SUPERFAMILY 1.75 HMM library and genome assignments server


Class I glutamine amidotransferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Class I glutamine amidotransferase-like [ 52317] (9)
Families:   Class I glutamine amidotransferases (GAT) [ 52318] (11)
  A4 beta-galactosidase middle domain [ 82351]
  DJ-1/PfpI [ 52325] (9)
  Catalase, C-terminal domain [ 52328]
  Aspartyl dipeptidase PepE [ 52331]
  ThuA-like [ 110486]
  LD-carboxypeptidase A N-terminal domain-like [ 142074]
  HTS-like [ 142077]
  STM3548-like [ 159492]


Superfamily statistics
Genomes (3,254) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,863 248,652 68
Proteins 47,281 248,123 68


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process1.32e-070Least InformativeDirect
Biological Process (BP)single-organism metabolic process5.158e-060Least InformativeDirect
Biological Process (BP)regulation of cellular process0.87961Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.062241.273e-11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.013693.514e-10Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.8741Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.076324.657e-10Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.040251.208e-09Least InformativeInherited
Biological Process (BP)response to stimulus0.73821Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97021Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process5.207e-060Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process5.477e-070Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process2.69e-070Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process9.913e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.688e-153.755e-15Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process2.091e-060Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process7.866e-050Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00078639.309e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0065990.4261Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.07761Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.098161Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus1.627e-060.009417Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.41281Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.15451Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.69551Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.41071Moderately InformativeInherited
Biological Process (BP)cellular response to stress1.772e-060.003822Moderately InformativeInherited
Biological Process (BP)regulation of localization0.065971Moderately InformativeInherited
Biological Process (BP)ion transport0.069790.9239Moderately InformativeInherited
Biological Process (BP)organic substance transport0.18670.9829Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.59321Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0085830.04535Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.022730.02561Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process2.784e-080.006589Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.008571Moderately InformativeInherited
Biological Process (BP)system process0.061151Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process1.122e-074.605e-05InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process9.277e-081.086e-14InformativeDirect
Biological Process (BP)response to oxidative stress1.688e-156.071e-14InformativeDirect
Biological Process (BP)response to inorganic substance6.805e-067.866e-09InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00075710InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00058371.056e-05InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway1.533e-050.0004718InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0055220.7422InformativeInherited
Biological Process (BP)positive regulation of transport0.00048840.1204InformativeInherited
Biological Process (BP)nitrogen compound transport0.0092550.1512InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.004080.109InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression1.781e-060.04598InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process1.154e-060.007588InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.029230.02023InformativeInherited
Biological Process (BP)regulation of ion transport0.00039180.01698InformativeInherited
Biological Process (BP)alcohol metabolic process0.14481InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process1.399e-050.03642InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0079550.02017InformativeInherited
Biological Process (BP)vitamin metabolic process0.0063910.02457InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.11620.4968InformativeInherited
Biological Process (BP)single-organism behavior4.417e-050.1348InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.20640.8804InformativeInherited
Biological Process (BP)synaptic transmission1.778e-050.1912InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels6.614e-070.0001189Highly InformativeDirect
Biological Process (BP)lactate metabolic process00Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process6.885e-076.335e-08Highly InformativeDirect
Biological Process (BP)neurotransmitter transport7.238e-088.85e-05Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process2.02e-073.563e-12Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process2.208e-136.572e-12Highly InformativeDirect
Biological Process (BP)regulation of proton transport1.24e-117.769e-10Highly InformativeDirect
Biological Process (BP)monoamine transport5.659e-118.398e-10Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport1.818e-077.117e-06Highly InformativeDirect
Biological Process (BP)adult behavior3.243e-090.0001842Highly InformativeDirect
Biological Process (BP)regulation of protein stability4.548e-091.405e-06Highly InformativeDirect
Biological Process (BP)regulation of transporter activity2.103e-094.29e-06Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process2.044e-087.004e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species2.452e-065.093e-11Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport1.328e-076.388e-05Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process3.341e-052.177e-08Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process8.849e-083.037e-10Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide5.959e-092.132e-09Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process2.643e-061.138e-05Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process5.929e-076.634e-06Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process5.679e-102.694e-10Highly InformativeDirect
Biological Process (BP)vitamin B6 metabolic process0.0004262.166e-05Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process1.72e-122.069e-11Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.00070430Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway4.146e-065.575e-05Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.030020.004562Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00012410.06151Highly InformativeInherited
Biological Process (BP)regulation of membrane potential9.333e-070.001735Highly InformativeInherited
Biological Process (BP)regulation of binding5.793e-070.001221Highly InformativeInherited
Biological Process (BP)cellular modified amino acid biosynthetic process0.015710.09443Highly InformativeInherited
Biological Process (BP)locomotory behavior2.331e-070.002146Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.0019890.0003143Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.6881Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.85941Moderately InformativeInherited
Molecular Function (MF)lyase activity0.00050640.001638Moderately InformativeInherited
Molecular Function (MF)peptidase activity2.052e-081.214e-09InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.00058652.278e-07InformativeDirect
