SUPERFAMILY 1.75 HMM library and genome assignments server


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (2,489) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 287,530 740,558 522
Proteins 279,281 721,372 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process7.092e-090Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process5.542e-120Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00017744.219e-05Moderately InformativeDirect
Biological Process (BP)single-organism developmental process11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization2.205e-050.01103Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.0033930.09725Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.87711Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.021630Moderately InformativeInherited
Biological Process (BP)reproduction0.9161Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process10.1604Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.81520.05169Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process10.9383Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.66010.8303Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process10.0004795Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process10.002764Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.8784Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus10.07867Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.007394Moderately InformativeInherited
Biological Process (BP)protein oligomerization00InformativeDirect
Biological Process (BP)fatty acid metabolic process00InformativeDirect
Biological Process (BP)regulation of hormone levels1.142e-120InformativeDirect
Biological Process (BP)steroid metabolic process2.242e-061.533e-13InformativeDirect
Biological Process (BP)polysaccharide metabolic process0.00022331.086e-13InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00061463.432e-10InformativeDirect
Biological Process (BP)tetrapyrrole metabolic process0.00065421.795e-06InformativeDirect
Biological Process (BP)cardiovascular system development0.13391InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.011450.02097InformativeInherited
Biological Process (BP)vitamin metabolic process0.052270.3106InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.14267.782e-12InformativeInherited
Biological Process (BP)sexual reproduction0.13491InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.25581InformativeInherited
Biological Process (BP)single organism reproductive process0.32991InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process00.003729InformativeInherited
Biological Process (BP)cellular amide metabolic process0.0061630.006477InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.39020.5729InformativeInherited
Biological Process (BP)response to light stimulus0.85081InformativeInherited
Biological Process (BP)response to external stimulus11InformativeInherited
Biological Process (BP)multi-organism reproductive process0.0049520.7086InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.18230.8305InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.18710.0768InformativeInherited
Biological Process (BP)retinoid metabolic process02.531e-07Highly InformativeDirect
Biological Process (BP)protein tetramerization08.85e-05Highly InformativeDirect
Biological Process (BP)pteridine-containing compound metabolic process1.641e-120Highly InformativeDirect
Biological Process (BP)nonribosomal peptide biosynthetic process3.734e-067.096e-05Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process6.686e-060Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.020731Highly InformativeInherited
Biological Process (BP)quinone cofactor metabolic process0.011460.7355Highly InformativeInherited
Biological Process (BP)female gamete generation2.876e-051Highly InformativeInherited
Biological Process (BP)detection of visible light0.0016140.000215Highly InformativeInherited
Biological Process (BP)phototransduction0.0070270.006257Highly InformativeInherited
Biological Process (BP)multi-multicellular organism process0.00074610.2455Highly InformativeInherited
Biological Process (BP)steroid biosynthetic process0.015349.172e-07Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.13350.06657Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.3720.001531Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.00014891Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.00052621Moderately InformativeInherited
Molecular Function (MF)isomerase activity0.99980.02753Moderately InformativeInherited
Molecular Function (MF)lyase activity10.1001Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)nucleotide binding03.842e-06InformativeDirect
Molecular Function (MF)racemase and epimerase activity5.111e-060InformativeDirect
Molecular Function (MF)carbon-oxygen lyase activity0.89238.14e-14InformativeInherited
Molecular Function (MF)receptor activity0.75081InformativeInherited
Molecular Function (MF)molecular transducer activity0.89321InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor7.302e-110Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.00014170Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors10.1669Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.11891Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.018030.0006998Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.65050Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.99651Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00092395.354e-06Moderately InformativeDirect
Cellular Component (CC)microbody8.491e-080InformativeDirect
Cellular Component (CC)microbody part3.813e-050.000403Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 4.219e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 1.728e-13 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 7.835e-15 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 3.869e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0004795 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.01103 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.09725 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1204 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07867 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8784 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.8303 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9383 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05169 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.002764 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1604 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.007394 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) protein oligomerization 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) steroid metabolic process 1.533e-13 Informative Direct
Biological Process (BP) polysaccharide metabolic process 1.086e-13 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 3.432e-10 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 1.795e-06 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 7.782e-12 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1.827e-09 Informative Direct
