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L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,412) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 118,645 124,782 63
Proteins 92,762 101,598 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.69110Least InformativeInherited
Biological Process (BP)single-organism cellular process0.067170.000001882Least InformativeInherited
Biological Process (BP)biological regulation0.041550.00000000000004046Least InformativeInherited
Biological Process (BP)cellular developmental process0.13090.000000001373Moderately InformativeInherited
Biological Process (BP)cellular localization0.039551Moderately InformativeInherited
Biological Process (BP)signaling0.0020250Moderately InformativeInherited
Biological Process (BP)immune system process0.040310Moderately InformativeInherited
Biological Process (BP)cell communication0.0080930Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.11450.00000000002271Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.092450.06516Moderately InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.0000062510.00001557InformativeDirect
Biological Process (BP)regulation of immune response0.025210.00000001455InformativeInherited
Biological Process (BP)positive regulation of immune system process0.016350.000000000001162InformativeInherited
Biological Process (BP)regulation of defense response0.55120.000000000002112InformativeInherited
Biological Process (BP)epithelium development0.018411InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.00000069980.0001565Highly InformativeDirect
Biological Process (BP)innate immune response-activating signal transduction0.00003990.0000000000008755Highly InformativeDirect
Biological Process (BP)pigmentation0.0000083670.06798Highly InformativeInherited
Molecular Function (MF)molecular function regulator0.018950.3211Moderately InformativeInherited
Molecular Function (MF)phosphatase regulator activity0.00037810.00002063Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.87911Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13731Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.72451Least InformativeInherited
Cellular Component (CC)nuclear part0.025871Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000047080.0000005563Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.00072660.03044Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000001882 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000000004046 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.001653 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000000006237 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000002271 Moderately Informative Direct
Biological Process (BP) system development 0.0000005791 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000001373 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00005232 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00008905 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000005265 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000001103 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005195 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02661 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9334 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.06516 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9908 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8285 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02364 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01764 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0287 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.7256 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.000000000001162 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.000487 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 0.00001557 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000002334 Informative Direct
Biological Process (BP) immune response 0.000000001708 Informative Direct
Biological Process (BP) behavior 0.00001994 Informative Direct
Biological Process (BP) response to bacterium 0.0002187 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000002112 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000006509 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0.00001283 Informative Direct
Biological Process (BP) regulation of growth 0.00001301 Informative Direct
Biological Process (BP) locomotion 0.000000001073 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000004387 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0000502 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000002583 Informative Direct
Biological Process (BP) cell development 0.00004365 Informative Direct
Biological Process (BP) regulation of immune response 0.00000001455 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00002582 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0001298 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00001259 Informative Direct
Biological Process (BP) reproductive system development 0.00003711 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00003243 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.7178 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.579 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0928 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.06486 Informative Inherited
Biological Process (BP) anion transport 0.09304 Informative Inherited
Biological Process (BP) transmembrane transport 0.227 Informative Inherited
Biological Process (BP) post-embryonic development 0.02837 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1562 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4758 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1696 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.0804 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0033 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.4109 Informative Inherited
Biological Process (BP) circulatory system development 0.2425 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4366 Informative Inherited
Biological Process (BP) protein oligomerization 0.6306 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3944 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3559 Informative Inherited
Biological Process (BP) regulation of locomotion 0.8836 Informative Inherited
Biological Process (BP) regulation of secretion 0.9647 Informative Inherited
Biological Process (BP) negative regulation of transport 0.05323 Informative Inherited
Biological Process (BP) secretion 0.03547 Informative Inherited
Biological Process (BP) generation of neurons 0.01755 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.004102 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3728 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.2747 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3285 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00468 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1217 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.07692 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.9556 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03996 Informative Inherited
Biological Process (BP) central nervous system development 0.3089 Informative Inherited
Biological Process (BP) defense response to other organism 0.008917 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9279 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6091 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1925 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5689 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.06241 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.05296 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.006069 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9837 Informative Inherited
Biological Process (BP) cell death 0.04385 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7654 Informative Inherited
Biological Process (BP) phosphorylation 0.004973 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3174 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.4702 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.001946 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.5062 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell growth 0.0006096 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0002227 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0001565 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.0000000000004249 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.0000003506 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.00006068 Highly Informative Direct
Biological Process (BP) innate immune response-activating signal transduction 0.0000000000008755 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000001098 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000003149 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000153 Highly Informative Direct
Biological Process (BP) protein secretion 0.00002285 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000008394 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000009229 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.0003077 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0002903 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0007232 Highly Informative Direct
Biological Process (BP) regeneration 0.000149 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0001517 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000001125 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000002617 Highly Informative Direct
Biological Process (BP) neuron development 0.0000000001971 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.000008094 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0004043 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0002854 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0.00002865 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000000000001314 Highly Informative Direct
Biological Process (BP) reactive oxygen species metabolic process 0.000009846 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.03771 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002905 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.205 Highly Informative Inherited
Biological Process (BP) nuclear export 0.2173 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.2851 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6562 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.004963 Highly Informative Inherited
Biological Process (BP) cell migration 0.215 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9434 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.08751 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.4772 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.1964 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.02966 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.7357 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.001663 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.2106 Highly Informative Inherited
