SUPERFAMILY 1.75 HMM library and genome assignments server

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(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,998) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 95,150 606,944 385
Proteins 92,734 597,563 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0000001599Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0328InformativeInherited
Disease Ontology (DO)sphingolipidosis0.0000000001645Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.002114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.009413Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.03685Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.06314Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1416Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1786Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4858Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4873Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.0598Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.06155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.06884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.08521Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1177Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.3055Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.3331Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.3479Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.5885Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5908Moderately InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.00005882InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0.0009407InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.007276InformativeInherited
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.0158InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.01696InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.01881InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.05183InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.1173InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.1664InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.7429InformativeInherited
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.000000168Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.0000046Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.00001792Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0002712Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0003314Highly InformativeDirect
Phenotypic Abnormality (PA)Coarse facial features0.0009867Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal retinal vascular morphology0.2056Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.3212Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.1644Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1877Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1887Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.6191Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.00002773Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.003315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1869Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2197Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.00001154InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.0005473InformativeDirect
Mammalian Phenotype (MP)premature death0.000778InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.01506InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.06465InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.06765InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.1772InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2399InformativeInherited
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.0000002317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.0000005954Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.00003381Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver lobule morphology0.0001795Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lysosome physiology0.0003797Highly InformativeDirect
Mammalian Phenotype (MP)paralysis0.0007042Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.005064Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0123Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.3656Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.7954Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2121Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1151InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002319Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02612Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5298Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000007392InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle0.00007291Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0.0000000000001752Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups0.9693Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 293 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 293 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]