SUPERFAMILY 1.75 HMM library and genome assignments server


L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,410) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 119,682 124,782 63
Proteins 93,765 101,598 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process4.738e-060Least InformativeDirect
Biological Process (BP)regulation of cellular process0.4670.8886Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.36780.000123Least InformativeInherited
Biological Process (BP)developmental process0.0025720Least InformativeInherited
Biological Process (BP)multicellular organismal process0.035720Least InformativeInherited
Biological Process (BP)localization0.76440.6496Least InformativeInherited
Biological Process (BP)response to stimulus0.20980Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.66511Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.81621Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.91591Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.65391Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.96021Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0066791Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.81410.1914Moderately InformativeInherited
Biological Process (BP)nervous system development0.34820.03156Moderately InformativeInherited
Biological Process (BP)cell differentiation0.42181Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.74421.112e-11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.8740.0006026Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.019951Moderately InformativeInherited
Biological Process (BP)cellular localization0.58180.8428Moderately InformativeInherited
Biological Process (BP)immune system process0.18240Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.19021Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.79141Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00057071.431e-10InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.065410.9588InformativeInherited
Biological Process (BP)regulation of growth0.33891.008e-09InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.037640.1105InformativeInherited
Biological Process (BP)regulation of nervous system development0.075640.2331InformativeInherited
Biological Process (BP)regulation of cell development0.11754.382e-07InformativeInherited
Biological Process (BP)generation of neurons0.26920.04799InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.36740.02082InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.026916.038e-07InformativeInherited
Biological Process (BP)leukocyte activation0.023510.9437InformativeInherited
Biological Process (BP)immune effector process0.045940.2663InformativeInherited
Biological Process (BP)immune response0.27010InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.051061InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.15521InformativeInherited
Biological Process (BP)B cell activation8.317e-061.052e-05Highly InformativeDirect
Biological Process (BP)regulation of cell size0.00032961.525e-06Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.0012131.246e-11Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0019365.584e-11Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.0091845.603e-05Highly InformativeInherited
Biological Process (BP)leukocyte proliferation0.0011950.006799Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.018570.144Highly InformativeInherited
Biological Process (BP)mRNA catabolic process0.3380.0004896Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0041680.5468Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.66951Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.2640.0009342InformativeInherited
Molecular Function (MF)nuclease activity0.0086660.3714InformativeInherited
Molecular Function (MF)phosphatase regulator activity1.119e-064.812e-09Highly InformativeDirect
Cellular Component (CC)protein complex0.551Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.21511Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.68121Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)nuclear part0.0041761Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.23331Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex7.017e-052.987e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000123 Least Informative Direct
Biological Process (BP) localization 0.6496 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8886 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) tissue development 9.612e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.175e-10 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1.017e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.112e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0004509 Moderately Informative Direct
Biological Process (BP) reproduction 5.507e-13 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0006026 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001061 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0004297 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.05326 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3121 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00236 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8125 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1653 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03156 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1914 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.7311 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002602 Moderately Informative Inherited
Biological Process (BP) organ development 0.001744 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4652 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06136 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8428 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) biological adhesion 1.431e-10 Informative Direct
Biological Process (BP) gland development 0.0001514 Informative Direct
Biological Process (BP) regulation of anatomical structure size 6.038e-07 Informative Direct
Biological Process (BP) regulation of cell development 4.382e-07 Informative Direct
Biological Process (BP) cell projection organization 9.314e-12 Informative Direct
Biological Process (BP) response to other organism 3.079e-09 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.368e-07 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.924e-11 Informative Direct
Biological Process (BP) regulation of growth 1.008e-09 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) reproductive system development 2.819e-12 Informative Direct
Biological Process (BP) regulation of immune response 1.943e-10 Informative Direct
Biological Process (BP) developmental process involved in reproduction 1.396e-09 Informative Direct
Biological Process (BP) regulation of defense response 1.999e-09 Informative Direct
Biological Process (BP) locomotion 3.722e-08 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.903e-07 Informative Direct
Biological Process (BP) localization of cell 5.423e-06 Informative Direct
Biological Process (BP) phosphorylation 5.896e-06 Informative Direct
Biological Process (BP) positive regulation of immune system process 8.069e-06 Informative Direct
Biological Process (BP) growth 1.926e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 3.431e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001371 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002449 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.000441 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0006289 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.4777 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3263 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1657 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9588 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9359 Informative Inherited
Biological Process (BP) tube development 0.6768 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.08178 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7561 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3889 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2331 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08671 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3139 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1186 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.7961 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02082 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9202 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02541 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6966 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.003736 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2843 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.4834 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8371 Informative Inherited
Biological Process (BP) response to nutrient levels 0.06381 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to lipid 0.1008 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01314 Informative Inherited
Biological Process (BP) generation of neurons 0.04799 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1105 Informative Inherited
Biological Process (BP) central nervous system development 0.2388 Informative Inherited
Biological Process (BP) cellular component movement 0.1165 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5211 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.1003 Informative Inherited
Biological Process (BP) anion transport 0.3959 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.21 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1398 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6495 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.3844 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.514 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.7281 Informative Inherited
Biological Process (BP) microtubule-based process 0.8076 Informative Inherited
Biological Process (BP) protein transport 0.5103 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8916 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.003412 Informative Inherited
Biological Process (BP) response to wounding 0.08261 Informative Inherited
Biological Process (BP) leukocyte activation 0.9437 Informative Inherited
Biological Process (BP) immune effector process 0.2663 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) B cell activation 1.052e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 1.525e-06 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.246e-11 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.079e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 5.584e-11 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 2.653e-06 Highly Informative Direct
Biological Process (BP) cell adhesion 9.054e-06 Highly Informative Direct
Biological Process (BP) axon development 0.0005635 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 5.603e-05 Highly Informative Direct
Biological Process (BP) post-embryonic development 4.958e-10 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0004896 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 2.462e-14 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 2.186e-12 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.29e-09 Highly Informative Direct
