SUPERFAMILY 1.75 HMM library and genome assignments server

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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 23,557 171,867 69
Proteins 23,470 171,398 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01477Least InformativeInherited
Disease Ontology (DO)organ system cancer0.41Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.00001427Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00002088Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.00008671Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.001414Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.001955Moderately InformativeInherited
Disease Ontology (DO)artery disease0.004978Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02744Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.08271Moderately InformativeInherited
Disease Ontology (DO)brain disease0.2604Moderately InformativeInherited
Disease Ontology (DO)migraine0.00001098InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.0000612InformativeDirect
Disease Ontology (DO)asthma0.0001194InformativeDirect
Disease Ontology (DO)nephritis0.0003477InformativeDirect
Disease Ontology (DO)hypertension0.29InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3351InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.0001006Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0004213Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.0008482Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.02114Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05301Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05623Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07393Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08417Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1746Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4364Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5833Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0007203Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008933Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0.001115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.003573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.003584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.003602Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.003681Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.005715Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.006118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.007291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.0129Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.02912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.03224Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03746Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.03814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04381Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.06517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1375Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.2758Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.000006822InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.00002529InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.00009498InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001721InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002726InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003076InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0003084InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol level0.0004078InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0005007InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0005981InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006373InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0006631InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0006819InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0009014InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0009398InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001038InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.00119InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.001509InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.002071InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.002087InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.002422InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.002764InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.006026InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006475InformativeInherited
Mammalian Phenotype (MP)seizures0.006738InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.009024InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.01063InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.01184InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.01234InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01343InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01714InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.02895InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.03195InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0324InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.04091InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04321InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.9137InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.0000000002034Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000002034Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000001002Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.00000002762Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.0000000581Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.00000008789Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.00000008789Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.00000008789Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.000000249Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000003333Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.0000007126Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0000007921Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.0000009867Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000001328Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.000001461Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.000003514Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.000003525Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.00000378Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.000004978Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.000005607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000007974Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.000008411Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000009384Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00001413Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.0000148Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.00002035Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.00003738Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00003738Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.00009958Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001122Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0001321Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0.0001446Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0001612Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002116Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.0002297Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0003812Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004544Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.0007431Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.5233Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.007011InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.6696InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000002236Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.00000007129Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.0000004194Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.003495Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.811Highly InformativeInherited
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.8683Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]