SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

SGNH hydrolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   SGNH hydrolase [ 52266] (9)
Families:   Esterase [ 52267]
  Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 [ 52270]
  Acetylhydrolase [ 52273] (2)
  Rhamnogalacturonan acetylesterase [ 52276]
  TAP-like [ 89594] (2)
  Hypothetical protein alr1529 [ 102240]
  Putative acetylxylan esterase-like [ 142058] (2)
  YxiM C-terminal domain-like [ 159482]
  BT2961-like [ 159485] (2)

Superfamily statistics
Genomes (2,593) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 20,131 101,637 19
Proteins 19,786 99,608 19

Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.0005310Least InformativeDirect
Molecular Function (MF)transferase activity0.87541Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0000048080Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00047760.0002891InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000010780InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.8211 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0003071 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0006942 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.1387 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2059 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.0000006519 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.00002224 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.002233 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.000005838 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.00001069 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0002891 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.00003706 Highly Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001098 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Sialate O-acetylesterase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0.00000000003971Moderately InformativeDirect
Biological processCarbohydrate metabolism0.00519Moderately InformativeInherited
Biological processLipid degradation0InformativeDirect
Biological processVirus entry into host cell4.848e-16InformativeDirect
Biological processPolysaccharide degradation0.000001189InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Cellular componentMembrane0.008853Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentViral envelope protein0Highly InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0.0001374InformativeDirect
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013830 SSF52266 Protein matches

This entry represents the SGNH hydrolase-type esterase domain, which has a similar fold to flavoproteins, namely a three-layer alpha/beta/alpha structure, where the beta-sheets are composed of five parallel strands. Enzymes containing this domain act as esterases and lipases, but have little sequence homology to true lipases [PubMed10801485, PubMed15522763]. Proteins containing this type of esterase domain have been found in a variety of hydrolases; those with structural information include an esterase from Streptomyces scabies [PubMed7773790]; the esterase domain of viral haemagglutinin-esterase surface glycoproteins (influenza C virus, coronaviruses and toroviruses) [PubMed9817207]; mammalian acetylhydrolases [PubMed11522926]; fungal rhamnogalacturonan acetylesterase [PubMed11752785]; and the multifunctional enzyme thioesterase I (TAP) from Escherichia coli [PubMed12842470]. SGNH hydrolase-type esterase domains contain unique hydrogen bond network that stabilizes their catalytic centres; they usually contain the catalytic triad Ser/Acid/His.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SGNH hydrolase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the SGNH hydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]