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Inosine monophosphate dehydrogenase (IMPDH) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Inosine monophosphate dehydrogenase (IMPDH) [ 51412]
Families:   Inosine monophosphate dehydrogenase (IMPDH) [ 51413]


Superfamily statistics
Genomes (2,955) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,957 50,358 13
Proteins 9,565 49,296 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process0.036440.000136Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.079370.00008185Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.022110.00007564Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.041520.0004106Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.022450.00006308Least InformativeInherited
Biological Process (BP)primary metabolic process0.18240.01676Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.044980.000001358Least InformativeInherited
Biological Process (BP)single-organism cellular process0.58270.3208Least InformativeInherited
Biological Process (BP)ribose phosphate metabolic process0.00012580.00001345Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process0.000019210.00000000000002741Moderately InformativeDirect
Biological Process (BP)glycosyl compound metabolic process0.012720.001346Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0110.000000001482Moderately InformativeInherited
Biological Process (BP)guanosine-containing compound metabolic process0.00000067750.000000000000005508Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.0000000093380Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00007564 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000005411 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0004106 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000001358 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00006308 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000136 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00008185 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.3208 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01676 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.000000001482 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.00001345 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.0000001602 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00000000000002741 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000009224 Moderately Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.001346 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.5706 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.003544 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1103 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.000125 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00001629 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000000001899 Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000000000005508 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0001073 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.566 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.0000001951InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01362InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)gamete0InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.2468Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.001584InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated0.0192InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.06641InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase0Highly InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000004104Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.0000000106Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.00000002841Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.0000003821Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis2.435e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding0.00000000003839Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFMN0.0000001143InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0006489Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.000009496Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.0001517Moderately InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0.000000000000001364InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Inosine monophosphate dehydrogenase (IMPDH) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Inosine monophosphate dehydrogenase (IMPDH) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]