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Class I glutamine amidotransferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Class I glutamine amidotransferase-like [ 52317] (9)
Families:   Class I glutamine amidotransferases (GAT) [ 52318] (11)
  A4 beta-galactosidase middle domain [ 82351]
  DJ-1/PfpI [ 52325] (9)
  Catalase, C-terminal domain [ 52328]
  Aspartyl dipeptidase PepE [ 52331]
  ThuA-like [ 110486]
  LD-carboxypeptidase A N-terminal domain-like [ 142074]
  HTS-like [ 142077]
  STM3548-like [ 159492]


Superfamily statistics
Genomes (3,256) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,907 248,652 68
Proteins 47,321 248,123 68


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000067430Least InformativeDirect
Biological Process (BP)biosynthetic process0.0000017080Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000016610Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000000015260Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00021170.00000002155Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0000021530Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000018830Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000000030920Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00059710Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00000002540.000005977Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0013550.4287Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.021690.6505Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.33411Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.064860.09923Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.066281Moderately InformativeInherited
Biological Process (BP)response to stress0.27431Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.04240.1169Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.16811Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00056780.03045Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.000033860.0001226InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.00000009330.000000002056InformativeDirect
Biological Process (BP)response to oxidative stress0.000000013250.0000000261InformativeDirect
Biological Process (BP)response to inorganic substance0.00016990.0001InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.0000037040.00003152InformativeDirect
Biological Process (BP)water-soluble vitamin biosynthetic process0.000015590.0000000006078InformativeDirect
Biological Process (BP)pteridine-containing compound metabolic process0.0000000074850.00000000002364InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process0.00000000000045070.0005631InformativeDirect
Biological Process (BP)negative regulation of molecular function0.012990.1686InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.087270.06655InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.93230.9621InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00047810.48InformativeInherited
Biological Process (BP)regulation of ion transport0.000083870.001832InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.041840.3793InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.015970InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.00028870.001306InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.0024770.3415InformativeInherited
Biological Process (BP)positive regulation of transport0.0013460.1196InformativeInherited
Biological Process (BP)alcohol metabolic process0.14351InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.0083470.01661InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.1560.4584InformativeInherited
Biological Process (BP)amine metabolic process0.0011510.001154InformativeInherited
Biological Process (BP)lactate metabolic process0.000000041970.0000001514Highly InformativeDirect
Biological Process (BP)tryptophan metabolic process0.00081050.0002132Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process0.0000000011320.000000000004278Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.0000002440.00000000001163Highly InformativeDirect
Biological Process (BP)thiamine biosynthetic process0.0000000088870.000000007031Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process0.0000009240.0000002955Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transporter activity0.0000000040290.0000005545Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.00000000056940.00001607Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.000000000066450.000000004331Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.0000013220.00001615Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000046210.00000003967Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.0000000050.0000002363Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.000050210.000002222Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process0.000000026270.0000000003477Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.000000082570.0000001514Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.000020850.00005074Highly InformativeDirect
Biological Process (BP)vitamin B6 metabolic process0.0000090530.0000001856Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00000012530.00001932Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.000029610.00006966Highly InformativeDirect
Biological Process (BP)response to copper ion0.00000016650.0002522Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.00000024940.00000003396Highly InformativeDirect
Biological Process (BP)detoxification0.00000040780.00000227Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000026520.002476Highly InformativeInherited
Biological Process (BP)cellular modified amino acid biosynthetic process0.0016420.04862Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.016930.3667Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.64331Least InformativeInherited
Molecular Function (MF)lyase activity0.000000022620.0000004299Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.42470.5885Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding0.0053261Moderately InformativeInherited
Molecular Function (MF)hydro-lyase activity0.000019940.00000185InformativeDirect
Molecular Function (MF)ligase activity0.00015240InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.025530.000353InformativeInherited
Molecular Function (MF)carbon-carbon lyase activity0.031740.002074InformativeInherited
Molecular Function (MF)RNA binding0.00020270.6863InformativeInherited
Molecular Function (MF)mRNA binding0.00000000041890.000992Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups0.0000028210.000008323Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring nitrogenous groups0.0002220.0000001554Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.00000000000056590Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002155 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000000001975 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.0003233 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000005977 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00008235 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000003192 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.000377 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4287 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.6505 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.09923 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.002701 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1169 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03045 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0001226 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000000002056 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000000261 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000000002633 Informative Direct
Biological Process (BP) response to inorganic substance 0.0001 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00003152 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0.0000000006078 Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 0.00000000002364 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000001691 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0005631 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.1686 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.06655 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.9621 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.48 Informative Inherited
Biological Process (BP) regulation of ion transport 0.001832 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.3793 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001306 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.3415 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1196 Informative Inherited
Biological Process (BP) central nervous system development 0.9527 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01661 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.4584 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.001551 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.2766 Informative Inherited
Biological Process (BP) circulatory system development 0.8237 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) amine metabolic process 0.001154 Informative Inherited
Biological Process (BP) lactate metabolic process 0.0000001514 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 0.0002132 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 0.000000000004278 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.00000000001163 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0.000000000003271 Highly Informative Direct
Biological Process (BP) pyrimidine nucleoside triphosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.0000000009987 Highly Informative Direct
Biological Process (BP) thiamine biosynthetic process 0.000000007031 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 0.0000002955 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000005545 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00001607 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.000000004331 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.00001615 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00000003967 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0000002363 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0.000002222 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000000003477 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000001514 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.00005074 Highly Informative Direct
Biological Process (BP) vitamin B6 metabolic process 0.0000001856 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00001932 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00006966 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.00000000001546 Highly Informative Direct
Biological Process (BP) response to copper ion 0.0002522 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00000003396 Highly Informative Direct
Biological Process (BP) detoxification 0.00000227 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0000145 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.02206 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.002476 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.04862 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.3667 Highly Informative Inherited
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.002537 Highly Informative Inherited
Biological Process (BP) nucleoside triphosphate biosynthetic process 0.01046 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.0000004299 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.5885 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000353 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000004293 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00000185 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.002062 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.002074 Informative Inherited
Molecular Function (MF) RNA binding 0.6863 Informative Inherited
Molecular Function (MF) mRNA binding 0.000992 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000008335 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000008323 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.0000001554 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.04771 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4663 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.7389 Moderately Informative Inherited
Cellular Component (CC) cilium 0.06816 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.9243 Informative Inherited
Cellular Component (CC) cell projection part 0.3971 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.9975Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.2799Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.8592Moderately InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0.000000007861InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0.165InformativeInherited
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)male fertile0.0004724Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.000001827Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.5434Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00000002434Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0.002146InformativeInherited
Enzyme Commission (EC)Omega peptidases0.231InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.2603InformativeInherited
Enzyme Commission (EC)Hexosyltransferases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.003284Highly InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processFolate biosynthesis0.000000001201Highly InformativeDirect
Biological processFertilization0.00001304Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentVirion1Moderately InformativeInherited
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionPyridoxal phosphate0Highly InformativeDirect
Post-translational modificationHydrolase0.002216Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtease0.8379Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease0.00000000000005568InformativeDirect
Post-translational modificationCarboxypeptidase0.0002384Highly InformativeDirect
Post-translational modificationOxidation0.000003875Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0000000002372Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.8451Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0.0000000000000294InformativeDirect
UniPathway (UP)polyketide biosynthesis0.655InformativeInherited
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class I glutamine amidotransferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Class I glutamine amidotransferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]