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Nicotinate/Quinolinate PRTase C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Nicotinate/Quinolinate PRTase C-terminal domain-like [ 51690] (2)
Families:   NadC C-terminal domain-like [ 51691] (4)
  Monomeric nicotinate phosphoribosyltransferase C-terminal domain [ 110910]


Superfamily statistics
Genomes (3,024) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,837 31,551 9
Proteins 5,793 31,431 9


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000000000002184 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000002726 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000000113 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00000000002132 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000000332 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000005885 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000004123 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000009126 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004332 Least Informative Direct
Biological Process (BP) response to stimulus 0.1825 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.000000000002958 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000006732 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000001667 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000007127 Moderately Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.00001653 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00002532 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000759 Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.09529 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0.000006535InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002638 SSF51690 Protein matches
Abstract Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [PubMed9016724, PubMed8561507]. Unlike , this domain also includes the molybdenum transport system protein ModD.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinate/Quinolinate PRTase C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Nicotinate/Quinolinate PRTase C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]