SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,190) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,422 38,066 39
Proteins 11,407 38,043 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000000003741 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000003936 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000000446 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000002892 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8474 Least Informative Inherited
Biological Process (BP) developmental process 0.8412 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1867 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000866 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00007697 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.007547 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.007769 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.002275 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1908 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1443 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8771 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.001125 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.003976 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.02022 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3341 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.646 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.0125 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.5837 Moderately Informative Inherited
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0 Informative Direct
Biological Process (BP) sexual reproduction 0.00000000005298 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000001118 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00002444 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00004153 Informative Direct
Biological Process (BP) hexose metabolic process 0.0001355 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0005317 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0006182 Informative Direct
Biological Process (BP) organelle assembly 0.002895 Informative Inherited
Biological Process (BP) cell cycle process 0.5076 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.001539 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.1219 Informative Inherited
Biological Process (BP) phosphorylation 0.7233 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04276 Informative Inherited
Biological Process (BP) cell projection organization 0.9774 Informative Inherited
Biological Process (BP) microtubule-based process 0.002083 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.03032 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6551 Informative Inherited
Biological Process (BP) protein catabolic process 0.7535 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.004813 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.00184 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.02439 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01098 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7707 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) epithelium development 0.1566 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.09747 Informative Inherited
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to heat 0.00000006227 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000003254 Highly Informative Direct
Biological Process (BP) cilium organization 0.0000005449 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000001062 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000003739 Highly Informative Direct
Biological Process (BP) mitosis 0.000004317 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.000005854 Highly Informative Direct
Biological Process (BP) spindle organization 0.00002144 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.00007032 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0001049 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0001194 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0001637 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0004041 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.01374 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.001613 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.005751 Highly Informative Inherited
Molecular Function (MF) binding 0.00001006 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.936 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.006222 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3491 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.003509 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1162 Informative Inherited
Molecular Function (MF) kinase activity 0.1881 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00008774 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00483 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000009048 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01038 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01331 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.000007361 Informative Direct
Cellular Component (CC) plastid 0.51 Informative Inherited
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) sperm part 0.00000005688 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.0003018 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3024Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.0008866InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000000536Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00001911Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.000000001522Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001681Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000001871Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000004858Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000009733Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000002397Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0008993Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000000005003InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000009571InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000002196InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0000000007122InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000006756InformativeDirect
Worm Phenotype (WP)transgene expression increased0.000001055InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001813InformativeDirect
Worm Phenotype (WP)sick0.0003375InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.04992InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.2477InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000009709Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00000002015Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0000000963Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00006487Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.01172Least InformativeInherited
Zebrafish Anatomy (ZA)liver0.0009756Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.07829Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2507Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001535Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.04905Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.00002071InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.00007933InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.008521InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.00004379Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002735Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.001968Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.009658Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002353InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004208InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.0000002666Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]