SUPERFAMILY 1.75 HMM library and genome assignments server

Single hybrid motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Barrel-sandwich hybrid [ 51229] (4)
Superfamily:   Single hybrid motif [ 51230]
Families:   Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)


Superfamily statistics
Genomes (3,188) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,882 120,557 16
Proteins 21,107 109,526 16


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0003716 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01071 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000000000072 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000001471 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00008958 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00009874 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0002875 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.05898 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4063 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5012 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2208 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.041 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.03002 Moderately Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.000000002889 Informative Direct
Biological Process (BP) hexose metabolic process 0.00000005112 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000002256 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0000004172 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00002874 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00006754 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.2571 Informative Inherited
Biological Process (BP) protein oligomerization 0.032 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.001517 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.04809 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1561 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.000000004493 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.000000007426 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.000003226 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00001537 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00005202 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.00008545 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00125 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.000000002841 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.001651 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01934 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000000002227 Informative Direct
Molecular Function (MF) amide binding 0.00000000003358 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000279 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.1281 Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000004617 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00004792 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.464 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1901 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1487 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0000000004229 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0003725 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.622 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) lipid particle 0.0000000000004352 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.0000000000523 Informative Direct
Cellular Component (CC) plastid 0.001411 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0.000000000001568Least InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.1167Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.0000000000521Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.000001983Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.06682Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.0001012Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.01681Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of urogenital tract0.00000658InformativeDirect
Disease Ontology (DO)liver disease0.0108InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.02152Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.05606Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00003978Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.001844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01133Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3101Moderately InformativeInherited
Phenotypic Abnormality (PA)Lethargy0.00002634InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.00008823InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0.00009088InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0001018InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.0003283InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)heart0.0006836InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001935Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.003552Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.7109Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0008019InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.00000000001398Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.6498Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases2.432e-16InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.3029InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00000001577Highly InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.008093Least InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)biotin0.0000000000003508InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0.00000000004272Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processLipid biosynthesis9.345e-16InformativeDirect
Biological processFatty acid metabolism0.00000000000002166InformativeDirect
Biological processGluconeogenesis0.000000003425Highly InformativeDirect
Biological processSodium transport0.00000116Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0.0000000000002572Moderately InformativeDirect
Molecular functionSodium0.000167InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.0000006294Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation0.00004551Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.00000000001559Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.00002003Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.3973Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.000000000000002238Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.00000000006633Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.000215Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)gluconeogenesis0.000000000000009691InformativeDirect
UniPathway (UP)metabolic intermediate degradation0.00000539InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.00008596InformativeDirect
UniPathway (UP)L-leucine degradation0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation0.000000000001796Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis0.00000000002302Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011053 SSF51230 Protein matches
Abstract

The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PubMed8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PubMed10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PubMed10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PubMed8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]