SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,192) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,437 38,066 39
Proteins 11,421 38,043 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000002084 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4626 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) response to stress 0.00000000004208 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7679 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1613 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7288 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08833 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1254 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03538 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01335 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4405 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) mitochondrion organization 0.0004438 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000723 Informative Direct
Biological Process (BP) regulation of organelle organization 0.1061 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1145 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1547 Informative Inherited
Biological Process (BP) protein localization to organelle 0.009438 Informative Inherited
Biological Process (BP) epithelium development 0.5867 Informative Inherited
Biological Process (BP) embryo development 0.4336 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.05189 Informative Inherited
Biological Process (BP) response to inorganic substance 0.155 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.004296 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5066 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01897 Informative Inherited
Biological Process (BP) microtubule-based process 0.06083 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2824 Informative Inherited
Biological Process (BP) cell cycle process 0.6949 Informative Inherited
Biological Process (BP) protein targeting 0.1427 Informative Inherited
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.000006126 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000006973 Highly Informative Direct
Biological Process (BP) pigmentation 0.00004417 Highly Informative Direct
Biological Process (BP) vesicle localization 0.000231 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0003566 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000663 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.001844 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01609 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.3234 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.04542 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.01637 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.0285 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.03541 Highly Informative Inherited
Molecular Function (MF) binding 0.2391 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.002376 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.6715 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.2634 Informative Inherited
Molecular Function (MF) kinase activity 0.3937 Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000006234 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0038 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.004024 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.0275 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01073 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.2891 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0001759 Informative Direct
Cellular Component (CC) secretory vesicle 0.1492 Informative Inherited
Cellular Component (CC) plastid 0.5407 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0009818 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.0002625Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.069Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1349Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.1093Moderately InformativeInherited
Mammalian Phenotype (MP)increased body weight0.000252InformativeDirect
Mammalian Phenotype (MP)embryonic lethality0.003728InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.0006307Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000001013Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000004416Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00000144Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00005963Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.000000000703Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000001381Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001471Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000001908Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000007453Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001671Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0006732Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.007018Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.05497Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1134Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1559Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1708Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000377InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000000943InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000001664InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000003711InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000002216InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000002019InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000002401InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000001061InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001683InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00000368InformativeDirect
Worm Phenotype (WP)gonad development variant0.00005963InformativeDirect
Worm Phenotype (WP)sick0.0003731InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.01325InformativeInherited
Worm Phenotype (WP)life span variant0.02267InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.02695InformativeInherited
Worm Phenotype (WP)mitosis variant0.1081InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2218InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7614InformativeInherited
Worm Phenotype (WP)oocytes small0.00000000000001408Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00000001647Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000007319Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000006762Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000001369Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000006819Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.0000538Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004695Highly InformativeDirect
Worm Phenotype (WP)extended life span0.0007374Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0004889InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.157Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4981Least InformativeInherited
Fly Anatomy (FA)adult circulatory system0.00000008105InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)immune system0.000851InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.08147Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2973Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001387Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.01033Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.03113Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.000007472InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0008644InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00491InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.000001382Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002746Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.00198Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.00967Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002358InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004212InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCell projection0.2331Moderately InformativeInherited
Cellular componentCilium0.00000007722InformativeDirect
DomainTransit peptide0.0000008427Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]