SUPERFAMILY 1.75 HMM library and genome assignments server


Aldolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Aldolase [ 51569] (8)
Families:   Class I aldolase [ 51570] (12)
  Class II FBP aldolase [ 51591] (2)
  5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [ 51594]
  Class I DAHP synthetase [ 51599] (2)
  HMGL-like [ 89494] (3)
  NeuB-like [ 110368] (2)
  GatZ-like [ 141837]
  Class-II DAHP synthetase [ 141840]


Superfamily statistics
Genomes (3,244) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,193 271,666 106
Proteins 45,038 271,510 106


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00097847.589e-12Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00074255.457e-13Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.51140.2427Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.13420.8351Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.19330.8775Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.93891Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.174e-120Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00019190.000505Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process2.32e-095.576e-15Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.00016281.396e-12Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.0024496.699e-14Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.10960.191Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.75120.9003Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.30933.569e-11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0014890.004751Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.14510.3054Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.063670.1834Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.83331Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.057530.176Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.4490.7912Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process1.553e-052.475e-05InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)pigment metabolic process2.917e-081.206e-07InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process2.682e-062.208e-08InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process0.0066280.0003379InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.030660.2467InformativeInherited
Biological Process (BP)hexose metabolic process0.17310.2959InformativeInherited
Biological Process (BP)glycolysis6.015e-082.622e-08Highly InformativeDirect
Biological Process (BP)porphyrin-containing compound biosynthetic process4.358e-123.514e-10Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process1.264e-062.452e-10Highly InformativeDirect
Biological Process (BP)heme metabolic process3.587e-061.221e-06Highly InformativeDirect
Biological Process (BP)pigment biosynthetic process1.265e-098.199e-10Highly InformativeDirect
Biological Process (BP)glyoxylate metabolic process8.229e-061.178e-05Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process1.401e-074.528e-10Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process0.002430.0008812Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding9.588e-061.023e-07Moderately InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity00InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.15052.535e-06InformativeInherited
Molecular Function (MF)aldehyde-lyase activity1.039e-100Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.31720.0001132Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 7.589e-12 Least Informative Direct
Biological Process (BP) single-organism metabolic process 5.457e-13 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2427 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8351 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.8775 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 3.569e-11 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000505 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 6.699e-14 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.576e-15 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.396e-12 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9003 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.191 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.004751 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3054 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1834 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.176 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.7912 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0003379 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 2.475e-05 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 3.32e-06 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 1.206e-07 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 2.208e-08 Informative Direct
Biological Process (BP) response to inorganic substance 0.3831 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.06533 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.02531 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2467 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.204 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1939 Informative Inherited
Biological Process (BP) hexose metabolic process 0.2959 Informative Inherited
Biological Process (BP) glycolysis 2.622e-08 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 3.514e-10 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 2.22e-05 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 2.452e-10 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 1.027e-07 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0002162 Highly Informative Direct
Biological Process (BP) heme metabolic process 1.221e-06 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 8.199e-10 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.0008812 Highly Informative Direct
Biological Process (BP) glyoxylate metabolic process 1.178e-05 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 4.528e-10 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.00071 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 1.023e-07 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 2.535e-06 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.3087 Informative Inherited
Molecular Function (MF) aldehyde-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0.0001132 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.2184 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9709 Least Informative Inherited
Cellular Component (CC) plastid 0.0003823 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0001411Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2153Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.02426Moderately InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.0001421InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0005719InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.3103Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.303Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0002697InformativeDirect
Xenopus ANatomical entity (XAN)kidney0.002593InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0004677Least InformativeDirect
Plant ANatomical entity (PAN)leaf0.0004951Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.0005109Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0.005372Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.005949Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01078Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.0618Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6297Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon2.614e-06Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0.0001467Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0002512InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0002809Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processNitrogen fixation0.0009843InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processHeme biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis1.679e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism3.454e-07Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate metabolism0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0InformativeDirect
UniPathway (UP)chorismate biosynthesis0InformativeDirect
UniPathway (UP)organic acid metabolism8.658e-07InformativeDirect
UniPathway (UP)L-isoleucine biosynthesis4.333e-06Highly InformativeDirect
UniPathway (UP)aldonic acid degradation6.156e-05Highly InformativeDirect
UniPathway (UP)glycolysis0.0001046Highly InformativeDirect
UniPathway (UP)organic acid biosynthesis0.001342Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aldolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Aldolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]