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L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,419) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 119,601 245,591 63
Proteins 93,513 195,792 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.53730.06003Least InformativeInherited
Biological Process (BP)biological regulation0.0039740Least InformativeInherited
Biological Process (BP)response to stimulus0.6860Least InformativeInherited
Biological Process (BP)cellular localization0.057771Moderately InformativeInherited
Biological Process (BP)cell differentiation0.010070.9428Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.23610.000000000008135Moderately InformativeInherited
Biological Process (BP)single organism signaling0.014790Moderately InformativeInherited
Biological Process (BP)immune system process0.024740Moderately InformativeInherited
Biological Process (BP)cell communication0.0096770Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.1450.5539Moderately InformativeInherited
Biological Process (BP)tissue development0.011251Moderately InformativeInherited
Biological Process (BP)intracellular transport0.015750.9147InformativeInherited
Biological Process (BP)regulation of immune response0.042070.0000000004905InformativeInherited
Biological Process (BP)positive regulation of immune system process0.047870.0000000000002452InformativeInherited
Biological Process (BP)regulation of defense response0.60840.0000000001545InformativeInherited
Biological Process (BP)epithelium development0.017741InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.0000010090.0001941Highly InformativeDirect
Biological Process (BP)pigmentation0.00000071790.08224Highly InformativeInherited
Biological Process (BP)activation of innate immune response0.039260.00000000004319Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.93910.08447Highly InformativeInherited
Molecular Function (MF)molecular function regulator0.0012280.235Moderately InformativeInherited
Molecular Function (MF)phosphatase regulator activity0.00027150.00001995Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.98221Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.10521Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.88541Least InformativeInherited
Cellular Component (CC)nuclear part0.063851Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000048950.0000009505Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.00049620.03392Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005219 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.06003 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0000000001191 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00002199 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00002475 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000008135 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000001097 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000003096 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000006221 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000985 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7729 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5292 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.009253 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0821 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8189 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9428 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7066 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002444 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7506 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.02512 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02914 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.996 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7933 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5539 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2135 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell activation 0.0002061 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000000000002452 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0003573 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000008392 Informative Direct
Biological Process (BP) immune response 0.0000003294 Informative Direct
Biological Process (BP) behavior 0.000006854 Informative Direct
Biological Process (BP) response to wounding 0.000002873 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000001007 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000001545 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000117 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000000002537 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000000001422 Informative Direct
Biological Process (BP) growth 0.0000002604 Informative Direct
Biological Process (BP) regulation of growth 0.00000005945 Informative Direct
Biological Process (BP) locomotion 0.00000000001797 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00004568 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000001568 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0007513 Informative Direct
Biological Process (BP) regulation of immune response 0.0000000004905 Informative Direct
Biological Process (BP) localization of cell 0.0000001426 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000007535 Informative Direct
Biological Process (BP) reproductive system development 0.00000245 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002776 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00005098 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1243 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.5929 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3159 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.212 Informative Inherited
Biological Process (BP) anion transport 0.1774 Informative Inherited
Biological Process (BP) transmembrane transport 0.1558 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01472 Informative Inherited
Biological Process (BP) circulatory system development 0.426 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1765 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.04429 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1257 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001024 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6395 Informative Inherited
Biological Process (BP) protein oligomerization 0.7846 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1842 Informative Inherited
Biological Process (BP) regulation of secretion 0.7348 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01046 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02441 Informative Inherited
Biological Process (BP) protein transport 0.5022 Informative Inherited
Biological Process (BP) secretion by cell 0.3255 Informative Inherited
Biological Process (BP) cell development 0.004673 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.00266 Informative Inherited
Biological Process (BP) generation of neurons 0.101 Informative Inherited
Biological Process (BP) post-embryonic development 0.0369 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01316 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.332 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.6395 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1016 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002541 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.005117 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03188 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.1028 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.04983 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5181 Informative Inherited
Biological Process (BP) central nervous system development 0.146 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.006884 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6676 Informative Inherited
Biological Process (BP) phosphorylation 0.002902 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4673 Informative Inherited
Biological Process (BP) response to bacterium 0.002773 Informative Inherited
Biological Process (BP) cellular response to lipid 0.5122 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cell death 0.04293 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.05576 Informative Inherited
Biological Process (BP) intracellular transport 0.9147 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.007481 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06529 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.3149 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0009858 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000306 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.000679 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0001941 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.00000000004319 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.0000000005515 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0002252 Highly Informative Direct
Biological Process (BP) sex differentiation 0.000003551 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001272 Highly Informative Direct
Biological Process (BP) protein secretion 0.00008704 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000393 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.000000000005797 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000002433 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000000000008804 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0001265 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0009807 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.000002772 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0000000007368 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0001586 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000002022 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000003604 Highly Informative Direct
