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Single hybrid motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Barrel-sandwich hybrid [ 51229] (4)
Superfamily:   Single hybrid motif [ 51230]
Families:   Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)


Superfamily statistics
Genomes (3,189) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,894 120,557 16
Proteins 21,117 109,526 16


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001602 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00004319 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1657 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000000001208 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000003385 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000009102 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00001258 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.7221 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6804 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.007088 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4676 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6942 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8919 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.06822 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1329 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02507 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04312 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.6026 Moderately Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000001794 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00008362 Informative Direct
Biological Process (BP) protein oligomerization 0.000846 Informative Direct
Biological Process (BP) response to inorganic substance 0.1934 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.004631 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.9024 Informative Inherited
Biological Process (BP) behavior 0.2434 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.001594 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.002608 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.5436 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.05502 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.4755 Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.0000000000008894 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0.0000000005133 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.000000003993 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0000001409 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000003044 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.000003911 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00001181 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.000649 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.01525 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1469 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.001352 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8729 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000001981 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002531 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01537 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000000003326 Informative Direct
Molecular Function (MF) amide binding 0.0000000009217 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.00003501 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.00003591 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.02502 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.001191 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.03495 Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00000009241 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000049 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.03794 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00003252 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9004 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000000000003136 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.3025 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03808 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) lipid particle 0.000000000004024 Informative Direct
Cellular Component (CC) plastid 0.005849 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0.000000000001568Least InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.1167Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.0000000000521Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.000001983Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1102Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.0001012Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0158Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.04093Moderately InformativeInherited
Disease Ontology (DO)liver disease0.01021InformativeInherited
Disease Ontology (DO)primary biliary cirrhosis0.00000594Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03077Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4473Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00003649Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0.002333Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01281Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.05281Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2817Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.0000004259InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.000002014InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.00002785InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0001395InformativeDirect
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.0003115InformativeDirect
Phenotypic Abnormality (PA)Aciduria0.00551InformativeInherited
Phenotypic Abnormality (PA)Hyperglycinuria0.00000135Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.03727Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00002612Moderately InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000003843InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)eye0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001938Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.003571Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.7116Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0008028InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.000000000003365Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.6728Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00000001867Highly InformativeDirect
Enzyme Commission (EC)Oxaloacetate decarboxylase0.00000624Highly InformativeDirect
Enzyme Commission (EC)Forming carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.001998Least InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)biotin0.0000000000004284InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0.00000000002215Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processLipid biosynthesis2.435e-16InformativeDirect
Biological processFatty acid metabolism0.000000000000005656InformativeDirect
Biological processGluconeogenesis0.00000003516Highly InformativeDirect
Biological processSodium transport0.000001198Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0.00000000000009184Moderately InformativeDirect
Molecular functionSodium0.0002024InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.0000005935Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation0.0001935Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.000000000005482Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.000024Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.4299Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis4.579e-16Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.00000000008438Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.00007537Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)gluconeogenesis0.00000000000001269InformativeDirect
UniPathway (UP)metabolic intermediate degradation0.000005943InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.00008585InformativeDirect
UniPathway (UP)L-leucine degradation0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation0.000000000002297Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis0.000000000003858Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011053 SSF51230 Protein matches
Abstract

The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PubMed8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PubMed10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PubMed10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PubMed8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]