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Inosine monophosphate dehydrogenase (IMPDH) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Inosine monophosphate dehydrogenase (IMPDH) [ 51412]
Families:   Inosine monophosphate dehydrogenase (IMPDH) [ 51413]


Superfamily statistics
Genomes (2,962) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,985 57,977 13
Proteins 9,589 56,333 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.3750.2829Least InformativeInherited
Biological Process (BP)primary metabolic process0.18590.01996Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.036280.0001251Least InformativeInherited
Biological Process (BP)single-organism cellular process0.4670.307Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.039790.0001772Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.021070.00005581Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.021420.00004567Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.043620.000003473Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.000019130.000000000000001925Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.010580.00009669Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.012130.000000002172Moderately InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.0010740.000002211InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.000015970.000000000004996Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.0000000074810Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00005581 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00004567 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0001251 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0001772 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000003473 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000007373 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.2829 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.307 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01996 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00009669 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000002172 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.000001086 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00001697 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00003598 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001177 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.003835 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.5877 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1078 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.000002211 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000000000005576 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00001599 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0001233 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000000000004996 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0001401 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.323 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.0000001951InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01362InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis2.442e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding0.0001644Least InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFlavoprotein0.2091Moderately InformativeInherited
Molecular functionPotassium0InformativeDirect
Molecular functionFMN0.0000001157InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Inosine monophosphate dehydrogenase (IMPDH) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Inosine monophosphate dehydrogenase (IMPDH) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]