SUPERFAMILY 1.75 HMM library and genome assignments server

Inosine monophosphate dehydrogenase (IMPDH) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Inosine monophosphate dehydrogenase (IMPDH) [ 51412]
Families:   Inosine monophosphate dehydrogenase (IMPDH) [ 51413]


Superfamily statistics
Genomes (2,955) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,957 50,358 13
Proteins 9,565 49,296 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.015530.0000000219Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0680.00000008378Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.028890.00000007847Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.040610.0000001302Least InformativeInherited
Biological Process (BP)biosynthetic process0.15290.000000001133Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.034050.0000000002028Least InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0005080.0000000000003122Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.060790.000000008094Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.060880.00000001708Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.052740.000000004928Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.11920.0000001593Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.12570.000000006033Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.11050.003242Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.064490.0000000003258Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0073120.000000000000009148Moderately InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.000032660InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process11InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.0071190.0000001501InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.020390.889InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate metabolic process0.000079550.0000003248Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process0.001140.000000000000778Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0000000040590Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.000010480.02492InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.17660.000000000009942InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.000018880Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000219 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00000008378 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000001133 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000002028 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000001302 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000007847 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000003258 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000008094 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00000001708 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000000000000009148 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000004928 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000000003122 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000001593 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000000006033 Moderately Informative Direct
Biological Process (BP) immune system process 0.00152 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.003242 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.3317 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01336 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.4193 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.0000003464 Informative Direct
Biological Process (BP) leukocyte activation 0.000000001997 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000001501 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.00005587 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.889 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.001297 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.007289 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.000567 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.0000003248 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000000000778 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.06622 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.000000000009942 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000117 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.02492 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.0000001951InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01362InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)gamete0InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.2417Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.001106InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.01473InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis4.711e-16Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding0.000000000006058Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFlavoprotein0.02787Moderately InformativeInherited
Molecular functionNADP0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionFMN0.00000000373InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0003711Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.00000515Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.0001164Moderately InformativeDirect
UniPathway (UP)isoprenoid biosynthesis8.993e-16InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Inosine monophosphate dehydrogenase (IMPDH) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Inosine monophosphate dehydrogenase (IMPDH) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]