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FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,969) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,193 73,264 4
Proteins 20,783 70,062 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.36050.2779Least InformativeInherited
Biological Process (BP)primary metabolic process0.48131Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.15650Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000020570Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.0004660Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.064290.363Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.1130.3243Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.032711Moderately InformativeInherited
Biological Process (BP)cellular lipid catabolic process0.00069720.000001399InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.014840.00000001465InformativeInherited
Biological Process (BP)glycerolipid catabolic process0.000000011770.0000000003222Highly InformativeDirect
Biological Process (BP)neutral lipid metabolic process0.0030720.000009743Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00019690.000000000001467Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0000000016460Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000047460Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.002286 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2779 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000007291 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2279 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.363 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3243 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.345 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8192 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05376 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.000004572 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000000005067 Informative Direct
Biological Process (BP) drug metabolic process 0.0000009664 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00005394 Informative Direct
Biological Process (BP) cellular lipid catabolic process 0.000001399 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00001945 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000001465 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000000000006948 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000000001439 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.00002044 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000000345 Informative Direct
Biological Process (BP) cell death 0.008917 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.249 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.001739 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.2002 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.003349 Informative Inherited
Biological Process (BP) neutral lipid metabolic process 0.000009743 Highly Informative Direct
Biological Process (BP) phospholipid catabolic process 0.0001227 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0000422 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000009509 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000000000000001945 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.00002392 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0001077 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00001141 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0003895 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0.0000000003222 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00001936 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.005523 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.04873 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000000001467 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.4515 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.3904 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8466 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.002575 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0003585 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) amide binding 0.0003592 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.007336 Informative Inherited
Molecular Function (MF) vitamin binding 0.0000003809 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000000009261 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.001957 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) phospholipase activity 0.006257 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.01115 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6473 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00003921 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.03245 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000004036 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000001787 Informative Direct
Cellular Component (CC) lipid particle 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000002604Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000002991InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000008493InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000000000003708Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.00003222Moderately InformativeDirect
Disease Ontology (DO)overnutrition0.000002102InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0004242InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.03961Least InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.001737Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01755Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2438Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000000851InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001408InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.009308InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000004165Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.0000000001133Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.0000001644Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.00000001464InformativeDirect
Biological processSporulation0.00008483InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Cellular componentMembrane0.00000000000002788Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000002913Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.00001712InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransmembrane0.000003572Least InformativeDirect
DomainCoiled coil0.00003895Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionCalcium0.00002659Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase0.0001866Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.00000000000002866Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.000001919Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.1113Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000000000004071InformativeDirect
UniPathway (UP)glycerol metabolism0.00000002275InformativeDirect
UniPathway (UP)polyketide biosynthesis0.000001065InformativeDirect
UniPathway (UP)glycerolipid degradation0Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis9.148e-16Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis0.00005312Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0001572Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]