SUPERFAMILY 1.75 HMM library and genome assignments server

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(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,996) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 94,637 483,521 385
Proteins 92,266 475,748 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.70941Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process00.00392Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.39611Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.0000000000009040.0000006826Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.000016980.00002419Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.0000050540Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000000000091240.0007802Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00000020460Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0003121Moderately InformativeInherited
Biological Process (BP)response to organic substance0.10290.3457Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00036720.1724Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system development0.22421Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.062730Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.20551Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00010081Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.000000026370.008629Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0021671Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.069811Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0059421Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000850.9084Moderately InformativeInherited
Biological Process (BP)reproduction0.41241Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0011250.3921Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress0.000021510.00000001744InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.00000000000014780InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000054870.0001927InformativeDirect
Biological Process (BP)response to cytokine0.00000000004050InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.0000000000000046470InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.00000059110.0000000000002605InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000001280.00006669InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000000094730.0003437InformativeDirect
Biological Process (BP)cell wall organization or biogenesis00InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000000000000045140InformativeDirect
Biological Process (BP)regulation of locomotion0.0000000029960.001883InformativeInherited
Biological Process (BP)positive regulation of developmental process0.000000018930.1105InformativeInherited
Biological Process (BP)regulation of cell cycle0.000000068141InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.00000000008120.7132InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.000000010451InformativeInherited
Biological Process (BP)response to radiation0.0000011520.02448InformativeInherited
Biological Process (BP)tissue development0.000018621InformativeInherited
Biological Process (BP)regulation of cell proliferation0.0000018381InformativeInherited
Biological Process (BP)cellular lipid catabolic process0.31930.01299InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.058840.00000000000436InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.60750.00003079InformativeInherited
Biological Process (BP)cell death0.19891InformativeInherited
Biological Process (BP)regulation of growth0.0000000023790.001933InformativeInherited
Biological Process (BP)multi-organism reproductive process11InformativeInherited
Biological Process (BP)polysaccharide catabolic process0.000000000083460Highly InformativeDirect
Biological Process (BP)regulation of cell growth0.000000000000020390.000000001733Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process00.000006149Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process0.00021640Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000013210.000000000000003764Highly InformativeDirect
Biological Process (BP)oligosaccharide catabolic process0.00000084910Highly InformativeDirect
Biological Process (BP)response to UV0.000000000870Highly InformativeDirect
Biological Process (BP)response to virus0.00000096150.00000000001177Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration00.0000171Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.000022520.00000000003494Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.00000056490Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.0000024760.000000000000003764Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)negative regulation of growth0.000000000000080180.0000000000005549Highly InformativeDirect
Biological Process (BP)response to antibiotic00.0000000000001201Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.00062150.0001068Highly InformativeDirect
Biological Process (BP)cellular response to abiotic stimulus00Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.0000000000000090330.000000002483Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle phase transition00.000000000158Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.004840.000000000000007367Highly InformativeInherited
Biological Process (BP)positive regulation of cellular component biogenesis0.0000000000000016070.03586Highly InformativeInherited
Biological Process (BP)response to estrogen0.00055190.001617Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation00.002145Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0016320.000000004895Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.01247Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.00000000000002321Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.00000041950InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)molecular transducer activity0.000000039540.413InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds0.000000000067360Highly InformativeDirect
Molecular Function (MF)peptidoglycan muralytic activity0.00012450.0001707Highly InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity0.000037921Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.0055510.00001467Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00096340.0007402Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00045190Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.051030.01443Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)cell surface0.000045270.00002935InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000000034840InformativeDirect
Cellular Component (CC)lytic vacuole0.021750.00001869InformativeInherited
Cellular Component (CC)anchored component of membrane0.0000000000028680Highly InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.04220.0008508Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.00392 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000005269 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0000006826 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00002419 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0007802 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8752 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1724 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3457 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.3345 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.008629 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6504 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2818 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9084 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3853 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9683 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3921 Moderately Informative Inherited
Biological Process (BP) cell activation 0.00005885 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0006217 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.00000000000436 Informative Direct
Biological Process (BP) response to oxidative stress 0.00000001744 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000000002653 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001927 Informative Direct
Biological Process (BP) secretion by cell 0.00001713 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0000000000002605 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00006669 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0003437 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000001273 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.00003079 Informative Direct
Biological Process (BP) positive regulation of transport 0.2612 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.03105 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001883 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1105 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.7132 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to radiation 0.02448 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1491 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7982 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1186 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0309 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2113 Informative Inherited
Biological Process (BP) regulation of defense response 0.06569 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3025 Informative Inherited
Biological Process (BP) membrane organization 0.2718 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.03808 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) anion transport 0.7793 Informative Inherited
Biological Process (BP) organic acid transport 0.04582 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9015 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular lipid catabolic process 0.01299 Informative Inherited
Biological Process (BP) secondary metabolic process 0.9362 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.001023 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.09007 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.8944 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.04624 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.01659 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02321 Informative Inherited
Biological Process (BP) immune response 0.6323 Informative Inherited
Biological Process (BP) immune effector process 0.3418 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) regulation of growth 0.001933 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000000001733 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0005401 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00003146 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.000000005607 Highly Informative Direct