Biological Process (BP) metal ion transport 3.938e-06 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.391e-08 Informative Direct
Biological Process (BP) muscle system process 9.714e-07 Informative Direct
Biological Process (BP) blood circulation 1.209e-06 Informative Direct
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.005854 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02951 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.003126 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.00866 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1405 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.001222 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.821 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.02097 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.3106 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) secretion 0.01185 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9373 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.006477 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.5746 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.5729 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.5207 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.001001 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.01057 Informative Inherited
Biological Process (BP) hexose metabolic process 0.8305 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.7086 Informative Inherited
Biological Process (BP) regulation of system process 0.04746 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.002511 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.0768 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.003729 Informative Inherited
Biological Process (BP) retinoid metabolic process 2.531e-07 Highly Informative Direct
Biological Process (BP) protein tetramerization 8.85e-05 Highly Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 7.096e-05 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) detection of visible light 0.000215 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 9.172e-07 Highly Informative Direct
Biological Process (BP) protein homooligomerization 4.134e-05 Highly Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 4.008e-15 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 9.438e-05 Highly Informative Direct
Biological Process (BP) aerobic respiration 4.725e-10 Highly Informative Direct
Biological Process (BP) response to cadmium ion 7.042e-06 Highly Informative Direct
Biological Process (BP) lipopolysaccharide biosynthetic process 2.282e-07 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) digestion 0 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 1.53e-14 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.939e-12 Highly Informative Direct
Biological Process (BP) adult behavior 2.457e-12 Highly Informative Direct
Biological Process (BP) neuromuscular process 1.061e-10 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 7.514e-10 Highly Informative Direct
Biological Process (BP) response to hypoxia 2.155e-09 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.979e-07 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 2.957e-07 Highly Informative Direct
Biological Process (BP) glutamine family amino acid biosynthetic process 8.372e-07 Highly Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 9.718e-07 Highly Informative Direct
Biological Process (BP) response to ethanol 1.73e-06 Highly Informative Direct
Biological Process (BP) photorespiration 2.179e-05 Highly Informative Direct
Biological Process (BP) inner ear development 5.981e-05 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 7.095e-05 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.0007793 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.01063 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03211 Highly Informative Inherited
Biological Process (BP) sensory perception 0.006238 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.9503 Highly Informative Inherited
Biological Process (BP) feeding behavior 0.09885 Highly Informative Inherited
Biological Process (BP) diol metabolic process 0.1871 Highly Informative Inherited
Biological Process (BP) quinone cofactor metabolic process 0.7355 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1032 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.1777 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 1 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.6144 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.7067 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.1531 Highly Informative Inherited
Biological Process (BP) epidermis development 0.001105 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.07367 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.3034 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01949 Highly Informative Inherited
Biological Process (BP) phototransduction 0.006257 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.2455 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.9026 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.008999 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.5146 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.06657 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.03374 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.004439 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001531 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.02753 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.1001 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 3.842e-06 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity 8.14e-14 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 3.511e-09 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.249e-06 Informative Direct
Molecular Function (MF) transition metal ion binding 0.00415 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.0006998 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 1.106e-08 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.192e-08 Highly Informative Direct
Molecular Function (MF) ion channel activity 1.647e-05 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 7.157e-05 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.1069 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.1669 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.9153 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.006636 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.057 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 5.354e-06 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0001084 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0002453 Moderately Informative Direct
Cellular Component (CC) extracellular region 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.02096 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) external encapsulating structure 1.809e-06 Informative Direct
Cellular Component (CC) plastid 2.151e-10 Informative Direct
Cellular Component (CC) synapse 0.008505 Informative Inherited
