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NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 360,848 2,691,178 522
Proteins 349,772 2,618,985 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000000000003598Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000003141InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006968InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002386InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00002386InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000006012Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.0000000000104Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000002282Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000000001952Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001785Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0.000000004825Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0.0000001173Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001901Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.0000008852Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase0.00004289Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6221Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.5445Moderately InformativeInherited
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.3949InformativeInherited
Phenotypic Abnormality (PA)Coma0.1111Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8627Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4573InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.4615Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9419Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.6565InformativeInherited
Worm Phenotype (WP)vulva development variant0.7895InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7306Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3952Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0003566InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.00001351Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.3261Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.6875Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.742Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8215Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5504Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.6079Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.8791Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.892Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.5729InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.1135Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.0006154Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.4734Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.0000102Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.001024Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)intestine0.0007614InformativeDirect
Xenopus ANatomical entity (XAN)tail0.1823InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.6651InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.1237Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001272Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002166Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001621Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002333Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.0226Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3203Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5577Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0001265Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005295Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007583Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000000005166InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.000000000003656InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C=C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000001665Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.000000000004264Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0000000004983Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.0000000006569Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.000001219Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.000003281Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000005695Highly InformativeDirect
Enzyme Commission (EC)2-methylbutanoate polyketide synthase0.0000267Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00008042Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0009697Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donors1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Other lyases1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 507 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 507 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]