SUPERFAMILY 1.75 HMM library and genome assignments server

Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (2,992) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,468 145,240 69
Proteins 23,382 145,127 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.43980.002902Least InformativeInherited
Biological Process (BP)response to stimulus0.57790.1968Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00070940.0000002736Moderately InformativeDirect
Molecular Function (MF)binding0.31031Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.00000000025760Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000000024860Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000010580.00000000000000467Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000010530.000000000000001593Moderately InformativeDirect
Molecular Function (MF)nucleotide binding0.0000000004650InformativeDirect
Molecular Function (MF)electron carrier activity0.00000023620.0000000000002587InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.000000000000001340InformativeDirect
Molecular Function (MF)cofactor binding0.00000000000001760InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor0.0000050890.05805Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.847 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.7844 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.002902 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1968 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.7727 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.281 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000005781 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000182 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000002736 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00008525 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.8069 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2973 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01516 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1496 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1022 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.01061 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05633 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06124 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01837 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4952 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.7595 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8983 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9651 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0003892 Informative Direct
Biological Process (BP) response to bacterium 0.00000002635 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00000003974 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0000323 Informative Direct
Biological Process (BP) regulation of ion transport 0.0002005 Informative Direct
Biological Process (BP) regulation of system process 0.00003035 Informative Direct
Biological Process (BP) negative regulation of transport 0.000004934 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.003874 Informative Inherited
Biological Process (BP) response to lipid 0.003328 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1231 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.001432 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.1753 Informative Inherited
Biological Process (BP) superoxide metabolic process 0.0001212 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000002273 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.00001211 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002508 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.04139 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000000000000467 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000000001593 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000000000002587 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00001947 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.1966 Informative Inherited
Molecular Function (MF) amino acid binding 0.000001038 Highly Informative Direct
Molecular Function (MF) heme binding 0.0000001539 Highly Informative Direct
Molecular Function (MF) NADP binding 0.0000009358 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.02012 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.06153 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.05805 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0002813 Moderately Informative Direct
Cellular Component (CC) membrane region 0.005391 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01587Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3878Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.00001422Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00002016Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.0002164Moderately InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0003852Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.001899Moderately InformativeInherited
Disease Ontology (DO)artery disease0.00495Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02862Moderately InformativeInherited
Disease Ontology (DO)migraine0.00000905InformativeDirect
Disease Ontology (DO)malaria0.00002821InformativeDirect
Disease Ontology (DO)asthma0.000116InformativeDirect
Disease Ontology (DO)hypertension0.2878InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3392InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.00009528Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.000894Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.02233Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04326Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05852Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07681Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08188Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2042Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.471Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4758Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.004555Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.004749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.005435Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.007922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01126Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01363Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.01739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.04193Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.06528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.09469Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.09732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.09891Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1024Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1087Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2843Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.000003772InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.00003118InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.0001035InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0001244InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001608InformativeDirect
Mammalian Phenotype (MP)abnormal circulating amino acid level0.0004321InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0.000746InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.0007539InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0007579InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.000777InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0009253InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001135InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.001374InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.001689InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.002501InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.003305InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.00366InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006774InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.007106InformativeInherited
Mammalian Phenotype (MP)seizures0.008536InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.008809InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.009869InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.00991InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01046InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.01589InformativeInherited
Mammalian Phenotype (MP)fibrosis0.01763InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.02412InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.03507InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04471InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.05141InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06273InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.1574InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.2392InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.912InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.0000000001276Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000001276Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000001987Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000000544Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.00000007095Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000001435Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000001435Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.000000176Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.0000003052Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000004991Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.0000007675Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0000008769Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.0000009973Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000001573Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.000002153Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.000002369Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.000003749Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000004415Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.000006019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000008005Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.000008005Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00001037Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00001174Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.00001667Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.00001853Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0000195Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00002764Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00004628Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.00006733Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.00009143Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001038Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0001066Highly InformativeDirect
Mammalian Phenotype (MP)partial prenatal lethality0.0002028Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.0002451Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002729Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.000482Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0005439Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0008377Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.1265Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.4582Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.003711InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9193InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000004625Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.00000005025Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.000007019Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.002634Highly InformativeInherited
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.8194Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.9514Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.006858Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.00001963InformativeDirect
Biological processSteroid metabolism0.00002041InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.00000006383Highly InformativeDirect
Biological processSteroid biosynthesis0.0000006524Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.000001701Moderately InformativeDirect
Cellular componentCell membrane0.3623Moderately InformativeInherited
Cellular componentCell inner membrane0.00007986InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionIron0.00003179Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionHeme0.000001391InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.6839Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)tRNA modification0.000184InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]