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BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,049) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 16,988 54,599 22
Proteins 12,160 42,265 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000004577 Least Informative Direct
Biological Process (BP) biological regulation 0.0002837 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000003947 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8826 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000007773 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000001664 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0008292 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000008051 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000001967 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.09351 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9033 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4861 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1689 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4267 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3957 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.8383 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3994 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.03232 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3458 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1192 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4186 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1083 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.06092 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.908 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.05036 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9935 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.05439 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2797 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4771 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002916 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07945 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell death 0.0001544 Informative Direct
Biological Process (BP) response to radiation 0.000001654 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0004245 Informative Direct
Biological Process (BP) ncRNA processing 0.00000001303 Informative Direct
Biological Process (BP) ribosome biogenesis 0.00000000000007621 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002898 Informative Direct
Biological Process (BP) ATP metabolic process 0.0004466 Informative Direct
Biological Process (BP) chromosome organization 0.000001426 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.4539 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.01275 Informative Inherited
Biological Process (BP) regulation of protein localization 0.001459 Informative Inherited
Biological Process (BP) epithelium development 0.4155 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.593 Informative Inherited
Biological Process (BP) microtubule-based process 0.3703 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.002124 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.007635 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2101 Informative Inherited
Biological Process (BP) cell activation 0.004054 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5178 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.06557 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.2667 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2473 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3649 Informative Inherited
Biological Process (BP) localization of cell 0.6494 Informative Inherited
Biological Process (BP) embryo development 0.02943 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0452 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1486 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1707 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8006 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.01321 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.007226 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.003586 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2743 Informative Inherited
Biological Process (BP) regulation of system process 0.1181 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4715 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) generation of neurons 0.4622 Informative Inherited
Biological Process (BP) cell development 0.8444 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4327 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.009242 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001025 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1154 Informative Inherited
Biological Process (BP) immune effector process 0.02723 Informative Inherited
Biological Process (BP) immune response 0.7287 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000004843 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0001682 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0000000342 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0007251 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00001568 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000001188 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000003438 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00007172 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0004749 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0001817 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0000008322 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.00000001011 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.000001658 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000003094 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00003798 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0000000000675 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000000502 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00001242 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0001204 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000002785 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.0000005455 Highly Informative Direct
Biological Process (BP) cytokinesis 0.2876 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2234 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.02918 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.007325 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.07014 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.005978 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.02716 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.006403 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.003522 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.002308 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1148 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.03156 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.05314 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.6515 Highly Informative Inherited
Biological Process (BP) neuron development 0.7496 Highly Informative Inherited
Biological Process (BP) germ cell development 0.00177 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1494 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.01882 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01933 Highly Informative Inherited
Molecular Function (MF) binding 0.0003646 Least Informative Direct
Molecular Function (MF) transferase activity 0.000008995 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.3808 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3643 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.0304 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8044 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.883 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.04701 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.0004336 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.000000000000001615 Informative Direct
Molecular Function (MF) ligase activity 0.000000002454 Informative Direct
Molecular Function (MF) enzyme binding 0.0001312 Informative Direct
Molecular Function (MF) phospholipid binding 0.02617 Informative Inherited
Molecular Function (MF) receptor binding 0.9197 Informative Inherited
Molecular Function (MF) phosphatase activity 0.1201 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.006123 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0000000002498 Highly Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0.000000001385 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002639 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0001693 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000000004009 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000007429 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00001922 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.0004556 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.005376 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000007611 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.4796 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.00797 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000007482 Informative Direct
Cellular Component (CC) chromosome 0.00000000000008706 Informative Direct
Cellular Component (CC) cell surface 0.4252 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000000001646 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00001706 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.05148 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.0291 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processrRNA processing0.00000000003906InformativeDirect
Biological processDNA repair0.0000000003079InformativeDirect
Biological processDNA recombination0.000003766InformativeDirect
Biological processMeiosis0.0007044InformativeDirect
Biological processDNA synthesis0.00000000001572Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor0.0000006666Moderately InformativeDirect
DomainCoiled coil0.00000000001585Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000000006378Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000005315Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]