Biological Process (BP) renal system process 0.00000000775 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.000006149 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.000000000000007367 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.000000004895 Highly Informative Direct
Biological Process (BP) amino acid transport 0.0003477 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000000000000003764 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.0000005734 Highly Informative Direct
Biological Process (BP) protein secretion 0.0000000204 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.000002574 Highly Informative Direct
Biological Process (BP) response to virus 0.00000000001177 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0000171 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00001847 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003114 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0002326 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.000002698 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.000000003923 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00001356 Highly Informative Direct
Biological Process (BP) neutrophil activation 0.00002995 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00000000003494 Highly Informative Direct
Biological Process (BP) leukocyte degranulation 0.00007171 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000000000000003764 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000000005549 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.0000000000001201 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00001931 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000000000002211 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.00001609 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000006303 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0002156 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.0005295 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00000000001444 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0.0001068 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000002483 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle phase transition 0.000000000158 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000001849 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.03586 Highly Informative Inherited
Biological Process (BP) response to estrogen 0.001617 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.08649 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.002145 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.01594 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.003393 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.2038 Highly Informative Inherited
Biological Process (BP) pigmentation 0.1417 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.7237 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3873 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01247 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) viral process 0.1736 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.003329 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.7613 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.000001755 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00006238 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000004938 Informative Direct
Molecular Function (MF) receptor binding 0.6889 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.413 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.00001467 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.00000000135 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0.0001707 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0008385 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0007402 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.01758 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.01443 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00001869 Informative Direct
Cellular Component (CC) cell surface 0.00002935 Informative Direct
Cellular Component (CC) secretory granule 0.0006253 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) vacuolar part 0.00001238 Informative Direct
Cellular Component (CC) apical part of cell 0.0006554 Informative Direct
Cellular Component (CC) membrane region 0.0000001148 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.6462 Informative Inherited
Cellular Component (CC) side of membrane 0.04694 Informative Inherited
Cellular Component (CC) plasma membrane region 0.2365 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.00000000000001641 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.0001208 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00002022 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0008508 Highly Informative Direct
Cellular Component (CC) symplast 0.000009942 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00009422 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.001287 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.1157 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0000001513Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0332InformativeInherited
Disease Ontology (DO)sphingolipidosis0.0000000001608Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.00001516Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.0008961Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0165Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.05164Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.191Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3399Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3436Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.004649Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01659Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.02332Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.05856Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.08603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.2272Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3471Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.4725Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.6184Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.8639Moderately InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.000175InformativeDirect
Phenotypic Abnormality (PA)Abnormality of abdomen morphology0.009949InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.01687InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.03139InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.05308InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.1881InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.2216InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.4627InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.7287InformativeInherited
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.0000004753Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.000004041Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.00004623Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0003367Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0004369Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.01683Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2531Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.1659Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.189Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1891Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.6202Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.000028Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.003293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1884Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3972Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.00001151InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.0005738InformativeDirect
Mammalian Phenotype (MP)premature death0.0007853InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.01518InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.06563InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.06844InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2386InformativeInherited
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.00000023Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.0000006097Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.00003374Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver lobule morphology0.0001792Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lysosome physiology0.000378Highly InformativeDirect
Mammalian Phenotype (MP)paralysis0.0006983Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.0054Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.01224Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.3642Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02607Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5297Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000007362InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle0.00007257Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0.00000000000003142Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle0.000008912Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response0.000002801InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization0.000003754Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0.00000005InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
Cellular componentCell wall0.000002093Highly InformativeDirect
DiseaseGlycogen storage disease0.00000000106InformativeDirect
DiseaseDental caries0.0000000000003008Highly InformativeDirect
DiseaseMucopolysaccharidosis0.00000004213Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000001289InformativeDirect
DomainEGF-like domain0.00001137InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.0000889InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0.000000004585InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.000000000000002722Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0001738Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)cellulose degradation0Highly InformativeDirect
UniPathway (UP)glycogen degradation0.000000003458Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0003777Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.003584Highly InformativeInherited
UniPathway (UP)cell surface structure biogenesis0.02947Highly InformativeInherited
UniPathway (UP)trehalose metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]