SUPERFAMILY 1.75 HMM library and genome assignments server


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,253) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 358,705 1,613,957 522
Proteins 347,712 1,580,963 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.00025190Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process1.163e-090Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.081e-060Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.68391Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.056861Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0080060Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process10.02185Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.12650Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process10.0007073Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process10.08251Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.9193Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.96380.3177Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.26070.002225Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.51271Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.73360.6964Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.01341Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process1.085e-138.174e-12InformativeDirect
Biological Process (BP)regulation of hormone levels2.404e-082.309e-11InformativeDirect
Biological Process (BP)protein complex assembly5.418e-051.647e-05InformativeDirect
Biological Process (BP)secondary metabolic process0.00012690InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00016198.543e-07InformativeDirect
Biological Process (BP)cardiovascular system development0.19241InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.48482.229e-09InformativeInherited
Biological Process (BP)cellular amide metabolic process0.025010.1016InformativeInherited
Biological Process (BP)vitamin metabolic process0.089660.7424InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0071732.596e-09InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.12690.0001097InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.40089.62e-10InformativeInherited
Biological Process (BP)sexual reproduction0.73081InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.88761InformativeInherited
Biological Process (BP)single organism reproductive process0.95941InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.97260.09738InformativeInherited
Biological Process (BP)multi-multicellular organism process0.025531InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process1.72e-150.006455InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.12840.03821InformativeInherited
Biological Process (BP)retinoid metabolic process09.137e-08Highly InformativeDirect
Biological Process (BP)protein tetramerization01.949e-05Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process1.972e-120Highly InformativeDirect
Biological Process (BP)pentose metabolic process5.007e-078.716e-09Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process1.654e-066.899e-06Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.00010739.519e-09Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00018858.888e-07Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.30080.1739Highly InformativeInherited
Biological Process (BP)artery morphogenesis1.762e-090.01092Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.27091Highly InformativeInherited
Biological Process (BP)quinone cofactor metabolic process0.012061Highly InformativeInherited
Biological Process (BP)quinone metabolic process0.022690.1766Highly InformativeInherited
Biological Process (BP)nucleotide-sugar metabolic process0.0012810Highly InformativeInherited
Biological Process (BP)female gamete generation0.00094451Highly InformativeInherited
Biological Process (BP)steroid biosynthetic process0.010844.318e-07Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.095910.0671Highly InformativeInherited
Biological Process (BP)isoprenoid biosynthetic process0.0042840.01998Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.99080.68Moderately InformativeInherited
Molecular Function (MF)isomerase activity10.01794Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups5.176e-151.264e-14InformativeDirect
Molecular Function (MF)nucleotide binding4.453e-101.693e-07InformativeDirect
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)receptor activity11InformativeInherited
Molecular Function (MF)racemase and epimerase activity0.0082580InformativeInherited
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding7.921e-110Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor6.04e-090Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors10.02264Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors3.249e-060.001476Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.58421Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.055152.183e-05Highly InformativeInherited
Cellular Component (CC)cytoplasmic part10.1451Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)microbody1.584e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0007073 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3153 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01341 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9193 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.6964 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3177 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.002225 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.08251 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.02185 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 8.174e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 2.309e-11 Informative Direct
Biological Process (BP) protein complex assembly 1.647e-05 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 8.543e-07 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 2.596e-09 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 1.161e-10 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0001097 Informative Direct
Biological Process (BP) alcohol metabolic process 9.037e-05 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 9.62e-10 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 2.229e-09 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 1.025e-05 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4996 Informative Inherited
Biological Process (BP) single-organism behavior 0.9846 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1744 Informative Inherited
Biological Process (BP) pigment metabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.002586 Informative Inherited
Biological Process (BP) lipid catabolic process 0.05888 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.1016 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.7424 Informative Inherited
Biological Process (BP) blood circulation 0.00244 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.01299 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002033 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.7264 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.09738 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1676 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.08929 Informative Inherited
Biological Process (BP) multi-multicellular organism process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.6568 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.03821 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.006455 Informative Inherited
Biological Process (BP) retinoid metabolic process 9.137e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 1.949e-05 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) pentose metabolic process 8.716e-09 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 6.899e-06 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 9.519e-09 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 8.888e-07 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 4.393e-05 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 4.318e-07 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 2.744e-09 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 1.614e-13 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000569 Highly Informative Direct
Biological Process (BP) aerobic respiration 1.629e-08 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 1.944e-15 Highly Informative Direct
Biological Process (BP) digestion 3.77e-15 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 6.176e-10 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 5.948e-09 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 9.97e-09 Highly Informative Direct
Biological Process (BP) adult behavior 2.682e-07 Highly Informative Direct
Biological Process (BP) neuromuscular process 5.381e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.584e-06 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.37e-05 Highly Informative Direct
Biological Process (BP) circadian rhythm 3.938e-05 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 8.173e-05 Highly Informative Direct
