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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,197) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,508 54,680 39
Proteins 11,492 54,588 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00002791 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8783 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.207 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.213 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.02758 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1759 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1876 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04537 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06336 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.002907 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2027 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6755 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) mitochondrion organization 0.000001211 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1703 Informative Inherited
Biological Process (BP) protein localization to organelle 0.007759 Informative Inherited
Biological Process (BP) tissue development 0.974 Informative Inherited
Biological Process (BP) embryo development 0.4793 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.002724 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1827 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.02673 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.06926 Informative Inherited
Biological Process (BP) regulation of secretion 0.1413 Informative Inherited
Biological Process (BP) response to metal ion 0.1499 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1489 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02496 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.005161 Informative Inherited
Biological Process (BP) organelle localization 0.1099 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2543 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5788 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.009196 Informative Inherited
Biological Process (BP) intracellular protein transport 0.2521 Informative Inherited
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.0000002759 Highly Informative Direct
Biological Process (BP) fertilization 0.0000004161 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0000107 Highly Informative Direct
Biological Process (BP) pigmentation 0.00006206 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000175 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0003381 Highly Informative Direct
Biological Process (BP) vesicle localization 0.0003586 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0005286 Highly Informative Direct
Biological Process (BP) gastrulation 0.01614 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2906 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.06822 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.01303 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.0362 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.003154 Highly Informative Inherited
Molecular Function (MF) binding 0.2403 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.6968 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.2823 Informative Inherited
Molecular Function (MF) kinase activity 0.419 Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.2783 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plastid 0.4218 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.000288 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.0002634Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06849Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1274Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5342Moderately InformativeInherited
Mammalian Phenotype (MP)increased body weight0.0002434InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.002497InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.0006002Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000001732Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000004566Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002206Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00006488Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.003072Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0000000006933Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001356Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000001375Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000002006Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000007948Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001751Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.000001659Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0007051Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.006636Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.05927Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.07281Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1129Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1542Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1651Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000385InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000008962InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000001537InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000003601InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000002171InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000002137InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000002221InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000002335InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000001059InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001676InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000001796InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.00003988InformativeDirect
Worm Phenotype (WP)gonad development variant0.00005894InformativeDirect
Worm Phenotype (WP)sick0.000365InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.008457InformativeInherited
Worm Phenotype (WP)mitosis variant0.09668InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2252InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7466InformativeInherited
Worm Phenotype (WP)oocytes small0.00000000000001471Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.00000000006378Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00000001562Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000007072Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000006233Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000001278Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000006517Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00005322Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004731Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.000489InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.08444Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3022Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001426Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.01014Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.03241Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.000007485InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0008699InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.006523InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.000001434Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002746Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.00198Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.00967Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002358InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004212InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000007376Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.02352Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000002149Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.000003088Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCell projection0.305Moderately InformativeInherited
Cellular componentCilium0.0000001297InformativeDirect
DomainTransit peptide0.0000002742Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]