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BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,046) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,816 34,129 22
Proteins 12,059 29,023 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000001783 Least Informative Direct
Biological Process (BP) biological regulation 0.0002898 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000000133 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000004461 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000003913 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00001975 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000001355 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.08402 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.8264 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.08918 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3991 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4952 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001429 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9649 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3922 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3196 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.09151 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.54 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02866 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1366 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.106 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1042 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4808 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9547 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9197 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.04247 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 0.1023 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.09159 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003851 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.05856 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell death 0.0004596 Informative Direct
Biological Process (BP) response to radiation 0.000001491 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0002032 Informative Direct
Biological Process (BP) ncRNA processing 0.00000001686 Informative Direct
Biological Process (BP) ribosome biogenesis 0.00000000000005766 Informative Direct
Biological Process (BP) single organism reproductive process 0.00005312 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0005188 Informative Direct
Biological Process (BP) ATP metabolic process 0.0004428 Informative Direct
Biological Process (BP) chromosome organization 0.000002981 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.4666 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.01054 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.3419 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.003837 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.7147 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.006191 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2414 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4986 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.1105 Informative Inherited
Biological Process (BP) actin filament-based process 0.4493 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.07529 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2494 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3679 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002895 Informative Inherited
Biological Process (BP) cell activation 0.003995 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.03771 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1517 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.06296 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1472 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.7233 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.01012 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) immune response 0.7104 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2741 Informative Inherited
Biological Process (BP) regulation of system process 0.2008 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3797 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) generation of neurons 0.4881 Informative Inherited
Biological Process (BP) cell development 0.7492 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.005961 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01862 Informative Inherited
Biological Process (BP) immune effector process 0.02758 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.364 Informative Inherited
Biological Process (BP) embryo development 0.01922 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000004021 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00000002386 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0005659 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00001171 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00000009211 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000003367 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00007093 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000435 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0001742 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0000007757 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.000000006351 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.000001524 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000002935 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00000000002603 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000000000003058 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00001651 Highly Informative Direct
Biological Process (BP) cell division 0.0001968 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0001142 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000003141 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.000002347 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.02844 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.07346 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.005403 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.004041 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.01468 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.004097 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.002323 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.0156 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1002 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.02103 Highly Informative Inherited
Biological Process (BP) neuron development 0.7471 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1196 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.5742 Highly Informative Inherited
Biological Process (BP) germ cell development 0.001258 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1477 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01568 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6716 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.000005107 Least Informative Direct
Molecular Function (MF) binding 0.002295 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.3573 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3602 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.02615 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.7817 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.8793 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0489 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.0004878 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ligase activity 0.00000001096 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.005866 Informative Inherited
Molecular Function (MF) phospholipid binding 0.02224 Informative Inherited
Molecular Function (MF) enzyme binding 0.04368 Informative Inherited
Molecular Function (MF) receptor binding 0.864 Informative Inherited
Molecular Function (MF) phosphatase activity 0.1122 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00000232 Highly Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0.000000001316 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002305 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000592 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000000003586 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000007622 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000015 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.004995 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0.000000000000004679 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001677 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000000003347 Moderately Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.00000006863 Informative Direct
Cellular Component (CC) chromosome 0.0000000000001414 Informative Direct
Cellular Component (CC) cell surface 0.3683 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000000001506 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00001094 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.04397 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.04074 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.0000001913Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.00000000001455InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer0.00000000000009206Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.0003071InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.2989Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.766Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01299Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.0633Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.05427InformativeInherited
Phenotypic Abnormality (PA)Sloping forehead0.00008711Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.001008Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the breast0.003285Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01925Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02329Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06183Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1048Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1309Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0000009566Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0003292Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.004505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004543Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01723Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.03954Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.04273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.04851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.2763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.0000000003493InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0000000005579InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.000001405InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0001962InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0004637InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.002036InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.002729InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.002858InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.02902InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2155InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.000000003024Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0000006461Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00006898Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00007529Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.000171Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.004883Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.3802Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.8536Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2005Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5479Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.01063InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0004353Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive0.00001348Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0004423Least InformativeDirect
Xenopus ANatomical entity (XAN)egg0.00009027Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5305InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Forming phosphoric ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0.00000000004313InformativeDirect
Biological processDNA recombination0.000003954InformativeDirect
Biological processMeiosis0.0006719InformativeDirect
Biological processDNA synthesis0.00000000001624Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor0.0000006963Moderately InformativeDirect
DomainCoiled coil0.00000000001586Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000000007161Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000005362Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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