SUPERFAMILY 1.75 HMM library and genome assignments server

L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,411) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 120,250 124,782 63
Proteins 94,178 101,598 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.71961Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.87021Least InformativeInherited
Biological Process (BP)regulation of cellular process0.42520.8595Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.28750.000001353Least InformativeInherited
Biological Process (BP)developmental process0.0025380Least InformativeInherited
Biological Process (BP)multicellular organismal process0.025270Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.78611Least InformativeInherited
Biological Process (BP)single-organism cellular process0.052150.000005514Least InformativeInherited
Biological Process (BP)localization0.81650.9023Least InformativeInherited
Biological Process (BP)response to stimulus0.21650Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.72861Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.95661Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.8921Least InformativeInherited
Biological Process (BP)regulation of cellular component organization0.86680.3858Moderately InformativeInherited
Biological Process (BP)nervous system development0.22160.03524Moderately InformativeInherited
Biological Process (BP)cell differentiation0.39731Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.88120.0008736Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.65730.00000000002373Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.020411Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.087150.000001142Moderately InformativeInherited
Biological Process (BP)organ development0.12120.0007468Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)cellular localization0.070730.00483Moderately InformativeInherited
Biological Process (BP)immune system process0.17760Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.95231Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0068211Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.81531Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00056880.000000000197InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.06780.9667InformativeInherited
Biological Process (BP)regulation of growth0.3160.0000000004662InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.035920.1132InformativeInherited
Biological Process (BP)generation of neurons0.22050.04987InformativeInherited
Biological Process (BP)regulation of nervous system development0.07670.2509InformativeInherited
Biological Process (BP)regulation of cell development0.11590.0000001115InformativeInherited
Biological Process (BP)regulation of MAPK cascade0.022350.00005723InformativeInherited
Biological Process (BP)leukocyte activation0.023390.9392InformativeInherited
Biological Process (BP)gland development0.076150.004785InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.019020.00000006303InformativeInherited
Biological Process (BP)cytoplasmic transport0.0035250.6585InformativeInherited
Biological Process (BP)cell proliferation0.010140.3354InformativeInherited
Biological Process (BP)immune effector process0.04580.2612InformativeInherited
Biological Process (BP)immune response0.26080InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.060391InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.16251InformativeInherited
Biological Process (BP)regulation of cell size0.00041540.000003084Highly InformativeDirect
Biological Process (BP)B cell activation0.0000083990.00001173Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.0011460.00000000001757Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0021070.00000000003453Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.011910.00007297Highly InformativeInherited
Biological Process (BP)leukocyte proliferation0.001130.006399Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.018530.1426Highly InformativeInherited
Biological Process (BP)mRNA catabolic process0.34630.0004745Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0024040.2299Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.70021Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.38460.0004011InformativeInherited
Molecular Function (MF)nuclease activity0.010570.4424InformativeInherited
Molecular Function (MF)phosphatase regulator activity0.0000031630.00000000695Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.62851Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.22051Least InformativeInherited
Cellular Component (CC)protein complex0.54491Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.23731Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0029041Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.00007060.000003407Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000005514 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001353 Least Informative Direct
Biological Process (BP) localization 0.9023 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.9619 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8595 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0009919 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0004175 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00005094 Moderately Informative Direct
Biological Process (BP) organ development 0.0007468 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000000004688 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0008736 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000001142 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000002373 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000001172 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.00483 Moderately Informative Inherited
Biological Process (BP) tissue development 0.004477 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2148 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6595 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8906 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.04181 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03524 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3858 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0467 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3254 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02493 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001477 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00003705 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000000516 Informative Direct
Biological Process (BP) cellular component movement 0.0009459 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0007347 Informative Direct
Biological Process (BP) response to bacterium 0.0001015 Informative Direct
Biological Process (BP) phosphorylation 0.0000000008188 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000006134 Informative Direct
Biological Process (BP) biological adhesion 0.000000000197 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000008724 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00003249 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000000009095 Informative Direct
Biological Process (BP) growth 0.00002131 Informative Direct
Biological Process (BP) regulation of growth 0.0000000004662 Informative Direct
Biological Process (BP) locomotion 0.00000004832 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0006595 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.00005723 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000000001592 Informative Direct
Biological Process (BP) reproductive structure development 0.0000000000003759 Informative Direct
Biological Process (BP) regulation of immune response 0.0000000001724 Informative Direct
Biological Process (BP) localization of cell 0.000003092 Informative Direct
Biological Process (BP) regulation of cell development 0.0000001115 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000005007 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005761 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000006303 Informative Direct
Biological Process (BP) defense response to other organism 0.0001599 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000075 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0008769 Informative Direct
Biological Process (BP) negative regulation of signaling 0.6761 Informative Inherited
