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Hedgehog/intein (Hint) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Hedgehog/intein (Hint) domain [ 51293]
Superfamily:   Hedgehog/intein (Hint) domain [ 51294] (2)
Families:   Hedgehog C-terminal (Hog) autoprocessing domain [ 51295]
  Intein (protein splicing domain) [ 51298] (4)


Superfamily statistics
Genomes (876) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,722 8,058 9
Proteins 2,570 7,640 9


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000344 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.6553 Least Informative Inherited
Biological Process (BP) biological regulation 0.3671 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.00364 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6114 Least Informative Inherited
Biological Process (BP) response to stimulus 0.06481 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0.00000000002225 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.0001689 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0008276 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0001423 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00004407 Moderately Informative Direct
Biological Process (BP) signaling 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0008287 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000001288 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000004791 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000003218 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.0001902 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.6723 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1509 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.08119 Moderately Informative Inherited
Biological Process (BP) gene expression 0.08406 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.1336 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.006971 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01237 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.003992 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004185 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8211 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2825 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001904 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.005482 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.00004481 Informative Direct
Biological Process (BP) proteolysis 0.000005666 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000003465 Informative Direct
Biological Process (BP) central nervous system development 0.0000706 Informative Direct
Biological Process (BP) embryo development 0.00000000003241 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0001043 Informative Direct
Biological Process (BP) growth 0.00002463 Informative Direct
Biological Process (BP) locomotion 0.0008375 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000000004191 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000009771 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000001045 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0004771 Informative Direct
Biological Process (BP) generation of neurons 0.000003143 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000175 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001399 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001282 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.01579 Informative Inherited
Biological Process (BP) cell development 0.284 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.001423 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.223 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.00634 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09037 Informative Inherited
Biological Process (BP) epithelium development 0.02535 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01145 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05313 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.09474 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01941 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7454 Informative Inherited
Biological Process (BP) circulatory system development 0.008376 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0007046 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000003306 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00008296 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000003181 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0003424 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00007457 Highly Informative Direct
Biological Process (BP) appendage development 0.000001876 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0001914 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000006378 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000002168 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.0004874 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000002496 Highly Informative Direct
Biological Process (BP) protein maturation 0.000006385 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0001312 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000265 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000001916 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00142 Highly Informative Inherited
Biological Process (BP) neuron development 0.006866 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.007996 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.005094 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) brain development 0.08441 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02191 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.04239 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.008012 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.02708 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.002533 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.03252 Highly Informative Inherited
Molecular Function (MF) binding 0.757 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000002149 Moderately Informative Direct
Molecular Function (MF) protein binding 0.4812 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.00001187 Informative Direct
Molecular Function (MF) calcium ion binding 0.0001144 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.000002231 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0.00000000001853Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002567Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0007016Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.003052Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0.5033InformativeInherited
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.0000003949Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of long bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of body height0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00009114Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0008053Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.005332Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000001477Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00000007696Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00003609Moderately InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0000000000005583InformativeDirect
Worm Phenotype (WP)body length variant0.000000001645InformativeDirect
Worm Phenotype (WP)body width variant0.00000000336InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)small0.0000000000009018Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.000000000001686Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.00000000002544Highly InformativeDirect
Worm Phenotype (WP)body vacuole0.00000001434Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.000000208Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.08262Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0000001518Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.002559Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000005111Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.00000000002552Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.0008762Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.00005891InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0.00000001428Highly InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.5922Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0.0004492Moderately InformativeDirect
Biological processIon transport0.01002Moderately InformativeInherited
Biological processDNA replication0InformativeDirect
Biological processDNA recombination0.000004InformativeDirect
Biological processIntron homing0Highly InformativeDirect
Biological processSOS response0.0002508Highly InformativeDirect
Biological processHydrogen ion transport0.0003575Highly InformativeDirect
Cellular componentMembrane0.0001193Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.000000007689Moderately InformativeDirect
Cellular componentPrimosome0Highly InformativeDirect
DomainSignal0.00001931Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.8559Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.00000000000002606Moderately InformativeDirect
Post-translational modificationProtease0.0000001272Moderately InformativeDirect
Post-translational modificationIsomerase0.005652Moderately InformativeInherited
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationEndonuclease0.000441InformativeDirect
Post-translational modificationInitiation factor0.0006498InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationProtein splicing0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)DNA replication0.00000000000002897Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hedgehog/intein (Hint) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Hedgehog/intein (Hint) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]