SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,255) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 358,775 1,613,957 522
Proteins 347,805 1,580,963 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00000000015610Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.000000003101Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process10.9686Least InformativeInherited
Biological Process (BP)primary metabolic process0.94851Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00051510Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000024560.0000000000002903Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)system development11Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)signaling11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.001741Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00004871Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.91671Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0041660Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative biosynthetic process0.75281Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.04766Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00082410.0005429InformativeDirect
Biological Process (BP)fatty acid metabolic process00.00000000003917InformativeDirect
Biological Process (BP)regulation of hormone levels0.00000000067220.00000003109InformativeDirect
Biological Process (BP)drug metabolic process0.00029870.00006836InformativeDirect
Biological Process (BP)secondary metabolic process0.000014050InformativeDirect
Biological Process (BP)pteridine-containing compound metabolic process0.000007580.000000000001071InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00025770.000000003533InformativeDirect
Biological Process (BP)protein oligomerization00.000000000007008InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process00.0004177InformativeDirect
Biological Process (BP)circulatory system development0.26461InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.0025130.00000000000087InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.54080.2036InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.0067710.000003745InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.03320.001238InformativeInherited
Biological Process (BP)pigment metabolic process0.17531InformativeInherited
Biological Process (BP)multi-organism reproductive process0.741InformativeInherited
Biological Process (BP)multicellular organism reproduction0.66641InformativeInherited
Biological Process (BP)single organism reproductive process0.92481InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.73581InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.078130.000000000000003692InformativeInherited
Biological Process (BP)steroid metabolic process0.000040540.0000000005125Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.0000036150Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.000085950.00000004658Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.00000061090Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000018590.0000791Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000050970.000001007Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.21661Highly InformativeInherited
Biological Process (BP)quinone metabolic process0.0022050.97Highly InformativeInherited
Biological Process (BP)female gamete generation0.00086611Highly InformativeInherited
Biological Process (BP)multi-multicellular organism process0.00057480.3463Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000000001770Moderately InformativeDirect
Molecular Function (MF)anion binding0.50040.07466Moderately InformativeInherited
Molecular Function (MF)isomerase activity0.83660.00132Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.00007030InformativeDirect
Molecular Function (MF)coenzyme binding00InformativeDirect
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)signal transducer activity11InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.00022580Highly InformativeDirect
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding0.0000000000000065880Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.62780.03058Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.0000073930.1869Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.92021Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)microbody0.010420.00000000000000601InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000003101 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9686 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000002782 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.0000000003482 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000000002903 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.5857 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4851 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.6055 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3483 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.04766 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.02268 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00000000000087 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.000006576 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0005429 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00000000003917 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000002949 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.000002346 Informative Direct
Biological Process (BP) nucleoside diphosphate metabolic process 0.0007875 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000003109 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000000000003692 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.00003784 Informative Direct
Biological Process (BP) drug metabolic process 0.00006836 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000003745 Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 0.000000000001071 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.0000000000002236 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000000003533 Informative Direct
Biological Process (BP) ATP metabolic process 0.00003335 Informative Direct
Biological Process (BP) protein oligomerization 0.000000000007008 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0004177 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0001737 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000001096 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2036 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) pigment metabolic process 1 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.001238 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.7804 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.139 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.602 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.4143 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.7303 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1178 Informative Inherited
Biological Process (BP) fermentation 0.0002744 Highly Informative Direct
Biological Process (BP) NADP metabolic process 0.00000005681 Highly Informative Direct
Biological Process (BP) steroid metabolic process 0.0000000005125 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000002505 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.0000000007488 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0002211 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.00000004658 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000000002328 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000000000000003692 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.0000791 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.000001007 Highly Informative Direct
Biological Process (BP) vitamin B6 metabolic process 0.0002379 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.000002108 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.01229 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.07348 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.004354 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2303 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.8598 Highly Informative Inherited
Biological Process (BP) apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.01956 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1939 Highly Informative Inherited
Biological Process (BP) single-organism behavior 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 0.97 Highly Informative Inherited
Biological Process (BP) cellular response to xenobiotic stimulus 0.006293 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 1 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.01304 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.07633 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) glycoside metabolic process 0.0159 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.9822 Highly Informative Inherited
Biological Process (BP) pyridine-containing compound biosynthetic process 0.3615 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.3463 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.1284 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.03693 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 1 Highly Informative Inherited