Biological Process (BP) regulation of protein localization 0.04364 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6524 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9667 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.01108 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.1395 Informative Inherited
Biological Process (BP) response to acid chemical 0.2714 Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9218 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1087 Informative Inherited
Biological Process (BP) tube development 0.9001 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8863 Informative Inherited
Biological Process (BP) protein oligomerization 0.4473 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1642 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3867 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1132 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.006795 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.05091 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2509 Informative Inherited
Biological Process (BP) regulation of response to wounding 1 Informative Inherited
Biological Process (BP) cell division 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2208 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.2883 Informative Inherited
Biological Process (BP) sensory organ development 0.5872 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.006864 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8747 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1121 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8656 Informative Inherited
Biological Process (BP) generation of neurons 0.04987 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1179 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3535 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.4703 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.7068 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.08684 Informative Inherited
Biological Process (BP) single-organism behavior 0.007732 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3339 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9025 Informative Inherited
Biological Process (BP) cell proliferation 0.3354 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.008648 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.7503 Informative Inherited
Biological Process (BP) central nervous system development 0.2948 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.7412 Informative Inherited
Biological Process (BP) anion transport 0.4645 Informative Inherited
Biological Process (BP) organic acid transport 0.1041 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03482 Informative Inherited
Biological Process (BP) epithelium development 0.9023 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1192 Informative Inherited
Biological Process (BP) response to lipid 0.1329 Informative Inherited
Biological Process (BP) gland development 0.004785 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.8796 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.6585 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.07219 Informative Inherited
Biological Process (BP) protein transport 0.3238 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04952 Informative Inherited
Biological Process (BP) immune effector process 0.2612 Informative Inherited
Biological Process (BP) leukocyte activation 0.9392 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0000000008521 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000005249 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0000000003502 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0002781 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0004745 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00000003674 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001428 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0.00001209 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000003084 Highly Informative Direct
Biological Process (BP) gonad development 0.0008093 Highly Informative Direct
Biological Process (BP) epidermis development 0.0000001385 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.000000001909 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000001757 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00000000003453 Highly Informative Direct
Biological Process (BP) telencephalon development 0.00000001564 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0000009045 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.00002262 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00002926 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) B cell activation 0.00001173 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0003579 Highly Informative Direct
Biological Process (BP) innate immune response 0.00004613 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000000000000001913 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.000000002661 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000000001469 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0009786 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0000000006338 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001907 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.000001352 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00001089 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000004474 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.000779 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0000001504 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00007297 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0008098 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.000001533 Highly Informative Direct
Biological Process (BP) cell adhesion 0.7713 Highly Informative Inherited
Biological Process (BP) regulation of cytokine production involved in immune response 0.02434 Highly Informative Inherited
Biological Process (BP) hormone transport 0.08677 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.4465 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 0.03667 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.005053 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.1358 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2921 Highly Informative Inherited
Biological Process (BP) regulation of chemotaxis 0.4976 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.01396 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.4526 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.7372 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.1639 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.1798 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.00376 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.06178 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.009384 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.7226 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.1744 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.002736 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.07543 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01055 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1378 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.6946 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.003125 Highly Informative Inherited
Biological Process (BP) response to UV 0.1105 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.006399 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.8571 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.02212 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.006119 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01328 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.001626 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001985 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.0838 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.004798 Highly Informative Inherited
Biological Process (BP) nuclear export 0.02386 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.09828 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1611 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.004175 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.463 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.00194 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.1347 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.8931 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001154 Highly Informative Inherited
