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Flavoproteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Flavoproteins [ 52218] (8)
Families:   Flavodoxin-related [ 52219] (5)
  Cytochrome p450 reductase N-terminal domain-like [ 52231] (3)
  Quinone reductase [ 52235] (3)
  Hypothetical protein SP1951 [ 102234]
  Hypothetical protein YwqN [ 102237]
  NADPH-dependent FMN reductase [ 89590] (4)
  Flavoprotein NrdI [ 110477]
  WrbA-like [ 117474] (2)

Superfamily statistics
Genomes (2,336) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 18,187 60,855 69
Proteins 18,103 60,775 69

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.84141Least InformativeInherited
Molecular Function (MF)oxidoreductase activity1.04e-120Moderately InformativeDirect
Molecular Function (MF)anion binding5.209e-052.048e-12Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding0.0021250.0005556Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.0014140.0004174Moderately InformativeInherited
Molecular Function (MF)nucleotide binding9.158e-070InformativeDirect
Molecular Function (MF)electron carrier activity9.076e-090InformativeDirect
Molecular Function (MF)cofactor binding4.547e-100InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1272 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9382 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005043 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9196 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2336 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0006053 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 5.78e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0007886 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 2.114e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0009676 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.05591 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07669 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001086 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1929 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5225 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.803 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1185 Moderately Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.0005476 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 1.087e-06 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.01406 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.005636 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4004 Informative Inherited
Biological Process (BP) regulation of ion transport 0.00358 Informative Inherited
Biological Process (BP) defense response 0.3268 Informative Inherited
Biological Process (BP) response to lipid 0.006753 Informative Inherited
Biological Process (BP) response to other organism 0.001292 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.009947 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.1006 Informative Inherited
Biological Process (BP) arginine metabolic process 1.001e-07 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 8.758e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.493e-09 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001204 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.758e-06 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 2.048e-12 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.0005556 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.0004174 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.2371 Informative Inherited
Molecular Function (MF) heme binding 1.743e-06 Highly Informative Direct
Molecular Function (MF) NADP binding 1.112e-06 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.04469 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.1942 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7669 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4306 Least Informative Inherited
Cellular Component (CC) cytosol 0.0002682 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.1979 Moderately Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 9.394e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH2.025e-13Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1.761e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4629Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation3.249e-12InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor4.895e-06InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions4.025e-05InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0294Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3839Least InformativeInherited
Disease Ontology (DO)brain disease5.507e-06Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease1.52e-05Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer1.888e-05Moderately InformativeDirect
Disease Ontology (DO)cognitive disorder2.827e-05Moderately InformativeDirect
Disease Ontology (DO)vascular disease0.0009792Moderately InformativeDirect
Disease Ontology (DO)lung disease0.001386Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.00207Moderately InformativeInherited
Disease Ontology (DO)kidney disease0.005482Moderately InformativeInherited
Disease Ontology (DO)heart disease0.07106Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.08193Moderately InformativeInherited
Disease Ontology (DO)malaria3.193e-05InformativeDirect
Disease Ontology (DO)asthma0.0001294InformativeDirect
Disease Ontology (DO)nephritis0.0003481InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.01654InformativeInherited
Disease Ontology (DO)hypertension0.3796InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3839InformativeInherited
Disease Ontology (DO)coronary heart disease0.0002033Highly InformativeDirect
Disease Ontology (DO)pre-eclampsia0.0008724Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02137Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05458Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08594Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2174Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4703Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4926Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.0001124Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.00369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.004281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.005189Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.005553Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.009028Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01135Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.014Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.01861Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.02521Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.03031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0552Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.06955Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.07783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2573Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2914Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3826Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level2.808e-06InformativeDirect
Mammalian Phenotype (MP)pathological neovascularization2.665e-05InformativeDirect
Mammalian Phenotype (MP)abnormal urination8.818e-05InformativeDirect
Mammalian Phenotype (MP)abnormal stomach morphology0.0001463InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0003155InformativeDirect
Mammalian Phenotype (MP)other phenotype0.0003627InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0005172InformativeDirect
Mammalian Phenotype (MP)abnormal circulating amino acid level0.0005336InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0008245InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0008891InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001081InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001237InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.00145InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.001562InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.002413InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.00266InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.003131InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.003637InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.004114InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.004359InformativeInherited
Mammalian Phenotype (MP)abnormal artery morphology0.005525InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.006372InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.007021InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.008016InformativeInherited
Mammalian Phenotype (MP)seizures0.009887InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01028InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.01289InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01818InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.02808InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03377InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.05883InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0702InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.07971InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.09572InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy2.013e-10Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis2.013e-10Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis3.106e-09Highly InformativeDirect
Mammalian Phenotype (MP)enlarged stomach6.306e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality8.42e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level1.403e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis1.766e-07Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis1.766e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology2.206e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level2.713e-07Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia6.601e-07Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion6.601e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level1.17e-06Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion1.944e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis3.009e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level3.657e-06Highly InformativeDirect
Mammalian Phenotype (MP)hypertension4.031e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level4.856e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology5.326e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing6.282e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density8.482e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number8.482e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level9.167e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure1.403e-05Highly InformativeDirect
Mammalian Phenotype (MP)polyuria1.601e-05Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis2.531e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure4.778e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level8.216e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization8.505e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate8.818e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001263Highly InformativeDirect
Mammalian Phenotype (MP)partial prenatal lethality0.000216Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone remodeling0.0002705Highly InformativeDirect
Mammalian Phenotype (MP)decreased survivor rate0.0004809Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004911Highly InformativeDirect
Mammalian Phenotype (MP)decreased cardiac muscle contractility0.000553Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.000685Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.0007135Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.004148Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.1157Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1.537e-13InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen5.959e-10InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.4508InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1.997e-11Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions3.723e-05Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.2131Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.9752Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.001601Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism1.099e-05InformativeDirect
Biological processNitrogen fixation1.395e-05InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis3.776e-08Highly InformativeDirect
Biological processSteroid biosynthesis3.924e-07Highly InformativeDirect
Cellular componentEndoplasmic reticulum1.614e-07Moderately InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNAD0Moderately InformativeDirect
Molecular functionIron5.691e-07Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionHeme1.975e-07InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.6578Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)nitrate reduction0InformativeDirect
UniPathway (UP)tRNA modification0.0001798InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect
UniPathway (UP)nitric oxide reduction0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Flavoproteins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Flavoproteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.