SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,963) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,114 73,264 4
Proteins 20,710 70,062 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.093620Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000052880Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.069830.7002Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.12621Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.000081030.000000107InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.011760.0000005965InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.0097340.01211Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0053230Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00000087870Moderately InformativeDirect
Molecular Function (MF)lipase activity6.761e-160Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000097150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.006297 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000000136 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000004258 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000000003813 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.1672 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.684 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1754 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7002 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.865 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.775 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7943 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3075 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7459 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.00003333 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0009574 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000000000000001938 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00001046 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000000000001078 Informative Direct
Biological Process (BP) lipid localization 0.0004459 Informative Direct
Biological Process (BP) lipid catabolic process 0.000000107 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000000000721 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00001201 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000005965 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.00000005238 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000000002793 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00009867 Informative Direct
Biological Process (BP) apoptotic process 0.2314 Informative Inherited
Biological Process (BP) peptide metabolic process 0.0212 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.006765 Informative Inherited
Biological Process (BP) anion transport 0.1816 Informative Inherited
Biological Process (BP) organic acid transport 0.007709 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.6242 Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.00003399 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001598 Highly Informative Direct
Biological Process (BP) pathogenesis 0.000002596 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.0000002254 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000007595 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000000000000007347 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.000000000000001938 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.00003656 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.00000316 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001183 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000001612 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000038 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.04253 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.003429 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.01211 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.8302 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7759 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.1184 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.672 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5579 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003063 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000004715 Informative Direct
Molecular Function (MF) lipid binding 0.03597 Informative Inherited
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001017 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0000006576 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.4591 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.07635 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.187 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00001598 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0001464 Moderately Informative Direct
Cellular Component (CC) cytosol 0.1061 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1268 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000007724 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000001687 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000002604Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000002991InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000008493InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000000000003708Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.00003178Moderately InformativeDirect
Disease Ontology (DO)overnutrition0.000002228InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0004145InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01151Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2842Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000004236InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.006077InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000004016Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.00000000006893Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.000000002347InformativeDirect
Biological processSporulation0.00003359InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processLipid degradation0Highly InformativeDirect
Biological processAntibiotic biosynthesis0.00000000000007897Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002308Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.000001504InformativeDirect
Cellular componentLipid droplet0.000000000000006951Highly InformativeDirect
DomainTransmembrane0.00000005481Least InformativeDirect
DomainCoiled coil0.000006241Moderately InformativeDirect
Molecular functionCalcium0.0000005389Moderately InformativeDirect
Molecular functionNADP9.203e-16InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.000001112Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001712Least InformativeDirect
Post-translational modificationGlycoprotein0.0005356Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.00000000000003698Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.000003359Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.08631Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis4.527e-16InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000003819InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000000008326InformativeDirect
UniPathway (UP)glycerol metabolism0.00000008179InformativeDirect
UniPathway (UP)glycerolipid degradation0Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000000000001036Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis0.00001825Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.00012Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]