SUPERFAMILY 1.75 HMM library and genome assignments server


Single hybrid motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Barrel-sandwich hybrid [ 51229] (4)
Superfamily:   Single hybrid motif [ 51230]
Families:   Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)


Superfamily statistics
Genomes (3,187) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,866 120,557 16
Proteins 21,090 109,526 16


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0001997 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 1.721e-12 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 2.177e-10 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 1.776e-06 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.237e-06 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 2.384e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 5.121e-05 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0005103 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.5444 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2386 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.07024 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2385 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 2.115e-07 Informative Direct
Biological Process (BP) hexose metabolic process 2.647e-07 Informative Direct
Biological Process (BP) cellular amide metabolic process 1.876e-06 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 5.381e-05 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.2476 Informative Inherited
Biological Process (BP) protein complex assembly 0.0108 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.002574 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.05696 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2506 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.07888 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 3.77e-15 Highly Informative Direct
Biological Process (BP) aerobic respiration 4.847e-09 Highly Informative Direct
Biological Process (BP) protein tetramerization 3.055e-06 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 7.667e-06 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 4.308e-05 Highly Informative Direct
Biological Process (BP) protein homooligomerization 8.728e-05 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00116 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8588 Least Informative Inherited
Molecular Function (MF) anion binding 0.02119 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.796e-12 Informative Direct
Molecular Function (MF) amide binding 3.148e-11 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 3.27e-05 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.143 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 5.354e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 4.478e-05 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.4814 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.3443 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01819 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 2.662e-09 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0004933 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.08234 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8437 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 1.239e-11 Informative Direct
Cellular Component (CC) plastid 0.002771 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1.568e-12Least InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.1167Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra5.21e-11Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase1.983e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04054Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.0004325Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.009328Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02431Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of urogenital tract3.007e-06InformativeDirect
Disease Ontology (DO)liver disease0.005729InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brain morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis3.602e-05Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01097Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.122Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0InformativeDirect
Phenotypic Abnormality (PA)Lethargy1.138e-05InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia4.108e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0.0002683InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.0003177InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)heat sensitivity0.0005708InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)heart0.0006826InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001935Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.003552Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.7109Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0008019InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases8.274e-12Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.6244Moderately InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.281InformativeInherited
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase1.576e-08Highly InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism3.897e-11Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processLipid biosynthesis9.352e-16InformativeDirect
Biological processFatty acid metabolism2.232e-14InformativeDirect
Biological processGluconeogenesis3.297e-09Highly InformativeDirect
Biological processSodium transport1.14e-06Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide1.434e-12Moderately InformativeDirect
Molecular functionSodium0.0001644InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionPyruvate6.115e-07Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation4.116e-05Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism1.582e-11Least InformativeDirect
UniPathway (UP)amino-acid metabolism2.022e-05Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.3979Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis2.231e-15Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis6.681e-11Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.0002166Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)gluconeogenesis9.876e-15InformativeDirect
UniPathway (UP)metabolic intermediate degradation5.397e-06InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation8.659e-05InformativeDirect
UniPathway (UP)L-leucine degradation0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation1.799e-12Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis2.296e-11Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011053 SSF51230 Protein matches
Abstract

The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PubMed8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PubMed10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PubMed10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PubMed8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]