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Caspase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Caspase-like [ 52128]
Superfamily:   Caspase-like [ 52129] (2)
Families:   Caspase catalytic domain [ 52130] (7)
  Gingipain R (RgpB), N-terminal domain [ 52137]


Superfamily statistics
Genomes (975) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,641 19,385 38
Proteins 4,558 19,152 38


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000016960.000002049Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000078320.000000000000001925Least InformativeDirect
Biological Process (BP)response to stimulus0.000034840.0007246Least InformativeDirect
Biological Process (BP)biological regulation0.000093520.00008367Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00020510.0000002561Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00000000061650.01365Least InformativeInherited
Biological Process (BP)primary metabolic process0.0057310.01395Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.014330.8042Least InformativeInherited
Biological Process (BP)cell differentiation0.000000000066650.00000093Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000023820Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00013210.0000000000025Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.016750.00000000003451Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.05870.7383Moderately InformativeInherited
Biological Process (BP)single organism signaling0.19820.337Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.033770.0008363Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0001590.01496Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00040710.09849Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0077450.1675Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.020541Moderately InformativeInherited
Biological Process (BP)cell communication0.18030.2765Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0011350.00001156Moderately InformativeInherited
Biological Process (BP)animal organ development0.54090.05767Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)cell death00InformativeDirect
Biological Process (BP)intracellular signal transduction0.000032390.0001464InformativeDirect
Biological Process (BP)generation of neurons0.000000088230.0007475InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.000025470.00002305InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.055630.0000001209InformativeInherited
Biological Process (BP)cellular response to lipid0.012090.01132InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.039550.05971InformativeInherited
Biological Process (BP)regulation of proteolysis0.0072860InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.016630.0002387InformativeInherited
Biological Process (BP)regulation of cell differentiation0.00052160.02699InformativeInherited
Biological Process (BP)regulation of nervous system development0.005530.05829InformativeInherited
Biological Process (BP)response to nitrogen compound0.019420.05876InformativeInherited
Biological Process (BP)regulation of apoptotic process00.9121InformativeInherited
Biological Process (BP)response to acid chemical0.00020790.0151InformativeInherited
Biological Process (BP)regulation of growth0.0002090.04495InformativeInherited
Biological Process (BP)regulation of cell growth0.0000000011010.00001907Highly InformativeDirect
Biological Process (BP)apoptotic process0.00095060.00000005917Highly InformativeDirect
Biological Process (BP)regulation of cell size0.0000000000057120.00000001678Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.00000000037070.0000008611Highly InformativeDirect
Biological Process (BP)response to retinoic acid0.0000000060320.00001454Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0000057370.0000000000009251Highly InformativeDirect
Biological Process (BP)response to antibiotic0.0000000070560.00000000003874Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity0.0000000048550Highly InformativeDirect
Biological Process (BP)cellular response to acid chemical0.000077730.001979Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.00016230.005244Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0000097050.001563Highly InformativeInherited
Biological Process (BP)camera-type eye development0.000017080.04369Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.20060.307Least InformativeInherited
Molecular Function (MF)molecular function regulator0.00074580.00009057Moderately InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides10.6721InformativeInherited
Molecular Function (MF)enzyme binding0.023120.0003262InformativeInherited
Molecular Function (MF)protease binding0.00000014730.00000005881Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase activity0.00000002560Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00067450.0000003663Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000002049 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000001925 Least Informative Direct
Biological Process (BP) response to stimulus 0.0007246 Least Informative Direct
Biological Process (BP) biological regulation 0.00008367 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000002561 Least Informative Direct
Biological Process (BP) primary metabolic process 0.01395 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.01365 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8042 Least Informative Inherited
Biological Process (BP) response to organic substance 0.00001156 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000093 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000000025 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000016 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000000003451 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0008363 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.7383 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.337 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01496 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01431 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1675 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7078 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9111 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7705 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2765 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.09849 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3859 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2796 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.05767 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0002387 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000007637 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001464 Informative Direct
Biological Process (BP) generation of neurons 0.0007475 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000001209 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002305 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.603 Informative Inherited
Biological Process (BP) cellular response to lipid 0.01132 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.05971 Informative Inherited
Biological Process (BP) post-embryonic development 0.3482 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02699 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.05829 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.9121 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.05876 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.7958 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.004455 Informative Inherited
Biological Process (BP) response to acid chemical 0.0151 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01392 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.05595 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7406 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.3818 Informative Inherited
Biological Process (BP) regulation of growth 0.04495 Informative Inherited
Biological Process (BP) regulation of cell growth 0.00001907 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00000005917 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000001678 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0005149 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000008611 Highly Informative Direct
Biological Process (BP) viral process 0.000002842 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.000002052 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0.00000000000001422 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00001454 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0000000000009251 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00001319 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.00000000003874 Highly Informative Direct
Biological Process (BP) protein maturation 0.00000000002784 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0007529 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.001979 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.005244 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001563 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.01169 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.02549 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.04369 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.307 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.00009057 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.0003262 Informative Direct
Molecular Function (MF) enzyme activator activity 0.01632 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.001046 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.6721 Informative Inherited
Molecular Function (MF) protease binding 0.00000005881 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000002223 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000003663 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0005713 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.9724 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.1018 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.00004966 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processVirulence0.000001202Moderately InformativeDirect
Biological processImmunity0.0003995Moderately InformativeDirect
Biological processInnate immunity0.000002306InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Caspase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Caspase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]