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BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,049) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 16,988 67,938 22
Proteins 12,160 53,277 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.0000001918Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.00000000001341InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.00000000000009281Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3761Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.003692Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.009269Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.03839Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.07354Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.006375InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.006525InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.01999InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.04671InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.07921InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1419InformativeInherited
Phenotypic Abnormality (PA)Ovarian neoplasm0.00003932Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal breast morphology0.004978Highly InformativeInherited
Phenotypic Abnormality (PA)Slanting of the palpebral fissure0.01419Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.019Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02318Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06156Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.104Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1305Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0000008961Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0003226Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.004508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004512Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.017Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.03985Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.04286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.04858Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.2755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.0000000003225InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0000000005632InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.000001343InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0002035InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0004561InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.002012InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.002741InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.002861InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.02923InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2156InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.3477InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.000000003048Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0000006229Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00006902Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00007644Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001716Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.004892Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.3904Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.919Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2051Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5782Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.01063InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.000435Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive0.0002573Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0004956InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5253InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Forming phosphoric ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]