SUPERFAMILY 1.75 HMM library and genome assignments server


FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (2,488) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 114,460 270,247 171
Proteins 102,003 248,105 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.11511Least InformativeInherited
Biological Process (BP)regulation of cellular process0.26411Least InformativeInherited
Biological Process (BP)response to stimulus0.2141Least InformativeInherited
Biological Process (BP)homeostatic process0.00067961Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.022490.9338Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.050661Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.0013511.027e-08InformativeInherited
Molecular Function (MF)binding0.3541Least InformativeInherited
Molecular Function (MF)oxidoreductase activity1.067e-090Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding0.049760.0601Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.060580.05541Moderately InformativeInherited
Molecular Function (MF)anion binding0.50939.685e-15Moderately InformativeInherited
Molecular Function (MF)cofactor binding6.165e-050InformativeDirect
Molecular Function (MF)nucleotide binding0.0018380InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors2.218e-090Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00077630Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.25220.1835Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0016080.03483Least InformativeInherited
Cellular Component (CC)organelle envelope0.00079410Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.9466 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5272 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 4.871e-06 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001631 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0003345 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0006432 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9338 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.9271 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.1847 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.3084 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.04039 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3138 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 1.027e-08 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 3.329e-14 Informative Direct
Biological Process (BP) cellular component disassembly 7.423e-10 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 2.003e-09 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 4.755e-08 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1.541e-05 Informative Direct
Biological Process (BP) steroid metabolic process 5.607e-05 Informative Direct
Biological Process (BP) response to inorganic substance 9.023e-05 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0002334 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0006334 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.5595 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9219 Informative Inherited
Biological Process (BP) apoptotic process 0.4069 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1568 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.921 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.04499 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3019 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.08386 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001759 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01354 Informative Inherited
Biological Process (BP) actin filament-based process 0.6353 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.002415 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 7.145e-14 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 1.052e-13 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 9.778e-13 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 3.314e-12 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 3.944e-11 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 4.243e-08 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 9.486e-07 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 7.605e-06 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 3.881e-05 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 5.319e-05 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.0001487 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0.000291 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.0003761 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0.01811 Highly Informative Inherited
Biological Process (BP) histone modification 0.2591 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.4713 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.03079 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.7167 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.9688 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 1 Highly Informative Inherited
Biological Process (BP) oxidative phosphorylation 0.002042 Highly Informative Inherited
Biological Process (BP) respiratory electron transport chain 0.04969 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0186 Highly Informative Inherited
Biological Process (BP) diol metabolic process 0.1011 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.4448 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.3825 Highly Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.4349 Highly Informative Inherited
Biological Process (BP) cellular component disassembly involved in execution phase of apoptosis 0.4179 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.005108 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.003741 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.01084 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.002888 Highly Informative Inherited
Biological Process (BP) quinone biosynthetic process 0.01082 Highly Informative Inherited
Biological Process (BP) quinone cofactor metabolic process 0.1946 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.6027 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.08276 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.008304 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.9534 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 9.685e-15 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5691 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.0601 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.05541 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 4.93e-12 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.3132 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.03197 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.03404 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 3.911e-12 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0005378 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0005542 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0.0005903 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.3476 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01236 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.02173 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.03483 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1835 Least Informative Inherited
Cellular Component (CC) membrane 0.4098 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) respiratory chain 4.533e-13 Informative Direct
Cellular Component (CC) mitochondrial membrane part 6.855e-11 Informative Direct
Cellular Component (CC) plastid 1.259e-05 Informative Direct
Cellular Component (CC) microbody 0.0005308 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1.853e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)7.24e-12Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)3.923e-11Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen7.326e-09Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor2.146e-05Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.636Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7289Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.6956Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis4.904e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased CSF lactate0.0002588Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2803Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4445Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2716Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.3824Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.05288InformativeInherited
Mammalian Phenotype (MP)abnormal aggression-related behavior0.0006836Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.002797Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.1228Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7714InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen1.214e-08Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase4.235e-07Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0.00483Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.02122Highly InformativeInherited
Enzyme Commission (EC)With other, known, acceptors0.1014Highly InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.1239Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4321Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.6731Highly InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.6805Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.719Highly InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0.8472Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.8919Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis3.842e-07Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processCytolysis1.516e-12InformativeDirect
Biological processSteroid metabolism2.024e-07InformativeDirect
Biological processElectron transport0.0004839InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism2.253e-10Highly InformativeDirect
Biological processAbscisic acid biosynthesis3e-10Highly InformativeDirect
Biological processThiamine biosynthesis4.326e-10Highly InformativeDirect
Biological processPhospholipid biosynthesis7.352e-08Highly InformativeDirect
Biological processHeme biosynthesis1.808e-05Highly InformativeDirect
Biological processMethanogenesis8.996e-05Highly InformativeDirect
Biological processAntibiotic biosynthesis0.0001045Highly InformativeDirect
Biological processHemolysis0.0005439Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0113Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome6.943e-06InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversitySelenocysteine4.324e-15InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionFMN1.534e-09InformativeDirect
Molecular functionMercury1.63e-14Highly InformativeDirect
Molecular functionLIM domain2.363e-08Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationGTPase activation2.198e-09InformativeDirect
Post-translational modificationAntimicrobial7.215e-09InformativeDirect
Post-translational modificationToxin0.9813InformativeInherited
Post-translational modificationAntibiotic6.687e-14Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin1.099e-10Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism2.488e-08Least InformativeDirect
UniPathway (UP)lipid metabolism0.0013Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)energy metabolism7.735e-13Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.5887Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)one-carbon metabolism1Moderately InformativeInherited
UniPathway (UP)organic acid metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)hormone metabolism0InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis3.177e-12InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis5.169e-12InformativeDirect
UniPathway (UP)siderophore metabolism2.861e-11InformativeDirect
UniPathway (UP)methanogenesis0.0003372InformativeDirect
UniPathway (UP)organic acid biosynthesis0.06381InformativeInherited
UniPathway (UP)terpene metabolism0.1884InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis0Highly InformativeDirect
UniPathway (UP)alanine metabolism0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)coenzyme M-coenzyme B heterodisulfide reduction3.091e-12Highly InformativeDirect
UniPathway (UP)opine metabolism1.508e-11Highly InformativeDirect
UniPathway (UP)auxin metabolism1.411e-07Highly InformativeDirect
UniPathway (UP)sarcosine degradation5.143e-07Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0.0002547Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0.008399Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]