SUPERFAMILY 1.75 HMM library and genome assignments server


RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (809) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 60,791 57,411 12
Proteins 54,971 52,483 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.89771Least InformativeInherited
Biological Process (BP)response to stimulus10.1341Least InformativeInherited
Biological Process (BP)protein metabolic process0.55370.3894Least InformativeInherited
Biological Process (BP)cellular catabolic process0.27830.1239Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.45130.1954Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.1411Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.55570.3754Moderately InformativeInherited
Biological Process (BP)protein catabolic process0.000040330InformativeDirect
Biological Process (BP)proteolysis0.00015440.0000000001747InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00042310.00000000003919InformativeDirect
Biological Process (BP)response to light stimulus0.0069030.01433InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.0039820.00000000000001761InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.0000040270Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.0000080890.00000005279Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00031620Highly InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.00016780.000000000001121InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity0.000034280Highly InformativeDirect
Cellular Component (CC)protein complex10.0006225Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.00036920InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.1341 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3894 Least Informative Inherited
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.000000000000007281 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000001432 Moderately Informative Direct
Biological Process (BP) immune system process 0.000001194 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000002916 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0004869 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.9112 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3754 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9765 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8092 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3975 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1239 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1954 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.5852 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3963 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.962 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.8056 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2531 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0.0000000001747 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000000003919 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.00000000000001761 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to other organism 0.000000000000007281 Informative Direct
Biological Process (BP) regulation of cytokine production 0.000000000000007281 Informative Direct
Biological Process (BP) reproductive system development 0.0000000004229 Informative Direct
Biological Process (BP) immune response 0.000000001372 Informative Direct
Biological Process (BP) regulation of response to stress 0.000000001779 Informative Direct
Biological Process (BP) regulation of immune response 0.000000004449 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00000002848 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000006493 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000001255 Informative Direct
Biological Process (BP) response to hormone stimulus 0.000004713 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00001156 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00005319 Informative Direct
Biological Process (BP) positive regulation of transport 0.0007996 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00232 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2959 Informative Inherited
Biological Process (BP) regulation of locomotion 0.6583 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01499 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9829 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4869 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.7485 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.005584 Informative Inherited
Biological Process (BP) growth 0.9866 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.4889 Informative Inherited
Biological Process (BP) programmed cell death 0.8132 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.01433 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.04408 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.04739 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01425 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2857 Informative Inherited
Biological Process (BP) response to lipid 0.08842 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.3505 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.755 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01675 Informative Inherited
Biological Process (BP) immune effector process 0.6346 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1579 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.005337 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000005279 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.000000000009899 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00000000006179 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000003361 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0000000007081 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000000008481 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.00000005871 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000009044 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000001102 Highly Informative Direct
Biological Process (BP) activation of immune response 0.000001183 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000001378 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000002369 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000004461 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.00000495 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.000009285 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.000009707 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00001147 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.00006519 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0001146 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.0001329 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0.0002584 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0003359 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0008061 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.6664 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.233 Highly Informative Inherited
Biological Process (BP) regulation of interleukin-1 beta production 0.7274 Highly Informative Inherited
Biological Process (BP) cell growth 0.1017 Highly Informative Inherited
Biological Process (BP) developmental growth 0.9479 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.2813 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) DNA replication 0.4737 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.03817 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.06472 Highly Informative Inherited
Biological Process (BP) response to UV 0.6646 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01863 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.04533 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6905 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00135 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.05093 Highly Informative Inherited
Biological Process (BP) ossification 0.001477 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.2128 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.2039 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.05761 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.5931 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.04279 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.3188 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.4896 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.8481 Highly Informative Inherited
Biological Process (BP) innate immune response 0.007351 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.000135 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.000000000001121 Informative Direct
Molecular Function (MF) amide binding 0.000002266 Informative Direct
Molecular Function (MF) lipid binding 0.5724 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1524 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.07225 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.9956 Informative Inherited
Molecular Function (MF) receptor activity 0.4322 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.6279 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000001019 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00001286 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00003597 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0002088 Highly Informative Direct
Cellular Component (CC) protein complex 0.0006225 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.5387 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2355 Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.000008032 Highly Informative Direct
Cellular Component (CC) myofilament 0.00006054 Highly Informative Direct
Cellular Component (CC) replisome 0.0002142 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02265 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5563 Highly Informative Inherited
Cellular Component (CC) cell body 0.3066 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.002331 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.97 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000175Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.01386Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2803Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0001593InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003843InformativeDirect
Disease Ontology (DO)Crohn's disease0.000007987Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0001967Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1635Moderately InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.0003324Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.08357Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0002161Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.002044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1714Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.2598Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0005659InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.05492InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.05821InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.9613InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000005747Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00003349Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.000104Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.495Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to infection0.5211Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.9966Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.5472Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation induced paralysis0.0003916InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001317Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther0.00008324Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5625Least InformativeInherited
Enzyme Commission (EC)Lyases0.748Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.00000005393InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.01107InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.000000000000006605Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000007529Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000004547Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.000000000002225Moderately InformativeDirect
Biological processDifferentiation0.0001218Moderately InformativeDirect
Biological processCell cycle0.3648Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis0.000003132InformativeDirect
Biological processBiological rhythms0.000008705InformativeDirect
Cellular componentNucleus0.00000006096Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.00000000001578Moderately InformativeDirect
Cellular componentCell projection0.01048Moderately InformativeInherited
Cellular componentCilium0.008204Highly InformativeInherited
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionActin-binding0.000000001178InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000004197Moderately InformativeDirect
Post-translational modificationKinase0.006874Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation0.00000003635InformativeDirect
Post-translational modificationDioxygenase0.0009199Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000001444Least InformativeDirect
Post-translational modificationGlycoprotein0.000002544Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]