Biological Process (BP) seed development 0.05025 Highly Informative Inherited
Biological Process (BP) cell division 0.07366 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.003361 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.002239 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.9612 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.001401 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3474 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8778 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.02712 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.06282 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.01799 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.06005 Highly Informative Inherited
Biological Process (BP) pigmentation 0.06798 Highly Informative Inherited
Biological Process (BP) brain development 0.6514 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.8769 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7025 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.008014 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5519 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01569 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.08999 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 0.01585 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.1274 Highly Informative Inherited
Biological Process (BP) protein folding 0.7455 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.05875 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.7733 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.007311 Highly Informative Inherited
Biological Process (BP) mRNA metabolic process 0.4339 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.05841 Highly Informative Inherited
Molecular Function (MF) binding 0.000000002171 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0002931 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.3211 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1117 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.0000001843 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000001179 Informative Direct
Molecular Function (MF) amide binding 0.00002814 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.04311 Informative Inherited
Molecular Function (MF) enzyme binding 0.8989 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.01758 Informative Inherited
Molecular Function (MF) nuclease activity 0.4757 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.1181 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.132 Informative Inherited
Molecular Function (MF) receptor binding 0.01645 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000001782 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.00002063 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00000005691 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000003696 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.05939 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.04056 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00000001381 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000001077 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.941 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.004631 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.03047 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.008195 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0000001183 Informative Direct
Cellular Component (CC) cell surface 0.00000000001954 Informative Direct
Cellular Component (CC) cell junction 0.00003675 Informative Direct
Cellular Component (CC) site of polarized growth 0.0003679 Informative Direct
Cellular Component (CC) membrane region 0.00000005554 Informative Direct
Cellular Component (CC) synapse 0.002791 Informative Inherited
Cellular Component (CC) plasma membrane region 0.7683 Informative Inherited
Cellular Component (CC) neuron projection 0.4021 Informative Inherited
Cellular Component (CC) cell projection part 0.03835 Informative Inherited
Cellular Component (CC) vacuolar part 0.02664 Informative Inherited
Cellular Component (CC) lytic vacuole 0.006745 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00187 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.4344 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.00000155 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.0001826 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.0000005563 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.0001003 Highly Informative Direct
Cellular Component (CC) growth cone 0.00001967 Highly Informative Direct
Cellular Component (CC) extracellular matrix 0.00000001181 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000272 Highly Informative Direct
Cellular Component (CC) symplast 0.000000000006503 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.1773 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.1756 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.03044 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 1 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000756Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000441InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000003813Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.0000000001091Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04712Least InformativeInherited
Disease Ontology (DO)immune system disease0.4912Least InformativeInherited
Disease Ontology (DO)sensory system disease0.3524Moderately InformativeInherited
Disease Ontology (DO)blood coagulation disease0.585Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.6696Moderately InformativeInherited
Disease Ontology (DO)myopia0.0008569InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004266InformativeInherited
Disease Ontology (DO)filariasis0.000003754Highly InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.000129Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.9928Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.8475InformativeInherited
Phenotypic Abnormality (PA)Stomatocytosis0.0001651Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2034Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6327Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.9721Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9776Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4105Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7211Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7222Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.8413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.8973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.905Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.03535InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.07655InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.1094InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1503InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2345InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2939InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6462InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.0001009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skin tensile strength0.0001244Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.0002349Highly InformativeDirect
Mammalian Phenotype (MP)decreased macrophage cytokine production0.0004814Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system regeneration0.0006334Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.003595Highly InformativeInherited
Mammalian Phenotype (MP)abnormal susceptibility to weight loss0.0675Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.08769Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.08775Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.2415Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)myopodia present0.0007258Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.4368Least InformativeInherited
Fly Anatomy (FA)nervous system0.5588Least InformativeInherited
Fly Anatomy (FA)neuron0.1266Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.2315Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.4323Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1185Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.3328Moderately InformativeInherited
Zebrafish Anatomy (ZA)olfactory system0.08342Highly InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.5169Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.00002972Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000335Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7325Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0002076InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Protein geranylgeranyltransferase type II0.0000000006501Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000008904Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.0000004655Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.08798Least InformativeInherited
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.0002141Moderately InformativeDirect
Drugbank ATC_code (DB)protein kinase inhibitors0.0007357Moderately InformativeDirect
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues0.00001209InformativeDirect
Drugbank ATC_code (DB)antiparasitic products, insecticides and repellents0.006401InformativeInherited
Drugbank ATC_code (DB)afatinib0.00002828Highly InformativeDirect
Drugbank ATC_code (DB)antimalarials0.00008201Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processVirulence0.0004064Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis0.00000000002644InformativeDirect
Biological processWnt signaling pathway0.0003176InformativeDirect
Biological processSensory transduction0.01956InformativeInherited
Biological processBlood coagulation0.00000000002399Highly InformativeDirect
Biological processmRNA transport0.0000000007548Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00005256Highly InformativeDirect
Biological processVision0.00009304Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000353Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.000000000000002263Moderately InformativeDirect
Cellular componentEndosome0.0000000005761Moderately InformativeDirect
Cellular componentCytoskeleton0.000000004886Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.000000005824InformativeDirect
Cellular componentSpliceosome0.00002901InformativeDirect
Cellular componentSynapse0.0001386InformativeDirect
Cellular componentCell wall0.000000000005732Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.009451Least InformativeInherited
Molecular functionATP-binding0.000000002754Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.2741Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationExonuclease0.000000000008446InformativeDirect
Post-translational modificationIon channel0.000000004797InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0000000001657Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation0.000000000000001883InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0004667Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]