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Metallo-dependent hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Metallo-dependent hydrolases [ 51556] (18)
Families:   Adenosine/AMP deaminase [ 51557] (2)
  Dihydroorotase [ 63917]
  Cytosine deaminase catalytic domain [ 69390]
  alpha-subunit of urease, catalytic domain [ 51560]
  Hydantoinase (dihydropyrimidinase), catalytic domain [ 75073] (5)
  SAH/MTA deaminase-like [ 82258] (3)
  Isoaspartyl dipeptidase, catalytic domain [ 89489]
  N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain [ 82261]
  D-aminoacylase, catalytic domain [ 82264]
  TatD Mg-dependent DNase-like [ 82267] (4)
  Phosphotriesterase-like [ 51564] (2)
  Renal dipeptidase [ 75079]
  Uronate isomerase-like [ 75082] (2)
  Adenine deaminase-like [ 141816]
  PP1699/LP2961-like [ 141819] (5)
  DR0824-like [ 159397]
  Imidazolonepropionase-like [ 159400] (3)
  Zn-dependent arginine carboxypeptidase-like [ 159408] (3)


Superfamily statistics
Genomes (3,238) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 42,455 266,539 96
Proteins 42,166 265,580 96


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000000065680Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00017120.000003212Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process0.0009860Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.003470.0000001019Least InformativeInherited
Biological Process (BP)response to stimulus0.064471Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0087750Least InformativeInherited
Biological Process (BP)biological regulation0.029091Least InformativeInherited
Biological Process (BP)biosynthetic process0.6310.1708Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.040920Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.011680Least InformativeInherited
Biological Process (BP)primary metabolic process0.013171Least InformativeInherited
Biological Process (BP)regulation of localization0.00000000060910.0005674Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process0.00000000070120.000000000003426Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.00000000092890.0001751Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000027820.00000000003356Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000034810.0000000006882Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.00058070.000000000000001925Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00050420.4973Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.0024730Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.000034010.001212Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.12340.9828Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00000012110.00279Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000000000015140.1431Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.0000000000068820.1605Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000000000010590.2783Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0049580Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.024810.00000000001612Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.075980.0000000002186Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.57611Moderately InformativeInherited
Biological Process (BP)regulation of cellular component movement00.000000000000007296InformativeDirect
Biological Process (BP)regulation of locomotion00.000000000000131InformativeDirect
Biological Process (BP)regulation of proteolysis00.00000001151InformativeDirect
Biological Process (BP)negative regulation of molecular function00.0000001848InformativeDirect
Biological Process (BP)regulation of hydrolase activity00.000003752InformativeDirect
Biological Process (BP)negative regulation of cell death0.00000000033770.000003441InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000072320.00000003413InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process0.00000012670.000004388InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.0000025990.0000000005818InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000005710InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.00034340InformativeDirect
Biological Process (BP)glycosyl compound metabolic process0.0003490.000000000000007296InformativeDirect
Biological Process (BP)negative regulation of cellular biosynthetic process0.63411InformativeInherited
Biological Process (BP)response to nitrogen compound0.022360.6543InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.025940.04695InformativeInherited
Biological Process (BP)response to oxidative stress0.0000050460.03866InformativeInherited
Biological Process (BP)response to metal ion0.32470.2614InformativeInherited
Biological Process (BP)regulation of apoptotic process00.001228InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.30681InformativeInherited
Biological Process (BP)negative regulation of cellular component movement00Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity00Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity00Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion00Highly InformativeDirect
Biological Process (BP)response to drug00.00000000001223Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process00.0000004625Highly InformativeDirect
Biological Process (BP)cellular response to calcium ion0.0000000000020080.0000002144Highly InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00000000046680.0002826Highly InformativeDirect
Biological Process (BP)purine-containing compound catabolic process0.00000000048590Highly InformativeDirect
Biological Process (BP)nucleoside catabolic process0.000000011470Highly InformativeDirect
Biological Process (BP)nucleoside biosynthetic process0.000000043040.0000005378Highly InformativeDirect
Biological Process (BP)nucleobase metabolic process0.0000044960Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000093620.0001166Highly InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.26991Least InformativeInherited
Molecular Function (MF)molecular function regulator0.0000000000010050.001126Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.0031990.0000000226Moderately InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)metal ion binding00.0369Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)lyase activity0.12280.6389Moderately InformativeInherited
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.00000000000003442InformativeDirect
Molecular Function (MF)zinc ion binding00.000000002481InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000000025460InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.0000060030.0002439InformativeDirect
Molecular Function (MF)phospholipid binding0.00000028550.1626InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides00.07173InformativeInherited
Molecular Function (MF)nuclease activity0.1470.2526InformativeInherited
Molecular Function (MF)cysteine-type endopeptidase inhibitor activity00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process00Highly InformativeDirect
Molecular Function (MF)exopeptidase activity00Highly InformativeDirect
Molecular Function (MF)modified amino acid binding00Highly InformativeDirect
Molecular Function (MF)deaminase activity00Highly InformativeDirect
Molecular Function (MF)metallopeptidase activity00.00000000000004665Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.0000000000026860.00000005663Highly InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines0.00000047220.0000000000004231Highly InformativeDirect
Molecular Function (MF)deoxyribonuclease activity0.0000046730.0002477Highly InformativeDirect
Molecular Function (MF)carboxy-lyase activity0.00018730.004334Highly InformativeInherited
