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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,199) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,609 54,680 39
Proteins 11,593 54,588 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000001388 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3138 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2932 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1192 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.04593 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1692 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3099 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08996 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01132 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3481 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6184 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9916 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) mitochondrion organization 0.000002239 Informative Direct
Biological Process (BP) regulation of protein localization 0.002662 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1736 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01092 Informative Inherited
Biological Process (BP) embryo development 0.6444 Informative Inherited
Biological Process (BP) epithelium development 0.7722 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.02409 Informative Inherited
Biological Process (BP) organelle localization 0.1227 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.002936 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04049 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.09101 Informative Inherited
Biological Process (BP) regulation of secretion 0.1885 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1456 Informative Inherited
Biological Process (BP) intracellular transport 0.002831 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6851 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3376 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01001 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04911 Informative Inherited
Biological Process (BP) protein transport 0.05587 Informative Inherited
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.0000003798 Highly Informative Direct
Biological Process (BP) fertilization 0.000000399 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00001936 Highly Informative Direct
Biological Process (BP) pigmentation 0.0001252 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001341 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002883 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005447 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0007578 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.01906 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.04585 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.4174 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01511 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.02292 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.09667 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.06678 Highly Informative Inherited
Biological Process (BP) protein targeting 0.001022 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.002675 Highly Informative Inherited
Molecular Function (MF) binding 0.7319 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.8089 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0.5229 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.3718 Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000009234 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plastid 0.4005 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0004228 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCell projection0.3167Moderately InformativeInherited
Cellular componentCilium0.0000001348InformativeDirect
DomainTransit peptide0.0000003087Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationIsopeptide bond0.000005141Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]