Biological Process (BP) protein folding 0.4532 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.00185 Highly Informative Inherited
Biological Process (BP) amide transport 0.07996 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.07043 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.002344 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.07933 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1426 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3521 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.6266 Highly Informative Inherited
Biological Process (BP) kidney development 0.3285 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3708 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.001352 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.314 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2445 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.2299 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.005137 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.0004011 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.000000002243 Informative Direct
Molecular Function (MF) kinase activity 0.00005112 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00002476 Informative Direct
Molecular Function (MF) amide binding 0.00000004233 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.167 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.07199 Informative Inherited
Molecular Function (MF) enzyme binding 0.1377 Informative Inherited
Molecular Function (MF) nuclease activity 0.4424 Informative Inherited
Molecular Function (MF) protein complex binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.01129 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000001117 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.00000000695 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000000001188 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000008643 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.4044 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000001345 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000000002857 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000000000000006018 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.6582 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02815 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.8382 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000006135 Informative Direct
Cellular Component (CC) cell surface 0.00000002351 Informative Direct
Cellular Component (CC) integral component of membrane 0.00000327 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0005646 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) synapse 0.0367 Informative Inherited
Cellular Component (CC) vacuolar part 0.01532 Informative Inherited
Cellular Component (CC) lytic vacuole 0.007662 Informative Inherited
Cellular Component (CC) plasma membrane region 0.02409 Informative Inherited
Cellular Component (CC) cell junction 0.004449 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.2926 Informative Inherited
Cellular Component (CC) nuclear envelope 0.01302 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.000003407 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002261 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000000008925 Highly Informative Direct
Cellular Component (CC) symplast 0.00000000002322 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.08662 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.01065 Highly Informative Inherited
Cellular Component (CC) pore complex 0.003377 Highly Informative Inherited
Cellular Component (CC) chromatin 0.9643 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.8982 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000756Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000441InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000003813Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.0000000001091Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06362Least InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.007405InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.01948InformativeInherited
Disease Ontology (DO)filariasis0.00004916Highly InformativeDirect
Disease Ontology (DO)aspergillosis0.0004935Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Hyperpituitarism0.0001278Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1916Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6416Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4779Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.6552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7074Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.7683Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9462Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.07827InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.204InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.3929InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3986InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.4462InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.8092InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00009261Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.0003493Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.107Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.1419Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2438Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present0.00002555Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7947Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001465InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000004485Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000004956Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001397Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.002539Moderately InformativeInherited
Drugbank ATC_code (DB)antineoplastic agents0.2849Moderately InformativeInherited
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues0.0001918InformativeDirect
Drugbank ATC_code (DB)protein kinase inhibitors0.0004154InformativeDirect
Drugbank ATC_code (DB)afatinib0.00004055Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis0.00000000001674InformativeDirect
Biological processVirulence0.0000819InformativeDirect
Biological processWnt signaling pathway0.000207InformativeDirect
Biological processSensory transduction0.1327InformativeInherited
Biological processBlood coagulation0.00000000001518Highly InformativeDirect
Biological processmRNA transport0.000000000112Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00001665Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0005286Highly InformativeDirect
Biological processVision0.0005651Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0001156Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome0.000000000007261Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000035Moderately InformativeDirect
Cellular componentCytoskeleton0.0000001189Moderately InformativeDirect
Cellular componentCell projection0.0000005517Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001077Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000001693InformativeDirect
Cellular componentSynapse0.000002151InformativeDirect
Cellular componentSpliceosome0.00001095InformativeDirect
Cellular componentHost cytoplasm0.0003202InformativeDirect
Cellular componentLysosome0.0004726InformativeDirect
Cellular componentCell wall0.0000000000002405Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000000000003154Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.0693Least InformativeInherited
Molecular functionATP-binding0.0000009989Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.2048Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease0.000000000002108InformativeDirect
Post-translational modificationIon channel0.000000001492InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000001634Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation0.000000000000001355InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0003957Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]