Biological Process (BP) photorespiration 0.0003312 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000445 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0007926 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.1739 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2439 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.01092 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.02849 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7565 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3593 Highly Informative Inherited
Biological Process (BP) ear development 0.02868 Highly Informative Inherited
Biological Process (BP) quinone cofactor metabolic process 1 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 0.1766 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.001997 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.001332 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.9118 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.6816 Highly Informative Inherited
Biological Process (BP) lactate metabolic process 0.01686 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.1209 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.1996 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.1605 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.8784 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1718 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.0671 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.119 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.01998 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1045 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.68 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.01794 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.2944 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.264e-14 Informative Direct
Molecular Function (MF) nucleotide binding 1.693e-07 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1414 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.0013 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 2.183e-05 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 2.756e-06 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0002317 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.0006472 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.365 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.02264 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.001476 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.1214 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.4534 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1451 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.3255 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) plastid 7.894e-05 Informative Direct
Cellular Component (CC) contractile fiber part 1 Informative Inherited
Cellular Component (CC) synapse part 0.886 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.007053 Informative Inherited
Cellular Component (CC) postsynaptic membrane 2.355e-06 Highly Informative Direct
Cellular Component (CC) cilium part 0.116 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.00105 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) intrinsic to organelle membrane 0.4031 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.113 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.7202 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors3.598e-12Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives3.141e-14InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.968e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.386e-05InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.386e-05InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase6.012e-14Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase1.04e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase2.282e-11Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase1.952e-10Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.785e-09Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase4.825e-09Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)1.173e-07Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.901e-07Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase8.852e-07Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase4.289e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.2775InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.9947Moderately InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0002328Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2353Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7661Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3527Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0002944InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0.0005292Least InformativeDirect
Fly Phenotype (FP)electrophoretic variant9.502e-07InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system4.421e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001235Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002096Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001596Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002281Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02256Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3203Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5542Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005212Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007478Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage5.145e-12InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups5.988e-13InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase4.907e-14Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase1.225e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.279e-09Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase2.807e-08Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.15e-07Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase8.665e-07Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.462e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.21e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0003747Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.008609Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance1.542e-05InformativeDirect
Biological processLipid biosynthesis0.05823InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis5.402e-10Highly InformativeDirect
Biological processAntibiotic biosynthesis3.086e-09Highly InformativeDirect
Biological processSteroid biosynthesis3.697e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentEndoplasmic reticulum0.0004251Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet1.684e-09Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation9.1e-05Least InformativeDirect
Post-translational modificationADP-ribosylation5.53e-09InformativeDirect
Post-translational modificationS-nitrosylation5.117e-08InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism2.325e-09Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1.437e-07Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)fermentation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis8.971e-16InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation3.491e-10InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis2.267e-06InformativeDirect
UniPathway (UP)heterocycle biosynthesis5.231e-06InformativeDirect
UniPathway (UP)terpene metabolism6.489e-06InformativeDirect
UniPathway (UP)toxin biosynthesis7.274e-06InformativeDirect
UniPathway (UP)hormone biosynthesis9.291e-06InformativeDirect
UniPathway (UP)antibiotic biosynthesis8.538e-05InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0001278InformativeDirect
UniPathway (UP)pigment biosynthesis0.0001573InformativeDirect
UniPathway (UP)alkaloid metabolism0.07058InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)carbohydrate acid metabolism1InformativeInherited
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis2.271e-16Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis1.341e-15Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis1.552e-14Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis3.106e-14Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism1.369e-13Highly InformativeDirect
UniPathway (UP)alanine degradation1.037e-12Highly InformativeDirect
UniPathway (UP)polyol biosynthesis1.036e-11Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway2.268e-09Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis2.258e-08Highly InformativeDirect
UniPathway (UP)galactose metabolism1.377e-06Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis8.841e-06Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0.000381Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.0008434Highly InformativeDirect
UniPathway (UP)opine metabolism0.005845Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.03995Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08173Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.3421Highly InformativeInherited
UniPathway (UP)sterol biosynthesis0.9454Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]