Cellular Component (CC) cell projection part 0.8159 Informative Inherited
Cellular Component (CC) neuron part 1 Informative Inherited
Cellular Component (CC) contractile fiber part 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microbody part 0.000403 Highly Informative Direct
Cellular Component (CC) cell wall 1.547e-09 Highly Informative Direct
Cellular Component (CC) lipid particle 2.42e-06 Highly Informative Direct
Cellular Component (CC) synaptic membrane 8.463e-11 Highly Informative Direct
Cellular Component (CC) axon part 3.608e-08 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.074e-07 Highly Informative Direct
Cellular Component (CC) sarcomere 0.679 Highly Informative Inherited
Cellular Component (CC) Golgi membrane 0.878 Highly Informative Inherited
Cellular Component (CC) integral to organelle membrane 0.02208 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.01473 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.1179 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.9842 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors3.598e-12Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives3.141e-14InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.968e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.386e-05InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.386e-05InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase6.012e-14Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase1.04e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase2.282e-11Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase1.952e-10Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.785e-09Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase4.825e-09Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)1.173e-07Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.901e-07Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase8.852e-07Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase4.289e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.1891InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.9947Moderately InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0002328Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2353Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization0.3517Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0003292InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant8.915e-07InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system4.091e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)androecium0.0007217Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0.0009406Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0.001436Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.001495Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02111Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0006083Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0008717Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage1.342e-12InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups6.121e-12InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)In cyclic amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I4.771e-16Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase1.026e-13Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase2.519e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.956e-09Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase3.244e-08Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase2.065e-07Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase9.809e-07Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase7.111e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.428e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0004107Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)0.0006672Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00958Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.02032Least InformativeInherited
Drugbank ATC_code (DB)respiratory system0.0004825Moderately InformativeDirect
Drugbank ATC_code (DB)dermatologicals0.001697Moderately InformativeInherited
Drugbank ATC_code (DB)other ophthalmologicals1Moderately InformativeInherited
Drugbank ATC_code (DB)vitamin a, plain2.912e-08InformativeDirect
Drugbank ATC_code (DB)retinol2.912e-08InformativeDirect
Drugbank ATC_code (DB)retinol2.912e-08InformativeDirect
Drugbank ATC_code (DB)retinol2.912e-08InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance1.359e-05InformativeDirect
Biological processLipid biosynthesis0.1109InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPhospholipid biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPyridoxine biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis4.636e-16Highly InformativeDirect
Biological processHistidine biosynthesis6.819e-10Highly InformativeDirect
Biological processAntibiotic biosynthesis3.316e-06Highly InformativeDirect
Biological processSteroid biosynthesis4.705e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet1.073e-07Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionPhosphopantetheine0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.569e-11InformativeDirect
Post-translational modificationADP-ribosylation1.917e-07InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism4.718e-09Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism4.219e-07Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation3.613e-10InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis1.287e-06InformativeDirect
UniPathway (UP)terpene metabolism4.805e-06InformativeDirect
UniPathway (UP)heterocycle biosynthesis8.73e-06InformativeDirect
UniPathway (UP)toxin biosynthesis2.774e-05InformativeDirect
UniPathway (UP)polyketide biosynthesis8.235e-05InformativeDirect
UniPathway (UP)pigment biosynthesis0.0001732InformativeDirect
UniPathway (UP)alkaloid metabolism0.0777InformativeInherited
UniPathway (UP)hormone metabolism0.2447InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)fatty acid degradation0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)fermentation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis1.771e-15Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis1.088e-14Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis1.627e-14Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism1.433e-13Highly InformativeDirect
UniPathway (UP)polyol biosynthesis1.082e-11Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis1.205e-09Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway6.281e-09Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis1.216e-08Highly InformativeDirect
UniPathway (UP)galactose metabolism2.768e-06Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis7.314e-06Highly InformativeDirect
UniPathway (UP)opine metabolism0.005846Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.03445Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08143Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.09695Highly InformativeInherited
UniPathway (UP)sterol biosynthesis0.9632Highly InformativeInherited
UniPathway (UP)alanine metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]