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L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,417) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 119,146 245,591 63
Proteins 93,150 195,792 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.73930.1688Least InformativeInherited
Biological Process (BP)response to stimulus0.63310Least InformativeInherited
Biological Process (BP)biological regulation0.010990Least InformativeInherited
Biological Process (BP)cellular localization0.051811Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.044070.00000000000001783Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.12610.0000000000003986Moderately InformativeInherited
Biological Process (BP)single organism signaling0.0074790Moderately InformativeInherited
Biological Process (BP)immune system process0.041960Moderately InformativeInherited
Biological Process (BP)cell communication0.0058680Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.092570.2406Moderately InformativeInherited
Biological Process (BP)positive regulation of immune response0.0050830.000000000002099InformativeInherited
Biological Process (BP)regulation of defense response0.60870.0000000000478InformativeInherited
Biological Process (BP)tissue development0.0096640.9094InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.000000094350.000009504Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium0.00000040760.000158Highly InformativeDirect
Biological Process (BP)pigmentation0.0000094050.1001Highly InformativeInherited
Biological Process (BP)activation of innate immune response0.041250.0000000002703Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.93930.1799Highly InformativeInherited
Molecular Function (MF)molecular function regulator0.018230.3842Moderately InformativeInherited
Molecular Function (MF)phosphatase regulator activity0.00027840.00001472Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.041481Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.10121Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.98791Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.8981Least InformativeInherited
Cellular Component (CC)nuclear part0.059281Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.0000003920.0000009141Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.00054340.03106Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001264 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1688 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) system development 0.000002748 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000000001783 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000000003986 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000001325 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000009843 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00001358 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000002603 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000000000005638 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000000001706 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00002226 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7977 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.002242 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.9904 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2406 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7934 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.006064 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.006461 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6064 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.004676 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6778 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.03017 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1652 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9339 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune response 0.000000000002099 Informative Direct
Biological Process (BP) immune response 0.0000001804 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000009353 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000478 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000000002463 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000000498 Informative Direct
Biological Process (BP) locomotion 0.00000000007983 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000000007365 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000001236 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000002191 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000004092 Informative Direct
Biological Process (BP) growth 0.0000005418 Informative Direct
Biological Process (BP) reproductive system development 0.0000006395 Informative Direct
Biological Process (BP) behavior 0.000002767 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00002726 Informative Direct
Biological Process (BP) regulation of growth 0.00003508 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00005825 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00008059 Informative Direct
Biological Process (BP) cell activation 0.0001387 Informative Direct
Biological Process (BP) response to bacterium 0.000275 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0004143 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005867 Informative Direct
Biological Process (BP) cell development 0.0006641 Informative Direct
Biological Process (BP) response to nitrogen compound 0.8277 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.003622 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4145 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.06078 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.06922 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) anion transport 0.1406 Informative Inherited
Biological Process (BP) transmembrane transport 0.379 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.01237 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.03942 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) tissue development 0.9094 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4954 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.006175 Informative Inherited
Biological Process (BP) protein oligomerization 0.7073 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03022 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.003294 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.01948 Informative Inherited
Biological Process (BP) negative regulation of transport 0.02088 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02384 Informative Inherited
Biological Process (BP) regulation of secretion 0.8737 Informative Inherited
Biological Process (BP) generation of neurons 0.1851 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.004194 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.4802 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.3091 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.03652 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1185 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2335 Informative Inherited
Biological Process (BP) cell death 0.01873 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0116 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.9349 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.3053 Informative Inherited
Biological Process (BP) central nervous system development 0.1371 Informative Inherited
Biological Process (BP) defense response to other organism 0.01109 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5784 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6364 Informative Inherited
Biological Process (BP) phosphorylation 0.003333 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1172 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5933 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.4077 Informative Inherited
Biological Process (BP) cellular response to lipid 0.5119 Informative Inherited
Biological Process (BP) secretion by cell 0.2531 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.0677 Informative Inherited
Biological Process (BP) circulatory system development 0.3518 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.005526 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06261 Informative Inherited
Biological Process (BP) post-embryonic development 0.02161 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.2858 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.000009504 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000158 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.0000000002703 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000000001194 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000000002265 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.00000000003164 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000000001829 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000003835 Highly Informative Direct
Biological Process (BP) neuron development 0.000000006691 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00000001595 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000001804 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000004707 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000006399 Highly Informative Direct
Biological Process (BP) sex differentiation 0.000004709 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00001108 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000177 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.00002033 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.00003445 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.00003476 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0.00003655 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00005767 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00005966 Highly Informative Direct
Biological Process (BP) protein secretion 0.00006394 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00007664 Highly Informative Direct
Biological Process (BP) nuclear export 0.0001375 Highly Informative Direct
Biological Process (BP) cell growth 0.000221 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0002593 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0003181 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.000487 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0005594 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0006214 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0007375 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.0009438 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.8688 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1069 Highly Informative Inherited
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.01123 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3914 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.2908 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6869 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.5205 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.01898 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.2464 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.04212 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.004932 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.02355 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.1475 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.327 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.8246 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.004738 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.008615 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.09862 Highly Informative Inherited
