SUPERFAMILY 1.75 HMM library and genome assignments server


Hedgehog/intein (Hint) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Hedgehog/intein (Hint) domain [ 51293]
Superfamily:   Hedgehog/intein (Hint) domain [ 51294] (2)
Families:   Hedgehog C-terminal (Hog) autoprocessing domain [ 51295]
  Intein (protein splicing domain) [ 51298] (4)


Superfamily statistics
Genomes (867) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,659 8,058 9
Proteins 2,507 7,640 9


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.0000000001975 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000003936 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00004165 Least Informative Direct
Biological Process (BP) protein metabolic process 0.1332 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2543 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.02523 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3207 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5259 Least Informative Inherited
Biological Process (BP) localization 0.8176 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6213 Least Informative Inherited
Biological Process (BP) cell differentiation 0.0000000000001121 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0000001646 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000005727 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000003155 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000005182 Moderately Informative Direct
Biological Process (BP) reproduction 0.0001976 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0002331 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0003853 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.02404 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2801 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001886 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05966 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.03203 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.1025 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001153 Moderately Informative Inherited
Biological Process (BP) organ development 0.9879 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9478 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1164 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.00601 Moderately Informative Inherited
Biological Process (BP) gene expression 0.001092 Moderately Informative Inherited
Biological Process (BP) tissue development 0.05292 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8757 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01219 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01959 Moderately Informative Inherited
Biological Process (BP) cell-cell signaling 0.00000001361 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000002863 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000001735 Informative Direct
Biological Process (BP) cardiovascular system development 0.000002634 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000005891 Informative Direct
Biological Process (BP) embryonic organ development 0.000008133 Informative Direct
Biological Process (BP) generation of neurons 0.00003151 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.00005499 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00008425 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000106 Informative Direct
Biological Process (BP) programmed cell death 0.0001083 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000122 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0001963 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001984 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000235 Informative Direct
Biological Process (BP) localization of cell 0.0003058 Informative Direct
Biological Process (BP) epithelium development 0.0003742 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0004222 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0004905 Informative Direct
Biological Process (BP) response to lipid 0.0006337 Informative Direct
Biological Process (BP) regulation of locomotion 0.0007063 Informative Direct
Biological Process (BP) tube development 0.0008464 Informative Direct
Biological Process (BP) cell projection organization 0.01889 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03172 Informative Inherited
Biological Process (BP) muscle structure development 0.04291 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2428 Informative Inherited
Biological Process (BP) reproductive system development 0.002568 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.002053 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.006281 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.004478 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.006255 Informative Inherited
Biological Process (BP) sensory organ development 0.002419 Informative Inherited
Biological Process (BP) central nervous system development 0.001763 Informative Inherited
Biological Process (BP) gland development 0.00544 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001353 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4921 Informative Inherited
Biological Process (BP) cellular component movement 0.05883 Informative Inherited
Biological Process (BP) locomotion 0.003775 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0155 Informative Inherited
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) protein processing 0.00000000003156 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0000000004247 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000000003537 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.000000005448 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00000008177 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0000001702 Highly Informative Direct
Biological Process (BP) tissue homeostasis 0.0000001957 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0000002767 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000000432 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0000004648 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.000001379 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000001684 Highly Informative Direct
Biological Process (BP) axon development 0.000005353 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00002243 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00002486 Highly Informative Direct
Biological Process (BP) ossification 0.0000253 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00003644 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00003718 Highly Informative Direct
Biological Process (BP) respiratory system development 0.00007591 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00008259 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.00009973 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0001099 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0001136 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000136 Highly Informative Direct
Biological Process (BP) renal system development 0.0001473 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0002033 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.0002972 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0004886 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0005375 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0005744 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.07992 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.001751 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.0317 Highly Informative Inherited
Biological Process (BP) stem cell development 0.003152 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.05191 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.03531 Highly Informative Inherited
Molecular Function (MF) binding 0.6857 Least Informative Inherited
Molecular Function (MF) cation binding 0.00001522 Moderately Informative Direct
Molecular Function (MF) receptor binding 0.000001802 Informative Direct
Molecular Function (MF) transition metal ion binding 0.02294 Informative Inherited
Molecular Function (MF) calcium ion binding 0.0000000001332 Highly Informative Direct
Cellular Component (CC) membrane 0.2081 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0001228 Moderately Informative Direct
Cellular Component (CC) extracellular matrix 0.000001196 Informative Direct
Cellular Component (CC) cell surface 0.0005495 Informative Direct
Cellular Component (CC) membrane raft 0.0000008401 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00000000001853Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002567Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0007016Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.003052Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0.5033InformativeInherited
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.0000003949Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002941Least InformativeInherited
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.000000008407Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00000001472Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00001403Moderately InformativeDirect
Worm Phenotype (WP)body length variant0.0000000003673InformativeDirect
Worm Phenotype (WP)body width variant0.0000000005843InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)small0.000000000000244Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0000000000003481Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.000000000003131Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00000006465Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0000001851Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.06398Highly InformativeInherited

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000001371Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.00379Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.000000000003705Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.00000000003803Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.0008578Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)DNA helicase0.000000000000003087InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.00005432InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0.0000000139Highly InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.5495Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0.0005493Moderately InformativeDirect
Biological processIon transport0.009382Moderately InformativeInherited
Biological processDNA replication0InformativeDirect
Biological processDNA recombination0.000008432InformativeDirect
Biological processIntron homing0Highly InformativeDirect
Biological processSOS response0.0001972Highly InformativeDirect
Biological processHydrogen ion transport0.0003494Highly InformativeDirect
Cellular componentMembrane0.00005258Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.000000004192Moderately InformativeDirect
Cellular componentPrimosome0Highly InformativeDirect
DomainSignal0.00002232Least InformativeDirect
Molecular functionZinc0.0000126Least InformativeDirect
Molecular functionNucleotide-binding0.00005844Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionCalcium0.000000007304Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.8032Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationNuclease4.432e-16Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.00000000000002328Moderately InformativeDirect
Post-translational modificationProtease0.00000009797Moderately InformativeDirect
Post-translational modificationIsomerase0.00504Moderately InformativeInherited
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationInitiation factor0.0006259InformativeDirect
Post-translational modificationEndonuclease0.0007157InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationProtein splicing0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)DNA replication0.00000000000002699Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hedgehog/intein (Hint) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Hedgehog/intein (Hint) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]