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Triosephosphate isomerase (TIM) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Triosephosphate isomerase (TIM) [ 51351]
Families:   Triosephosphate isomerase (TIM) [ 51352]


Superfamily statistics
Genomes (3,171) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,959 24,998 46
Proteins 3,945 24,979 46


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00000039620.0000007352Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00000041560.0000005845Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000016010.000002622Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000012710.0000000003033Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000015420.000009856Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0015210.0004992Least InformativeInherited
Biological Process (BP)biosynthetic process0.42280.2193Least InformativeInherited
Biological Process (BP)primary metabolic process0.014730.03345Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.0029040.003408Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000000000002320Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00000000000031220Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.000000000028250.000000000000003764Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.00000000053730.000000000000187Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.00000041330.000000002669Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.061340.03992Moderately InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process00InformativeDirect
Biological Process (BP)ATP metabolic process00InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process00InformativeDirect
Biological Process (BP)phosphorylation0.00000033290.0001869InformativeDirect
Biological Process (BP)monosaccharide metabolic process0.00001090.0000005418InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.000040110.000004393InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process0.00070870.00000006954InformativeDirect
Biological Process (BP)glycolytic process00.00000000002045Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.00000000000021120.0000000001289Highly InformativeDirect
Biological Process (BP)glucose metabolic process0.00000000000066820Highly InformativeDirect
Biological Process (BP)glyceraldehyde-3-phosphate metabolic process0.00056790.000001752Highly InformativeDirect
Molecular Function (MF)isomerase activity00Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.00000020390.0000000000955InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000007352 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000005845 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000002622 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000003033 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000009856 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004992 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2193 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03345 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.003408 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000000000187 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000002669 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.03992 Moderately Informative Inherited
Biological Process (BP) nucleoside diphosphate metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0.0001869 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000005418 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000004393 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.00000006954 Informative Direct
Biological Process (BP) glycolytic process 0.00000000002045 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000000001289 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0.000001752 Highly Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.0000000000955 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)glycolysis0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000652 SSF51351 Protein matches
Abstract

Triosephosphate isomerase (TIM) [PubMed2204417] is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production. It is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism [PubMed2005961]. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder [PubMed12023819].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Triosephosphate isomerase (TIM) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Triosephosphate isomerase (TIM) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]