SUPERFAMILY 1.75 HMM library and genome assignments server


Formate/glycerate dehydrogenase catalytic domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Formate/glycerate dehydrogenase catalytic domain-like [ 52283] (3)
Families:   Formate/glycerate dehydrogenases, substrate-binding domain [ 52284] (7)
  L-alanine dehydrogenase-like [ 52297] (2)
  S-adenosylhomocystein hydrolase [ 52300]


Superfamily statistics
Genomes (2,948) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 18,787 101,227 34
Proteins 18,602 101,046 28


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 5.192e-12 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.002512 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9613 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 2.468e-05 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5029 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.6463 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8251 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6469 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.943 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01947 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7804 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.5027 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02087 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.4435 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.3107 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.1567 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.03293 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.00578 Moderately Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.0006481 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0004847 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0002888 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.0007474 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.02049 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.3119 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.4726 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.4799 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.00269 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.5568 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.004872 Informative Inherited
Biological Process (BP) sulfur compound catabolic process 1.669e-07 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 7.394e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.777 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.008887 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 6.583e-09 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 3.678e-05 Informative Direct
Molecular Function (MF) cofactor binding 3.448e-14 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.3016 Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.0002745 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.03551 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.6431 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1512 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 9.596e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.001709 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04378 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1619 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.2181Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.992e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.08813InformativeInherited
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3084Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.03436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.004103InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.08496Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.004609InformativeInherited
Plant ANatomical entity (PAN)vascular bundle4.291e-06Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.04064InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.2036InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Formate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.278e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.9794Moderately InformativeInherited
Biological processOne-carbon metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP2.075e-11InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism8.166e-14Least InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)alanine metabolism0InformativeDirect
UniPathway (UP)L-alanine degradation via dehydrogenase pathway0Highly InformativeDirect
UniPathway (UP)L-lysine degradation1.198e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formate/glycerate dehydrogenase catalytic domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Formate/glycerate dehydrogenase catalytic domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]