SUPERFAMILY 1.75 HMM library and genome assignments server


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,253) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 358,657 1,613,957 522
Proteins 347,684 1,580,963 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process9.769e-050Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.824e-060Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process4.669e-090Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.53461Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.063241Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0040060Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process10.03126Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.11840Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.73310.8547Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.25060.008153Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.90210.519Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.44111Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process10.001194Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process10.1002Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.8846Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.01818Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process4.652e-143.565e-12InformativeDirect
Biological Process (BP)regulation of hormone levels2.388e-082.819e-11InformativeDirect
Biological Process (BP)secondary metabolic process0.00017830InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00016171.165e-06InformativeDirect
Biological Process (BP)amide biosynthetic process0.00040874.005e-05InformativeDirect
Biological Process (BP)protein oligomerization3.261e-150InformativeDirect
Biological Process (BP)cardiovascular system development0.19271InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.42151.607e-09InformativeInherited
Biological Process (BP)vitamin metabolic process0.11120.826InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0056512.411e-09InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.086794.462e-05InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.35028.719e-10InformativeInherited
Biological Process (BP)sexual reproduction0.73421InformativeInherited
Biological Process (BP)single organism reproductive process0.96131InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.88781InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.79290.07694InformativeInherited
Biological Process (BP)multi-multicellular organism process0.026430.8493InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process00.00434InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.1440.04616InformativeInherited
Biological Process (BP)retinoid metabolic process05.116e-08Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process6.231e-050Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process6.874e-055.405e-07Highly InformativeDirect
Biological Process (BP)pentose metabolic process5.252e-071.545e-08Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process3.981e-051.741e-09Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process1.947e-120Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process2.699e-061.063e-05Highly InformativeDirect
Biological Process (BP)protein tetramerization02.14e-05Highly InformativeDirect
Biological Process (BP)artery morphogenesis1.746e-090.01041Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.30321Highly InformativeInherited
Biological Process (BP)quinone cofactor metabolic process0.0080861Highly InformativeInherited
Biological Process (BP)female gamete generation0.00094511Highly InformativeInherited
Biological Process (BP)steroid biosynthetic process0.012124.402e-07Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.10180.07362Highly InformativeInherited
Biological Process (BP)isoprenoid biosynthetic process0.0061160.0201Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.97380.496Moderately InformativeInherited
Molecular Function (MF)isomerase activity10.01454Moderately InformativeInherited
Molecular Function (MF)nucleotide binding2.851e-106.686e-08InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups1.331e-156.053e-15InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)receptor activity11InformativeInherited
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)racemase and epimerase activity0.0087990InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors1.264e-060.0009461Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor9.959e-090Highly InformativeDirect
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding2.265e-110Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors10.05039Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.59991Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.057592.137e-05Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.1984Least InformativeInherited
Cellular Component (CC)microbody1.687e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3613 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01818 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8846 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8547 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.519 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.008153 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001194 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.1002 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.03126 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.008404 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 4.462e-05 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0001093 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 7.136e-11 Informative Direct
Biological Process (BP) fatty acid metabolic process 3.565e-12 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 5.07e-06 Informative Direct
Biological Process (BP) regulation of hormone levels 2.819e-11 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 8.719e-10 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 1.165e-06 Informative Direct
Biological Process (BP) amide biosynthetic process 4.005e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 2.411e-09 Informative Direct
Biological Process (BP) protein oligomerization 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 1.607e-09 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.465 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5847 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.173 Informative Inherited
Biological Process (BP) pigment metabolic process 0.9679 Informative Inherited
Biological Process (BP) muscle system process 0.002959 Informative Inherited
Biological Process (BP) lipid catabolic process 0.04498 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.826 Informative Inherited
Biological Process (BP) blood circulation 0.002546 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.01287 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002341 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.7698 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.07694 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1654 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.06639 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.8493 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.591 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.04616 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00434 Informative Inherited
Biological Process (BP) retinoid metabolic process 5.116e-08 Highly Informative Direct
Biological Process (BP) response to hypoxia 2.694e-05 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 1.938e-15 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 3.085e-09 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 4.402e-07 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0004351 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 6.466e-10 Highly Informative Direct
Biological Process (BP) digestion 3.755e-15 Highly Informative Direct
Biological Process (BP) circadian rhythm 6.656e-05 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 1.045e-09 Highly Informative Direct
Biological Process (BP) aerobic respiration 8.94e-09 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 2.765e-13 Highly Informative Direct
Biological Process (BP) photorespiration 0.0003289 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 2.401e-06 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 7.24e-09 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 5.405e-07 Highly Informative Direct
Biological Process (BP) pentose metabolic process 1.545e-08 Highly Informative Direct
Biological Process (BP) adult behavior 2.803e-07 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0004725 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.741e-09 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 3.459e-14 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 1.063e-05 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0006268 Highly Informative Direct
Biological Process (BP) neuromuscular process 4.992e-07 Highly Informative Direct
