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FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (3,259) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 141,969 774,211 171
Proteins 126,735 699,647 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.69691Least InformativeInherited
Biological Process (BP)biological regulation0.54271Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.430.01469Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.65361Least InformativeInherited
Biological Process (BP)biosynthetic process0.7031Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.32241Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.32531Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.87650Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.96041Least InformativeInherited
Biological Process (BP)response to stimulus0.28991Least InformativeInherited
Biological Process (BP)regulation of biological quality0.053621Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.069610.7405Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.006270.0000000004154Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.02781Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.047641Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.13061Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.0002950.0001693InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.00031470.00009071InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.00023710.06513InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.00073220.1397InformativeInherited
Biological Process (BP)thiamine biosynthetic process0.0000023010.0005144Highly InformativeDirect
Molecular Function (MF)binding0.67131Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0000000018190Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.028540Moderately InformativeInherited
Molecular Function (MF)anion binding0.49210Moderately InformativeInherited
Molecular Function (MF)coenzyme binding0.000013060InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.0000000014910.00000000000004592Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.24360.6729Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.52251Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01469 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0000000004154 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000003566 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0001031 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0003228 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.05144 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7405 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.06338 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.03525 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.0001693 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00009071 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) electron transport chain 0 Informative Direct
Biological Process (BP) amine metabolic process 0.0000000002144 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.000000146 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000002023 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.0000003466 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000001603 Informative Direct
Biological Process (BP) cellular respiration 0.00001791 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00005619 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00011 Informative Direct
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) response to metal ion 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.05556 Informative Inherited
Biological Process (BP) ATP metabolic process 0.03749 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.8189 Informative Inherited
Biological Process (BP) cellular protein complex assembly 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.9264 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.6339 Informative Inherited
Biological Process (BP) secondary metabolic process 0.001632 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.8023 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.7941 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.06513 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.1397 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.6415 Informative Inherited
Biological Process (BP) pigment metabolic process 0.00197 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.002269 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.3965 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.006994 Informative Inherited
Biological Process (BP) thiamine biosynthetic process 0.0005144 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000000003952 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000000005039 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000003175 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0000001427 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.000003917 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.000005576 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.00001101 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.00003336 Highly Informative Direct
Biological Process (BP) NADH dehydrogenase complex assembly 0.00008437 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex I biogenesis 0.00009073 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.000161 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0005553 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.0007688 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.6854 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 0.01588 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2477 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.03701 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.3313 Highly Informative Inherited
Biological Process (BP) NADP metabolic process 0.4384 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.001604 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.7322 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.8067 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.1633 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.009786 Highly Informative Inherited
Biological Process (BP) purine-containing compound catabolic process 0.1577 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.2835 Highly Informative Inherited
Biological Process (BP) demethylation 0.003197 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.006427 Highly Informative Inherited
Biological Process (BP) secondary alcohol metabolic process 0.2935 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.3657 Highly Informative Inherited
Biological Process (BP) polyamine metabolic process 0.02521 Highly Informative Inherited
Biological Process (BP) citrate metabolic process 0.08647 Highly Informative Inherited
Biological Process (BP) aerobic respiration 1 Highly Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.1136 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 0.000002952 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.4056 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.00000000000004592 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.0000003182 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0000000000006249 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.000000008148 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0001294 Highly Informative Direct
Molecular Function (MF) NAD binding 0.9388 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.03299 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on iron-sulfur proteins as donors 0.05715 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.001623 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.01072 Highly Informative Inherited
Molecular Function (MF) prenyltransferase activity 0.008684 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6729 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.0000000003809 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.00000000006292 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.4044 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) respiratory chain complex 0.000000003311 Informative Direct
Cellular Component (CC) outer membrane 0.000000197 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0004661 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.001107 Informative Inherited
Cellular Component (CC) Rab-protein geranylgeranyltransferase complex 0.00000000004537 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.002943 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000000001853Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)0.00000000000724Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)0.00000000003923Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000007326Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00002146Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0.000001865Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processCytolysis0.000000000004463InformativeDirect
Biological processElectron transport0.000001895InformativeDirect
Biological processSteroid metabolism0.000002994InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0.00000000000118Highly InformativeDirect
Biological processGlycerol metabolism0.000000001654Highly InformativeDirect
Biological processAntibiotic biosynthesis0.0000001247Highly InformativeDirect
Biological processPhospholipid metabolism0.0000001362Highly InformativeDirect
Biological processHeme biosynthesis0.00007892Highly InformativeDirect
Biological processHemolysis0.0001337Highly InformativeDirect
Biological processMethanogenesis0.0001495Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.1406Moderately InformativeInherited
Cellular componentCell projection0.4496Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000002953InformativeDirect
Cellular componentCilium0.0276InformativeInherited
Cellular componentMicrosome0Highly InformativeDirect
Cellular componentFlagellum0.0000000276Highly InformativeDirect
Coding sequence diversitySelenocysteine0.000000000000009012InformativeDirect
DiseasePrimary mitochondrial disease0.000459Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainLIM domain0.0000000138Highly InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMercury0.000000000000153Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationGTPase activation0.0000000007833InformativeDirect
Post-translational modificationAntimicrobial0.000000001758InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationAntibiotic0.000000000000005641Highly InformativeDirect
Post-translational modificationMonooxygenase0.00000000009987Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0.000000004276Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]