Biological Process (BP) citrate metabolic process 0.629 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.03463 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.07466 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.7973 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.00132 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.4997 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.139 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.0004153 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.0003453 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.0000731 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 0.0000000681 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00000001691 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.2022 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.1826 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.05289 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.1869 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.6612 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.03058 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.5388 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.08308 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.7026 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.00000005013 Informative Direct
Cellular Component (CC) plastid 0.0001807 Informative Direct
Cellular Component (CC) microbody 0.00000000000000601 Informative Direct
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) transport vesicle 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.002251 Informative Inherited
Cellular Component (CC) extracellular matrix 1 Highly Informative Inherited
Cellular Component (CC) contractile fiber part 1 Highly Informative Inherited
Cellular Component (CC) myofibril 1 Highly Informative Inherited
Cellular Component (CC) intrinsic component of organelle membrane 0.08806 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1494 Highly Informative Inherited
Cellular Component (CC) coated vesicle 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000000000003598Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000003141InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006968InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002386InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00002386InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000006012Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.0000000000104Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000002282Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000000001952Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001785Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0.000000004825Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0.0000001173Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001901Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.0000008852Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase0.00004289Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9962Least InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8493Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4434InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.4593Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.932Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.6052InformativeInherited
Worm Phenotype (WP)vulva development variant0.7751InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0009808Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7626Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3954Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0003609InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.0000005534Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.5321Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5612Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.674Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8349Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.4267Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.5163Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.6927Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.8695Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.4842InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.06862Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.03915Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.000002754Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0.0002052InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0002291InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001274Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002164Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001608Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002332Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02247Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3199Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5571Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005289Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007573Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000000005181InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.00000000003605InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C=C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.0000000000000298Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000000754Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0000000008308Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.000000006562Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.00000007751Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000009314Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006093Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.00002794Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00003496Highly InformativeDirect
Enzyme Commission (EC)10-deoxymethynolide syntase0.00008317Highly InformativeDirect
Enzyme Commission (EC)Narbonolide synthase0.00008317Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0004746Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.008007Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donors1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Other lyases1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)sensory organs0.004505Least InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.00005184Moderately InformativeDirect
Drugbank ATC_code (DB)other ophthalmologicals0.001123Moderately InformativeInherited
Drugbank ATC_code (DB)nasal preparations0.002304Moderately InformativeInherited
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.03001Moderately InformativeInherited
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)retinoids for topical use in acne0.00000001319InformativeDirect
Drugbank ATC_code (DB)corticosteroids for systemic use0.0003441InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000003693Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000003693Highly InformativeDirect
Drugbank ATC_code (DB)retinol0.0000000003693Highly InformativeDirect
Drugbank ATC_code (DB)fomepizole0.000009389Highly InformativeDirect
Drugbank ATC_code (DB)phenol and derivatives0.00005224Highly InformativeDirect
Drugbank ATC_code (DB)medicated dressings0.0002804Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance0.000005241InformativeDirect
Biological processLipid biosynthesis0.007816InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis0.0000000008553Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000001178Highly InformativeDirect
Biological processSteroid biosynthesis0.00005649Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentEndoplasmic reticulum0.0007416Moderately InformativeDirect
Cellular componentMitochondrion0.4263Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.0008347InformativeDirect
Cellular componentLipid droplet0.0000002594Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001273Least InformativeDirect
Post-translational modificationS-nitrosylation0.00005268InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect
Post-translational modificationADP-ribosylation0.00000001076Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism2.305e-16Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.00000000003258Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0.00001977Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0001485Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.5589Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)fermentation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0.000000000000002264InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0000000003317InformativeDirect
UniPathway (UP)hormone biosynthesis0.0000001387InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.0000004667InformativeDirect
UniPathway (UP)toxin biosynthesis0.0000009802InformativeDirect
UniPathway (UP)steroid metabolism0.000002739InformativeDirect
UniPathway (UP)heterocycle biosynthesis0.000007746InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0001111InformativeDirect
UniPathway (UP)pigment biosynthesis0.0002547InformativeDirect
UniPathway (UP)terpene biosynthesis0.000305InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)carbohydrate acid metabolism1InformativeInherited
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis2.305e-16Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.000000000000003611Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0.000000000000007607Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis0.00000000000005745Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism0.000000000000187Highly InformativeDirect
UniPathway (UP)alanine degradation0.000000000001341Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.000000000014Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway0.0000000006527Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.00000001758Highly InformativeDirect
UniPathway (UP)galactose metabolism0.000001231Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0.00001031Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.00004474Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0.0004152Highly InformativeDirect
UniPathway (UP)opine metabolism0.006159Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08211Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.08977Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.3728Highly InformativeInherited
UniPathway (UP)sterol biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]