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dUTPase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-clip [ 51268] (7)
Superfamily:   dUTPase-like [ 51283]
Families:   dUTPase-like [ 51284] (4)


Superfamily statistics
Genomes (2,942) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,660 30,834 16
Proteins 5,489 29,385 15


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00000000000033850.000000000006509Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000000000040640.00000000007043Least InformativeDirect
Biological Process (BP)primary metabolic process0.00000071830.00005497Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00000077370.00000005387Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000000000035970.000000000005045Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000000000028070.00000000003379Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.7380.7357Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00033530.01316Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.00000015770.000000002375Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00000000077890.000000000001525Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.016350.001487Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0045810.0005104Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0054970.0008882Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.00016890.000002963InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000022360.0000000003203InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000011630.00000043InformativeDirect
Biological Process (BP)nucleoside triphosphate catabolic process0.000000010680.0000000000003023Highly InformativeDirect
Biological Process (BP)pyrimidine nucleoside triphosphate metabolic process00Highly InformativeDirect
Biological Process (BP)nucleotide catabolic process0.00012830.000002919Highly InformativeDirect
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process00Highly InformativeDirect
Biological Process (BP)deoxyribonucleotide metabolic process00Highly InformativeDirect
Biological Process (BP)deoxyribose phosphate metabolic process00Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound catabolic process0.0000000025460.0000000000002331Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000000000000029530.0000000000000227Least InformativeDirect
Molecular Function (MF)binding0.51140.9494Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.012450.003118Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.000037790.0000009937InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.018270.01199InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines0.000000000099930.0000000003465Highly InformativeDirect
Molecular Function (MF)deaminase activity0.000000024490.000000008477Highly InformativeDirect
Molecular Function (MF)nucleoside-triphosphate diphosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000006509 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00000000007043 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00005497 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000005387 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000005045 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000003379 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.7357 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01316 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.000000002375 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0008882 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0005104 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000000001525 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.001487 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.000002963 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000000003203 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000043 Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 0.0000000000003023 Highly Informative Direct
Biological Process (BP) pyrimidine nucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.000002919 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0.0000000000002331 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000000000227 Least Informative Direct
Molecular Function (MF) binding 0.9494 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.003118 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.0000009937 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.01199 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.0000000003465 Highly Informative Direct
Molecular Function (MF) deaminase activity 0.000000008477 Highly Informative Direct
Molecular Function (MF) nucleoside-triphosphate diphosphatase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0.09958Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0.00000000001499InformativeDirect
Enzyme Commission (EC)dUTP diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirus entry into host cell0.0006099InformativeDirect
Biological processViral genome integration0Highly InformativeDirect
Biological processNucleotide metabolism0Highly InformativeDirect
Biological processDNA integration0.000000007475Highly InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationAspartyl protease0Highly InformativeDirect
Post-translational modificationRNA-directed DNA polymerase4.413e-16Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dUTPase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the dUTPase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]