SUPERFAMILY 1.75 HMM library and genome assignments server


Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (764) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,854 13,980 4
Proteins 8,488 13,589 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.005625 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9156 Least Informative Inherited
Biological Process (BP) developmental process 0.9699 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.102 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.179e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 4.852e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 3.042e-07 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.142e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001813 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0007407 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8633 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004284 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01087 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4517 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4854 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of response to stress 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 1.219e-12 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 8.883e-12 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 5.489e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.724e-09 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 1.446e-07 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.304e-06 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.452e-05 Informative Direct
Biological Process (BP) regulation of kinase activity 0.2121 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4366 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.003389 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.6817 Informative Inherited
Biological Process (BP) regulation of secretion 0.1519 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7941 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5775 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.07323 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3301 Informative Inherited
Biological Process (BP) regulation of growth 0.03916 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.5595 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3146 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to lipid 0.001027 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8498 Informative Inherited
Biological Process (BP) regulation of locomotion 0.8931 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.008317 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.05423 Informative Inherited
Biological Process (BP) immune effector process 0.2161 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02256 Informative Inherited
Biological Process (BP) generation of neurons 0.06723 Informative Inherited
Biological Process (BP) regulation of cell development 0.1925 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.07017 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) phosphorylation 0.5275 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9514 Informative Inherited
Biological Process (BP) leukocyte activation 0.4211 Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 9.067e-15 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 1.596e-14 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.926e-12 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.061e-11 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 2.614e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 6.102e-11 Highly Informative Direct
Biological Process (BP) negative regulation of growth 6.351e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 8.961e-09 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 3.024e-07 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 7.208e-07 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 2.735e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 3.113e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 3.947e-06 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 3.048e-05 Highly Informative Direct
Biological Process (BP) defense response to bacterium 3.797e-05 Highly Informative Direct
Biological Process (BP) gonad development 4.615e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 5.042e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0005074 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0006168 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.02362 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.2669 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.003857 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.02654 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.04345 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001115 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.002774 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.09369 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.006589 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.05096 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.04455 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.2783 Highly Informative Inherited
Biological Process (BP) response to fungus 0.3143 Highly Informative Inherited
Biological Process (BP) innate immune response 0.06159 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.2715 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4066 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.8992 Highly Informative Inherited
Molecular Function (MF) binding 4.334e-12 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.001883 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 1.621e-10 Informative Direct
Molecular Function (MF) amide binding 2.226e-10 Informative Direct
Molecular Function (MF) RNA binding 3.132e-09 Informative Direct
Molecular Function (MF) receptor binding 2.227e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 0.01889 Informative Inherited
Molecular Function (MF) enzyme binding 0.06454 Informative Inherited
Molecular Function (MF) peptide binding 2.822e-14 Highly Informative Direct
Molecular Function (MF) kinase binding 2.762e-07 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.794e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.244 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.008954 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 1.366e-10 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.243e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.09623 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5994 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.06349 Moderately Informative Inherited
Cellular Component (CC) endosome 4.637e-13 Informative Direct
Cellular Component (CC) cell surface 1.177e-10 Informative Direct
Cellular Component (CC) integral to membrane 4.64e-06 Informative Direct
Cellular Component (CC) lytic vacuole 0.02744 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 4.177e-10 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 3.079e-08 Highly Informative Direct
Cellular Component (CC) lysosome 3.644e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1228Least InformativeInherited
Disease Ontology (DO)lung disease2.916e-10Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.01697Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02033Moderately InformativeInherited
Disease Ontology (DO)asthma4.544e-12InformativeDirect
Disease Ontology (DO)opportunistic mycosis2.034e-08InformativeDirect
Disease Ontology (DO)malaria3.461e-06InformativeDirect
Disease Ontology (DO)liver disease0.0008247InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009082InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.0233InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03633InformativeInherited
Disease Ontology (DO)muscular disease0.2606InformativeInherited
Disease Ontology (DO)aspergillosis1.609e-10Highly InformativeDirect
Disease Ontology (DO)filariasis9.352e-10Highly InformativeDirect
Disease Ontology (DO)dermatomyositis5.61e-05Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0006615Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype1.064e-08Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2274Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2694Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3075Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7317Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7817Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection1.894e-09Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology8.799e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level1.811e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.002445Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.01093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.01442Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.03011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.04632Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.05399Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1938Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.2715Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5144Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection1.501e-10InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001864InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002087InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0004997InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.00111InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001829InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.001977InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01689InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.02994InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04184InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06821InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.08025InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.08305InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1345InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.1859InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1902InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.196InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2024InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2977InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3527InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3944InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4643InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5806InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6764InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8086InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion1.443e-14Highly InformativeDirect
Mammalian Phenotype (MP)colitis2.939e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion6.262e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level9.884e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.000257Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0002775Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0003503Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003503Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003609Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0004327Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0005252Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.00309Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003749Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.006508Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.062Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.09698Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.1034Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.298Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.3169Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense1.804e-09InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.277e-15Moderately InformativeDirect
Cellular componentEndoplasmic reticulum3.561e-09Moderately InformativeDirect
Cellular componentCell projection1.437e-06Moderately InformativeDirect
Cellular componentLysosome1.249e-10InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]