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FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,965) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,123 73,264 4
Proteins 20,719 70,062 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.42271Least InformativeInherited
Biological Process (BP)single-organism cellular process0.44551Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.13090Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000015190Moderately InformativeDirect
Molecular Function (MF)hydrolase activity0.00057960.0000000000005377Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.000000012960Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.00000096210Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.004004 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9576 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000000001409 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000002812 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.969 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8392 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4002 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0001046 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00000001028 Informative Direct
Biological Process (BP) drug metabolic process 0.000001268 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00003696 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000001606 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0000000000001647 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00008461 Informative Direct
Biological Process (BP) lipid catabolic process 0.001292 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.004688 Informative Inherited
Biological Process (BP) cell death 0.002677 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.8856 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.004453 Informative Inherited
Biological Process (BP) pathogenesis 0.00004489 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.0000002372 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000001032 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000006445 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00009266 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000000000000007239 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000421 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0.0000004365 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.0003382 Highly Informative Direct
Biological Process (BP) ammonium ion metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.07958 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.2274 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01411 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.1098 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000000005377 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.5931 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01014 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.3265 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8519 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) amide binding 0.0003523 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.007635 Informative Inherited
Molecular Function (MF) phospholipid binding 0.003114 Informative Inherited
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000009996 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.002357 Highly Informative Inherited
Molecular Function (MF) phospholipase activity 0.008686 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.01271 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4721 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00002489 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.03752 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000002143 Informative Direct
Cellular Component (CC) lipid particle 0.000000000001013 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00000006458 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000002604Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000002991InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000008493InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000000000003708Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.00003222Moderately InformativeDirect
Disease Ontology (DO)overnutrition0.000002036InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0004431InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01899Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2521Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000000009638InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.01012InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000004487Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.0000000001118Highly InformativeDirect
Enzyme Commission (EC)10-deoxymethynolide syntase0.000000005742Highly InformativeDirect
Enzyme Commission (EC)Narbonolide synthase0.000000005742Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.0000001714Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.00000001339InformativeDirect
Biological processSporulation0.00008654InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentMembrane0.00000000000000957Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000001612Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.00001069InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransmembrane0.000001267Least InformativeDirect
DomainCoiled coil0.00002558Moderately InformativeDirect
Molecular functionCalcium0.00002106Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.00000000000002961Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.000001787Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.1121Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000000004056InformativeDirect
UniPathway (UP)glycerol metabolism0.0000000213InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000002316InformativeDirect
UniPathway (UP)glycerolipid degradation0Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis9.126e-16Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis0.00005313Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0001571Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]