SUPERFAMILY 1.75 HMM library and genome assignments server

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Aldolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Aldolase [ 51569] (8)
Families:   Class I aldolase [ 51570] (12)
  Class II FBP aldolase [ 51591] (2)
  5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [ 51594]
  Class I DAHP synthetase [ 51599] (2)
  HMGL-like [ 89494] (3)
  NeuB-like [ 110368] (2)
  GatZ-like [ 141837]
  Class-II DAHP synthetase [ 141840]


Superfamily statistics
Genomes (3,252) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 45,312 253,295 106
Proteins 45,157 252,892 106


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000000000000031440Least InformativeDirect
Biological Process (BP)biosynthetic process0.00025580.000000000000001925Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000041550.005714Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.02090.4964Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.000027410.01159Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.084510.8627Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00000035480.001856Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.74930.6634Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000000000000067340Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process0.0000000000007270Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy0.00000000000098860.000000000000003734Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.000000000023150.000000002504Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.00000000013130Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000000012270.00000001092Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00016990Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.35520.8397Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.059760.00000000002442Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.310.5759Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.026110.09325Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.0019560.01106Moderately InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process00InformativeDirect
Biological Process (BP)ATP metabolic process00InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process00.000000000000003734InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.0000000000000031440InformativeDirect
Biological Process (BP)tetrapyrrole metabolic process0.000000000028160InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process0.00000000081420.0000000000002422InformativeDirect
Biological Process (BP)monosaccharide metabolic process0.00000048060.0000000005269InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.00013180.00000000003532InformativeDirect
Biological Process (BP)dicarboxylic acid metabolic process0.098790.02523InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.14340.4112InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process11InformativeInherited
Biological Process (BP)pigment metabolic process0.00046140.006486InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.95811InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process10.03632InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.15260.02132InformativeInherited
Biological Process (BP)phosphorylation0.00077320.1977InformativeInherited
Biological Process (BP)glyceraldehyde-3-phosphate metabolic process0.0000000025020.0000000007426Highly InformativeDirect
Biological Process (BP)heme biosynthetic process0.000000069670.000001078Highly InformativeDirect
Biological Process (BP)glycolytic process0.0000003580.0000000003551Highly InformativeDirect
Biological Process (BP)glucose 6-phosphate metabolic process0.0000017420.000004236Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.0000048770.000009882Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.000006440.000001206Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process0.29340.01304Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.022530.06635Highly InformativeInherited
Biological Process (BP)aldehyde catabolic process0.0038770.0002868Highly InformativeInherited
Biological Process (BP)glyoxylate metabolic process0.033550.01047Highly InformativeInherited
Biological Process (BP)branched-chain amino acid metabolic process0.007190.00000004184Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.1180.000004708InformativeInherited
Molecular Function (MF)aldehyde-lyase activity0.000000000000031960Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.33240.00004457Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000000001925 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.6634 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005714 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.4964 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01159 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8627 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001856 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000002504 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000001092 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.00000000002442 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8397 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5759 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.09325 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01106 Moderately Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000000000000003734 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0000000000002422 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000000005269 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000000003532 Informative Direct
Biological Process (BP) response to metal ion 0.02686 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.02523 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.4112 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.006486 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.03632 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.02132 Informative Inherited
Biological Process (BP) phosphorylation 0.1977 Informative Inherited
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0.0000000007426 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.000001078 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0000000003551 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0.000004236 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000009882 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.000001206 Highly Informative Direct
Biological Process (BP) dicarboxylic acid biosynthetic process 0.00005989 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.0002868 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000004184 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0007816 Highly Informative Direct
Biological Process (BP) chorismate metabolic process 0.00000007744 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.000003145 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.01304 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.06635 Highly Informative Inherited
Biological Process (BP) glyoxylate metabolic process 0.01047 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.000004708 Informative Direct
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.6223 Informative Inherited
Molecular Function (MF) aldehyde-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0.00004457 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1902 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plastid 0.0002871 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0001411Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processNitrogen fixation0.0009125InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processHeme biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0.0000115Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionManganese0.000000000000002459Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aldolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Aldolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]