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Inosine monophosphate dehydrogenase (IMPDH) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Inosine monophosphate dehydrogenase (IMPDH) [ 51412]
Families:   Inosine monophosphate dehydrogenase (IMPDH) [ 51413]

 Superfamily statistics
Genomes (2,298) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 7,934 22,239 13
Proteins 7,602 21,642 10

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00012941.987e-13Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.777e-063.329e-14Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process0.094891.154e-05Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.18026.651e-05Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.2132.835e-05Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.13853.208e-05Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process4.645e-070.0008484Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.054079.635e-09Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.039821.857e-08Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.058412.086e-09Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.10072.35e-07Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.14716.443e-08Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.16060.7381Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.079261.008e-11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.14545.721e-12Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.015146.956e-12Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.0028570.08135Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0014340.01149Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00036391.51e-05InformativeDirect
Biological Process (BP)nucleotide biosynthetic process7.838e-053.218e-08InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00049059.634e-05InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process9.524e-090InformativeDirect
Molecular Function (MF)transferase activity0.084131Least InformativeInherited
Molecular Function (MF)oxidoreductase activity8.618e-130Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups1.608e-081.165e-08InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.38481.442e-09InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor2.222e-050Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor6.777e-137.525e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 1.154e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 6.651e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 1.987e-13 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.329e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.835e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.208e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000157 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.008e-11 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 9.635e-09 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.857e-08 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 5.721e-12 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0008484 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.086e-09 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 6.956e-12 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 2.35e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 6.443e-08 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.7381 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.02903 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.08135 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01149 Moderately Informative Inherited
Biological Process (BP) cell activation 1.422e-09 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.51e-05 Informative Direct
Biological Process (BP) cell proliferation 1.355e-08 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 1.727e-07 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 3.218e-08 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 9.634e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 1.915e-05 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.003875 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.007817 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.0008289 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0001198 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 9.895e-11 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1.442e-09 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.165e-08 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7.525e-14 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5167 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001938 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups1.951e-07InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01362InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant ANatomical entity (PAN)plant sperm cell0InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3525Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.001596InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processIsoprene biosynthesis4.636e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding2.095e-13Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionIron0.762Moderately InformativeInherited
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFMN9.522e-07InformativeDirect
Molecular functionIron-sulfur1.463e-06InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0003761Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis4.805e-06Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.000121Moderately InformativeDirect
UniPathway (UP)isoprenoid biosynthesis8.907e-16InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Inosine monophosphate dehydrogenase (IMPDH) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Inosine monophosphate dehydrogenase (IMPDH) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.