SUPERFAMILY 1.75 HMM library and genome assignments server


Thiamin phosphate synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Thiamin phosphate synthase [ 51391]
Families:   Thiamin phosphate synthase [ 51392]


Superfamily statistics
Genomes (2,409) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,649 22,384 6
Proteins 3,637 22,346 6


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic cyclic compound metabolic process 1.555e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003804 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0004528 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0007127 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.03097 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001055 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 3.872e-09 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 2.753e-06 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 6.391e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 7.308e-06 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 8.004e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.913e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.005e-05 Moderately Informative Direct
Biological Process (BP) vitamin metabolic process 1.422e-14 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 1.572e-11 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 3.047e-09 Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 5.563e-11 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1605 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 2.956e-09 Informative Direct
Molecular Function (MF) kinase activity 3.911e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.7473Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.9401InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processThiamine biosynthesis0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)thiamine metabolism0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR003733 SSF51391 Protein matches
Abstract

Thiamine monophosphate synthase (TMP) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway [PubMed9139923].

TENI, a protein from Bacillus subtilis that regulates the production of several extracellular enzymes by reducing alkaline protease production belongs to this group [PubMed1898926].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiamin phosphate synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Thiamin phosphate synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]