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FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (3,259) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 141,969 774,211 171
Proteins 126,735 699,647 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.53091Least InformativeInherited
Biological Process (BP)biosynthetic process0.70631Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.32621Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.32891Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.95881Least InformativeInherited
Biological Process (BP)single-organism cellular process0.68451Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.43220.02107Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.6561Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.88180Least InformativeInherited
Biological Process (BP)response to stimulus0.26291Least InformativeInherited
Biological Process (BP)regulation of biological quality0.053241Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0065710.0000000005378Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.028291Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.048521Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.070090.708Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.13251Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.00032630.0001578InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.00033290.00009342InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.00023880.0694InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.00076740.139InformativeInherited
Biological Process (BP)thiamine biosynthetic process0.0000024120.0005865Highly InformativeDirect
Molecular Function (MF)binding0.741Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0000000016750Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.028330Moderately InformativeInherited
Molecular Function (MF)anion binding0.53010Moderately InformativeInherited
Molecular Function (MF)coenzyme binding0.000012470InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.000000001630.00000000000008156Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.23260.848Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.51421Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.02107 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0000000005378 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000001404 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.00006813 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0002274 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.08668 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04843 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.03446 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.708 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.0001578 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00009342 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) electron transport chain 0 Informative Direct
Biological Process (BP) amine metabolic process 0.0000000003163 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000002324 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.000000681 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000001944 Informative Direct
Biological Process (BP) cellular respiration 0.00003651 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00006692 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001971 Informative Direct
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) response to metal ion 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.4376 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.05372 Informative Inherited
Biological Process (BP) ATP metabolic process 0.0434 Informative Inherited
Biological Process (BP) cellular protein complex assembly 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.5723 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.001857 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.7855 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.6297 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.0694 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.139 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.5796 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.003715 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.003076 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) nicotinamide nucleotide metabolic process 0.9044 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.008873 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) thiamine biosynthetic process 0.0005865 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000000003059 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000000005534 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000003242 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.000000686 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.000003782 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.000006693 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.00001593 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.00003307 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.0001647 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.0002079 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000391 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0008246 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.01946 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.04431 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.3551 Highly Informative Inherited
Biological Process (BP) NADP metabolic process 0.4202 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.6734 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.7462 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.9705 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.1638 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.009499 Highly Informative Inherited
Biological Process (BP) purine-containing compound catabolic process 0.1566 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.4022 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.00638 Highly Informative Inherited
Biological Process (BP) polyamine metabolic process 0.01891 Highly Informative Inherited
Biological Process (BP) secondary alcohol metabolic process 0.2736 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.3378 Highly Informative Inherited
Biological Process (BP) demethylation 0.007452 Highly Informative Inherited
Biological Process (BP) citrate metabolic process 0.08915 Highly Informative Inherited
Biological Process (BP) aerobic respiration 1 Highly Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.1132 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 0.000004069 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.4169 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.00000000000008156 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.0000003677 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.00000000000008926 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.00000002867 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00004718 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0304 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on iron-sulfur proteins as donors 0.06239 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.009449 Highly Informative Inherited
Molecular Function (MF) prenyltransferase activity 0.009159 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.003137 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.848 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.3879 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) respiratory chain complex 0.000000002774 Informative Direct
Cellular Component (CC) outer membrane 0.0000002553 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0003292 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.0004517 Informative Direct
Cellular Component (CC) Rab-protein geranylgeranyltransferase complex 0.00000000005922 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.003435 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000000001853Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)0.00000000000724Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)0.00000000003923Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000007326Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00002146Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.009778Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5578Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8433Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.005538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4809Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis0.0005317Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7727Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.796Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8687Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.7088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mitochondrion morphology0.01438Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.01796Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.3498Least InformativeInherited
Worm Phenotype (WP)life span variant0.00000008035InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0002594InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.8867Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.0000000178InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000000009067Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase0.0000000008489Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0.00000002857Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.0000002214Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.0005762Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.1519Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.3732Highly InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.6375Highly InformativeInherited
Enzyme Commission (EC)Transposing C=C bonds0.8089Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.8118Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.945Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous1Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0.000001608Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processCytolysis0.000000000001887InformativeDirect
Biological processElectron transport0.0000016InformativeDirect
Biological processSteroid metabolism0.000002377InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0.00000000003674Highly InformativeDirect
Biological processGlycerol metabolism0.000000001559Highly InformativeDirect
Biological processPhospholipid metabolism0.000000124Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000313Highly InformativeDirect
Biological processHeme biosynthesis0.00007579Highly InformativeDirect
Biological processMethanogenesis0.0001459Highly InformativeDirect
Biological processHemolysis0.0002039Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.1284Moderately InformativeInherited
Cellular componentCell projection0.4164Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000002894InformativeDirect
Cellular componentCilium0.02592InformativeInherited
Cellular componentMicrosome0Highly InformativeDirect
Cellular componentFlagellum0.00000002458Highly InformativeDirect
Coding sequence diversitySelenocysteine0.000000000000009131InformativeDirect
DiseasePrimary mitochondrial disease0.0003839Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainLIM domain0.00000001315Highly InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMercury0.0000000000001486Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationGTPase activation0.0000000006511InformativeDirect
Post-translational modificationAntimicrobial0.00000000401InformativeDirect
Post-translational modificationToxin0.9923InformativeInherited
Post-translational modificationAntibiotic0.00000000000001859Highly InformativeDirect
Post-translational modificationMonooxygenase0.0000000007282Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0.000000003053Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.00001224Least InformativeDirect
UniPathway (UP)lipid metabolism0.002214Least InformativeInherited
UniPathway (UP)cofactor metabolism0.02851Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0.000000000009846Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0004505Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.002473Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)one-carbon metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)organic acid metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)steroid metabolism0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0.0000000000001911InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.000000000006871InformativeDirect
UniPathway (UP)siderophore metabolism0.000000000008793InformativeDirect
UniPathway (UP)thiamine metabolism0.00000000001392InformativeDirect
UniPathway (UP)purine degradation0.00004775InformativeDirect
UniPathway (UP)methanogenesis0.0006903InformativeDirect
UniPathway (UP)toxin biosynthesis0.00181InformativeInherited
UniPathway (UP)L-glutamate metabolism0.006923InformativeInherited
UniPathway (UP)organic acid biosynthesis0.1732InformativeInherited
UniPathway (UP)purine base metabolism0.4998InformativeInherited
UniPathway (UP)alkaloid metabolism0.7245InformativeInherited
UniPathway (UP)ureide metabolism0.9769InformativeInherited
UniPathway (UP)terpene biosynthesis1InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)coenzyme M-coenzyme B heterodisulfide reduction0.00000000000666Highly InformativeDirect
UniPathway (UP)opine metabolism0.0000000008625Highly InformativeDirect
UniPathway (UP)auxin metabolism0.00000004714Highly InformativeDirect
UniPathway (UP)alkaloid degradation0.0000001073Highly InformativeDirect
UniPathway (UP)sarcosine degradation0.0000005322Highly InformativeDirect
UniPathway (UP)urate degradation0.000006914Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0.0004623Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.0008749Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0.005635Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]