SUPERFAMILY 1.75 HMM library and genome assignments server

Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (775) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,720 13,980 4
Proteins 9,298 13,589 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00000000001821 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000005083 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.8404 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.008019 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.698 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1415 Least Informative Inherited
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000000578 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000005275 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00007739 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0001811 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0005323 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.9448 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3408 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004627 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5173 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.004404 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.09075 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003031 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9134 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000006789 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000003882 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.00000002033 Informative Direct
Biological Process (BP) defense response to other organism 0.00000002982 Informative Direct
Biological Process (BP) response to bacterium 0.0000008357 Informative Direct
Biological Process (BP) regulation of cell activation 0.00001396 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00002067 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000478 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0006441 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0007041 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9387 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9745 Informative Inherited
Biological Process (BP) epithelium development 0.702 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7096 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7628 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5534 Informative Inherited
Biological Process (BP) regulation of growth 0.03969 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.001188 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.073 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.4256 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.003446 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8655 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9134 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.02174 Informative Inherited
Biological Process (BP) response to cytokine 0.08539 Informative Inherited
Biological Process (BP) immune effector process 0.2094 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02425 Informative Inherited
Biological Process (BP) generation of neurons 0.09189 Informative Inherited
Biological Process (BP) regulation of cell development 0.1365 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.2528 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) phosphorylation 0.02141 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01101 Informative Inherited
Biological Process (BP) leukocyte activation 0.4171 Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.00000000000001752 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.000000000001993 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000000000003584 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000000000009272 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000000001997 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0000002494 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0000007858 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000001624 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.000002071 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000003742 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.000005563 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000008104 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00006484 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00009658 Highly Informative Direct
Biological Process (BP) gonad development 0.0001402 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0002174 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0007813 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0008337 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.003401 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02007 Highly Informative Inherited
Biological Process (BP) regulation of cytokine production involved in immune response 0.0786 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.1859 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.05193 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.05353 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001706 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.008489 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.001859 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.005293 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.04972 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2848 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1168 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.01782 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.02826 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.3787 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.8944 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000009053 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.002338 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0000000003089 Informative Direct
Molecular Function (MF) amide binding 0.0000000003474 Informative Direct
Molecular Function (MF) RNA binding 0.00000004064 Informative Direct
Molecular Function (MF) receptor binding 0.00004436 Informative Direct
Molecular Function (MF) protein dimerization activity 0.02731 Informative Inherited
Molecular Function (MF) enzyme binding 0.1056 Informative Inherited
Molecular Function (MF) peptide binding 0.0000000000000621 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0000006843 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000002723 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.01518 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4041 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00002356 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00006105 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00009375 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.6906 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.158 Moderately Informative Inherited
Cellular Component (CC) endosome 0.000000000001383 Informative Direct
Cellular Component (CC) cell surface 0.0000000004333 Informative Direct
Cellular Component (CC) integral component of membrane 0.4555 Informative Inherited
Cellular Component (CC) lytic vacuole 0.02905 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.000000000677 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.00000004705 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1257Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.06101Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.5333Moderately InformativeInherited
Disease Ontology (DO)asthma0.000000000004502InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.00000002913InformativeDirect
Disease Ontology (DO)malaria0.000003362InformativeDirect
Disease Ontology (DO)myositis0.0006583InformativeDirect
Disease Ontology (DO)liver disease0.0008712InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009655InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02211InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03737InformativeInherited
Disease Ontology (DO)aspergillosis0.0000000001658Highly InformativeDirect
Disease Ontology (DO)filariasis0.0000000009563Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.0000505Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0006878Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000115Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2326Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2413Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3306Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7361Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7853Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00001003Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001843Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.01166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.0142Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.02913Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.04908Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.05563Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1531Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.2716Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.7492Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0000000001302InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001943InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001943InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0004909InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.001184InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001889InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.001936InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01752InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.03346InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04183InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06275InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.07902InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.08458InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1395InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.1564InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1941InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.197InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.2018InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.3099InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3661InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4521InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5875InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6741InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8098InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.8874InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00000000000001419Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0000002766Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00006554Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level0.00009685Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.000267Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0002715Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.000345Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003684Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003704Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000425Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0006165Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.003055Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003721Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.006163Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.06528Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1015Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.1054Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2962Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.3256Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0.000000001858InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000000128Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000003899Moderately InformativeDirect
Cellular componentCell projection0.000001499Moderately InformativeDirect
Cellular componentLysosome0.0000000001256InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]