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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (2,997) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,514 145,240 69
Proteins 23,428 145,127 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.44160.0001165Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.53151Least InformativeInherited
Biological Process (BP)response to stimulus0.10810.007859Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00016880.00000002084Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.23220.8048Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.077470.4865Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.045930.09155Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0054650.0002323Moderately InformativeInherited
Biological Process (BP)protein oligomerization0.0015130.002803InformativeInherited
Biological Process (BP)xenobiotic metabolic process0.000023240.00005977Highly InformativeDirect
Biological Process (BP)protein homotetramerization0.000083580.000001499Highly InformativeDirect
Molecular Function (MF)binding0.45080.8853Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00000000048960Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000000078860.00000001124Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000063890Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.19830.73Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000075120.00000000000009774InformativeDirect
Molecular Function (MF)ribonucleotide binding0.0039020.000001237InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity0.00000021140.0002752Highly InformativeDirect
Molecular Function (MF)FMN binding00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.002410.05954Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001165 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.6868 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007859 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2512 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5719 Least Informative Inherited
Biological Process (BP) response to biotic stimulus 0.00006274 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000002084 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0002323 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.4924 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8048 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4865 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.09155 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6831 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9332 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1606 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.07866 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3711 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1471 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4809 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2354 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03526 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2406 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.656 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3556 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001827 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2201 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8428 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.05855 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.575 Moderately Informative Inherited
Biological Process (BP) response to bacterium 0.0000000001182 Informative Direct
Biological Process (BP) lipid localization 0.000003869 Informative Direct
Biological Process (BP) organic acid transport 0.000006754 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000005413 Informative Direct
Biological Process (BP) negative regulation of transport 0.0003004 Informative Direct
Biological Process (BP) regulation of cytokine production 0.001512 Informative Inherited
Biological Process (BP) secretion by cell 0.00358 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.01229 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4283 Informative Inherited
Biological Process (BP) protein oligomerization 0.002803 Informative Inherited
Biological Process (BP) regulation of defense response 0.02997 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.006478 Informative Inherited
Biological Process (BP) regulation of ion transport 0.002028 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3016 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.05934 Informative Inherited
Biological Process (BP) anion transport 0.001262 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.07978 Informative Inherited
Biological Process (BP) regulation of system process 0.003919 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4116 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.009377 Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.00001422 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.00000004558 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00005977 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.00002858 Highly Informative Direct
Biological Process (BP) protein secretion 0.0000003824 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000002782 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.000001499 Highly Informative Direct
Molecular Function (MF) binding 0.8853 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000001124 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.9812 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.73 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.00000000000009774 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000001237 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000002948 Informative Direct
Molecular Function (MF) coenzyme binding 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0.000276 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00008827 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0002752 Highly Informative Direct
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000004901 Highly Informative Direct
Molecular Function (MF) NADP binding 0.000007956 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.004836 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.05954 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5368 Least Informative Inherited
Cellular Component (CC) whole membrane 0.03196 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0001587 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.02728Least InformativeInherited
Disease Ontology (DO)organ system cancer0.5055Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.00008529Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.0001717Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.0003715Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0005159Moderately InformativeDirect
Disease Ontology (DO)artery disease0.002004Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.01576Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.04684Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.04898Moderately InformativeInherited
Disease Ontology (DO)brain disease0.149Moderately InformativeInherited
Disease Ontology (DO)migraine0.000005177InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00002921InformativeDirect
Disease Ontology (DO)peripheral nervous system neoplasm0.00004079InformativeDirect
Disease Ontology (DO)asthma0.00004079InformativeDirect
Disease Ontology (DO)lymphoma0.00006697InformativeDirect
Disease Ontology (DO)nephritis0.0001684InformativeDirect
Disease Ontology (DO)hypertension0.2882InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.00003413Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0002027Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.0004137Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.02132Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05315Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05638Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07394Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08471Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1747Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4375Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5837Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0007168Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008956Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0.001122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.003569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.003592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.003623Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.004087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.005756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.006125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01296Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01333Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.02937Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.03234Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.03836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04419Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.0657Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1374Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.2763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.000006881InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.00002518InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.00009683InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001716InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002719InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0003126InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003155InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol level0.0004103InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0005051InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0005964InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006351InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0006608InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0006887InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0008966InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0009481InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001047InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.001187InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.001509InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.002089InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.002104InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.00246InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.002804InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.006056InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006503InformativeInherited
Mammalian Phenotype (MP)seizures0.006889InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.008956InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.01052InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.01186InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.01233InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01336InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01741InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.02859InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.03214InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.03232InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.04076InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04326InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.9137InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.0000000002027Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000002027Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.0000000009997Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.00000002755Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.0000000579Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.00000008772Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.00000008772Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.00000008772Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.0000002889Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000003337Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.0000007092Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0000007895Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.0000009808Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000001324Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.000001454Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.0000035Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.000003513Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000003762Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.000004957Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.000005587Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000007924Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.000008857Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000009341Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00001409Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.00001548Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.00002193Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density0.00003726Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00003726Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.00009904Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001109Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0001347Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0.0001495Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0001608Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.0002426Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0003811Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004501Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.0007404Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.4997Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.006349InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9709InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000000003906Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.00000005976Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.00000088Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.003412Highly InformativeInherited
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.8599Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.914Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.007851Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0.000000007983InformativeDirect
Biological processNitrogen fixation0.00002088InformativeDirect
Biological processLipid biosynthesis0.8122InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.0000000000004959Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000001804Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.000003202Moderately InformativeDirect
Cellular componentCell membrane0.1467Moderately InformativeInherited
Cellular componentMitochondrion0.171Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.00000001409InformativeDirect
Cellular componentCell inner membrane0.0001366InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionHeme0.0000003845InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.7061Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)tRNA modification0.0001665InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]