SUPERFAMILY 1.75 HMM library and genome assignments server


FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 140,153 0 171
Proteins 125,205 0 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.94811Least InformativeInherited
Biological Process (BP)regulation of cellular process0.66351Least InformativeInherited
Biological Process (BP)response to stimulus0.87731Least InformativeInherited
Biological Process (BP)homeostatic process0.026461Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.020851Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.11311Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.00023881.836e-06InformativeDirect
Biological Process (BP)cell redox homeostasis3.265e-087.254e-10Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity2.184e-120Moderately InformativeDirect
Molecular Function (MF)anion binding0.62015.935e-14Moderately InformativeInherited
Molecular Function (MF)cofactor binding0.0034930InformativeInherited
Molecular Function (MF)nucleotide binding0.051030InformativeInherited
Molecular Function (MF)antioxidant activity6.071e-120Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H3.231e-080Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors6.253e-080Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.31711Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.062510.6712Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.17391Least InformativeInherited
Cellular Component (CC)organelle envelope0.00082930Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.00099690Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 9.043e-10 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 1.57e-07 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 3.218e-05 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.03935 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.7657 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8933 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.07334 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.855 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4237 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8524 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 1.836e-06 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 1.922e-15 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 8.747e-10 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 7.131e-09 Informative Direct
Biological Process (BP) isoprenoid metabolic process 5.381e-08 Informative Direct
Biological Process (BP) regulation of hormone levels 1.006e-05 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0001072 Informative Direct
Biological Process (BP) cellular component disassembly 0.0002518 Informative Direct
Biological Process (BP) secondary metabolic process 0.0005626 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0008616 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.03657 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.9108 Informative Inherited
Biological Process (BP) response to inorganic substance 0.05393 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 1 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.09596 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.2142 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.1196 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.408 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.07383 Informative Inherited
Biological Process (BP) cell redox homeostasis 7.254e-10 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 4.511e-12 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 2.372e-09 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 1.172e-08 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 4.33e-08 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 7.917e-08 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 8.61e-08 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 2.008e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 9.831e-07 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 2.428e-06 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 4.04e-06 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 6.914e-06 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0001195 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0002431 Highly Informative Direct
Biological Process (BP) oxidative phosphorylation 0.0003899 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.02299 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1485 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5042 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) electron transport chain 0.003618 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.008319 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.5786 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.02688 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.7793 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.009947 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.05188 Highly Informative Inherited
Biological Process (BP) aerobic respiration 1 Highly Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.001583 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 5.935e-14 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 2.967e-10 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.03479 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.943 Informative Inherited
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 4.217e-14 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 4.189e-06 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.000315 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.01621 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.3112 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.03887 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6712 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 8.272e-07 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial membrane part 7.952e-10 Informative Direct
Cellular Component (CC) respiratory chain 0.000301 Informative Direct
Cellular Component (CC) organelle outer membrane 9.113e-15 Highly Informative Direct
Cellular Component (CC) Rab-protein geranylgeranyltransferase complex 8.428e-09 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.1336 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1.853e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)7.24e-12Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)3.923e-11Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen7.326e-09Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor2.146e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.01399Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5696Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7172Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.009414Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.6472Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis9.9e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased CSF lactate0.0004643Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0006196Highly InformativeDirect
Phenotypic Abnormality (PA)CNS demyelination0.0008101Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3839Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4551Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1014InformativeInherited
Mammalian Phenotype (MP)abnormal aggression-related behavior0.0009358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.003468Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.888InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1InformativeInherited
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor6.666e-11Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen1.314e-09Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor9.503e-08Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase5.144e-07Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.005256Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01309Highly InformativeInherited
Enzyme Commission (EC)With other, known, acceptors0.09844Highly InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.1758Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4526Highly InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7387Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.7799Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.8001Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.9073Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis1.118e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processCytolysis3.481e-12InformativeDirect
Biological processSteroid metabolism1.153e-06InformativeDirect
Biological processElectron transport0.0002928InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processAbscisic acid biosynthesis9.076e-12Highly InformativeDirect
Biological processGlycerol metabolism2.747e-10Highly InformativeDirect
Biological processThiamine biosynthesis5.317e-10Highly InformativeDirect
Biological processPhospholipid metabolism4.496e-08Highly InformativeDirect
Biological processAntibiotic biosynthesis3.643e-07Highly InformativeDirect
Biological processHeme biosynthesis5.406e-05Highly InformativeDirect
Biological processMethanogenesis0.0001133Highly InformativeDirect
Biological processHemolysis0.0004625Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.02362Moderately InformativeInherited
Cellular componentPlastid0.9188Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome1.031e-08InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversitySelenocysteine4.421e-15InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainLIM domain6.664e-09Highly InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury1.41e-14Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationGTPase activation2.942e-11InformativeDirect
Post-translational modificationAntimicrobial1.737e-08InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationAntibiotic1.423e-13Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin5.592e-09Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1.366e-07Least InformativeDirect
UniPathway (UP)lipid metabolism0.0002203Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)energy metabolism5.347e-13Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.1921Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)one-carbon metabolism1Moderately InformativeInherited
UniPathway (UP)organic acid metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)polyol degradation3.99e-14InformativeDirect
UniPathway (UP)isoprenoid biosynthesis4.971e-14InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis7.472e-12InformativeDirect
UniPathway (UP)siderophore metabolism3.236e-11InformativeDirect
UniPathway (UP)methanogenesis0.0003925InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000603InformativeDirect
UniPathway (UP)L-glutamate metabolism0.004652InformativeInherited
UniPathway (UP)organic acid biosynthesis0.07695InformativeInherited
UniPathway (UP)terpene metabolism0.1399InformativeInherited
UniPathway (UP)alkaloid metabolism0.3381InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)coenzyme M-coenzyme B heterodisulfide reduction3.731e-12Highly InformativeDirect
UniPathway (UP)opine metabolism1.75e-11Highly InformativeDirect
UniPathway (UP)auxin metabolism9.179e-08Highly InformativeDirect
UniPathway (UP)sarcosine degradation5.317e-07Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0.0002404Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0.006822Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]