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Hedgehog/intein (Hint) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Hedgehog/intein (Hint) domain [ 51293]
Superfamily:   Hedgehog/intein (Hint) domain [ 51294] (2)
Families:   Hedgehog C-terminal (Hog) autoprocessing domain [ 51295]
  Intein (protein splicing domain) [ 51298] (4)


Superfamily statistics
Genomes (880) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,762 15,347 9
Proteins 2,610 14,577 9


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0007645 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.6835 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01792 Least Informative Inherited
Biological Process (BP) biological regulation 0.4477 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09121 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5847 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.0109 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.4118 Least Informative Inherited
Biological Process (BP) cell communication 0.00000000000005766 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000125 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000355 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000000000007367 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0007617 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000006646 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000004779 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000002641 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.003248 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01267 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.06586 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05813 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001971 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001654 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.003857 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8025 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01421 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6637 Moderately Informative Inherited
Biological Process (BP) gene expression 0.08129 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2895 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.004354 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.005538 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.004281 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.005125 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.00007022 Informative Direct
Biological Process (BP) proteolysis 0.0003878 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000003879 Informative Direct
Biological Process (BP) cell-cell signaling 0.0000000000002023 Informative Direct
Biological Process (BP) central nervous system development 0.00008884 Informative Direct
Biological Process (BP) embryo development 0.0000000000754 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00009717 Informative Direct
Biological Process (BP) growth 0.00002612 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000000003349 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00001142 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000001286 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0005285 Informative Direct
Biological Process (BP) generation of neurons 0.000004098 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000001722 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001341 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001464 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0232 Informative Inherited
Biological Process (BP) locomotion 0.001134 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.001156 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.227 Informative Inherited
Biological Process (BP) sensory organ development 0.01036 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09155 Informative Inherited
Biological Process (BP) tissue development 0.2982 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0522 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.02537 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.02134 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7592 Informative Inherited
Biological Process (BP) circulatory system development 0.009179 Informative Inherited
Biological Process (BP) cell development 0.3188 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.007693 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0007868 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000002783 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00008418 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.0000006574 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0003002 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00009795 Highly Informative Direct
Biological Process (BP) appendage development 0.0000004943 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0002984 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000006388 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000002352 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.0005164 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000002697 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000005058 Highly Informative Direct
Biological Process (BP) protein maturation 0.00001435 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0001101 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0003072 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000002084 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00002165 Highly Informative Direct
Biological Process (BP) neuron development 0.007361 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.02652 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.01054 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.005084 Highly Informative Inherited
Biological Process (BP) brain development 0.09212 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01983 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.04679 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.01024 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.001502 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.02546 Highly Informative Inherited
Molecular Function (MF) binding 0.8278 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000003081 Moderately Informative Direct
Molecular Function (MF) receptor binding 0.0001001 Informative Direct
Molecular Function (MF) calcium ion binding 0.0001192 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.000002724 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00000000001853Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002567Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0007016Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.003052Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0.5033InformativeInherited
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.0000003949Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of long bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of body height0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001357Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0008631Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.006866Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000001471Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00000008102Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00003847Moderately InformativeDirect
Worm Phenotype (WP)body length variant0.000000001743InformativeDirect
Worm Phenotype (WP)body width variant0.000000003429InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)small0.0000000000009774Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.000000000001719Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.000000001147Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00000001889Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0000005326Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.1041Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0000001269Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.002373Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000004397Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.00000000002512Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.0007928Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.00005634InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0.00000001362Highly InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.5911Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0.0004507Moderately InformativeDirect
Biological processIon transport0.009999Moderately InformativeInherited
Biological processDNA replication0InformativeDirect
Biological processDNA recombination0.000003945InformativeDirect
Biological processIntron homing0Highly InformativeDirect
Biological processSOS response0.0002442Highly InformativeDirect
Biological processHydrogen ion transport0.0003504Highly InformativeDirect
Cellular componentMembrane0.0001269Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.000000008659Moderately InformativeDirect
Cellular componentPrimosome0Highly InformativeDirect
DomainSignal0.00002085Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.913Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.00000000000002429Moderately InformativeDirect
Post-translational modificationProtease0.0000001451Moderately InformativeDirect
Post-translational modificationIsomerase0.005925Moderately InformativeInherited
Post-translational modificationEndonuclease0.0004375InformativeDirect
Post-translational modificationInitiation factor0.0006797InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationProtein splicing0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)DNA replication0.00000000000002866Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hedgehog/intein (Hint) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Hedgehog/intein (Hint) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]