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Formate/glycerate dehydrogenase catalytic domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Formate/glycerate dehydrogenase catalytic domain-like [ 52283] (3)
Families:   Formate/glycerate dehydrogenases, substrate-binding domain [ 52284] (7)
  L-alanine dehydrogenase-like [ 52297] (2)
  S-adenosylhomocystein hydrolase [ 52300]


Superfamily statistics
Genomes (2,955) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 18,899 106,999 34
Proteins 18,711 106,387 28


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process00.0000008975Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00035080.7065Least InformativeInherited
Biological Process (BP)biological regulation0.0040061Least InformativeInherited
Biological Process (BP)regulation of developmental process0.0000011770.05479Moderately InformativeInherited
Biological Process (BP)system development0.000024150.7042Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.0014750.6009Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000002360.1263Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.0000054630.002811Moderately InformativeInherited
Biological Process (BP)sensory organ development0.0000000071410.0000001265InformativeDirect
Biological Process (BP)regulation of cell differentiation0.0000001140.0003892InformativeDirect
Biological Process (BP)generation of neurons0.00000012470.0007731InformativeDirect
Biological Process (BP)regulation of nervous system development0.0000000066920.000002308InformativeDirect
Biological Process (BP)membrane organization0.000000048790.0000000003825InformativeDirect
Biological Process (BP)cell development0.00000060010.007907InformativeInherited
Biological Process (BP)camera-type eye development0.000000000520.000000000001773Highly InformativeDirect
Biological Process (BP)cell maturation0.00000000018630.000000000000001945Highly InformativeDirect
Biological Process (BP)neuron development0.000000011470.00000141Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000008975 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000007796 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7065 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00002644 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00009895 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000009211 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.05479 Moderately Informative Inherited
Biological Process (BP) system development 0.7042 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.6009 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.6423 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.1437 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1856 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01126 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.03154 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1263 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.08473 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.002811 Moderately Informative Inherited
Biological Process (BP) sensory organ development 0.0000001265 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0003892 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.00004339 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0.0008235 Informative Direct
Biological Process (BP) generation of neurons 0.0007731 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000002308 Informative Direct
Biological Process (BP) membrane organization 0.0000000003825 Informative Direct
Biological Process (BP) cell development 0.007907 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.003921 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.01834 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.8514 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1329 Informative Inherited
Biological Process (BP) camera-type eye development 0.000000000001773 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000000218 Highly Informative Direct
Biological Process (BP) cell maturation 0.000000000000001945 Highly Informative Direct
Biological Process (BP) neuron development 0.00000141 Highly Informative Direct
Biological Process (BP) pattern specification process 0.05124 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.01166 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000516 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0.0000000000001692 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.0001582 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.00000001543 Highly Informative Direct
Molecular Function (MF) NAD binding 0.000000000000008674 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.9516 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0169 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1796 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.2181Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000002992InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.08813InformativeInherited
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.0007353InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3863Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.04708Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.1053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.006462InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.08514Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0008174InformativeDirect
Plant ANatomical entity (PAN)vascular bundle0.000004671Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.009511InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.2233InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.9738Moderately InformativeInherited
Biological processOne-carbon metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum1Moderately InformativeInherited
Cellular componentMicrosome0.0003885Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0.0000002929Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid degradation0.675Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.3298InformativeInherited
UniPathway (UP)L-serine biosynthesis0Highly InformativeDirect
UniPathway (UP)alanine degradation0Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.0000000007072Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0.00000001492Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formate/glycerate dehydrogenase catalytic domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Formate/glycerate dehydrogenase catalytic domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]