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Malate synthase G superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Malate synthase G [ 51645]
Families:   Malate synthase G [ 51646]


Superfamily statistics
Genomes (1,352) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,716 11,268 4
Proteins 1,714 11,244 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.019610.04339Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0042430.0001344Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.12070.06236Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.0000010220.0000000002632InformativeDirect
Biological Process (BP)glyoxylate metabolic process0.000000000048240Highly InformativeDirect
Molecular Function (MF)transferase activity0.0000083780.000001174Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00000000000030178.27e-16InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001344 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.04339 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6237 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0002148 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.06236 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0000000002632 Informative Direct
Biological Process (BP) glyoxylate metabolic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000001174 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 8.27e-16 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTricarboxylic acid cycle0InformativeDirect
Cellular componentCytoplasm0.000000007665Least InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011076 SSF51645 Protein matches
Abstract

This entry represents the core TIM beta/alpha barrel found in malate synthase and in related proteins such as the beta subunit of citrate lyase.

Malate synthase catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM beta/alpha-barrel fold [PubMed10715138].

This entry is also represented by citrate lyase beta subunit , a component of citrate lyase , which catalyses the interconversion of citrate with acetate and oxaloacetate.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Malate synthase G domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Malate synthase G superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]