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NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,262) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 360,848 2,030,253 522
Proteins 349,772 1,973,150 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.0000000000073860Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.80880.00008955Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process0.72891Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000061510Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00014730.0000000002704Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.012551Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.000022261Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.00000000049130.02291Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.034620Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.86491Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.93781Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.001782Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.0000000007809Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.49560.01117Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.00027760.00000000000004251InformativeDirect
Biological Process (BP)fatty acid metabolic process00.000000000009128InformativeDirect
Biological Process (BP)regulation of hormone levels0.00000000070710.00000001916InformativeDirect
Biological Process (BP)secondary metabolic process0.000005210InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000011720.00000000005685InformativeDirect
Biological Process (BP)protein oligomerization00.00000000002058InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process00.0001884InformativeDirect
Biological Process (BP)circulatory system development0.34481InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.030690.00009314InformativeInherited
Biological Process (BP)pigment metabolic process0.21251InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.046390.00000000000002102InformativeInherited
Biological Process (BP)multi-organism reproductive process0.63411InformativeInherited
Biological Process (BP)multicellular organism reproduction0.62041InformativeInherited
Biological Process (BP)single organism reproductive process0.89321InformativeInherited
Biological Process (BP)alcohol metabolic process0.0017190.0002637InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.43991InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.61190.2617InformativeInherited
Biological Process (BP)steroid biosynthetic process0.0000046340.000000003903Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000026310Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.00011250.00000005035Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.000000009490Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000015830.00004998Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000046130.0000006993Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.19171Highly InformativeInherited
Biological Process (BP)female gamete generation0.0014921Highly InformativeInherited
Biological Process (BP)polyol metabolic process11Highly InformativeInherited
Biological Process (BP)multi-multicellular organism process0.00057910.3801Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000000011660Moderately InformativeDirect
Molecular Function (MF)anion binding0.35970.02211Moderately InformativeInherited
Molecular Function (MF)lyase activity10.68Moderately InformativeInherited
Molecular Function (MF)isomerase activity0.87420.001327Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.000069620InformativeDirect
Molecular Function (MF)coenzyme binding00InformativeDirect
Molecular Function (MF)hydro-lyase activity0.95680InformativeInherited
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)signal transducer activity11InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.00014880Highly InformativeDirect
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding0.0000000000000170Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.53570.0214Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.00001160.2112Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.95151Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.02760.000081Highly InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.9467Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)bounding membrane of organelle11Moderately InformativeInherited
Cellular Component (CC)whole membrane11Moderately InformativeInherited
Cellular Component (CC)microbody0.011210InformativeInherited
Cellular Component (CC)microbody membrane0.000030910.000000002429Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00008955 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000272 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000002704 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000007809 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.05301 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.02291 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2762 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01117 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.01433 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3146 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.001782 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.007339 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00000000000004251 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000003117 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0002637 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000000009128 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000002792 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00003053 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000001916 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000000000002102 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000008776 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00009314 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.0000000000001094 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000000005685 Informative Direct
Biological Process (BP) ATP metabolic process 0.0000001755 Informative Direct
Biological Process (BP) protein oligomerization 0.00000000002058 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0001884 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0005722 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000005125 Informative Direct
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) pigment metabolic process 1 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.2843 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1455 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.5072 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.71 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.4952 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6207 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2617 Informative Inherited
Biological Process (BP) fermentation 0.000272 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000000003903 Highly Informative Direct
Biological Process (BP) NADP metabolic process 0.0000001539 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000003324 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.00000000001527 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.00000005035 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000000002897 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.0000000000002271 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.00004998 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.0000006993 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00000007058 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.004352 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.05306 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.04312 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.003838 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.001206 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.9484 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.03141 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2591 Highly Informative Inherited
Biological Process (BP) single-organism behavior 1 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.2301 Highly Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0.07529 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.3082 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.001209 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 1 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.003512 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.009998 Highly Informative Inherited
Biological Process (BP) fatty acid derivative biosynthetic process 0.001437 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 1 Highly Informative Inherited
Biological Process (BP) vitamin B6 metabolic process 0.001896 Highly Informative Inherited
Biological Process (BP) pyridine-containing compound biosynthetic process 0.4863 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.3801 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.2988 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.06018 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 1 Highly Informative Inherited
Biological Process (BP) citrate metabolic process 0.5834 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.0349 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02211 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.68 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.001327 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.1553 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.5728 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.0001071 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.0002438 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.000081 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 0.00000005251 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000000002744 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.07496 Highly Informative Inherited
Molecular Function (MF) vitamin binding 1 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.1952 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.0214 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.2112 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.599 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.07752 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.4398 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9467 Least Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle inner membrane 0.1107 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.8279 Moderately Informative Inherited
Cellular Component (CC) plastid 0.000008245 Informative Direct
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) respiratory chain complex 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.04297 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain 0.06936 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.8087 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00175 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0.0003764 Highly Informative Direct
Cellular Component (CC) lipid droplet 0.000908 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.00003325 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.000000002429 Highly Informative Direct
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) peroxisomal part 0.2585 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000000000003598Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000003141InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006968InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002386InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00002386InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000006012Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.0000000000104Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000002282Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000000001952Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001785Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0.000000004825Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0.0000001173Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001901Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.0000008852Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase0.00004289Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processAntibiotic resistance0.000007997InformativeDirect
Biological processLipid biosynthesis0.004915InformativeInherited
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processAntibiotic biosynthesis0.00000000004265Highly InformativeDirect
Biological processHistidine biosynthesis0.0000000005281Highly InformativeDirect
Biological processAlkaloid metabolism0.00000313Highly InformativeDirect
Biological processSteroid biosynthesis0.00008885Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet0.000000271Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.00002267Moderately InformativeDirect
Post-translational modificationAcetylation0.00004822Least InformativeDirect
Post-translational modificationADP-ribosylation0.0000001767InformativeDirect
Post-translational modificationS-nitrosylation0.0001097InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]