SUPERFAMILY 1.75 HMM library and genome assignments server


FMN-linked oxidoreductases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   FMN-linked oxidoreductases [ 51395]
Families:   FMN-linked oxidoreductases [ 51396] (18)


Superfamily statistics
Genomes (2,441) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 22,437 60,992 53
Proteins 22,329 60,906 53


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.74341Least InformativeInherited
Biological Process (BP)regulation of cellular process0.99091Least InformativeInherited
Biological Process (BP)biosynthetic process0.038210.04174Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.69770.04471Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0022290.000597Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.24480.06363Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.18990.06548Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.60723.367e-07Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.5191Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.1190.2592Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.17850.8053Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.19860.05528Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0036320.08349Moderately InformativeInherited
Biological Process (BP)reproduction0.082811Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.28330.7751Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.15320.6913Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0034980.0001775Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.22090.7248Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.40281Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process10.9423Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.00060360.007035Moderately InformativeInherited
Biological Process (BP)gene expression0.0070310.2956Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.00027460.1013Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.033692.751e-07Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.023740.03458Moderately InformativeInherited
Biological Process (BP)tRNA metabolic process1.585e-104.127e-09InformativeDirect
Biological Process (BP)RNA modification7.832e-104.525e-10InformativeDirect
Biological Process (BP)ncRNA processing4.195e-087.381e-07InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process3.351e-090InformativeDirect
Biological Process (BP)phospholipid metabolic process0.0021510.02614InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.015190.2847InformativeInherited
Biological Process (BP)multi-organism reproductive process7.69e-060.00142InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.0019132.942e-05InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.27060.7438InformativeInherited
Biological Process (BP)tRNA modification0.00019053.505e-05Highly InformativeDirect
Biological Process (BP)nucleobase metabolic process2.912e-100Highly InformativeDirect
Biological Process (BP)photorespiration6.139e-092.592e-10Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism7.261e-050.0004811Highly InformativeDirect
Biological Process (BP)multi-organism cellular process2.152e-050.0005755Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process5.75e-050.0003731Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process1.398e-112.853e-10Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.058740.07604Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.11650.725Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.28310.8961Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups6.071e-050.0002604InformativeDirect
Molecular Function (MF)cofactor binding5.817e-064.172e-10InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.66821InformativeInherited
Molecular Function (MF)nucleotide binding0.0058360.0004107InformativeInherited
Molecular Function (MF)prenyltransferase activity7.655e-071.716e-07Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor10.2291Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00018810.5264Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0014820.00299Least InformativeInherited
Cellular Component (CC)microbody1.849e-141.494e-14InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 3.367e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000597 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.04471 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.06363 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.04174 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.06548 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.751e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0001775 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2592 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.8053 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.05528 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0125 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.004563 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08349 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.7751 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.6913 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.7248 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.007035 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9423 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1776 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2956 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1013 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2061 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.03458 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 4.127e-09 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 2.976e-07 Informative Direct
Biological Process (BP) RNA modification 4.525e-10 Informative Direct
Biological Process (BP) ncRNA processing 7.381e-07 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 2.942e-05 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.02614 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.2847 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.3498 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.04541 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.00142 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.7438 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.002107 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.03443 Informative Inherited
Biological Process (BP) pyrimidine nucleoside metabolic process 1.522e-06 Highly Informative Direct
Biological Process (BP) tRNA modification 3.505e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid biosynthetic process 3.536e-11 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) photorespiration 2.592e-10 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0004811 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0005755 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0003731 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 2.853e-10 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.001556 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.07604 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.725 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.8961 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0004107 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0002604 Informative Direct
Molecular Function (MF) cofactor binding 4.172e-10 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) prenyltransferase activity 1.716e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 0.2291 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5264 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00299 Least Informative Inherited
Cellular Component (CC) microbody 1.494e-14 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With other acceptors1.427e-13InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor8.571e-05InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)1.803e-07Highly InformativeDirect
Enzyme Commission (EC)Dihydropyrimidine dehydrogenase (NADP(+))8.676e-07Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADPH)5.37e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0.2111Least InformativeInherited
Plant ANatomical entity (PAN)guard cell7.599e-06Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor5.381e-08Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase5.061e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processtRNA processing0InformativeDirect
Biological processLipid biosynthesis7.632e-15InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processPhospholipid biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentPeroxisome1.496e-13InformativeDirect
DomainGlutamine amidotransferase2.178e-05Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNAD0Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionIron-sulfur5.202e-06InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism1.8e-08Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism8.421e-13Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.063e-05Moderately InformativeDirect
UniPathway (UP)energy metabolism0.2093Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)organic acid biosynthesis3.782e-12InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0.2314InformativeInherited
UniPathway (UP)organic acid degradation1InformativeInherited
UniPathway (UP)beta-alanine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis1.115e-08Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 28 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FMN-linked oxidoreductases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 28 hidden Markov models representing the FMN-linked oxidoreductases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]