SUPERFAMILY 1.75 HMM library and genome assignments server

NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,254) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 359,094 1,613,957 522
Proteins 348,089 1,580,963 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000000000098880Least InformativeDirect
Biological Process (BP)biosynthetic process0.000086690Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)oxidation-reduction process00Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0000000055470Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.000097910Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0018970.00000000001104Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.31111Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.43521Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)reproductive process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.007805Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.13250Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process10.001894Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.24470.008254Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process10.0000001804Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.9769Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.73260.8577Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.9060.523Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process10.02365Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.53031Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0000000000000016820.0000000001942InformativeDirect
Biological Process (BP)protein oligomerization0.0000000000000032510InformativeDirect
Biological Process (BP)regulation of hormone levels0.000000023380.00000000002641InformativeDirect
Biological Process (BP)secondary metabolic process0.0000087460InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00020320.0000002295InformativeDirect
Biological Process (BP)amide biosynthetic process0.00040120.00003927InformativeDirect
Biological Process (BP)cardiovascular system development0.19161InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.086110.0000432InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.087230.000000000000009016InformativeInherited
Biological Process (BP)vitamin metabolic process0.11410.8722InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.011070.0000004591InformativeInherited
Biological Process (BP)pigment metabolic process0.093830.2473InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0055590.000000001404InformativeInherited
Biological Process (BP)sexual reproduction0.82681InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.83411InformativeInherited
Biological Process (BP)single organism reproductive process11InformativeInherited
Biological Process (BP)alcohol metabolic process0.0045910.0000004224InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.79310.04062InformativeInherited
Biological Process (BP)multi-multicellular organism process0.026210.8559InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process00.01625InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.11760.04254InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.34380.0000000007524InformativeInherited
Biological Process (BP)protein tetramerization00.00002515Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.0000000000019020Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000026880.00001045Highly InformativeDirect
Biological Process (BP)pentose metabolic process0.000003180.00000002244Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.000033370.0001022Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.000039110.000000001666Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000061450Highly InformativeDirect
Biological Process (BP)heme metabolic process0.000081960.000003366Highly InformativeDirect
Biological Process (BP)alditol metabolic process0.00033490.00000000005553Highly InformativeDirect
Biological Process (BP)retinoid metabolic process0.0008450.0000002016Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.26680.2086Highly InformativeInherited
Biological Process (BP)artery morphogenesis0.0000000017310.009904Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.30531Highly InformativeInherited
Biological Process (BP)quinone metabolic process0.047291Highly InformativeInherited
Biological Process (BP)female gamete generation0.0009311Highly InformativeInherited
Biological Process (BP)steroid biosynthetic process0.011560.0000003945Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.10230.07276Highly InformativeInherited
Biological Process (BP)isoprenoid biosynthetic process0.0068610.02164Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.0000065120Moderately InformativeDirect
Molecular Function (MF)anion binding0.9740.4944Moderately InformativeInherited
Molecular Function (MF)isomerase activity10.01362Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.000000000000001340.000000000000006942InformativeDirect
Molecular Function (MF)nucleotide binding0.00000000027920InformativeDirect
Molecular Function (MF)receptor activity11InformativeInherited
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)racemase and epimerase activity0.0088130InformativeInherited
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding0.000000000022890Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor0.0000000099270Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.0000009930.0008312Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors10.04895Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.9751Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.057810.00002163Highly InformativeInherited
Cellular Component (CC)cytoplasmic part10.5573Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)microbody0.00001650InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00000000001104 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000001804 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000263 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.8577 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3255 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.003823 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9769 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.523 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001894 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.007805 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.008254 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.02365 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0000000001942 Informative Direct
Biological Process (BP) protein oligomerization 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000000002641 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000002295 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00003927 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0000004224 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000000001404 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0000004591 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0000432 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.000000000000009016 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000000007524 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000000006976 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000002198 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00003966 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00005808 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of system process 0.6012 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.4685 Informative Inherited
Biological Process (BP) muscle system process 0.002619 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) blood circulation 0.002653 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.02873 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.8722 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5859 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002299 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01625 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2473 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.843 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.2023 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.07978 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1283 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.6023 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1698 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.8559 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.0127 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.7096 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.04062 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.04254 Informative Inherited
Biological Process (BP) protein tetramerization 0.00002515 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.00001045 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.00000002244 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0001022 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.000000001666 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) heme metabolic process 0.000003366 Highly Informative Direct
Biological Process (BP) alditol metabolic process 0.00000000005553 Highly Informative Direct
Biological Process (BP) retinoid metabolic process 0.0000002016 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0005982 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.00003319 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0000003945 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000000000000003707 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0000177 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.0000003886 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0006326 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.000000008917 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000000000000001913 Highly Informative Direct
Biological Process (BP) digestion 0.000000000000003707 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.000000000000007248 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.0000000000000406 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.000000000008513 Highly Informative Direct
Biological Process (BP) glycolytic process 0.00000000005638 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000002812 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.0000003032 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0000004862 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000001084 Highly Informative Direct
