SUPERFAMILY 1.75 HMM library and genome assignments server

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Enolase C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Enolase C-terminal domain-like [ 51604] (2)
Families:   Enolase [ 51605]
  D-glucarate dehydratase-like [ 51609] (13)


Superfamily statistics
Genomes (3,185) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,164 69,006 50
Proteins 11,136 68,939 50


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.0001907 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.7654 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2524 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.00725 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.00000000000005703 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000000006985 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000000000002723 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.000007339 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000007753 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00001445 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0008308 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.2869 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.007735 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6628 Moderately Informative Inherited
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000000001327 Informative Direct
Biological Process (BP) phosphorylation 0.000000005396 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000002414 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00001519 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.001407 Informative Inherited
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) glycolytic process 0.000000001199 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.000262 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.0004533 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.7567 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000008012 Least Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.00000000000031 Moderately Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.0000000000007513 Informative Direct
Molecular Function (MF) enzyme binding 0.00587 Informative Inherited
Molecular Function (MF) protease binding 0.0000009588 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.0000419 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000002288 Informative Direct
Cellular Component (CC) cell surface 0.00006917 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0005344InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0.000000003244Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.00002188Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Enolase C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Enolase C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]