SUPERFAMILY 1.75 HMM library and genome assignments server


BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (2,998) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 15,251 18,591 22
Proteins 11,121 14,935 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0002589 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.804e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7625 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0082 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03371 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 6.933e-10 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 5.843e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.896e-06 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3932 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003773 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01137 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4568 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01579 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3646 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.983 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.002564 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8762 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4869 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03002 Moderately Informative Inherited
Biological Process (BP) organ development 0.37 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.005428 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.631 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07789 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.0008572 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) RNA processing 1.641e-05 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 1.34e-09 Informative Direct
Biological Process (BP) ncRNA metabolic process 2.28e-07 Informative Direct
Biological Process (BP) chromosome organization 1.909e-05 Informative Direct
Biological Process (BP) regulation of cell cycle 9.142e-15 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.1601 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06689 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8552 Informative Inherited
Biological Process (BP) protein localization to organelle 0.06038 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.002706 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.0358 Informative Inherited
Biological Process (BP) epithelium development 0.8977 Informative Inherited
Biological Process (BP) microtubule-based process 0.01717 Informative Inherited
Biological Process (BP) protein complex assembly 0.05747 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.6138 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.01088 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.007499 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1931 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5681 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002322 Informative Inherited
Biological Process (BP) cell activation 0.02353 Informative Inherited
Biological Process (BP) mitochondrion organization 0.7792 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 0.4759 Informative Inherited
Biological Process (BP) regulation of growth 0.5231 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.6754 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.08736 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.5941 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.01865 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.05596 Informative Inherited
Biological Process (BP) central nervous system development 0.001427 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02749 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6416 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.004424 Informative Inherited
Biological Process (BP) cell death 0.2379 Informative Inherited
Biological Process (BP) immune response 0.7259 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.9829 Informative Inherited
Biological Process (BP) organelle localization 0.1813 Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 3.938e-07 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 5.01e-05 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.000116 Highly Informative Direct
Biological Process (BP) double-strand break repair 6.403e-05 Highly Informative Direct
Biological Process (BP) rRNA processing 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.279e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 8.625e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.528e-08 Highly Informative Direct
Biological Process (BP) telencephalon development 6.04e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0006342 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0001632 Highly Informative Direct
Biological Process (BP) B cell activation 1.56e-12 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0002104 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 4.594e-14 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 4.918e-12 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002894 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0003776 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.000842 Highly Informative Direct
Biological Process (BP) stem cell development 0.001786 Highly Informative Inherited
Biological Process (BP) renal system development 0.2878 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.04611 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001031 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.3806 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1781 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.64 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.009804 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2213 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1032 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.3358 Highly Informative Inherited
Biological Process (BP) meiosis 0.0443 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.01018 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.2499 Highly Informative Inherited
Biological Process (BP) cell division 0.01305 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001168 Highly Informative Inherited
Molecular Function (MF) binding 3.611e-07 Least Informative Direct
Molecular Function (MF) anion binding 0.2551 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.6525 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01485 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.01541 Moderately Informative Inherited
Molecular Function (MF) DNA binding 1.116e-06 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1.825e-07 Informative Direct
Molecular Function (MF) lipid binding 0.3885 Informative Inherited
Molecular Function (MF) receptor binding 0.9771 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.004229 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.05077 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0003026 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 5.82e-05 Highly Informative Direct
Molecular Function (MF) transcription factor binding 6.661e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 4.255e-05 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 6.117e-10 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.001598 Highly Informative Inherited
Molecular Function (MF) DNA polymerase activity 0.0972 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 2.924e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0329 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1.435e-05 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.5097 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 2.857e-08 Informative Direct
Cellular Component (CC) chromosome 6.446e-14 Informative Direct
Cellular Component (CC) nucleolus 7.68e-08 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 5.058e-05 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 2.03e-10 Highly Informative Direct
Cellular Component (CC) cell division site part 7.425e-06 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.002627 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.2585 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.6468 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0862Least InformativeInherited
Disease Ontology (DO)genetic disease5.365e-07Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease3.539e-11InformativeDirect
Disease Ontology (DO)breast carcinoma0.02563InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3152Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.0003525InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.009243Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.03851Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06545Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1036Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.002871Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004303Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.04566Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability1.863e-06InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism5.667e-05InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0003856InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.001038InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.001696InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.009483InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.01518InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.05718InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.1748InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2049InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair3.624e-10Highly InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation7.558e-09Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability1.556e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death4.74e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle6.369e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0002095Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blastocyst morphology0.0004395Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.0009563Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.08114Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.0007298Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.009728InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0003561Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive1.004e-05InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5141InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing4.2e-09InformativeDirect
Biological processDNA recombination2.981e-05InformativeDirect
Biological processMeiosis0.0002264InformativeDirect
Biological processDNA synthesis1.929e-09Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor4.603e-07Moderately InformativeDirect
DomainCoiled coil6.625e-12Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationUbl conjugation1.508e-05Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]