SUPERFAMILY 1.75 HMM library and genome assignments server

RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (821) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,833 57,411 12
Proteins 57,658 52,483 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus10.1994Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.68971Least InformativeInherited
Biological Process (BP)protein metabolic process0.30940.1929Least InformativeInherited
Biological Process (BP)cellular catabolic process0.053920.09894Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.15981Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.13120.1702Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.35410.3054Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.5770.000000000000009016Moderately InformativeInherited
Biological Process (BP)protein catabolic process0.000000079710InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0000021370.000000000005239InformativeDirect
Biological Process (BP)proteolysis0.0000053970.0000000001154InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal0.000014840InformativeDirect
Biological Process (BP)response to light stimulus0.0073060.01356InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.0000000027090Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00000022820Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.000008440.0000001561Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.047850.01748Highly InformativeInherited
Molecular Function (MF)transferase activity0.98961Least InformativeInherited
Molecular Function (MF)ubiquitin-protein transferase activity0.000013190Highly InformativeDirect
Cellular Component (CC)protein complex0.46860.0003277Least InformativeInherited
Cellular Component (CC)transferase complex0.000085030.0000000000002893Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.0000000028850InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1994 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1929 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000000009016 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000005148 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000004619 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000005683 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000008849 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.6564 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8343 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.273 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04179 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.002804 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.09894 Moderately Informative Inherited
Biological Process (BP) organ development 0.7969 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6842 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9813 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5017 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4551 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1702 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3054 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.412 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000000005239 Informative Direct
Biological Process (BP) proteolysis 0.0000000001154 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00000000000002422 Informative Direct
Biological Process (BP) regulation of defense response 0.00000000000004226 Informative Direct
Biological Process (BP) response to bacterium 0.0000000000001224 Informative Direct
Biological Process (BP) immune response 0.0000000038 Informative Direct
Biological Process (BP) reproductive structure development 0.00000001463 Informative Direct
Biological Process (BP) regulation of immune response 0.00000002364 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000002067 Informative Direct
Biological Process (BP) regulation of protein localization 0.00007181 Informative Direct
Biological Process (BP) defense response to other organism 0.0002443 Informative Direct
Biological Process (BP) regulation of secretion 0.0007215 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1103 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.4491 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.06238 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3631 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7386 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1222 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.187 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8717 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5997 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.06094 Informative Inherited
Biological Process (BP) cation homeostasis 0.6364 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001438 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.8745 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.005596 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07521 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.06655 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02101 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5366 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001605 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.4097 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1663 Informative Inherited
Biological Process (BP) epithelium development 0.6267 Informative Inherited
Biological Process (BP) regulation of growth 0.5465 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.01356 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.711 Informative Inherited
Biological Process (BP) protein maturation 0.07866 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.1472 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.795 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02431 Informative Inherited
Biological Process (BP) immune effector process 0.7088 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1783 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02969 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000001561 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0002289 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000001708 Highly Informative Direct
Biological Process (BP) epidermis development 0.0000000003632 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0000000009183 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000000001125 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00000007378 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0000004203 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.0000004869 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0000007005 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.000001225 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000001348 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000001915 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000002151 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0.000002408 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000006496 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00001336 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00001923 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002068 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0003465 Highly Informative Direct
Biological Process (BP) zymogen activation 0.0004158 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0006722 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.1288 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.001359 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.2704 Highly Informative Inherited
Biological Process (BP) regulation of interleukin-1 beta production 0.7336 Highly Informative Inherited
Biological Process (BP) DNA replication 0.438 Highly Informative Inherited
Biological Process (BP) response to UV 0.6902 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02872 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.01748 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.001045 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01398 Highly Informative Inherited
Biological Process (BP) ossification 0.001844 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.2161 Highly Informative Inherited
Biological Process (BP) developmental growth 0.9744 Highly Informative Inherited
Biological Process (BP) cell growth 0.1262 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2994 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response 0.9966 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.004279 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.01268 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.0258 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.287 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2436 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.5104 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.0733 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.1737 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.1629 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.8597 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000005402 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003223 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.9073 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3029 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) amide binding 0.000003787 Informative Direct
Molecular Function (MF) lipid binding 0.6304 Informative Inherited
Molecular Function (MF) enzyme binding 0.984 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.09446 Informative Inherited
Molecular Function (MF) receptor activity 0.2393 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4074 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000001639 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00001793 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00004071 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0004398 Highly Informative Direct
Cellular Component (CC) protein complex 0.0003277 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.0000000000002893 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.2693 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.283 Informative Inherited
Cellular Component (CC) receptor complex 0.03456 Highly Informative Inherited
Cellular Component (CC) cell body 0.348 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.8622 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5963 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000175Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.28Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0001698InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0004373InformativeDirect
Disease Ontology (DO)Crohn's disease0.000007943Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0002191Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3502Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1614Moderately InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.0003084Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.08511Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0002384Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.1796Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.2634Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0005339InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.05449InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.05663InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.9614InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000006088Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.000033Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0001004Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.5032Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to infection0.5233Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.9966Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.5472Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation induced paralysis0.0003916InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001317Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther0.00008324Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5648Least InformativeInherited
Enzyme Commission (EC)Lyases0.7505Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.00000005356InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.011InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.0000000000000064Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000007918Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000004493Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.000000000002164Moderately InformativeDirect
Biological processDifferentiation0.0001291Moderately InformativeDirect
Biological processCell cycle0.346Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis0.00000264InformativeDirect
Biological processBiological rhythms0.00001969InformativeDirect
Biological processAuxin signaling pathway0Highly InformativeDirect
Cellular componentNucleus0.0000000608Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.00000000001584Moderately InformativeDirect
Cellular componentCell projection0.01077Moderately InformativeInherited
Cellular componentCilium0.007911Highly InformativeInherited
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionActin-binding0.000000001188InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000003976Moderately InformativeDirect
Post-translational modificationKinase0.0069Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation0.00000003157InformativeDirect
Post-translational modificationDioxygenase0.0009619Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000001447Least InformativeDirect
Post-translational modificationGlycoprotein0.000002455Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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