SUPERFAMILY 1.75 HMM library and genome assignments server

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Caspase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Caspase-like [ 52128]
Superfamily:   Caspase-like [ 52129] (2)
Families:   Caspase catalytic domain [ 52130] (7)
  Gingipain R (RgpB), N-terminal domain [ 52137]


Superfamily statistics
Genomes (975) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,641 26,093 38
Proteins 4,558 25,794 38


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.06374Moderately InformativeInherited
Disease Ontology (DO)melanoma0.0009195Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Lymphadenopathy0.00007416Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.002001Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.003649Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01047Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01069Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1014Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8569Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.000001171Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00002718Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.02524Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.03552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.05217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08893Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1831Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.5134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.00000003597InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.00001882InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.001686InformativeInherited
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.002806InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.004548InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.006485InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.01057InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0549InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.1214InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.2153InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.5517InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.000001073Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.000004522Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.000005872Highly InformativeDirect
Mammalian Phenotype (MP)decreased physiological sensitivity to xenobiotic0.00004265Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001393Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0001404Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage apoptosis0.0004392Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0.000446Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen marginal zone morphology0.0009605Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.01225Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.03061Least InformativeInherited
Worm Phenotype (WP)somatic cell death variant0.00000000002795Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.00006024Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.06419Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3549Least InformativeInherited
Fly Anatomy (FA)neuron0.04381Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.07282Moderately InformativeInherited
Fly Anatomy (FA)gland0.0002259InformativeDirect
Fly Anatomy (FA)male organism0.0003057InformativeDirect
Fly Anatomy (FA)germline cell0.01638InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.000001909Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Caspase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Caspase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]