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BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,042) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,652 34,129 22
Proteins 11,964 29,023 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000007247 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000000005881 Least Informative Direct
Biological Process (BP) biological regulation 0.0001142 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stress 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000001937 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000005782 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000007242 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.00005661 Moderately Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.01516 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.01538 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8769 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1374 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5757 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07348 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6624 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01949 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.6028 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.07116 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.3167 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1107 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.003377 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4902 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001169 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2499 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8114 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.0747 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.01629 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3871 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.07407 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.05953 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) system development 0.1053 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.000000004771 Informative Direct
Biological Process (BP) ncRNA processing 0.00000001516 Informative Direct
Biological Process (BP) response to radiation 0.000001247 Informative Direct
Biological Process (BP) single organism reproductive process 0.00001456 Informative Direct
Biological Process (BP) organelle fission 0.00001799 Informative Direct
Biological Process (BP) cell death 0.0002314 Informative Direct
Biological Process (BP) ATP metabolic process 0.0003476 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0005613 Informative Direct
Biological Process (BP) regulation of protein localization 0.000709 Informative Direct
Biological Process (BP) regulation of organelle organization 0.2547 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6387 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1428 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.4923 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.007466 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 0.4591 Informative Inherited
Biological Process (BP) microtubule-based process 0.08215 Informative Inherited
Biological Process (BP) organelle assembly 0.9807 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1251 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001115 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.6285 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.01067 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02431 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2218 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.399 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00142 Informative Inherited
Biological Process (BP) actin filament-based process 0.4285 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1295 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.09463 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.06142 Informative Inherited
Biological Process (BP) embryo development 0.01731 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0268 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2194 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.03589 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1055 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.03495 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5699 Informative Inherited
Biological Process (BP) regulation of system process 0.1537 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3937 Informative Inherited
Biological Process (BP) generation of neurons 0.8918 Informative Inherited
Biological Process (BP) cell development 0.7361 Informative Inherited
Biological Process (BP) immune response 0.4378 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00000000002512 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0.0000000005856 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.000000002551 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.000000002579 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000002945 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00000002181 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.00000003606 Highly Informative Direct
Biological Process (BP) chromosome organization 0.000001974 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000002184 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000893 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.000009202 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.00001084 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.00001089 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00004116 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00006915 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00007325 Highly Informative Direct
Biological Process (BP) cell division 0.0001633 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000371 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000559 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0007426 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.2088 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.01874 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.006251 Highly Informative Inherited
Biological Process (BP) germ cell development 0.001179 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1772 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.002933 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.06852 Highly Informative Inherited
Biological Process (BP) gastrulation 0.0149 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.005514 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.06068 Highly Informative Inherited
Biological Process (BP) cell migration 0.3909 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.09249 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1591 Highly Informative Inherited
Biological Process (BP) neuron development 0.734 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.7968 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.004852 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.04483 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6795 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003817 Highly Informative Inherited
Molecular Function (MF) binding 0.0003904 Least Informative Direct
Molecular Function (MF) transferase activity 0.0005759 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.0000006261 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4277 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.01891 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.911 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.8697 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.02009 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.00000000000094 Informative Direct
Molecular Function (MF) ligase activity 0.00000002578 Informative Direct
Molecular Function (MF) DNA binding 0.0006094 Informative Direct
Molecular Function (MF) phospholipid binding 0.01949 Informative Inherited
Molecular Function (MF) enzyme binding 0.06629 Informative Inherited
Molecular Function (MF) receptor binding 0.8526 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.09172 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.2631 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.2312 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0000004293 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000004326 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000001971 Highly Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0.000008068 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0001071 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001885 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002134 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0006604 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.004889 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000000000001578 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000856 Least Informative Direct
Cellular Component (CC) protein complex 0.3923 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.00000001119 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000000632 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0001759 Informative Direct
Cellular Component (CC) cell surface 0.3453 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00000000000675 Highly Informative Direct
Cellular Component (CC) nucleolus 0.00002136 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.0001623 Highly Informative Direct
Cellular Component (CC) cell division site 0.0002597 Highly Informative Direct
Cellular Component (CC) chromatin 0.0003004 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.00000008602Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.000000000005184InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer0.00000000000002876Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.0003234InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2206Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2976Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01298Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.08454Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.2169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.05452InformativeInherited
Phenotypic Abnormality (PA)Sloping forehead0.00009011Highly InformativeDirect
Phenotypic Abnormality (PA)Attention deficit hyperactivity disorder0.0001179Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.02377Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02667Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05307Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1067Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1262Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.000001033Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0003685Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.006404Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.03959Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.04564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.04916Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.2751Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3048Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0000000006595InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0002074InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0005176InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.002084InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.002973InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.003006InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.02853InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2156InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.2361InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.0000000003612Highly InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.000000003436Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0000007432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00007234Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00007256Highly InformativeDirect
Mammalian Phenotype (MP)microcephaly0.0001016Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001846Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.004963Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.3294Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.8208Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.1565Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5082Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0106InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0003634Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive0.00001219Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0004324Least InformativeDirect
Xenopus ANatomical entity (XAN)egg0.0000933Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.0005939InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.4861InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Forming phosphoric ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0.0000000009903InformativeDirect
Biological processDNA recombination0.000004183InformativeDirect
Biological processMeiosis0.0005932InformativeDirect
Biological processDNA synthesis0.00000000001698Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor0.0000006138Moderately InformativeDirect
DomainCoiled coil0.00000000001469Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000000007816Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000003168Moderately InformativeDirect
Post-translational modificationADP-ribosylation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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