SUPERFAMILY 1.75 HMM library and genome assignments server


NAD(P)-linked oxidoreductase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   NAD(P)-linked oxidoreductase [ 51430]
Families:   Aldo-keto reductases (NADP) [ 51431] (15)


Superfamily statistics
Genomes (2,103) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 20,784 46,529 47
Proteins 20,664 46,442 47


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process4.587e-094.008e-15Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.34671Least InformativeInherited
Biological Process (BP)biosynthetic process0.60440.6046Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.0043040.3751Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.28410.7533Least InformativeInherited
Biological Process (BP)multicellular organismal process0.37421Least InformativeInherited
Biological Process (BP)small molecule biosynthetic process6.835e-051.86e-05Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process1.979e-050.0004474Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus7.83e-050.0006754Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.28451Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.72681Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.54021Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.92090.869Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.040860.07555Moderately InformativeInherited
Biological Process (BP)cellular localization0.65311Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.25331Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.24581Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.57041Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.45970.356Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.341Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.43771Moderately InformativeInherited
Biological Process (BP)organic substance transport0.53730.6957Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.042990.01339Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0013990.0003582Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.2110.07605Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.15040.6581Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.15270.1686Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.37410.8821Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.048760.1014Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0063980.008992Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.049160.01066Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0020590.002832Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.062720.01356Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.1520.188Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.30540.1338Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.10350.01188Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00059090.0001272InformativeDirect
Biological Process (BP)isoprenoid metabolic process9.824e-076.474e-07InformativeDirect
Biological Process (BP)vitamin metabolic process0.00023881.277e-05InformativeDirect
Biological Process (BP)response to oxidative stress6.893e-092.82e-11InformativeDirect
Biological Process (BP)steroid metabolic process00InformativeDirect
Biological Process (BP)regulation of hormone levels9.079e-099.695e-11InformativeDirect
Biological Process (BP)regulation of lipid metabolic process4.838e-050.0005984InformativeDirect
Biological Process (BP)cellular ketone metabolic process8.203e-061.33e-08InformativeDirect
Biological Process (BP)cellular amide metabolic process1.837e-066.255e-07InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process5.158e-054.301e-06InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0032520.04958InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process0.23741InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.5050.3645InformativeInherited
Biological Process (BP)response to organic cyclic compound0.029940.06061InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.0078890.02341InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.005450.1036InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.0022840.06993InformativeInherited
Biological Process (BP)cytoplasmic transport0.074950.1833InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.00088810.006724InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.035740.8616InformativeInherited
Biological Process (BP)response to lipid0.0069010.01173InformativeInherited
Biological Process (BP)response to inorganic substance0.14720.03094InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0026990.0009856InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0022760.06065InformativeInherited
Biological Process (BP)protein localization to organelle0.015820.05855InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.026110.05347InformativeInherited
Biological Process (BP)response to hormone stimulus0.00022550.004084InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.014470.008974InformativeInherited
Biological Process (BP)alcohol metabolic process0.00077270.008287InformativeInherited
Biological Process (BP)lipid catabolic process0.0010880.001311InformativeInherited
Biological Process (BP)protein transport0.10780.2929InformativeInherited
Biological Process (BP)retinoid metabolic process1.108e-113.329e-14Highly InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process00Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process7.98e-071.474e-05Highly InformativeDirect
Biological Process (BP)glutathione metabolic process1.644e-092.29e-07Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process8.729e-071.72e-07Highly InformativeDirect
Biological Process (BP)digestion5.615e-113.617e-10Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process9.749e-060.0001238Highly InformativeDirect
Biological Process (BP)glycoside metabolic process6.505e-144.008e-15Highly InformativeDirect
Biological Process (BP)nonribosomal peptide biosynthetic process1.595e-123.929e-13Highly InformativeDirect
Biological Process (BP)protein localization to nucleus8.187e-050.000853Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process6.653e-092.28e-08Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.00046960.0002803Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus2.069e-050.0003182Highly InformativeDirect
Biological Process (BP)alcohol catabolic process3.477e-052.448e-05Highly InformativeDirect
Biological Process (BP)response to cadmium ion3.185e-086.435e-08Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process2.281e-082.396e-08Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process5.176e-072.083e-07Highly InformativeDirect
Biological Process (BP)nuclear import2.514e-050.0003627Highly InformativeDirect
Biological Process (BP)regulation of ligase activity2.835e-092.154e-09Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling cascade3.412e-062.927e-06Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.10440.1686Highly InformativeInherited
Biological Process (BP)cellular response to organic cyclic compound0.015370.01665Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.24160.0447Highly InformativeInherited
Biological Process (BP)response to calcium ion0.00082470.004354Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.080.02757Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.046150.2548Highly InformativeInherited
Biological Process (BP)monosaccharide biosynthetic process0.02080.01575Highly InformativeInherited
Biological Process (BP)protein import0.00015040.001517Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding0.651Moderately InformativeInherited
Molecular Function (MF)protein binding11Moderately InformativeInherited
Molecular Function (MF)anion binding0.031210.06861Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.067970.975Moderately InformativeInherited
Molecular Function (MF)lipid binding0.00020180.0005777InformativeDirect
Molecular Function (MF)electron carrier activity0.0002482.674e-05InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)cofactor binding0.0089620.003816InformativeInherited
Molecular Function (MF)nucleotide binding0.18040.2679InformativeInherited
Molecular Function (MF)enzyme binding1.219e-060.002185InformativeInherited
Molecular Function (MF)carboxylic acid binding0.0064740.001898InformativeInherited
Molecular Function (MF)receptor activity0.051010.5192InformativeInherited
Molecular Function (MF)molecular transducer activity0.083660.5917InformativeInherited
Molecular Function (MF)steroid binding6.753e-073.763e-08Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding3.393e-053.293e-06Highly InformativeDirect
Molecular Function (MF)NADP binding1.81e-068.28e-07Highly InformativeDirect
Molecular Function (MF)monooxygenase activity0.21811Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.89491Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor0.057990.001682Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.0033980.01022Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors0.59720.5176Highly InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0050796.644e-05Least InformativeInherited