Biological Process (BP) neuron development 0.000000001548 Highly Informative Direct
Biological Process (BP) response to axon injury 0.00005843 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.00004259 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0.00004222 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000000003686 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.00006213 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00648 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.02253 Highly Informative Inherited
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.01345 Highly Informative Inherited
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.001051 Highly Informative Inherited
Biological Process (BP) positive regulation of transmembrane transport 0.03901 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.7044 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.001154 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.3904 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.7737 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.02427 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01774 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.01684 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.2972 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.00193 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.3314 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.7511 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.001733 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.01213 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.04 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.007181 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.9163 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.3209 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4827 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.1288 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.4645 Highly Informative Inherited
Biological Process (BP) seed development 0.1146 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 1 Highly Informative Inherited
Biological Process (BP) protein-DNA complex subunit organization 0.08619 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.2855 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.002027 Highly Informative Inherited
Biological Process (BP) regeneration 0.001329 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.04828 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.5499 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.08447 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4064 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.5518 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.0505 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.6482 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1072 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.06137 Highly Informative Inherited
Biological Process (BP) pigmentation 0.08224 Highly Informative Inherited
Biological Process (BP) forebrain development 0.0156 Highly Informative Inherited
Biological Process (BP) antimicrobial humoral response 0.1908 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.009021 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.00805 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.5122 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.3183 Highly Informative Inherited
Biological Process (BP) innate immune response 0.008906 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.3344 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01861 Highly Informative Inherited
Biological Process (BP) protein folding 0.8474 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.9328 Highly Informative Inherited
Biological Process (BP) nuclear export 0.2233 Highly Informative Inherited
Biological Process (BP) heart development 0.05448 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.389 Highly Informative Inherited
Biological Process (BP) response to fungus 0.5355 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.03948 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.007665 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.01898 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000002508 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00008907 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.235 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2925 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.00000002624 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000002235 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.000002383 Informative Direct
Molecular Function (MF) amide binding 0.0000006945 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.9193 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.01239 Informative Inherited
Molecular Function (MF) nuclease activity 0.546 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.009797 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.08996 Informative Inherited
Molecular Function (MF) receptor binding 0.06291 Informative Inherited
Molecular Function (MF) RNA binding 0.1618 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000000002046 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0000001176 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004183 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.00001995 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000007034 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.5578 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.2782 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000002728 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000001004 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000003423 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.004268 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.009757 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.00124 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0000002014 Informative Direct
Cellular Component (CC) cell surface 0.000000000000185 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001956 Informative Direct
Cellular Component (CC) membrane region 0.000000004154 Informative Direct
Cellular Component (CC) vacuolar part 0.02914 Informative Inherited
Cellular Component (CC) lytic vacuole 0.004573 Informative Inherited
Cellular Component (CC) endosome 0.004683 Informative Inherited
Cellular Component (CC) transporter complex 0.1813 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2085 Informative Inherited
Cellular Component (CC) side of membrane 0.9157 Informative Inherited
Cellular Component (CC) neuron projection 0.2547 Informative Inherited
Cellular Component (CC) plasma membrane region 0.3989 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.2547 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.0001426 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.00005803 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.0000009505 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.00004694 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000454 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.000000000000005967 Highly Informative Direct
Cellular Component (CC) growth cone 0.00003273 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0.0003177 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00001457 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000006731 Highly Informative Direct
Cellular Component (CC) symplast 0.000000000001355 Highly Informative Direct
Cellular Component (CC) dendrite 0.09119 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 0.0708 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.1769 Highly Informative Inherited
Cellular Component (CC) external side of plasma membrane 0.1602 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.03392 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000756Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000441InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000003813Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.0000000001091Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processVirulence0.0006254Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.00000000003164InformativeDirect
Biological processWnt signaling pathway0.0003574InformativeDirect
Biological processSensory transduction0.0224InformativeInherited
Biological processBlood coagulation0.00000000002873Highly InformativeDirect
Biological processmRNA transport0.000000001409Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00006721Highly InformativeDirect
Biological processVision0.00009359Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00063Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000001169Moderately InformativeDirect
Cellular componentCytoskeleton0.00000001556Moderately InformativeDirect
Cellular componentCell membrane0.0002154Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000001352InformativeDirect
Cellular componentSpliceosome0.00003415InformativeDirect
Cellular componentSynapse0.00005339InformativeDirect
Cellular componentCell wall0.000000000001988Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
Molecular functionNucleotide-binding0.001419Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationNuclease0.3077Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationExonuclease0.00000000001284InformativeDirect
Post-translational modificationIon channel0.000000001658InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0000000000616Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation0InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0005251Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]