Cellular Component (CC)apical part of cell00.00000000005345InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000003212 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000001019 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1708 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of localization 0.0005674 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000000003426 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0001751 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000003356 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000000006882 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00000000001612 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000002186 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0002222 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.4973 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001212 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9828 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.00279 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1431 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04725 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2783 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4558 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.004202 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1605 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.6835 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7085 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.000000000000007296 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000000131 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00000001151 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0000001848 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000003752 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000003441 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000003413 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000004388 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000000005818 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.000000000000007296 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.000000000004481 Informative Direct
Biological Process (BP) protein oligomerization 0.000000008122 Informative Direct
Biological Process (BP) response to wounding 0.0005521 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01584 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.09687 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.6543 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.04695 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03866 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5688 Informative Inherited
Biological Process (BP) organelle localization 0.2767 Informative Inherited
Biological Process (BP) response to metal ion 0.2614 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01896 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03719 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1416 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02312 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001228 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001238 Informative Inherited
Biological Process (BP) circulatory system development 0.6936 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) central nervous system development 0.9391 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.001822 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4029 Informative Inherited
Biological Process (BP) generation of neurons 0.005085 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1961 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.005896 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.318 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.785 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9049 Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) response to drug 0.00000000001223 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0000004625 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.0000002144 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002826 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside biosynthetic process 0.0000005378 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0001166 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.0000004203 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0000008264 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000001812 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.000007708 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000239 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00002681 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.0000589 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0001652 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.0002286 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.000281 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.02223 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0000000226 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.001126 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.0369 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.6389 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000000000003442 Informative Direct
Molecular Function (MF) zinc ion binding 0.000000002481 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0002439 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.0001511 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000000233 Informative Direct
Molecular Function (MF) phospholipid binding 0.1626 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.4768 Informative Inherited
Molecular Function (MF) ligase activity 0.2529 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.09814 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.07173 Informative Inherited
Molecular Function (MF) receptor binding 0.5059 Informative Inherited
Molecular Function (MF) nuclease activity 0.2526 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.02183 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) deaminase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.00000000000004665 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00000005663 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.0000000000004231 Highly Informative Direct
Molecular Function (MF) deoxyribonuclease activity 0.0002477 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00000513 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.00005976 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00008691 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.003395 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.004334 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0009518 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2752 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.3463 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1742 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0.00000000005345 Informative Direct
Cellular Component (CC) extracellular space 0.00007561 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0001945 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0002714 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.001057 Informative Inherited
Cellular Component (CC) neuron projection 0.001322 Informative Inherited
Cellular Component (CC) growth cone 0.000000000002194 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.000000002819 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.000007489 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6788Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)In cyclic amides0InformativeDirect
Enzyme Commission (EC)In cyclic amidines1InformativeInherited
Enzyme Commission (EC)Urease0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dihydroorotase0.0000002676Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processHistidine metabolism0Highly InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processNucleotide metabolism0Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentGPI-anchor0.000002301InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionIron0.0000000001606Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0.000169Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationMetalloprotease0.000000001943InformativeDirect
Post-translational modificationExonuclease0.0000002786InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the Metallo-dependent hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]