Biological Process (BP) seed development 0.1033 Highly Informative Inherited
Biological Process (BP) cell division 0.5546 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1051 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.9708 Highly Informative Inherited
Biological Process (BP) protein-DNA complex subunit organization 0.07678 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.00178 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9644 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.05231 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.0017 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.03304 Highly Informative Inherited
Biological Process (BP) pigmentation 0.1001 Highly Informative Inherited
Biological Process (BP) brain development 0.3813 Highly Informative Inherited
Biological Process (BP) antimicrobial humoral response 0.1827 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.007188 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.002942 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.05187 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.6582 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.188 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.3973 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5472 Highly Informative Inherited
Biological Process (BP) innate immune response 0.004952 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.3724 Highly Informative Inherited
Biological Process (BP) protein folding 0.8265 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.3545 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.05022 Highly Informative Inherited
Biological Process (BP) response to fungus 0.4553 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.1799 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01005 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.0155 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000003933 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00006301 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.3842 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2508 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.00000002134 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000004416 Informative Direct
Molecular Function (MF) amide binding 0.0000005883 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.9917 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.02124 Informative Inherited
Molecular Function (MF) nuclease activity 0.5284 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.009725 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.05045 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.05618 Informative Inherited
Molecular Function (MF) receptor binding 0.05749 Informative Inherited
Molecular Function (MF) RNA binding 0.1103 Informative Inherited
Molecular Function (MF) phosphatase regulator activity 0.00001472 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000001208 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000003123 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0003583 Highly Informative Direct
Molecular Function (MF) peptide binding 0.5309 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.3165 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.01639 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000007493 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000000003175 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.01712 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001151 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0000000000004065 Informative Direct
Cellular Component (CC) membrane region 0.000000003345 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000001094 Informative Direct
Cellular Component (CC) synapse 0.0002466 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004756 Informative Direct
Cellular Component (CC) neuron projection 0.2575 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.3137 Informative Inherited
Cellular Component (CC) lytic vacuole 0.007559 Informative Inherited
Cellular Component (CC) endosome 0.01058 Informative Inherited
Cellular Component (CC) side of membrane 0.9242 Informative Inherited
Cellular Component (CC) plasma membrane region 0.3242 Informative Inherited
Cellular Component (CC) vacuolar part 0.07027 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.1797 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.0000009141 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00003689 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.000000000000003141 Highly Informative Direct
Cellular Component (CC) symplast 0.000000000001106 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000001065 Highly Informative Direct
Cellular Component (CC) growth cone 0.00001769 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.00003441 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 0.0001045 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.0001215 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0004924 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0.0005201 Highly Informative Direct
Cellular Component (CC) cell body membrane 0.004901 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 0.05021 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.165 Highly Informative Inherited
Cellular Component (CC) external side of plasma membrane 0.1606 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.03106 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000756Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000441InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000003813Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.0000000001091Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05473Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.2504Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.34Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.6112Moderately InformativeInherited
Disease Ontology (DO)myopia0.0009059InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004209InformativeInherited
Disease Ontology (DO)filariasis0.000003967Highly InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.0001586Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.9983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.8651InformativeInherited
Phenotypic Abnormality (PA)Stomatocytosis0.0001777Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1957Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.589Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.9698Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9908Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2815Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.486Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.6478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.6557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.8531Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.8736Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.8928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.03587InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.03783InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.05812InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1993InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2172InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.3046InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6158InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.0001042Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skin tensile strength0.0001236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.000242Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system regeneration0.0006002Highly InformativeDirect
Mammalian Phenotype (MP)decreased macrophage cytokine production0.0006672Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.004792Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.05622Highly InformativeInherited
Mammalian Phenotype (MP)abnormal susceptibility to weight loss0.067Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.1414Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.2103Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)myopodia present0.0007074Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.7222Least InformativeInherited
Fly Anatomy (FA)somatic cell0.8072Least InformativeInherited
Fly Anatomy (FA)neuron0.2267Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.2825Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5436Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1388Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4245Moderately InformativeInherited
Zebrafish Anatomy (ZA)olfactory system0.1048Highly InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.5066Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.00003277Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0001721Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.736Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000001322InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.000347InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000002032Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000004259Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processVirulence0.0004892Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis0.00000000002971InformativeDirect
Biological processWnt signaling pathway0.00034InformativeDirect
Biological processSensory transduction0.02109InformativeInherited
Biological processBlood coagulation0.00000000002697Highly InformativeDirect
Biological processmRNA transport0.00000000131Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00006354Highly InformativeDirect
Biological processVision0.00009501Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0006453Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome0.00000000008115Moderately InformativeDirect
Cellular componentCytoskeleton0.00000001135Moderately InformativeDirect
Cellular componentCell membrane0.0004835Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000001021InformativeDirect
Cellular componentSpliceosome0.00003172InformativeDirect
Cellular componentSynapse0.0000565InformativeDirect
Cellular componentLysosome0.0009828InformativeDirect
Cellular componentCell wall0.00000000001058Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.002835Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.296Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationExonuclease0.00000000001118InformativeDirect
Post-translational modificationIon channel0.000000006307InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00000000002667Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation0InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0005165Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]