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RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (829) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 64,634 154,498 12
Proteins 58,396 140,599 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000175Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5479Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.003267Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1279Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2364Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.4071Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8572Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.00001183InformativeDirect
Disease Ontology (DO)allergic rhinitis0.00002464InformativeDirect
Disease Ontology (DO)periodontal disease0.001346InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.003183InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.000007656Highly InformativeDirect
Disease Ontology (DO)uveitis0.00007107Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001667Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1866Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2132Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2495Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.2877Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3513Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3829Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.002312Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1507Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.1531Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2239Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.5804Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.6648Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.7209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.8708Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.000123InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the uvea0.01001InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.02564InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.06205InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating protein level0.1214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the optic nerve0.2092InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.2155InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Optic neuritis0.000001565Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0000724Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated C-reactive protein level0.0000724Highly InformativeDirect
Phenotypic Abnormality (PA)Papule0.00007448Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0001163Highly InformativeDirect
Phenotypic Abnormality (PA)Uveitis0.0002058Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0006347Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the conjunctiva0.0007143Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.06233Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000513Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.003624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1073Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0009895InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.004279InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.181InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000001708Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to induced colitis0.00001466Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00007807Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.7018Moderately InformativeInherited
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001991Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical direction0.2512InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther0.00008363Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.7631Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.7792Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000004029InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000728InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.00000000000009571Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000003429Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000005892Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]