Biological Process (BP) polyol biosynthetic process 0.00001808 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00004211 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00005096 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0001279 Highly Informative Direct
Biological Process (BP) photorespiration 0.000326 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0003856 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0005189 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.2086 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.009904 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) ear development 0.02873 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2812 Highly Informative Inherited
Biological Process (BP) epidermis development 0.02218 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 1 Highly Informative Inherited
Biological Process (BP) inositol phosphate metabolic process 0.1906 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.005233 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.7362 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.7263 Highly Informative Inherited
Biological Process (BP) lactate metabolic process 0.02564 Highly Informative Inherited
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.8324 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.9134 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.241 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3678 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.07276 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.169 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 1 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.02164 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.002366 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4944 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3703 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.01362 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000000000000006942 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.00000992 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.001379 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0008312 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.000003821 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.00002163 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 0.0000004676 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0002371 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0008587 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.3755 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.04895 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.1207 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.4745 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5573 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.3107 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) lipid particle 0.00000005984 Informative Direct
Cellular Component (CC) plastid 0.00007647 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) synapse 1 Informative Inherited
Cellular Component (CC) contractile fiber part 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) transporter complex 0.01567 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.006725 Informative Inherited
Cellular Component (CC) postsynaptic membrane 0.000001043 Highly Informative Direct
Cellular Component (CC) ciliary part 0.6563 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.001059 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) integral component of organelle membrane 0.2876 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1137 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.7227 Highly Informative Inherited
Cellular Component (CC) coated vesicle 1 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000000000003598Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000003141InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006968InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002386InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00002386InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000006012Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.0000000000104Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000002282Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000000001952Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001785Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0.000000004825Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0.0000001173Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001901Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.0000008852Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase0.00004289Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.2887InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.9947Moderately InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0002328Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2353Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7763Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3584Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0002958InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.000001102InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.0000455Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001235Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002096Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001596Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002281Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02256Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3203Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5542Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005212Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007478Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000000005145InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.0000000000003433InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000004556Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000001139Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001198Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.00000002773Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001086Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000008661Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006409Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002193Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000372Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.008525Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.00004543Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.005974Least InformativeInherited
Drugbank ATC_code (DB)nasal preparations0.006194Moderately InformativeInherited
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.0251Moderately InformativeInherited
Drugbank ATC_code (DB)antifungals for topical use1Moderately InformativeInherited
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)retinoids for topical use in acne0.000000005166InformativeDirect
Drugbank ATC_code (DB)2-(4-chlorphenoxy)-ethanol0.00004685InformativeDirect
Drugbank ATC_code (DB)ethanol0.00004685InformativeDirect
Drugbank ATC_code (DB)vitamin a, plain0.0000000001387Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000001387Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000001387Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000001387Highly InformativeDirect
Drugbank ATC_code (DB)fomepizole0.000006289Highly InformativeDirect
Drugbank ATC_code (DB)ethanol0.00004685Highly InformativeDirect
Drugbank ATC_code (DB)nerve depressants0.00004685Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance0.000006151InformativeDirect
Biological processLipid biosynthesis0.07585InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis0.0000000005328Highly InformativeDirect
Biological processAntibiotic biosynthesis0.00000000221Highly InformativeDirect
Biological processSteroid biosynthesis0.00003428Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentEndoplasmic reticulum0.0003311Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet0.00000000169Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001069Least InformativeDirect
Post-translational modificationADP-ribosylation0.000000005541InformativeDirect
Post-translational modificationS-nitrosylation0.00000005132InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.000000002342Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0.0000001097Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.9862Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)fermentation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0.000000000000001124InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0000000003406InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.000002996InformativeDirect
UniPathway (UP)heterocycle biosynthesis0.000005273InformativeDirect
UniPathway (UP)terpene metabolism0.000006505InformativeDirect
UniPathway (UP)toxin biosynthesis0.000007306InformativeDirect
UniPathway (UP)hormone biosynthesis0.000009333InformativeDirect
UniPathway (UP)polyketide biosynthesis0.00004105InformativeDirect
UniPathway (UP)pigment biosynthesis0.0001586InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0001688InformativeDirect
UniPathway (UP)alkaloid metabolism0.07593InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)carbohydrate acid metabolism1InformativeInherited
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis2.278e-16Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis0.000000000000001345Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.00000000000001579Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis0.00000000000003139Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism0.0000000000001381Highly InformativeDirect
UniPathway (UP)alanine degradation0.000000000001043Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.00000000001042Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway0.000000002432Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.00000002196Highly InformativeDirect
UniPathway (UP)galactose metabolism0.000001373Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0.000009175Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0.0003821Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.0008451Highly InformativeDirect
UniPathway (UP)opine metabolism0.005856Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.03998Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08156Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.3421Highly InformativeInherited
UniPathway (UP)sterol biosynthesis0.945Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]