	metabolic intermediate biosynthesis	0.0002281	Moderately Informative	Direct
UniPathway (UP)	fatty acid biosynthesis	0	Informative	Direct
UniPathway (UP)	gluconeogenesis	9.984e-15	Informative	Direct
UniPathway (UP)	metabolic intermediate degradation	5.51e-06	Informative	Direct
UniPathway (UP)	Branched-chain amino-acid degradation	9.06e-05	Informative	Direct
UniPathway (UP)	L-leucine degradation	0	Highly Informative	Direct
UniPathway (UP)	L-lysine degradation via saccharopine pathway	0	Highly Informative	Direct
UniPathway (UP)	propanoyl-CoA degradation	1.505e-12	Highly Informative	Direct
UniPathway (UP)	malonyl-CoA biosynthesis	2.726e-11	Highly Informative	Direct
UniPathway (UP)	ketone degradation	1	Highly Informative	Inherited

Document: UP annotation of SCOP domains

InterPro annotation

Cross references IPR011053 SSF51230 Protein matches

Abstract
The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [ PubMed 8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [ PubMed 10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [ PubMed 10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [ PubMed 8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Single hybrid motif superfamily