Biological Process (BP) protein homooligomerization 3.87e-05 Highly Informative Direct
Biological Process (BP) protein tetramerization 2.14e-05 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0001005 Highly Informative Direct
Biological Process (BP) response to alcohol 0.2692 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.01041 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7846 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3603 Highly Informative Inherited
Biological Process (BP) ear development 0.02957 Highly Informative Inherited
Biological Process (BP) quinone cofactor metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.001776 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) sulfur compound catabolic process 0.05991 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.00232 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.9252 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.717 Highly Informative Inherited
Biological Process (BP) lactate metabolic process 0.01886 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.2425 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.2248 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.8751 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.2192 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.07362 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.1637 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.0201 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1245 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.496 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.01454 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3329 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 6.686e-08 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 6.053e-15 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1432 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.001357 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cation channel activity 0.0002257 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0009461 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4.219e-06 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 2.137e-05 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 4.655e-07 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.0006437 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.3763 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.05039 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.1208 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.4778 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1984 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.32 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) plastid 7.987e-05 Informative Direct
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) contractile fiber part 1 Informative Inherited
Cellular Component (CC) synapse part 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.006883 Informative Inherited
Cellular Component (CC) postsynaptic membrane 1.044e-06 Highly Informative Direct
Cellular Component (CC) cilium part 0.1314 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.001029 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) intrinsic to organelle membrane 0.3906 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1149 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.7216 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors3.598e-12Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives3.141e-14InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.968e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.386e-05InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.386e-05InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase6.012e-14Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase1.04e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase2.282e-11Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase1.952e-10Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.785e-09Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase4.825e-09Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)1.173e-07Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.901e-07Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase8.852e-07Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase4.289e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.2887InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.9947Moderately InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0002328Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2353Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7763Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3584Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0002958InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant1.102e-06InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system4.55e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001235Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002096Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001596Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002281Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02256Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3203Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5542Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005212Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007478Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage5.145e-12InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups3.433e-13InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase4.556e-14Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase1.139e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.198e-09Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase2.773e-08Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.086e-07Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase8.661e-07Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.409e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.193e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000372Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.008525Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance6.151e-06InformativeDirect
Biological processLipid biosynthesis0.07585InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis5.328e-10Highly InformativeDirect
Biological processAntibiotic biosynthesis2.21e-09Highly InformativeDirect
Biological processSteroid biosynthesis3.428e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentEndoplasmic reticulum0.0003311Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet1.69e-09Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001069Least InformativeDirect
Post-translational modificationADP-ribosylation5.541e-09InformativeDirect
Post-translational modificationS-nitrosylation5.132e-08InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism2.342e-09Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1.097e-07Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.9862Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)fermentation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis1.124e-15InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation3.406e-10InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis2.996e-06InformativeDirect
UniPathway (UP)heterocycle biosynthesis5.273e-06InformativeDirect
UniPathway (UP)terpene metabolism6.505e-06InformativeDirect
UniPathway (UP)toxin biosynthesis7.306e-06InformativeDirect
UniPathway (UP)hormone biosynthesis9.333e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis4.105e-05InformativeDirect
UniPathway (UP)pigment biosynthesis0.0001586InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0001688InformativeDirect
UniPathway (UP)alkaloid metabolism0.07593InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)carbohydrate acid metabolism1InformativeInherited
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis2.278e-16Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis1.345e-15Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis1.579e-14Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis3.139e-14Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism1.381e-13Highly InformativeDirect
UniPathway (UP)alanine degradation1.043e-12Highly InformativeDirect
UniPathway (UP)polyol biosynthesis1.042e-11Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway2.432e-09Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis2.196e-08Highly InformativeDirect
UniPathway (UP)galactose metabolism1.373e-06Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis9.175e-06Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0.0003821Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.0008451Highly InformativeDirect
UniPathway (UP)opine metabolism0.005856Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.03998Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08156Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.3421Highly InformativeInherited
UniPathway (UP)sterol biosynthesis0.945Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]