SUPERFAMILY 1.75 HMM library and genome assignments server


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,212) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 347,250 740,558 522
Proteins 336,798 721,372 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.00020871.931e-15Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process7.298e-100Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process7.444e-070Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process11Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.65611Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.044391Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process10.001459Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process10.06435Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.01280Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.99550.1981Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.30810.0008401Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.55050.8964Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.78440.563Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process10.01498Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.12970Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.0416Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process7.052e-141.395e-12InformativeDirect
Biological Process (BP)regulation of hormone levels2.854e-081.886e-11InformativeDirect
Biological Process (BP)steroid metabolic process2.826e-052.218e-12InformativeDirect
Biological Process (BP)protein complex assembly3.21e-056.412e-06InformativeDirect
Biological Process (BP)secondary metabolic process0.00012120InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.00017026.199e-07InformativeDirect
Biological Process (BP)cardiovascular system development0.16451InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.57852.34e-06InformativeInherited
Biological Process (BP)cellular amide metabolic process0.018960.07366InformativeInherited
Biological Process (BP)vitamin metabolic process0.083940.6851InformativeInherited
Biological Process (BP)nucleotide biosynthetic process10.05578InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0071471.864e-09InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.12857.262e-05InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.42745.738e-10InformativeInherited
Biological Process (BP)sexual reproduction0.69881InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.87351InformativeInherited
Biological Process (BP)single organism reproductive process0.93191InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process00.0546InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.13650.03168InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)retinoid metabolic process08.167e-08Highly InformativeDirect
Biological Process (BP)protein tetramerization04.176e-05Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process2.265e-120Highly InformativeDirect
Biological Process (BP)pentose metabolic process5.031e-071.17e-08Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process1.104e-065.836e-06Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.00010587.68e-09Highly InformativeDirect
Biological Process (BP)amide biosynthetic process0.00017391.654e-05Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00022644.055e-07Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.29310.1496Highly InformativeInherited
Biological Process (BP)artery morphogenesis1.946e-090.009754Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.26031Highly InformativeInherited
Biological Process (BP)quinone cofactor metabolic process0.010881Highly InformativeInherited
Biological Process (BP)quinone metabolic process0.019870.1713Highly InformativeInherited
Biological Process (BP)nucleotide-sugar metabolic process0.0063640Highly InformativeInherited
Biological Process (BP)female gamete generation0.00068381Highly InformativeInherited
Biological Process (BP)steroid biosynthetic process0.013264.663e-07Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.10340.06007Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)anion binding10.6082Moderately InformativeInherited
Molecular Function (MF)isomerase activity10.01558Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)cofactor binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups1.321e-158.492e-14InformativeDirect
Molecular Function (MF)nucleotide binding1.778e-101.317e-07InformativeDirect
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)receptor activity11InformativeInherited
Molecular Function (MF)racemase and epimerase activity0.0072580InformativeInherited
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding7.632e-110Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor5.383e-090Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors10.01156Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors2.623e-060.001161Highly InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.51471Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.061450.0003936Highly InformativeInherited
Cellular Component (CC)cytoplasmic part10.3543Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)microbody1.374e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1.931e-15 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0008401 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0416 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.563 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.8964 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1981 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001459 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.06435 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01498 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 1.395e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 1.886e-11 Informative Direct
Biological Process (BP) steroid metabolic process 2.218e-12 Informative Direct
Biological Process (BP) protein complex assembly 6.412e-06 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 6.199e-07 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 1.864e-09 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 7.262e-05 Informative Direct
Biological Process (BP) alcohol metabolic process 7.879e-05 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 5.738e-10 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 2.34e-06 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3329 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.8431 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1495 Informative Inherited
Biological Process (BP) pigment metabolic process 0.9822 Informative Inherited
Biological Process (BP) lipid catabolic process 0.04602 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.07366 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.6851 Informative Inherited
Biological Process (BP) blood circulation 0.001139 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.006066 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.001368 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.7098 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.05578 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.2191 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.08734 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.5571 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.03168 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0546 Informative Inherited
Biological Process (BP) retinoid metabolic process 8.167e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 4.176e-05 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) pentose metabolic process 1.17e-08 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 5.836e-06 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 7.68e-09 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 1.654e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 4.055e-07 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 7.308e-05 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 4.663e-07 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 1.932e-09 Highly Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 5.203e-11 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 1.096e-13 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0005244 Highly Informative Direct
Biological Process (BP) aerobic respiration 8.746e-09 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0 Highly Informative Direct
Biological Process (BP) digestion 3.746e-15 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 5.312e-10 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1.509e-09 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 8.949e-09 Highly Informative Direct
Biological Process (BP) neuromuscular process 1.138e-07 Highly Informative Direct
Biological Process (BP) adult behavior 1.636e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 5.707e-07 Highly Informative Direct
Biological Process (BP) response to hypoxia 2.236e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0001341 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0002347 Highly Informative Direct
