| Root: | SCOP hierarchy in SUPERFAMILY [ 0] (11) |
| Class: | Alpha and beta proteins (a/b) [ 51349] (141) |
| | Mainly parallel beta sheets (beta-alpha-beta units) |
| Fold: | NAD(P)-binding Rossmann-fold domains [ 51734] |
| | core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
| Superfamily: | NAD(P)-binding Rossmann-fold domains [ 51735] (12) |
| Families: | Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16) |
| | N-terminal all-beta domain defines family |
| | Tyrosine-dependent oxidoreductases [ 51751] (70) |
| | also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 |
| | Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22) |
| | family members also share a common alpha+beta fold in C-terminal domain |
| | Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10) |
| | this domain interrupts the other domain which defines family |
| | Siroheme synthase N-terminal domain-like [ 75110] (2) |
| | LDH N-terminal domain-like [ 51848] (8) |
| | 6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (17) |
| | the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
C-terminal domains also show some similarity |
| | Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11) |
| | extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site |
| | Potassium channel NAD-binding domain [ 63944] (4) |
| | Transcriptional repressor Rex, C-terminal domain [ 102174] |
| | CoA-binding domain [ 51900] (5) |
| | Ornithine cyclodeaminase-like [ 110436] (2) |
| | Pfam 02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet |
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 296 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 296 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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