SUPERFAMILY 1.75 HMM library and genome assignments server


Nucleotide-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleotide-binding domain [ 51970]
Superfamily:   Nucleotide-binding domain [ 51971] (3)
Families:   N-terminal domain of adrenodoxin reductase-like [ 51972] (5)
  D-aminoacid oxidase, N-terminal domain [ 51979]
  UDP-galactopyranose mutase, N-terminal domain [ 69427]


Superfamily statistics
Genomes (2,104) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,458 23,678 25
Proteins 7,115 20,336 21


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00.000466Least InformativeDirect
Biological Process (BP)response to stimulus01Least InformativeInherited
Biological Process (BP)multicellular organismal process01Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process07.082e-09Moderately InformativeDirect
Biological Process (BP)multi-organism process00.1261Moderately InformativeInherited
Biological Process (BP)reproduction00.2926Moderately InformativeInherited
Biological Process (BP)regulation of hormone levels01.629e-05InformativeDirect
Biological Process (BP)multi-organism reproductive process03.078e-05InformativeDirect
Biological Process (BP)single-organism behavior00.0001045InformativeDirect
Biological Process (BP)multicellular organismal reproductive process00.01008InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process00.004755InformativeInherited
Biological Process (BP)dicarboxylic acid metabolic process01.632e-12Highly InformativeDirect
Biological Process (BP)multi-multicellular organism process07.356e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000466 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.2813 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8769 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.09372 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3361 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 7.082e-09 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.492e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.736e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000128 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.9223 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.2191 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1261 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2926 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.04036 Moderately Informative Inherited
Biological Process (BP) regulation of hormone levels 1.629e-05 Informative Direct
Biological Process (BP) multi-organism reproductive process 3.078e-05 Informative Direct
Biological Process (BP) single-organism behavior 0.0001045 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.0001884 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0003163 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0007246 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000879 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.01008 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.7134 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.004755 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 1.632e-12 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 7.356e-06 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 4.008e-15 Highly Informative Direct
Biological Process (BP) glutamine family amino acid biosynthetic process 6.219e-08 Highly Informative Direct
Biological Process (BP) pyrimidine nucleoside metabolic process 8.26e-08 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01828 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.1116 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.1223 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 1.309e-06 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 7.234e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.09905 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.6392 Least Informative Inherited
Cellular Component (CC) mitochondrial part 7.395e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.01904 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001284 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.00166Least InformativeInherited
Enzyme Commission (EC)Methyltransferases4.935e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors5.545e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.1189Moderately InformativeInherited
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors4.213e-11InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.483e-07InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor3.472e-06InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09521InformativeInherited
Enzyme Commission (EC)Dihydropyrimidine dehydrogenase (NADP(+))0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADPH)2.152e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.002383Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.6448Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)0.01451InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.1249InformativeInherited
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors4.201e-12Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.825e-07Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor9.669e-06Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.06579Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.1313Least InformativeInherited
Biological processLipid metabolism0.01662Moderately InformativeInherited
Biological processAmino-acid biosynthesis0.1624Moderately InformativeInherited
Biological processSteroid metabolism2.811e-10InformativeDirect
Biological processtRNA processing5.431e-07InformativeDirect
Biological processElectron transport6.806e-07InformativeDirect
Cellular componentMitochondrion0.0007989Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DomainTransit peptide6.146e-05Moderately InformativeDirect
DomainRedox-active center0.0001034InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron7.893e-10Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionFMN4.612e-16InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0001939InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase1.751e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism1.429e-05Least InformativeDirect
UniPathway (UP)lipid metabolism0.0004432Least InformativeDirect
UniPathway (UP)organic acid metabolism1.349e-12Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism7.234e-09Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)terpene metabolism4.03e-11InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis2.699e-09InformativeDirect
UniPathway (UP)beta-alanine biosynthesis0Highly InformativeDirect
UniPathway (UP)cholesterol metabolism0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotide-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Nucleotide-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]