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Single hybrid motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Barrel-sandwich hybrid [ 51229] (4)
Superfamily:   Single hybrid motif [ 51230]
Families:   Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)


Superfamily statistics
Genomes (3,196) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 23,011 120,669 16
Proteins 21,233 110,904 16


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000003412 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002251 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000000006966 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000002442 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000006249 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00003054 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.1558 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9114 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.08963 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4914 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.6294 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1082 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.03839 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.07391 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.5464 Moderately Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0001144 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0003694 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0005157 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0005571 Informative Direct
Biological Process (BP) protein oligomerization 0.002714 Informative Inherited
Biological Process (BP) response to metal ion 0.09693 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.03194 Informative Inherited
Biological Process (BP) cellular respiration 0.857 Informative Inherited
Biological Process (BP) behavior 0.1694 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.71 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.5036 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.06536 Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.0000000000002271 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0.000000000817 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.000000005863 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.000000006775 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000001696 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.000000535 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.000002064 Highly Informative Direct
Biological Process (BP) protein maturation 0.000008559 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00001315 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0004192 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.07807 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.0152 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8972 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000001183 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00009537 Moderately Informative Direct
Molecular Function (MF) anion binding 0.003325 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000000154 Informative Direct
Molecular Function (MF) amide binding 0.0000000005242 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0003092 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.007531 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.008029 Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.0000000009795 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000002469 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000000196 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.1057 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000008395 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1453 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.00108 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) plastid 0.009424 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0.000000000001568Least InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.1167Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.0000000000521Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.000001983Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0.00000000002582Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processLipid biosynthesis2.442e-16InformativeDirect
Biological processFatty acid metabolism0.000000000000004737InformativeDirect
Biological processGluconeogenesis0.00000003443Highly InformativeDirect
Biological processSodium transport0.000001295Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0.00000000000001569Moderately InformativeDirect
Molecular functionSodium0.0002587InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate0.0000006248Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation0.000228Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011053 SSF51230 Protein matches
Abstract

The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PubMed8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PubMed10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PubMed10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PubMed8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]