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RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (822) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,641 57,411 12
Proteins 57,514 52,483 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.76651Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation0.32971Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to external stimulus0.10080.00000004963Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0076380.03063Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.15960.0006136Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.062130.000314Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.39810.8948Moderately InformativeInherited
Biological Process (BP)response to organic substance0.37020.0000002157Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.14490.7111Moderately InformativeInherited
Biological Process (BP)multi-organism process0.8350.002742Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.052380.1177Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.16441Moderately InformativeInherited
Biological Process (BP)signaling0.72330.849Moderately InformativeInherited
Biological Process (BP)immune system process0.4050.0005569Moderately InformativeInherited
Biological Process (BP)cell communication0.68120.3143Moderately InformativeInherited
Biological Process (BP)proteolysis0.00024090.000000002285InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.000065560InformativeDirect
Biological Process (BP)response to bacterium0.045860.00000008014InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0055080.00000006917InformativeInherited
Biological Process (BP)regulation of immune response0.43530.0000001957InformativeInherited
Biological Process (BP)response to radiation0.018820.4915InformativeInherited
Biological Process (BP)regulation of cytokine production0.0058730.0000000000006419InformativeInherited
Biological Process (BP)regulation of defense response0.018920.0000000008706InformativeInherited
Biological Process (BP)innate immune response-activating signal transduction0.000032640.00008241Highly InformativeDirect
Biological Process (BP)photoperiodism0.0000029730.0000009427Highly InformativeDirect
Biological Process (BP)protein modification by small protein conjugation0.000020640Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.000039170.000000001073Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.00000018090.001297Highly InformativeInherited
Biological Process (BP)response to molecule of bacterial origin0.0010930.00000006305Highly InformativeInherited
Biological Process (BP)modification-dependent protein catabolic process0.00000088810.009925Highly InformativeInherited
Biological Process (BP)regulation of circadian rhythm0.000028680.001373Highly InformativeInherited
Molecular Function (MF)transferase activity0.99571Least InformativeInherited
Molecular Function (MF)ubiquitin-like protein transferase activity0.00010680Highly InformativeDirect
Cellular Component (CC)membrane0.48991Least InformativeInherited
Cellular Component (CC)transferase complex0.00012090Moderately InformativeDirect
Cellular Component (CC)whole membrane0.10260.3956Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.074031Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.000000013630InformativeDirect
Cellular Component (CC)membrane region0.00057040.0002744InformativeDirect
Cellular Component (CC)SCF ubiquitin ligase complex0.00000000000026610Highly InformativeDirect
Cellular Component (CC)receptor complex0.0000020040.02268Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0005569 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000004963 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000002157 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000314 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0003022 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0006136 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.002742 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8948 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.03063 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2602 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1642 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7597 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.4858 Moderately Informative Inherited
Biological Process (BP) cell communication 0.3143 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7111 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3441 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1177 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) signaling 0.849 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1952 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0000000000006419 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000006917 Informative Direct
Biological Process (BP) proteolysis 0.000000002285 Informative Direct
Biological Process (BP) immune response 0.0000232 Informative Direct
Biological Process (BP) response to bacterium 0.00000008014 Informative Direct
Biological Process (BP) post-embryonic development 0.00005055 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000008706 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000000003084 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) regulation of immune response 0.0000001957 Informative Direct
Biological Process (BP) defense response to other organism 0.0002796 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7547 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7438 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell death 0.01312 Informative Inherited
Biological Process (BP) ion homeostasis 0.7268 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1779 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1335 Informative Inherited
Biological Process (BP) positive regulation of transport 0.3376 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03685 Informative Inherited
Biological Process (BP) regulation of secretion 0.09864 Informative Inherited
Biological Process (BP) regulation of protein localization 0.03591 Informative Inherited
Biological Process (BP) secretion 0.1213 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2047 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2481 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.009888 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.4751 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.04427 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02367 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7104 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.03694 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.5125 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.06603 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.47 Informative Inherited
Biological Process (BP) response to radiation 0.4915 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3843 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3764 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9535 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.632 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.9662 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9597 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.6703 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2347 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.619 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.00755 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7474 Informative Inherited
Biological Process (BP) reproductive system development 0.002638 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.8828 Informative Inherited
Biological Process (BP) cell cycle process 0.08125 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0000000000000208 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.00000006305 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000003856 Highly Informative Direct
Biological Process (BP) innate immune response-activating signal transduction 0.00008241 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0009051 Highly Informative Direct
