SUPERFAMILY 1.75 HMM library and genome assignments server

Aldolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Aldolase [ 51569] (8)
Families:   Class I aldolase [ 51570] (12)
  Class II FBP aldolase [ 51591] (2)
  5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [ 51594]
  Class I DAHP synthetase [ 51599] (2)
  HMGL-like [ 89494] (3)
  NeuB-like [ 110368] (2)
  GatZ-like [ 141837]
  Class-II DAHP synthetase [ 141840]


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,247 271,666 106
Proteins 45,092 271,510 106


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00096250.000000000007191Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00014770.00000000003043Least InformativeDirect
Biological Process (BP)single-organism cellular process0.81021Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.99451Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.39951Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.60970.2917Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.27830.9322Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00000000000079220Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00025490.0007783Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.000000043740.000001132Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.000000011190.00000000000002089Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00000010290.000001023Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.27820.2232Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.26130.3677Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.84731Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.16290.3329Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.79190.9154Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.1640.0000002337Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.28980.0000000000228Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0019520.0000000001305Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.15840.351Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.013840.03727Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.071470.2147Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.67190.5658Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.10130.628Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.0000072420.00001302InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)tetrapyrrole metabolic process0.00000000000014590InformativeDirect
Biological Process (BP)pigment metabolic process0.000000044750.00000001552InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.0000052770.00000002623InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process0.0090430.0002103InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.59630.7675InformativeInherited
Biological Process (BP)glycolytic process00Highly InformativeDirect
Biological Process (BP)porphyrin-containing compound biosynthetic process0.0000000000014830.000000000131Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.0000011540.000000000184Highly InformativeDirect
Biological Process (BP)heme metabolic process0.0000000000000016820Highly InformativeDirect
Biological Process (BP)pigment biosynthetic process0.00000011520.000001784Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.00000012640.0000000004087Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process0.0034750.001036Highly InformativeInherited
Biological Process (BP)glyoxylate metabolic process0.0011490.000321Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding0.0000097450.0000001055Moderately InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity00InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.10280.0000002953InformativeInherited
Molecular Function (MF)aldehyde-lyase activity0.000000000036030Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.29780.0001123Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.000000000007191 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000003043 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.2917 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9322 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000000000228 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0007783 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000002337 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000001132 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000000002089 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000001305 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000001023 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2232 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3677 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.3329 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9154 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.351 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03727 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2147 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.5658 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.628 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0002103 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00001302 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00001152 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.00000001552 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.00000002623 Informative Direct
Biological Process (BP) response to inorganic substance 0.3901 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.06548 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.02493 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.7675 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.0196 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1824 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.2035 Informative Inherited
Biological Process (BP) glycolytic process 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.000000000131 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.000000000184 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0000001156 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0002082 Highly Informative Direct
Biological Process (BP) heme metabolic process 0 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.000001784 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0001341 Highly Informative Direct
Biological Process (BP) glyoxylate metabolic process 0.000321 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0.0000000004087 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0006875 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.001036 Highly Informative Inherited
Biological Process (BP) lipopolysaccharide metabolic process 0.001699 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000001055 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0000002953 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.9622 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.3068 Informative Inherited
Molecular Function (MF) aldehyde-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0.0001123 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.2167 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9764 Least Informative Inherited
Cellular Component (CC) plastid 0.0003621 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0001411Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2153Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.02417Moderately InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.0001402InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0005658InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.312Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3043Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0002821InformativeDirect
Xenopus ANatomical entity (XAN)kidney0.002604InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0004677Least InformativeDirect
Plant ANatomical entity (PAN)leaf0.0004951Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.0005109Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0.005372Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.005949Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01078Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.0618Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6297Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon0.000002614Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0.0001467Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0002512InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.000229Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processNitrogen fixation0.0009854InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processHeme biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0.00001681Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.005371Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis2.278e-16Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0004492Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.001859Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.00411Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0.7145Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism1Moderately InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)carbohydrate acid metabolism0InformativeDirect
UniPathway (UP)organic acid degradation0.00000008179InformativeDirect
UniPathway (UP)amine and polyamine degradation0.0000001131InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.002187InformativeInherited
UniPathway (UP)metabolic intermediate degradation0.249InformativeInherited
UniPathway (UP)amino-sugar metabolism1InformativeInherited
UniPathway (UP)organic acid biosynthesis1InformativeInherited
UniPathway (UP)2-deoxy-D-ribose 1-phosphate degradation0Highly InformativeDirect
UniPathway (UP)L-leucine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway0Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate degradation0.0000000000002259Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via DAP pathway0.00001088Highly InformativeDirect
UniPathway (UP)2-oxosuberate biosynthesis0.00001754Highly InformativeDirect
UniPathway (UP)aldaric acid degradation0.0000398Highly InformativeDirect
UniPathway (UP)glyoxylate and dicarboxylate metabolism0.0002297Highly InformativeDirect
UniPathway (UP)aldonic acid degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aldolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Aldolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]