SUPERFAMILY 1.75 HMM library and genome assignments server

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(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,998) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 95,150 606,944 385
Proteins 92,734 597,563 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0000001569Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.03265InformativeInherited
Disease Ontology (DO)sphingolipidosis0.0000000001611Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.00007882Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.00176Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01013Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.027Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1042Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3524Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3835Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.4408Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.0521Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.06134Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.06244Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1227Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0.1876Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.4048Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.6521Moderately InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.0001106InformativeDirect
Phenotypic Abnormality (PA)Abnormal spleen morphology0.0002509InformativeDirect
Phenotypic Abnormality (PA)Cognitive impairment0.0009981InformativeDirect
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.01233InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.02693InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.04441InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.05233InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.07539InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.1935InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.7455InformativeInherited
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.000000191Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.00000558Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.0001252Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0001725Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0003386Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the retinal vasculature0.2275Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.1656Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1877Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1886Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.6181Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.00002774Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.00329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1643Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1856Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3972Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.00001159InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.0005477InformativeDirect
Mammalian Phenotype (MP)premature death0.0007799InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.01514InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.06426InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.06825InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.1769InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2381InformativeInherited
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.0000002312Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.0000006173Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.00003404Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver lobule morphology0.00018Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lysosome physiology0.0003785Highly InformativeDirect
Mammalian Phenotype (MP)paralysis0.000704Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.005075Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.01236Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.3653Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.8358Least InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.05383InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002744Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02607Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5297Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000007362InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle0.00007257Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0.0000000000001295Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]