SUPERFAMILY 1.73 HMM library and genome assignments server


Single hybrid motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   Barrel-sandwich hybrid [ 51229] (4)
  sandwich of half-barrel shaped beta-sheets
Superfamily:   Single hybrid motif [ 51230]
Families:   Biotinyl/lipoyl-carrier proteins and domains [ 51231] (6)


Superfamily statistics
Genomes (1,216) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 8,971 9,206 16
Proteins 8,313 8,396 16


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR011053 SSF51230 Protein matches
Abstract

The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PubMed8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PubMed10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PubMed10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PubMed8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Single hybrid motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Single hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]