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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (2,993) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,476 145,240 69
Proteins 23,390 145,127 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.51590.0002025Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.63681Least InformativeInherited
Biological Process (BP)response to stimulus0.23080.01063Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00075730.0000002701Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.025780.000542Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.28410.8102Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.069930.7653Moderately InformativeInherited
Biological Process (BP)protein oligomerization0.004790.005303InformativeInherited
Biological Process (BP)protein homotetramerization0.00041970.000005928Highly InformativeDirect
Biological Process (BP)cellular response to xenobiotic stimulus0.00053750.00003885Highly InformativeDirect
Molecular Function (MF)binding0.34250.827Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00000000034770Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000000029210.00000002626Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000033410Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.19170.71Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000082710.0000000000001022InformativeDirect
Molecular Function (MF)ribonucleotide binding0.00079970.0000005376InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.013050.1419InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity0.00000020290.0002724Highly InformativeDirect
Molecular Function (MF)FMN binding00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.0025460.05505Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0002025 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2834 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01063 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.537 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1702 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0000002701 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000542 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.3299 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02914 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8419 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1281 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8102 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7653 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.511 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6143 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4194 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1154 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6831 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3111 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3016 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02754 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2247 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2458 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5968 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001382 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01947 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0008252 Informative Direct
Biological Process (BP) response to bacterium 0.0000000000373 Informative Direct
Biological Process (BP) lipid localization 0.000003291 Informative Direct
Biological Process (BP) organic acid transport 0.00000642 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000004424 Informative Direct
Biological Process (BP) regulation of system process 0.0009178 Informative Direct
Biological Process (BP) negative regulation of transport 0.0002199 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.2027 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.05648 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.005234 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001661 Informative Inherited
Biological Process (BP) secretion 0.001697 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4323 Informative Inherited
Biological Process (BP) protein oligomerization 0.005303 Informative Inherited
Biological Process (BP) regulation of defense response 0.02608 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.01254 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04949 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.003098 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.008999 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3816 Informative Inherited
Biological Process (BP) regulation of ion transport 0.001876 Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.000011 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.00000003198 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.00003574 Highly Informative Direct
Biological Process (BP) protein secretion 0.0000003113 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000002891 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.000006878 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.000005928 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0.00003885 Highly Informative Direct
Biological Process (BP) reactive oxygen species metabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.827 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000002626 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.71 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.0000000000001022 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000005376 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000002928 Informative Direct
Molecular Function (MF) coenzyme binding 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.1419 Informative Inherited
Molecular Function (MF) monooxygenase activity 0.0003268 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00003281 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0002724 Highly Informative Direct
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000004096 Highly Informative Direct
Molecular Function (MF) NADP binding 0.00003391 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.005374 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.05505 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5454 Least Informative Inherited
Cellular Component (CC) whole membrane 0.03948 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0001106 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)immune system disease0.03155Least InformativeInherited
Disease Ontology (DO)organ system cancer0.2511Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00003843Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0001212Moderately InformativeDirect
Disease Ontology (DO)artery disease0.0005141Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.001824Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.004014Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.007303Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02323Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.02372Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.2445Moderately InformativeInherited
Disease Ontology (DO)migraine0.000001755InformativeDirect
Disease Ontology (DO)peripheral nervous system neoplasm0.000008781InformativeDirect
Disease Ontology (DO)asthma0.00000891InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00001121InformativeDirect
Disease Ontology (DO)lymphoma0.00002524InformativeDirect
Disease Ontology (DO)nephritis0.0000666InformativeDirect
Disease Ontology (DO)lupus erythematosus0.000512InformativeDirect
Disease Ontology (DO)hypertension0.2889InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000007295Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.00008518Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.0001714Highly InformativeDirect
Disease Ontology (DO)Alzheimer's disease0.0005933Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.02156Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0483Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0548Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.07728Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07846Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.178Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4556Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5594Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.000774Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0009544Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002708Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.002985Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.003149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.003453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.003594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.003767Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.006552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01095Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01936Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02081Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.03034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.03862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.04044Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.06752Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07565Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08893Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.129Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.2922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3303Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.000001193InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.000005467InformativeDirect
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.00002722InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.00009946InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001566InformativeDirect
Mammalian Phenotype (MP)abnormal circulating enzyme level0.0001995InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002927InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0003288InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol level0.0003331InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.000622InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0006636InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0007004InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0007295InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0007455InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0007907InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.0009741InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001052InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.00123InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.00159InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.002187InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.002226InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.002563InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.002917InformativeInherited
Mammalian Phenotype (MP)abnormal lipoprotein level0.004495InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00682InformativeInherited
Mammalian Phenotype (MP)seizures0.006983InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.01066InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0107InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.01241InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01929InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.02821InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03118InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.03401InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.04454InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0478InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.9196InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.0000000002158Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000002158Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000001067Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.00000002941Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach0.00000004916Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.00000009373Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.00000009373Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.00000009373Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.000000264Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.0000003555Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.0000007562Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0000008417Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000001046Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000001408Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00000147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.000001546Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.000003756Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000004026Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.000005267Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.000005585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.000008421Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.000008893Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.000009879Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00001495Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.00001565Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.00002063Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00003962Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0000944Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001186Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0001278Highly InformativeDirect
Mammalian Phenotype (MP)prenatal lethality, incomplete penetrance0.0001525Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0001708Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002239Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.0002378Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0004034Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004656Highly InformativeDirect
Mammalian Phenotype (MP)reduced fertility0.0007793Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.001608Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.5099Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.003683InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9686InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000000005424Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0.0000000641Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.0000007973Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.003403Highly InformativeInherited
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.8591Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.9227Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.00007408Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.007597Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0.00000000701InformativeDirect
Biological processNitrogen fixation0.00002055InformativeDirect
Biological processLipid biosynthesis0.8128InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.0000000000004591Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000001552Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.000002265Moderately InformativeDirect
Cellular componentMitochondrion0.1657Moderately InformativeInherited
Cellular componentCell membrane0.2952Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.00000001332InformativeDirect
Cellular componentCell inner membrane0.0001055InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNAD0Moderately InformativeDirect
Molecular functionIron0.00002398Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionHeme0.0000003476InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.7055Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)tRNA modification0.0001767InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]