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FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,970) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 22,204 110,240 4
Proteins 20,794 102,229 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.34730.2228Least InformativeInherited
Biological Process (BP)primary metabolic process0.45781Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.1410Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000017250Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00039670Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.058790.2734Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.031081Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.10290.242Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.0010210.000000171InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.015880.00000001768InformativeInherited
Biological Process (BP)glycerolipid catabolic process0.000000010190.00000000001469Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.00017010.000000000001604Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0000000014580Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000052440InformativeDirect
Molecular Function (MF)lipase activity0.0000000034070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.002628 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2228 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000002149 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.06765 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3862 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2213 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8584 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.242 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2734 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.000005523 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00000000002587 Informative Direct
Biological Process (BP) lipid catabolic process 0.000000171 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00006095 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000009067 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000001768 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000000000000003734 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000006151 Informative Direct
Biological Process (BP) alcohol metabolic process 0.2975 Informative Inherited
Biological Process (BP) cell death 0.01232 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.001837 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1205 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.004083 Informative Inherited
Biological Process (BP) phospholipid catabolic process 0.00001062 Highly Informative Direct
Biological Process (BP) pathogenesis 0.00001353 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000001088 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000000000000001925 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0000234 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0001309 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00001195 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0003333 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0.00000000001469 Highly Informative Direct
Biological Process (BP) lactone biosynthetic process 0.0000000000001694 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00002123 Highly Informative Direct
Biological Process (BP) apoptotic process 0.04582 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.008584 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.05798 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000000001604 Least Informative Direct
Molecular Function (MF) transferase activity 0.4209 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.4009 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8713 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.003021 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0004375 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) amide binding 0.0005729 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.007436 Informative Inherited
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.0000004528 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000009708 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.001921 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.01208 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.621 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.926 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.1726 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.03174 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000004016 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000003867 Informative Direct
Cellular Component (CC) lipid droplet 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000002604Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000002991InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000008493InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000000000003708Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.00000001614InformativeDirect
Biological processSporulation0.00009422InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentMembrane0.0000000000003117Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000004766Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.00002233InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransmembrane0.000005723Least InformativeDirect
DomainCoiled coil0.00004543Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionCalcium0.00004727Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase0.00005881Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]