SUPERFAMILY 1.75 HMM library and genome assignments server


GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,184) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,206 38,066 39
Proteins 11,194 38,043 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.761e-14 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.036e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.084e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.304e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9269 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2311 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.055e-05 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0001421 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.2883 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.0627 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1539 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.4065 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.00548 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.001784 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.002039 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.572 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3536 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6563 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001365 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.6082 Moderately Informative Inherited
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0 Informative Direct
Biological Process (BP) sexual reproduction 6.017e-11 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 1.35e-09 Informative Direct
Biological Process (BP) glycerolipid metabolic process 8.71e-08 Informative Direct
Biological Process (BP) phospholipid metabolic process 2.41e-06 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 3.727e-05 Informative Direct
Biological Process (BP) hexose metabolic process 0.0002126 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0006611 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000798 Informative Direct
Biological Process (BP) protein complex assembly 0.1369 Informative Inherited
Biological Process (BP) phosphorylation 0.5306 Informative Inherited
Biological Process (BP) response to inorganic substance 0.05377 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.004903 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.02914 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6345 Informative Inherited
Biological Process (BP) protein catabolic process 0.7355 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.007385 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.001913 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.04037 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01291 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7625 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) epithelium development 0.1998 Informative Inherited
Biological Process (BP) cell cycle process 0.4932 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.002442 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.1007 Informative Inherited
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) lipid modification 1.121e-08 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 1.058e-06 Highly Informative Direct
Biological Process (BP) response to heat 2.895e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 7.188e-06 Highly Informative Direct
Biological Process (BP) cilium organization 8.627e-06 Highly Informative Direct
Biological Process (BP) ATP metabolic process 1.113e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.0001182 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0001743 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000197 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0002274 Highly Informative Direct
Biological Process (BP) tissue homeostasis 0.0002326 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000532 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.005284 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.2981 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.002204 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.007453 Highly Informative Inherited
Molecular Function (MF) binding 0.0001788 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9941 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1841 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.005729 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.04259 Informative Inherited
Molecular Function (MF) kinase activity 0.07976 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 6.719e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.007104 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 3.292e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00594 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01345 Moderately Informative Inherited
Cellular Component (CC) secretory granule 7.658e-06 Informative Direct
Cellular Component (CC) plastid 0.5048 Informative Inherited
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) sperm part 5.377e-08 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.0004109 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant5.36e-07Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1.911e-05Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant1.522e-09Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal1.681e-09Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect1.871e-07Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant4.858e-07Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant9.733e-07Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant2.397e-06Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0008993Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb5.003e-12InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant9.571e-12InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant2.196e-10InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant7.122e-10InformativeDirect
Worm Phenotype (WP)pigmentation variant6.756e-07InformativeDirect
Worm Phenotype (WP)transgene expression increased1.055e-06InformativeDirect
Worm Phenotype (WP)protruding vulva1.813e-06InformativeDirect
Worm Phenotype (WP)sick0.0003375InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.04992InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.2477InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small9.709e-15Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses2.015e-08Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate9.63e-08Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant6.487e-05Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.01134Least InformativeInherited
Zebrafish Anatomy (ZA)liver0.0009248Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.07786Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.2504Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001535Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.04728Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle2.069e-05InformativeDirect
Xenopus ANatomical entity (XAN)hematological system7.929e-05InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00813InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region4.513e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002735Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.001968Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.009658Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage2.353e-08InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004208InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide2.784e-07Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]