SUPERFAMILY 1.75 HMM library and genome assignments server

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Thiamin phosphate synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Thiamin phosphate synthase [ 51391]
Families:   Thiamin phosphate synthase [ 51392]


Superfamily statistics
Genomes (2,415) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,664 22,151 6
Proteins 3,650 22,086 6


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000001392 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000001558 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000321 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000004445 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002012 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0003517 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.01662 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03198 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00000000004863 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000001027 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000003053 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000005131 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00001184 Moderately Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000000000000003734 Informative Direct
Biological Process (BP) thiamine biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0001161 Least Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.000000000005506 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processThiamine biosynthesis0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003733 SSF51391 Protein matches
Abstract

Thiamine monophosphate synthase (TMP) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway [PubMed9139923].

TENI, a protein from Bacillus subtilis that regulates the production of several extracellular enzymes by reducing alkaline protease production belongs to this group [PubMed1898926].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiamin phosphate synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Thiamin phosphate synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]