Biological Process (BP) telencephalon development 7.049e-09 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 7.248e-09 Highly Informative Direct
Biological Process (BP) protein phosphorylation 7.369e-08 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 2.391e-07 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 2.751e-07 Highly Informative Direct
Biological Process (BP) nuclear export 3.161e-07 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 4.602e-07 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 3.349e-06 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.598e-06 Highly Informative Direct
Biological Process (BP) innate immune response 1.786e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 2.706e-05 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 3.244e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 5.759e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 8.526e-05 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001644 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001959 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0002305 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0002638 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0007785 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000922 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.004161 Highly Informative Inherited
Biological Process (BP) hormone transport 0.08314 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.5536 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.004158 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.01981 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.00118 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2496 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9916 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2135 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3372 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.05518 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.00432 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.0238 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.05658 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.6617 Highly Informative Inherited
Biological Process (BP) response to UV 0.09654 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.09642 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.006799 Highly Informative Inherited
Biological Process (BP) cell division 0.2828 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6095 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01224 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6296 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01161 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.04237 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.07678 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.07005 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.003389 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.09788 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1923 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.03588 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001606 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.1131 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.4358 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.1779 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001221 Highly Informative Inherited
Biological Process (BP) protein folding 0.4444 Highly Informative Inherited
Biological Process (BP) amide transport 0.07674 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.09104 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1154 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.144 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.348 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.5415 Highly Informative Inherited
Biological Process (BP) renal system development 0.7814 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3501 Highly Informative Inherited
Molecular Function (MF) binding 0.0007004 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5468 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003995 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2378 Moderately Informative Inherited
Molecular Function (MF) receptor binding 1.452e-09 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0009342 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) amide binding 3.169e-08 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.743e-05 Informative Direct
Molecular Function (MF) kinase activity 4.241e-05 Informative Direct
Molecular Function (MF) lipid binding 0.151 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.04581 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.008905 Informative Inherited
Molecular Function (MF) RNA binding 0.005402 Informative Inherited
Molecular Function (MF) enzyme binding 0.1012 Informative Inherited
Molecular Function (MF) nuclease activity 0.3714 Informative Inherited
Molecular Function (MF) phosphatase regulator activity 4.812e-09 Highly Informative Direct
Molecular Function (MF) hormone binding 4.781e-12 Highly Informative Direct
Molecular Function (MF) peptide binding 7.499e-10 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1.439e-08 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.3998 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 7.687e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.495e-14 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01991 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.2182 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 8.373e-08 Informative Direct
Cellular Component (CC) endosome 3.656e-07 Informative Direct
Cellular Component (CC) neuron projection 0.8226 Informative Inherited
Cellular Component (CC) synapse part 0.00484 Informative Inherited
Cellular Component (CC) integral to membrane 0.8394 Informative Inherited
Cellular Component (CC) vacuolar part 0.01731 Informative Inherited
Cellular Component (CC) lytic vacuole 0.006404 Informative Inherited
Cellular Component (CC) cell-cell junction 0.005393 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00404 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.5346 Informative Inherited
Cellular Component (CC) nuclear envelope 0.006282 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 2.987e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 3.128e-15 Highly Informative Direct
Cellular Component (CC) symplast 2.148e-11 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0003381 Highly Informative Direct
Cellular Component (CC) pore complex 0.0008503 Highly Informative Direct
Cellular Component (CC) lysosome 0.02179 Highly Informative Inherited
Cellular Component (CC) dendrite 0.05166 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.0807 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.009866 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.884 Highly Informative Inherited
Cellular Component (CC) chromatin 0.9646 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.56e-06Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase4.41e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase3.813e-11Highly InformativeDirect
Enzyme Commission (EC)Peroxidase1.091e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.08047Least InformativeInherited
Disease Ontology (DO)central nervous system disease0.8208Moderately InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.005966InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.01948InformativeInherited
Disease Ontology (DO)filariasis4.74e-05Highly InformativeDirect
Disease Ontology (DO)aspergillosis0.0004653Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.007159Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2426Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6516Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1621Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2688Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5889Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.6286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.7077Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.01863InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1121InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.189InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.3934InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.4404InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.7993InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion8.528e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0008861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.001001Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.1024Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2103Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present2.555e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7956Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001468InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase4.552e-11Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase5.077e-09Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.00014Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis1.392e-11InformativeDirect
Biological processVirulence8.231e-05InformativeDirect
Biological processWnt signaling pathway0.0002086InformativeDirect
Biological processSensory transduction0.1301InformativeInherited
Biological processBlood coagulation1.261e-11Highly InformativeDirect
Biological processmRNA transport1.136e-10Highly InformativeDirect
Biological processRNA-mediated gene silencing1.679e-05Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0004916Highly InformativeDirect
Biological processVision0.000569Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0001086Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome1.286e-10Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.94e-08Moderately InformativeDirect
Cellular componentCytoskeleton1.144e-07Moderately InformativeDirect
Cellular componentCell projection5.569e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.028e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor1.718e-08InformativeDirect
Cellular componentSynapse2.054e-06InformativeDirect
Cellular componentSpliceosome1.107e-05InformativeDirect
Cellular componentHost cytoplasm0.0003239InformativeDirect
Cellular componentCell wall2.434e-13Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane3.479e-14Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.06997Least InformativeInherited
Molecular functionATP-binding1.014e-06Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.2042Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease2.131e-12InformativeDirect
Post-translational modificationIon channel1.486e-09InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond1.691e-06Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation1.353e-15InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0003988Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]