Molecular Function (MF)transaminase activity7.512e-051.353e-08Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity1.694e-110Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge3.165e-050.01065Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 4.657e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.273e-11 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.208e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.514e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0002896 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 3.755e-15 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.609e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 9.309e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.4261 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.009417 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003822 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9239 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9829 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.04535 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001278 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.02561 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001438 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.006589 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 4.605e-05 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 1.086e-14 Informative Direct
Biological Process (BP) response to oxidative stress 6.071e-14 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 2.28e-12 Informative Direct
Biological Process (BP) response to inorganic substance 7.866e-09 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 9.591e-08 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.056e-05 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0004718 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.7422 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1204 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1512 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.109 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.04598 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.007588 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01698 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.03642 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02017 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.02457 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.4968 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.1348 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.02023 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.8804 Informative Inherited
Biological Process (BP) synaptic transmission 0.1912 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.8308 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0001189 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide metabolic process 8.019e-12 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 0.0003143 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 6.335e-08 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 8.85e-05 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 3.563e-12 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 5.38e-10 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 6.572e-12 Highly Informative Direct
Biological Process (BP) regulation of proton transport 7.769e-10 Highly Informative Direct
Biological Process (BP) monoamine transport 8.398e-10 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 7.117e-06 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001842 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.405e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.29e-06 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 7.004e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 5.093e-11 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 6.388e-05 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 2.177e-08 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 3.037e-10 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 2.132e-09 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 1.138e-05 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 6.634e-06 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 2.694e-10 Highly Informative Direct
Biological Process (BP) vitamin B6 metabolic process 2.166e-05 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 3.788e-14 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 2.069e-11 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 8.624e-05 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 5.575e-05 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.004562 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.06151 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.001735 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001221 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.04996 Highly Informative Inherited
Biological Process (BP) guanosine-containing compound metabolic process 0.00926 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.09443 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.003186 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.002146 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.001638 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 1.214e-09 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0005374 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.134e-06 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 2.278e-07 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004619 Informative Inherited
Molecular Function (MF) exopeptidase activity 1.578e-06 Highly Informative Direct
Molecular Function (MF) transaminase activity 1.353e-08 Highly Informative Direct
Molecular Function (MF) antioxidant activity 1.441e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 2.431e-09 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0003668 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01065 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.07932 Least Informative Inherited
Cellular Component (CC) cytosol 1.245e-05 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.9975Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.2799Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.8592Moderately InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases7.861e-09InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0.165InformativeInherited
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)locomotion variant0.0001427Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to enzymatic treatment5.155e-05Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)male fertile0.0003711Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.2651Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.8517Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1.533e-05InformativeDirect
Enzyme Commission (EC)Omega peptidases0.1303InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.1426InformativeInherited
Enzyme Commission (EC)Hexosyltransferases1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.002005Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.1371Highly InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis2.372e-16Highly InformativeDirect
Biological processFolate biosynthesis7.797e-10Highly InformativeDirect
Biological processFertilization1.2e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionPyridoxal phosphate0Highly InformativeDirect
Post-translational modificationTransferase0.0255Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationProtease0.013Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease1.434e-14InformativeDirect
Post-translational modificationCarboxypeptidase0.0003431Highly InformativeDirect
Post-translational modificationOxidation8.962e-05Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism5.29e-10Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis3.266e-14InformativeDirect
UniPathway (UP)polyketide biosynthesis0.5398InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.8005InformativeInherited
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class I glutamine amidotransferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Class I glutamine amidotransferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]