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Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (775) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,543 13,980 4
Proteins 9,134 13,589 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00027280Least InformativeDirect
Biological Process (BP)response to stimulus0.018320Least InformativeInherited
Biological Process (BP)immune system process0.00000031410Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.0018770Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0020160Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.012360Moderately InformativeInherited
Biological Process (BP)regulation of immune response0.0000000023580InformativeDirect
Biological Process (BP)response to bacterium0.000017910.00000001035InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000073850InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001531 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000008663 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000001321 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.0000001289 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000001005 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00001142 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0001873 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002461 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0978 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.007858 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6955 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9994 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7082 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2912 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.2997 Moderately Informative Inherited
Biological Process (BP) reproduction 0.5161 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.6129 Moderately Informative Inherited
Biological Process (BP) response to stress 0.0011 Moderately Informative Inherited
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) response to bacterium 0.00000001035 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000000001902 Informative Direct
Biological Process (BP) multi-organism cellular process 0.000000000000204 Informative Direct
Biological Process (BP) secretion 0.00000000002899 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000001206 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001777 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000002047 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000005774 Informative Direct
Biological Process (BP) regulation of protein localization 0.08371 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3855 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2906 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.3478 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.004428 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.007223 Informative Inherited
Biological Process (BP) growth 0.3758 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05448 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.838 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.0373 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.5058 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.009285 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.0119 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1262 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1335 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.443 Informative Inherited
Biological Process (BP) cell development 0.3642 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8721 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5152 Informative Inherited
Biological Process (BP) generation of neurons 0.1348 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1357 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.739 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.002023 Informative Inherited
Biological Process (BP) reproductive system development 0.07762 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) central nervous system development 0.0931 Informative Inherited
Biological Process (BP) epithelium development 0.6245 Informative Inherited
Biological Process (BP) locomotion 0.6485 Informative Inherited
Biological Process (BP) phosphorylation 0.3201 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2061 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7316 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.1856 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.05662 Informative Inherited
Biological Process (BP) behavior 0.3499 Informative Inherited
Biological Process (BP) protein secretion 0 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) innate immune response-activating signal transduction 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000000000000007239 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.0000000005003 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000004697 Highly Informative Direct
Biological Process (BP) detection of stimulus 0.000001542 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.000004927 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0001498 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0001607 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0001954 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.0002908 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0004454 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0004677 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0009609 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00653 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.1601 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.4499 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2076 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.946 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.003045 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.7336 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4011 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.1138 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.5003 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.192 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7328 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.001466 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.0163 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.4549 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.09297 Highly Informative Inherited
Biological Process (BP) response to fungus 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.276 Highly Informative Inherited
Biological Process (BP) cell migration 0.2961 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.06347 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.0429 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.04682 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2266 Highly Informative Inherited
Molecular Function (MF) binding 0.00000004187 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0006822 Moderately Informative Direct
Molecular Function (MF) protein binding 0.6817 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.00000004415 Informative Direct
Molecular Function (MF) receptor binding 0.0000001468 Informative Direct
Molecular Function (MF) amide binding 0.0001429 Informative Direct
Molecular Function (MF) enzyme binding 0.1065 Informative Inherited
Molecular Function (MF) peptide binding 0.000001293 Highly Informative Direct
Molecular Function (MF) kinase binding 0.000008668 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1239 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000005993 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.04019 Least Informative Inherited
Cellular Component (CC) whole membrane 0.000000001347 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0000003692 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00002312 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00004659 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006548 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.1728 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) membrane region 0.00000000000000601 Informative Direct
Cellular Component (CC) cell surface 0.0000004562 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00009236 Informative Direct
Cellular Component (CC) lytic vacuole 0.01387 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.001807 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1442Least InformativeInherited
Disease Ontology (DO)nervous system disease0.9206Least InformativeInherited
Disease Ontology (DO)organ system cancer0.9741Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000004972Moderately InformativeDirect
Disease Ontology (DO)skin disease0.004388Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.004938Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01971Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1806Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.3254Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.6556Moderately InformativeInherited
Disease Ontology (DO)asthma0.000000000003306InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0000095InformativeDirect
Disease Ontology (DO)liver disease0.00007088InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0002305InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0005703InformativeDirect
Disease Ontology (DO)muscle tissue disease0.006068InformativeInherited
Disease Ontology (DO)lymphoma0.01425InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.01728InformativeInherited
Disease Ontology (DO)interstitial lung disease0.2185InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.4402InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.00000000001217Highly InformativeDirect
Disease Ontology (DO)filariasis0.0000000000234Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.000002853Highly InformativeDirect
Disease Ontology (DO)Chagas disease0.000005632Highly InformativeDirect
Disease Ontology (DO)mycosis fungoides0.00005543Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.000074Highly InformativeDirect
Disease Ontology (DO)meningitis0.00009572Highly InformativeDirect
Disease Ontology (DO)atopic dermatitis0.0006218Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0006285Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000005449Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000001773Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2956Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3329Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4599Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6312Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7569Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.000000001132Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000005394Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00006501Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00007619Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.003664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.01151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.03003Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.06369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1365Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1683Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.4616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.7548Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.00000000009329InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.00003593InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0002105InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002105InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002526InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002599InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.001348InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.02443InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.02523InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.0389InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.09668InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.1163InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1258InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1872InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1899InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1912InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.3017InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.4004InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4657InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.6048InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.657InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.7491InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.921InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.9224InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.972InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0Highly InformativeDirect
Mammalian Phenotype (MP)decreased macrophage cytokine production0.00000000004376Highly InformativeDirect
Mammalian Phenotype (MP)decreased immunoglobulin level0.000000001432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000004774Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.00003549Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0002425Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0003328Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003591Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003692Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0004981Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0005483Highly InformativeDirect
Mammalian Phenotype (MP)abnormal enterocyte physiology0.0008234Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0008634Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.002512Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003832Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.00557Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating alanine transaminase level0.01096Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.01373Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.0289Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.03474Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.05672Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2619Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.00003781InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome6.533e-16Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000000737Moderately InformativeDirect
Cellular componentGolgi apparatus0.00001476Moderately InformativeDirect
Cellular componentCell projection0.0000308Moderately InformativeDirect
Cellular componentLysosome0.0000000008991InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond9.502e-16Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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