SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (779) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,677 25,890 4
Proteins 9,253 25,118 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00032060Least InformativeDirect
Biological Process (BP)response to stimulus0.023620Least InformativeInherited
Biological Process (BP)immune system process0.00000057220Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.0016950Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0015730Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.01220Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0026710Moderately InformativeInherited
Biological Process (BP)positive regulation of immune response0.00000000026030InformativeDirect
Biological Process (BP)response to bacterium0.000023970.00000001055InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000003743 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000003906 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000002338 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00002167 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00004352 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001076 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0001734 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0005313 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.9275 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.05676 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5201 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.01304 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.09906 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1037 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6084 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1454 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.004908 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 0.2508 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1582 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune response 0 Informative Direct
Biological Process (BP) response to bacterium 0.00000001055 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000001761 Informative Direct
Biological Process (BP) secretion by cell 0.00000000005351 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000002789 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001886 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000004703 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00001486 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0004183 Informative Direct
Biological Process (BP) negative regulation of transport 0.00271 Informative Inherited
Biological Process (BP) regulation of secretion 0.07375 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.3416 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.002536 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2125 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.006213 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9884 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008984 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1623 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.05147 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9433 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.155 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.007801 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4335 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1349 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1431 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cell development 0.2578 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.9494 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5696 Informative Inherited
Biological Process (BP) defense response to other organism 0.001582 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.3288 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4689 Informative Inherited
Biological Process (BP) reproductive system development 0.1148 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) central nervous system development 0.03166 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0767 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.6987 Informative Inherited
Biological Process (BP) locomotion 0.7589 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) phosphorylation 0.3623 Informative Inherited
Biological Process (BP) growth 0.4225 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.252 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01032 Informative Inherited
Biological Process (BP) behavior 0.1304 Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) protein secretion 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.0000000000001027 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.0000000000008142 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.000000177 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.000001775 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.000007348 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.00003213 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.00006011 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00008382 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0001008 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0001928 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0002626 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0006112 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0007532 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0007536 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.001731 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.0293 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.176 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.4535 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1994 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.003385 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1221 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.7402 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.2439 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8484 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3212 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.02168 Highly Informative Inherited
Biological Process (BP) antimicrobial humoral response 0.07257 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.2243 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.02814 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.1202 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.03736 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.9903 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.003384 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.04474 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1541 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000597 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0009438 Moderately Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.00000003785 Informative Direct
Molecular Function (MF) receptor binding 0.000001314 Informative Direct
Molecular Function (MF) amide binding 0.0002856 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.2763 Informative Inherited
Molecular Function (MF) peptide binding 0.000002408 Highly Informative Direct
Molecular Function (MF) kinase binding 0.000008436 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.1198 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.1531 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0001567 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01318 Least Informative Inherited
Cellular Component (CC) whole membrane 0.00000002525 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000002758 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00002345 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0009706 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) membrane region 0.0000000000000193 Informative Direct
Cellular Component (CC) cell surface 0.000000003644 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0002416 Informative Direct
Cellular Component (CC) endosome 0.002194 Informative Inherited
Cellular Component (CC) lytic vacuole 0.01183 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0004673 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.9135Least InformativeInherited
Disease Ontology (DO)organ system cancer0.9728Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000005375Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.004875Moderately InformativeInherited
Disease Ontology (DO)skin disease0.005432Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01946Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1788Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.3308Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.6482Moderately InformativeInherited
Disease Ontology (DO)asthma0.000000000003094InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000008932InformativeDirect
Disease Ontology (DO)liver disease0.00007119InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0002358InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0005748InformativeDirect
Disease Ontology (DO)muscle tissue disease0.005925InformativeInherited
Disease Ontology (DO)lymphoma0.01465InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.01711InformativeInherited
Disease Ontology (DO)interstitial lung disease0.2196InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.4446InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.00000000001399Highly InformativeDirect
Disease Ontology (DO)filariasis0.00000000002214Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.000002715Highly InformativeDirect
Disease Ontology (DO)Chagas disease0.00000539Highly InformativeDirect
Disease Ontology (DO)mycosis fungoides0.0000538Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00007574Highly InformativeDirect
Disease Ontology (DO)meningitis0.00009344Highly InformativeDirect
Disease Ontology (DO)atopic dermatitis0.0006317Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0006405Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000006258Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000002681Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.3229Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3319Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4386Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6216Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7265Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000058Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00002007Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00005585Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.00342Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.005369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.03067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.06456Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1351Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2497Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.4599Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.72Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.00000000007136InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.00003254InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001872InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001939InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002651InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0007679InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.001932InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.02498InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03155InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.03864InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.1167InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1313InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1813InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1932InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1952InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2911InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3988InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.4605InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4649InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6524InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.7554InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8067InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.9199InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.9724InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0Highly InformativeDirect
Mammalian Phenotype (MP)decreased macrophage cytokine production0.00000000006922Highly InformativeDirect
Mammalian Phenotype (MP)decreased immunoglobulin level0.000000001144Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000004626Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.00003696Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0002296Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0003104Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.000334Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003486Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0004928Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0005291Highly InformativeDirect
Mammalian Phenotype (MP)abnormal enterocyte physiology0.0007776Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0008157Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.00251Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003695Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.005592Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.01472Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.02862Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.03501Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.05093Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2624Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.00004129InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000001602Moderately InformativeDirect
Cellular componentGolgi apparatus0.00001629Moderately InformativeDirect
Cellular componentCell projection0.00004976Moderately InformativeDirect
Cellular componentLysosome0.00000000008478InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · UniProtKB KeyWords (KW) · Internal database links ]