Biological Process (BP) photorespiration 0.0003576 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0007476 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0.0007601 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.1496 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.6118 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.009754 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.1128 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6936 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4672 Highly Informative Inherited
Biological Process (BP) inner ear development 0.01158 Highly Informative Inherited
Biological Process (BP) quinone cofactor metabolic process 1 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 0.1713 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.001239 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.8396 Highly Informative Inherited
Biological Process (BP) monosaccharide biosynthetic process 0.5746 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.08027 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.2174 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.1444 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.8422 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1212 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.09367 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.06007 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.1227 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.01524 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.06029 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6082 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.01558 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.187 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 8.492e-14 Informative Direct
Molecular Function (MF) nucleotide binding 1.317e-07 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1245 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.00103 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7.922e-16 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.0003936 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 2.528e-06 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.0004938 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.3369 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.01156 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.001161 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.12 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.03372 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.4367 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3543 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.2543 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) plastid 9.382e-05 Informative Direct
Cellular Component (CC) contractile fiber part 1 Informative Inherited
Cellular Component (CC) synapse part 0.8305 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) lipid particle 6.712e-07 Highly Informative Direct
Cellular Component (CC) synaptic membrane 7.401e-07 Highly Informative Direct
Cellular Component (CC) axon part 0.0003894 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.0007094 Highly Informative Direct
Cellular Component (CC) cilium 0.3613 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) intrinsic to organelle membrane 0.3602 Highly Informative Inherited
Cellular Component (CC) Golgi membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1121 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.6729 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 1 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors3.598e-12Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives3.141e-14InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.968e-06InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.386e-05InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.386e-05InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase6.012e-14Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase1.04e-11Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase2.282e-11Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase1.952e-10Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase1.785e-09Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase4.825e-09Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)1.173e-07Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.901e-07Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase8.852e-07Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase4.289e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.2618InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)early embryonic lethal0.9947Moderately InformativeInherited
Worm Phenotype (WP)one cell arrest early emb0.0002328Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2353Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization0.3474Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0002938InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant1.24e-06InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system4.321e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001235Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002096Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001596Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002281Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02256Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3203Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5542Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005212Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007478Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage5.145e-12InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups4.019e-13InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I4.808e-16Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase7.352e-14Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase1.82e-11Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase3.039e-08Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase1.584e-07Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase8.865e-07Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase6.819e-06Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.329e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0003946Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.009135Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Acting on phosphates1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in the other subclasses1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance1.369e-05InformativeDirect
Biological processLipid biosynthesis0.06037InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis5.972e-10Highly InformativeDirect
Biological processAntibiotic biosynthesis3.447e-09Highly InformativeDirect
Biological processSteroid biosynthesis3.579e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentLipid droplet9.866e-07Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001404Least InformativeDirect
Post-translational modificationADP-ribosylation4.844e-09InformativeDirect
Post-translational modificationS-nitrosylation1.735e-08InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.135Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis6.291e-15Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1.019e-13Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1.981e-13Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0.3246Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)pigment metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)pentose phosphate pathway0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid metabolism0InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)L-methionine biosynthesis5.933e-12InformativeDirect
UniPathway (UP)lipid degradation1.236e-11InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation1.218e-09InformativeDirect
UniPathway (UP)terpene metabolism3.756e-06InformativeDirect
UniPathway (UP)hormone biosynthesis0.0004337InformativeDirect
UniPathway (UP)aromatic compound degradation0.00259InformativeInherited
UniPathway (UP)alcohol biosynthesis0.03822InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis0.04215InformativeInherited
UniPathway (UP)alkaloid metabolism0.2369InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0.5675InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1InformativeInherited
UniPathway (UP)alanine metabolism1InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)cell wall biogenesis1InformativeInherited
UniPathway (UP)heterocycle biosynthesis1InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via de novo pathway0Highly InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)GDP-L-fucose biosynthesis0Highly InformativeDirect
UniPathway (UP)NAD(+) biosynthesis4.204e-15Highly InformativeDirect
UniPathway (UP)alanine degradation2.851e-07Highly InformativeDirect
UniPathway (UP)alpha-glycerophosphate cycle2.162e-05Highly InformativeDirect
UniPathway (UP)D-arabinitol metabolism2.162e-05Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis6.955e-05Highly InformativeDirect
UniPathway (UP)galactose metabolism0.0005784Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis0.0007929Highly InformativeDirect
UniPathway (UP)L-ascorbate biosynthesis0.0441Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.1079Highly InformativeInherited
UniPathway (UP)sterol biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]