Cellular Component (CC)cytosol1.489e-101.819e-10Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 4.008e-15 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6046 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3751 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7533 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0003582 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 1.86e-05 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0004474 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0006754 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.869 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.07555 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3944 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.86 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.356 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6957 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.01339 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.07605 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.6581 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1686 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8821 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1014 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.008992 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01066 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.002832 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01356 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.188 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2878 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1338 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.01188 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.0001272 Informative Direct
Biological Process (BP) isoprenoid metabolic process 6.474e-07 Informative Direct
Biological Process (BP) vitamin metabolic process 1.277e-05 Informative Direct
Biological Process (BP) response to oxidative stress 2.82e-11 Informative Direct
Biological Process (BP) steroid metabolic process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 9.695e-11 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0009856 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0005984 Informative Direct
Biological Process (BP) cellular ketone metabolic process 1.33e-08 Informative Direct
Biological Process (BP) cellular amide metabolic process 6.255e-07 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 4.301e-06 Informative Direct
Biological Process (BP) protein oligomerization 0.0001144 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.04958 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3645 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.06061 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02341 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1036 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.06993 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1833 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.006724 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.8616 Informative Inherited
Biological Process (BP) response to lipid 0.01173 Informative Inherited
Biological Process (BP) response to inorganic substance 0.03094 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06065 Informative Inherited
Biological Process (BP) protein localization to organelle 0.05855 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.05347 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.004084 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.008974 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.008287 Informative Inherited
Biological Process (BP) lipid catabolic process 0.001311 Informative Inherited
Biological Process (BP) metal ion transport 0.08178 Informative Inherited
Biological Process (BP) protein transport 0.2929 Informative Inherited
Biological Process (BP) retinoid metabolic process 3.329e-14 Highly Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 1.474e-05 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 2.29e-07 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 1.72e-07 Highly Informative Direct
Biological Process (BP) digestion 3.617e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0001238 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 4.008e-15 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 3.929e-13 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000853 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 2.28e-08 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.0002803 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0003182 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 2.448e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 6.435e-08 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 2.396e-08 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 2.083e-07 Highly Informative Direct
Biological Process (BP) nuclear import 0.0003627 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 2.154e-09 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 2.927e-06 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.1686 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.01665 Highly Informative Inherited
Biological Process (BP) response to corticosteroid stimulus 0.0447 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.02757 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.004354 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.2548 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.01575 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.00249 Highly Informative Inherited
Biological Process (BP) protein import 0.001517 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.06861 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.975 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.0005777 Informative Direct
Molecular Function (MF) electron carrier activity 2.674e-05 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) cofactor binding 0.003816 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2679 Informative Inherited
Molecular Function (MF) enzyme binding 0.002185 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.001898 Informative Inherited
Molecular Function (MF) receptor activity 0.5192 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.5917 Informative Inherited
Molecular Function (MF) steroid binding 3.763e-08 Highly Informative Direct
Molecular Function (MF) channel regulator activity 6.14e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 3.293e-06 Highly Informative Direct
Molecular Function (MF) NADP binding 8.28e-07 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 0.001682 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 0.01022 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.5176 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 6.644e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytosol 1.819e-10 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.4925Moderately InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor3.788e-08InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details) Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9531Least InformativeInherited
Biological processCarbohydrate metabolism2.761e-10Moderately InformativeDirect
Biological processIon transport5.199e-05Moderately InformativeDirect
Biological processLipid metabolism0.00025Moderately InformativeDirect
Biological processSteroid metabolism3.346e-09InformativeDirect
Biological processFatty acid metabolism0.4773InformativeInherited
Biological processPotassium transport0Highly InformativeDirect
Biological processVoltage-gated channel0Highly InformativeDirect
Biological processProstaglandin biosynthesis2.384e-13Highly InformativeDirect
Molecular functionNAD3.581e-08Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPotassium2.155e-12InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel2.699e-14InformativeDirect
Post-translational modificationAcetylation1.75e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1.512e-07Least InformativeDirect
UniPathway (UP)lipid metabolism0.4726Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate degradation1.049e-11Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism2.98e-11Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.592e-06Moderately InformativeDirect
UniPathway (UP)energy metabolism0.000116Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.003007Moderately InformativeInherited
UniPathway (UP)alkaloid metabolism3.75e-15InformativeDirect
UniPathway (UP)toxin biosynthesis9.806e-11InformativeDirect
UniPathway (UP)prostaglandin biosynthesis1.348e-14Highly InformativeDirect
UniPathway (UP)glutathione biosynthesis8.01e-10Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001395 SSF51430 Protein matches
Abstract

The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others [PubMed2498333]. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide binding proteins [PubMed2105951]. The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones [PubMed1621098].

Binding of the NADPH coenzyme causes a massive conformational change, reorienting a loop, effectively locking the coenzyme in place. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases [PubMed1447221].

Some proteins of this entry contain a K+ ion channel beta chain regulatory domain; these are reported to have oxidoreductase activity [PubMed10884227].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-linked oxidoreductase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the NAD(P)-linked oxidoreductase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]