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RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (826) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,335 57,411 12
Proteins 58,120 52,483 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.47191Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.80611Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation0.43331Least InformativeInherited
Biological Process (BP)response to external stimulus0.11570.000002424Moderately InformativeInherited
Biological Process (BP)multi-organism process0.8660.005171Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.078970.0004167Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.31330.6016Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.23640.00000000000008839Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.14290.5747Moderately InformativeInherited
Biological Process (BP)response to organic substance0.38160.0000005578Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0072920.02264Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.03470.001084Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.18491Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.012190.04207Moderately InformativeInherited
Biological Process (BP)cell communication0.6870.4628Moderately InformativeInherited
Biological Process (BP)single organism signaling0.57630.1943Moderately InformativeInherited
Biological Process (BP)immune system process0.25230.001182Moderately InformativeInherited
Biological Process (BP)proteolysis0.000032010.00000000003046InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0000059490InformativeDirect
Biological Process (BP)regulation of cytokine production0.0058280.0000000000002696InformativeInherited
Biological Process (BP)response to bacterium0.055420.00000002947InformativeInherited
Biological Process (BP)response to radiation0.020680.563InformativeInherited
Biological Process (BP)positive regulation of immune response0.084970.000000005375InformativeInherited
Biological Process (BP)regulation of defense response0.028420.000000000303InformativeInherited
Biological Process (BP)activation of innate immune response0.000042370.0000003943Highly InformativeDirect
Biological Process (BP)photoperiodism0.0000030510.000001084Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000000053190.00000001374Highly InformativeDirect
Biological Process (BP)proteolysis involved in cellular protein catabolic process0.00000019140.00000000000003469Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.000042370.0000000006429Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.0011110.00000004996Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation0.58810.001513Highly InformativeInherited
Biological Process (BP)regulation of circadian rhythm0.00002450.001638Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.0013120.07216Highly InformativeInherited
Molecular Function (MF)transferase activity0.89731Least InformativeInherited
Molecular Function (MF)ubiquitin-like protein transferase activity0.0000073160Highly InformativeDirect
Cellular Component (CC)membrane0.34611Least InformativeInherited
Cellular Component (CC)macromolecular complex0.33770.0325Least InformativeInherited
Cellular Component (CC)transferase complex0.00012010Moderately InformativeDirect
Cellular Component (CC)whole membrane0.14270.5794Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.078491Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.000000020950InformativeDirect
Cellular Component (CC)membrane region0.00080110.0004112InformativeDirect
Cellular Component (CC)SCF ubiquitin ligase complex0.00000000000021120Highly InformativeDirect
Cellular Component (CC)receptor complex0.0000017170.02482Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to external stimulus 0.000002424 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000000000008839 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000005578 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0004167 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001872 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.1943 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001182 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2085 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5133 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5336 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.701 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6016 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.427 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5747 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.04207 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02264 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005171 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001084 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.8357 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.4628 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0000000000002696 Informative Direct
Biological Process (BP) proteolysis 0.00000000003046 Informative Direct
Biological Process (BP) immune response 0.0002357 Informative Direct
Biological Process (BP) response to bacterium 0.00000002947 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000303 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000000002753 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of immune response 0.000000005375 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4632 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.657 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.7786 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3915 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3903 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.947 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.008123 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2744 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.742 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7526 Informative Inherited
Biological Process (BP) cell death 0.02096 Informative Inherited
Biological Process (BP) ion homeostasis 0.6882 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.04912 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.008684 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2901 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.03007 Informative Inherited
Biological Process (BP) post-embryonic development 0.00118 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02404 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01038 Informative Inherited
Biological Process (BP) actin filament-based process 0.02438 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.0355 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01608 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2293 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.0322 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7466 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.3664 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.6242 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1743 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5809 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2122 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.221 Informative Inherited
Biological Process (BP) reproductive system development 0.003351 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) response to radiation 0.563 Informative Inherited
Biological Process (BP) secretion by cell 0.2092 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3525 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5499 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.02499 Informative Inherited
Biological Process (BP) regulation of secretion 0.04224 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell activation 0.1513 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0000000000001763 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.0000003943 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.00000004996 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0006955 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.00001393 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001645 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.0008054 Highly Informative Direct
Biological Process (BP) protein secretion 0.000005524 Highly Informative Direct
Biological Process (BP) photoperiodism 0.000001084 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0002278 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.0000009616 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0001361 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.000009073 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00000001374 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000006944 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0000007864 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0008205 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000003814 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.000162 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.00000000000003469 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000000006429 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.00001551 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000789 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.0003172 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.00005491 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.004292 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.9395 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.003043 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.001023 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.1093 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.4314 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.001323 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1587 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.03529 Highly Informative Inherited
Biological Process (BP) DNA replication 0.3928 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.008776 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.003685 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01487 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7013 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.01577 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.001513 Highly Informative Inherited
Biological Process (BP) seed development 0.01882 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.001638 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07216 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.000006276 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001982 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.4598 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00007217 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.003119 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.09544 Informative Inherited
Molecular Function (MF) signal transducer activity 0.2126 Informative Inherited
Molecular Function (MF) iron ion binding 0.0005069 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0009092 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00000448 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0003318 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.02926 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.0325 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.5281 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0002764 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.5794 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.03314 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) membrane region 0.0004112 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000004906 Informative Direct
Cellular Component (CC) nucleoplasm part 0.9657 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.002062 Informative Inherited
Cellular Component (CC) protein-DNA complex 0.5408 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.0005156 Highly Informative Direct
Cellular Component (CC) SCF ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) myofibril 0.00000000000118 Highly Informative Direct
Cellular Component (CC) replisome 0.0002617 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000000009545 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02482 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.6294 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000175Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5473Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0058Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1557Moderately InformativeInherited
Disease Ontology (DO)syndrome0.1878Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.855Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.00002104InformativeDirect
Disease Ontology (DO)allergic rhinitis0.00003759InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type IV disease0.003213InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.00001952Highly InformativeDirect
Disease Ontology (DO)uveitis0.00008164Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0002293Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.03588Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.22Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5761Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6165Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.5155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.6047Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.0005631InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.00002015Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.06276Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0005228Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.1066Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0009822InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.004343InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1827InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000001858Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to induced colitis0.00001456Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00007764Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.6802Moderately InformativeInherited
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001692Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical direction0.2544InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther0.00008363Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.7461Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.7507Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000002906InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0006595InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.00000000000006425Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000003186Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000005886Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis0.00000007062Moderately InformativeDirect
Biological processCell cycle0.4225Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processMitosis0.000006497InformativeDirect
Biological processBiological rhythms0.0001203InformativeDirect
Biological processAuxin signaling pathway0Highly InformativeDirect
Cellular componentNucleus0.000000002078Least InformativeDirect
Cellular componentMembrane0.000004798Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000003583Moderately InformativeDirect
Cellular componentCell projection0.000007718Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000167Moderately InformativeDirect
Post-translational modificationKinase0.0001135Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationActin-binding0.000000000005603InformativeDirect
Post-translational modificationGTPase activation0.0000000909InformativeDirect
Post-translational modificationGlycoprotein0.00004697Least InformativeDirect
Post-translational modificationUbl conjugation0.0001377Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]