Biological Process (BP) protein secretion 0.000004862 Highly Informative Direct
Biological Process (BP) photoperiodism 0.0000009427 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of actin filament polymerization 0.000000008856 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.00000117 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0009235 Highly Informative Direct
Biological Process (BP) cell cycle phase transition 0.00000001784 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0003461 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0001624 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000007494 Highly Informative Direct
Biological Process (BP) detection of stimulus 0.0000005068 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000001073 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00006233 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.0000527 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01106 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.002777 Highly Informative Inherited
Biological Process (BP) negative regulation of protein polymerization 0.4809 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.2728 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.002592 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.03167 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.4131 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.001297 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.004995 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.1681 Highly Informative Inherited
Biological Process (BP) DNA replication 0.4648 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.009925 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.629 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.01326 Highly Informative Inherited
Biological Process (BP) seed development 0.01345 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.001373 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.5553 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.007328 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.000000667 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00007692 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.4052 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.4364 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0001281 Informative Direct
Molecular Function (MF) amide binding 0.002302 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.2337 Informative Inherited
Molecular Function (MF) enzyme binding 0.9621 Informative Inherited
Molecular Function (MF) signal transducer activity 0.3866 Informative Inherited
Molecular Function (MF) iron ion binding 0.0004445 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0007235 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00002581 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0003032 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7338 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.3956 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.02803 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01607 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0001403 Informative Direct
Cellular Component (CC) membrane region 0.0002744 Informative Direct
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.0004795 Highly Informative Direct
Cellular Component (CC) SCF ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) myofibril 0.000000000001041 Highly Informative Direct
Cellular Component (CC) replisome 0.0002505 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000000009101 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02268 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.03446 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 0.6891 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000175Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.3768Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5596Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.005739Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1605Moderately InformativeInherited
Disease Ontology (DO)syndrome0.1898Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8598Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.00002021InformativeDirect
Disease Ontology (DO)allergic rhinitis0.00003922InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type IV disease0.003217InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.00001876Highly InformativeDirect
Disease Ontology (DO)uveitis0.00008378Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.000226Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.03552Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.05597Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1119Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6091Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6164Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.02059Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1694Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.5156Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.6236Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.0005581InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.0002294Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0005738Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1294Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0004938Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.00259Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1076Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0006873InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.003345InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1792InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000001194Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to induced colitis0.00001033Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00006608Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.6958Moderately InformativeInherited
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001807Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.6885Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.226InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.4342InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.01565Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther0.00008363Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.6437Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.6483Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000001239InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.01607InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.00000000000001241Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000005949Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00003226Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis0.00000005603Moderately InformativeDirect
Biological processDifferentiation0.0009078Moderately InformativeDirect
Biological processCell cycle0.3985Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processMitosis0.000005267InformativeDirect
Biological processBiological rhythms0.0001062InformativeDirect
Biological processAuxin signaling pathway0Highly InformativeDirect
Cellular componentNucleus0.000000001361Least InformativeDirect
Cellular componentMembrane0.00002944Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000009189Moderately InformativeDirect
Cellular componentCell projection0.002499Moderately InformativeInherited
Cellular componentCilium0.03619InformativeInherited
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainLeucine-rich repeat0InformativeDirect
Molecular functionActin-binding0.0000000000384InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000003521Moderately InformativeDirect
Post-translational modificationKinase0.001596Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation0.00000007951InformativeDirect
Post-translational modificationPhosphoprotein0.00008004Least InformativeDirect
Post-translational modificationGlycoprotein0.0001655Least InformativeDirect
Post-translational modificationUbl conjugation0.0004263Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]