SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (3,252) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 141,316 617,051 171
Proteins 126,162 560,598 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.81591Least InformativeInherited
Biological Process (BP)regulation of cellular process0.47681Least InformativeInherited
Biological Process (BP)response to stimulus0.72431Least InformativeInherited
Biological Process (BP)regulation of biological quality0.1851Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.017731Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.099431Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.00040360.000005215InformativeDirect
Biological Process (BP)cell redox homeostasis0.00000000069790.000000000001629Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.00000000000014030Moderately InformativeDirect
Molecular Function (MF)anion binding0.45760.000000000000001562Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.000000003980InformativeDirect
Molecular Function (MF)cofactor binding0.00041360InformativeDirect
Molecular Function (MF)nucleotide binding0.011270InformativeInherited
Molecular Function (MF)antioxidant activity0.00000000000012120Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.000000010610Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.27391Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.044330.7683Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.12781Least InformativeInherited
Cellular Component (CC)organelle envelope0.00068640Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.00095140Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00000000004636 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.00000007846 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000007737 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.05034 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.68 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7165 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2464 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.02514 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.000005215 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000000000000003755 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000000001009 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000002565 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.00000008359 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00001202 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00001638 Informative Direct
Biological Process (BP) secondary metabolic process 0.000403 Informative Direct
Biological Process (BP) peptide metabolic process 0.0007213 Informative Direct
Biological Process (BP) negative regulation of transport 0.9869 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.08832 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.9724 Informative Inherited
Biological Process (BP) response to inorganic substance 0.07304 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.001052 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 1 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1163 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.09926 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.2583 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.1443 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.04138 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.5101 Informative Inherited
Biological Process (BP) cell redox homeostasis 0.000000000001629 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.0000000000009049 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000000004739 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000008501 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0000001268 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0000001652 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.0000006238 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000002044 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.000003591 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000006474 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.00007373 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0002164 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0002504 Highly Informative Direct
Biological Process (BP) oxidative phosphorylation 0.0004052 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0005041 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.02692 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1634 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5276 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) electron transport chain 0.005005 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.8264 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.02677 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.7625 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.00821 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.008973 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.06192 Highly Informative Inherited
Biological Process (BP) aerobic respiration 1 Highly Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.001733 Highly Informative Inherited
Biological Process (BP) sulfur compound catabolic process 0.01589 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000000000001562 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000000003835 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.04062 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.9653 Informative Inherited
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.00000000000002331 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.00001201 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0004388 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.02421 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.3178 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.02666 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7683 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000001283 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.000000001237 Informative Direct
Cellular Component (CC) respiratory chain 0.0003181 Informative Direct
Cellular Component (CC) organelle outer membrane 0.00000000000004807 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.1342 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000000001853Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)0.00000000000724Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)0.00000000003923Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000007326Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00002146Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)X-linked inheritance0.0006356InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.02878Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.685Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.7799Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.009816Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis0.0001582Highly InformativeDirect
Phenotypic Abnormality (PA)Gliosis0.0003251Highly InformativeDirect
Phenotypic Abnormality (PA)Increased CSF lactate0.0007621Highly InformativeDirect
Phenotypic Abnormality (PA)CNS demyelination0.0009817Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.388Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4574Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4461Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.003612Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8358InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1InformativeInherited
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000000006428Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000001319Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0.0000001265Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.0000005169Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.005407Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01305Highly InformativeInherited
Enzyme Commission (EC)With other, known, acceptors0.1004Highly InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.1696Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4529Highly InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7472Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.7817Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.8087Highly InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0.8657Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.9104Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0.000001213Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processCytolysis0.000000000003831InformativeDirect
Biological processSteroid metabolism0.0000003234InformativeDirect
Biological processElectron transport0.0003261InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0.00000000001409Highly InformativeDirect
Biological processGlycerol metabolism0.0000000004898Highly InformativeDirect
Biological processThiamine biosynthesis0.0000000005826Highly InformativeDirect
Biological processPhospholipid metabolism0.00000005403Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000475Highly InformativeDirect
Biological processHeme biosynthesis0.00005675Highly InformativeDirect
Biological processMethanogenesis0.0001155Highly InformativeDirect
Biological processHemolysis0.0004719Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.02648Moderately InformativeInherited
Cellular componentPlastid0.9202Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.00000001073InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversitySelenocysteine0.000000000000004395InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainLIM domain0.000000006914Highly InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury0.00000000000001428Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationGTPase activation0.0000000005765InformativeDirect
Post-translational modificationAntimicrobial0.00000001853InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationAntibiotic0.0000000000001507Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0.000000006039Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.0000001432Least InformativeDirect
UniPathway (UP)lipid metabolism0.0001843Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)energy metabolism0.0000000000006072Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.1995Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)one-carbon metabolism1Moderately InformativeInherited
UniPathway (UP)organic acid metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)choline metabolism0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)polyol degradation0.00000000000001165InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0.00000000000004986InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.000000000007428InformativeDirect
UniPathway (UP)siderophore metabolism0.00000000004845InformativeDirect
UniPathway (UP)methanogenesis0.0003935InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0008189InformativeDirect
UniPathway (UP)L-glutamate metabolism0.004941InformativeInherited
UniPathway (UP)organic acid biosynthesis0.07849InformativeInherited
UniPathway (UP)terpene metabolism0.1369InformativeInherited
UniPathway (UP)alkaloid metabolism0.189InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)coenzyme M-coenzyme B heterodisulfide reduction0.000000000003739Highly InformativeDirect
UniPathway (UP)opine metabolism0.00000000001754Highly InformativeDirect
UniPathway (UP)auxin metabolism0.00000009194Highly InformativeDirect
UniPathway (UP)sarcosine degradation0.0000005285Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0.0002771Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0.007587Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]