SUPERFAMILY 1.75 HMM library and genome assignments server

GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,191) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,437 38,066 39
Proteins 11,421 38,043 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000000001913 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000000000000003707 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000001908 Least Informative Direct
Biological Process (BP) localization 0.0000000002149 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.8802 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8549 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000001752 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000009856 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00001908 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001052 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0001535 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.1569 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.5806 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5398 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4925 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3226 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1728 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.04181 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.008779 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.3624 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.007331 Moderately Informative Inherited
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) sexual reproduction 0.0000000323 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000001142 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00002418 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00003001 Informative Direct
Biological Process (BP) hexose metabolic process 0.00004556 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00006593 Informative Direct
Biological Process (BP) microtubule-based process 0.0001786 Informative Direct
Biological Process (BP) cell cycle process 0.2142 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.04883 Informative Inherited
Biological Process (BP) organelle assembly 0.02791 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) phosphorylation 0.8643 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04427 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.001006 Informative Inherited
Biological Process (BP) cell projection organization 0.8183 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.001587 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.665 Informative Inherited
Biological Process (BP) protein catabolic process 0.758 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.1321 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.004811 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01793 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.007428 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01266 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.02132 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001344 Informative Inherited
Biological Process (BP) organelle fission 0.2448 Informative Inherited
Biological Process (BP) cell division 0.06414 Informative Inherited
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to heat 0.00000006869 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000003309 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000002072 Highly Informative Direct
Biological Process (BP) cilium organization 0.000002803 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000003318 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.00001158 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00007088 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00007742 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0001056 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0001201 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0002057 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0004016 Highly Informative Direct
Biological Process (BP) spindle organization 0.0006521 Highly Informative Direct
Biological Process (BP) nuclear division 0.0007645 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.01378 Highly Informative Inherited
Molecular Function (MF) binding 0.000008332 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9363 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3484 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.00346 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1159 Informative Inherited
Molecular Function (MF) kinase activity 0.1858 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000005579 Least Informative Direct
Cellular Component (CC) protein complex 0.00003507 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.005251 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000009899 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01008 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01287 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.000000001806 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0007127 Informative Direct
Cellular Component (CC) plastid 0.4851 Informative Inherited
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.0002997 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3032Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.0008768InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.07056Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.4986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.05662InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000000536Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00001911Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.000000001522Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001681Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000001871Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000004858Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000009733Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000002397Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0008993Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000000005003InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000009571InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000002196InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0000000007122InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000006756InformativeDirect
Worm Phenotype (WP)transgene expression increased0.000001055InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001813InformativeDirect
Worm Phenotype (WP)sick0.0003375InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.04992InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.2477InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000009709Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00000002015Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0000000963Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00006487Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.0109Least InformativeInherited
Zebrafish Anatomy (ZA)solid compound organ0.0008998Moderately InformativeDirect
Zebrafish Anatomy (ZA)liver and biliary system0.0009177Moderately InformativeDirect
Zebrafish Anatomy (ZA)immune system0.002578Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.07897Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2518Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001547Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.04976Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.00002073InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.00008149InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.008532InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.00004337Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002735Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.001968Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.009658Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002353InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004208InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.0000002819Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]