SUPERFAMILY 1.75 HMM library and genome assignments server


Inosine monophosphate dehydrogenase (IMPDH) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Inosine monophosphate dehydrogenase (IMPDH) [ 51412]
Families:   Inosine monophosphate dehydrogenase (IMPDH) [ 51413]


Superfamily statistics
Genomes (2,953) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,924 50,358 13
Proteins 9,538 49,296 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.015532.19e-08Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0688.378e-08Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.028897.847e-08Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.040611.302e-07Least InformativeInherited
Biological Process (BP)biosynthetic process0.15291.133e-09Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.034052.028e-10Least InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0005083.122e-13Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.060798.094e-09Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.060881.708e-08Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.052744.928e-09Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.11921.593e-07Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.12576.033e-09Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.11050.003242Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.064493.258e-10Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0073129.148e-15Moderately InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process3.266e-050InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process11InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.0071191.501e-07InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.020390.889InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate metabolic process7.955e-053.248e-07Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process0.001147.78e-13Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity4.059e-090Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H1.048e-050.02492InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.17669.942e-12InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor1.888e-050Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 2.19e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 8.378e-08 Least Informative Direct
Biological Process (BP) biosynthetic process 1.133e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.028e-10 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.302e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 7.847e-08 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 3.258e-10 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 8.094e-09 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.708e-08 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 9.148e-15 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 4.928e-09 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 3.122e-13 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.593e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 6.033e-09 Moderately Informative Direct
Biological Process (BP) immune system process 0.00152 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003242 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.3317 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01336 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.4193 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 3.464e-07 Informative Direct
Biological Process (BP) leukocyte activation 1.997e-09 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.501e-07 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 5.587e-05 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.889 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.001297 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.007289 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.000567 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 3.248e-07 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 7.78e-13 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.06622 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 9.942e-12 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000117 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.02492 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups1.951e-07InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01362InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)gamete0InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.2417Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.001106InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.01473InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis4.711e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding6.058e-12Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFlavoprotein0.02787Moderately InformativeInherited
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFMN3.73e-09InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0003711Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis5.15e-06Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.0001164Moderately InformativeDirect
UniPathway (UP)isoprenoid biosynthesis8.993e-16InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Inosine monophosphate dehydrogenase (IMPDH) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Inosine monophosphate dehydrogenase (IMPDH) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]