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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)


Superfamily statistics
Genomes (2,998) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 23,521 134,671 69
Proteins 23,435 134,380 69


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.43490.00007574Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.5441Least InformativeInherited
Biological Process (BP)response to stimulus0.13080.003687Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.0001740.0000000343Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.047190.1031Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.085940.533Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.24650.8531Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0061260.0001302Moderately InformativeInherited
Biological Process (BP)protein oligomerization0.0017580.003294InformativeInherited
Biological Process (BP)xenobiotic metabolic process0.000022930.00006271Highly InformativeDirect
Biological Process (BP)protein homotetramerization0.000078280.000001448Highly InformativeDirect
Molecular Function (MF)binding0.55630.8966Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00000000050740Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000000082510.000000008159Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000058850Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.20430.749Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000073780.00000000000009755InformativeDirect
Molecular Function (MF)ribonucleotide binding0.0039180.000003668InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity0.00000019850.0003492Highly InformativeDirect
Molecular Function (MF)FMN binding00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.0027810.06802Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00007574 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.003687 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6375 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2041 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5637 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0006301 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00005401 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000343 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0001302 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.1165 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7205 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9495 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.1031 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.533 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8531 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.207 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1629 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6116 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1753 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9634 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2473 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4059 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4711 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.07518 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03031 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3711 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3774 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8109 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5861 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8945 Moderately Informative Inherited
Biological Process (BP) response to bacterium 0.00000000004447 Informative Direct
Biological Process (BP) lipid localization 0.000005009 Informative Direct
Biological Process (BP) organic acid transport 0.000007441 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000006827 Informative Direct
Biological Process (BP) negative regulation of transport 0.000371 Informative Direct
Biological Process (BP) regulation of defense response 0.02964 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.007293 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001843 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.426 Informative Inherited
Biological Process (BP) protein oligomerization 0.003294 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4878 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) growth 0.2328 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.001971 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.01087 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3578 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.07062 Informative Inherited
Biological Process (BP) central nervous system development 0.5454 Informative Inherited
Biological Process (BP) anion transport 0.001411 Informative Inherited
Biological Process (BP) secretion by cell 0.003483 Informative Inherited
Biological Process (BP) protein transport 0.3513 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.009554 Informative Inherited
Biological Process (BP) regulation of system process 0.004757 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3126 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1006 Informative Inherited
Biological Process (BP) hemopoiesis 0.1351 Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.00002625 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.00000004707 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00006271 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.00002807 Highly Informative Direct
Biological Process (BP) protein secretion 0.0000004605 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000003262 Highly Informative Direct
Biological Process (BP) cell growth 0.0009348 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.00003929 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.000001448 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0004888 Highly Informative Direct
Biological Process (BP) response to ketone 0.001287 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1149 Highly Informative Inherited
Biological Process (BP) neuron development 0.6761 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.7636 Highly Informative Inherited
Molecular Function (MF) binding 0.8966 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000008159 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.9519 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.749 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.00000000000009755 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000003668 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000002236 Informative Direct
Molecular Function (MF) coenzyme binding 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0.0002437 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00009931 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0003492 Highly Informative Direct
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000004711 Highly Informative Direct
Molecular Function (MF) NADP binding 0.000007524 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.06802 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.004568 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6216 Least Informative Inherited
Cellular Component (CC) whole membrane 0.03395 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0001689 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0000000000002025Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000001761Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000003249InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004895InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00004025InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.007512Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0.000000008956InformativeDirect
Biological processNitrogen fixation0.00002051InformativeDirect
Biological processLipid biosynthesis0.8105InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.0000000000005041Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000001813Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.000003117Moderately InformativeDirect
Cellular componentCell membrane0.1617Moderately InformativeInherited
Cellular componentMitochondrion0.1697Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.00000001375InformativeDirect
Cellular componentCell inner membrane0.0001642InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionHeme0.0000003918InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]