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Hedgehog/intein (Hint) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Hedgehog/intein (Hint) domain [ 51293]
Superfamily:   Hedgehog/intein (Hint) domain [ 51294] (2)
Families:   Hedgehog C-terminal (Hog) autoprocessing domain [ 51295]
  Intein (protein splicing domain) [ 51298] (4)


Superfamily statistics
Genomes (882) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,765 15,347 9
Proteins 2,613 14,577 9


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000005318 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004916 Least Informative Direct
Biological Process (BP) response to stimulus 0.0683 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.008192 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3457 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.007968 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.453 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4142 Least Informative Inherited
Biological Process (BP) biological regulation 0.3856 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000000001896 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000000275 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00001137 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00005288 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00006797 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0002398 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0005664 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00633 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.4282 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1148 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01152 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6013 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0294 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.001208 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00787 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.609 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04464 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002131 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.0166 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.004986 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.00173 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1812 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.001724 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001296 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.004682 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3233 Moderately Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.000000000006182 Informative Direct
Biological Process (BP) embryo development 0.00000000002369 Informative Direct
Biological Process (BP) generation of neurons 0.0000001631 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000001889 Informative Direct
Biological Process (BP) growth 0.000001098 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000003418 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000005666 Informative Direct
Biological Process (BP) proteolysis 0.000009932 Informative Direct
Biological Process (BP) central nervous system development 0.00001555 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00001746 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00003564 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00004013 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00008499 Informative Direct
Biological Process (BP) locomotion 0.00008596 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0002406 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0003608 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.01957 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.007934 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01443 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.004413 Informative Inherited
Biological Process (BP) cell development 0.2212 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.08635 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01688 Informative Inherited
Biological Process (BP) circulatory system development 0.02625 Informative Inherited
Biological Process (BP) response to acid chemical 0.001968 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.006621 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002969 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.008244 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1556 Informative Inherited
Biological Process (BP) epithelium development 0.002013 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01862 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001114 Informative Inherited
Biological Process (BP) cell-cell signaling 0.00000000000008578 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000009204 Highly Informative Direct
Biological Process (BP) appendage development 0.00000001709 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00000003542 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000008957 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000003496 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0000005948 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000006643 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000002417 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000002573 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000003396 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000005995 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000006654 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00001564 Highly Informative Direct
Biological Process (BP) protein maturation 0.00003604 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0001288 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0001296 Highly Informative Direct
Biological Process (BP) cell growth 0.0001923 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0003961 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0005218 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0006318 Highly Informative Direct
Biological Process (BP) neuron development 0.002086 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.001763 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.004156 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.009956 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.004915 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.006228 Highly Informative Inherited
Biological Process (BP) heart development 0.01035 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.03922 Highly Informative Inherited
Molecular Function (MF) binding 0.8763 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000003174 Moderately Informative Direct
Molecular Function (MF) receptor binding 0.0001006 Informative Direct
Molecular Function (MF) calcium ion binding 0.0001204 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.0000005236 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00000000001853Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002567Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0007016Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.003052Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0.5033InformativeInherited
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.0000003949Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0.000441Moderately InformativeDirect
Biological processIon transport0.00998Moderately InformativeInherited
Biological processDNA replication0InformativeDirect
Biological processDNA recombination0.000003851InformativeDirect
Biological processIntron homing0Highly InformativeDirect
Biological processHydrogen ion transport0.0003428Highly InformativeDirect
Cellular componentMembrane0.0001398Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.000000009813Moderately InformativeDirect
Cellular componentPrimosome0Highly InformativeDirect
DomainSignal0.000023Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.9113Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.00000000000002331Moderately InformativeDirect
Post-translational modificationProtease0.0000001529Moderately InformativeDirect
Post-translational modificationIsomerase0.005871Moderately InformativeInherited
Post-translational modificationEndonuclease0.0004405InformativeDirect
Post-translational modificationInitiation factor0.0006706InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationProtein splicing0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hedgehog/intein (Hint) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Hedgehog/intein (Hint) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]