SUPERFAMILY 1.75 HMM library and genome assignments server


Class I glutamine amidotransferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Class I glutamine amidotransferase-like [ 52317] (9)
Families:   Class I glutamine amidotransferases (GAT) [ 52318] (11)
  A4 beta-galactosidase middle domain [ 82351]
  DJ-1/PfpI [ 52325] (9)
  Catalase, C-terminal domain [ 52328]
  Aspartyl dipeptidase PepE [ 52331]
  ThuA-like [ 110486]
  LD-carboxypeptidase A N-terminal domain-like [ 142074]
  HTS-like [ 142077]
  STM3548-like [ 159492]


Superfamily statistics
Genomes (3,254) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,855 248,652 68
Proteins 47,273 248,123 68


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process4.457e-070Least InformativeDirect
Biological Process (BP)single-organism metabolic process4.827e-060Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.020241.521e-11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0091721.687e-09Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.84721Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.025618.811e-10Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.011292.473e-09Least InformativeInherited
Biological Process (BP)response to stimulus0.71581Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.98811Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process3.446e-060Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process9.68e-080Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process4.963e-081.944e-15Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process2.282e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process3.988e-070Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process2.213e-050Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.0068350.4166Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.13341Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.71481Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death11Moderately InformativeInherited
Biological Process (BP)cellular response to stress1.058e-050.00534Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus4.334e-060.01232Moderately InformativeInherited
Biological Process (BP)regulation of localization0.055121Moderately InformativeInherited
Biological Process (BP)ion transport0.065580.9192Moderately InformativeInherited
Biological Process (BP)organic substance transport0.17590.9738Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0044640.02566Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.033480.05895Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.67661Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process1.049e-070.007662Moderately InformativeInherited
Biological Process (BP)system process0.056291Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.001380.0001446Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process5.935e-070.0001494InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process7.65e-081.091e-14InformativeDirect
Biological Process (BP)response to oxidative stress02.971e-14InformativeDirect
Biological Process (BP)response to inorganic substance1.874e-052.104e-08InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00075240InformativeDirect
Biological Process (BP)positive regulation of transport0.00033750.1101InformativeInherited
Biological Process (BP)nitrogen compound transport0.0086750.147InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.00410.08962InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0011372.19e-05InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression1.482e-060.04343InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.047270.02412InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process3.889e-060.008822InformativeInherited
Biological Process (BP)regulation of ion transport0.00042330.01491InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process9.991e-060.03976InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.014760.06003InformativeInherited
Biological Process (BP)vitamin metabolic process0.0053470.01498InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.088250.385InformativeInherited
Biological Process (BP)single-organism behavior3.366e-050.1212InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.19730.9512InformativeInherited
Biological Process (BP)synaptic transmission1.562e-050.1824InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels7.642e-070.0001039Highly InformativeDirect
Biological Process (BP)lactate metabolic process6.509e-150Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process3.319e-073.184e-07Highly InformativeDirect
Biological Process (BP)neurotransmitter transport6.761e-087.691e-05Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process1.215e-078.46e-13Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process7.564e-121.783e-10Highly InformativeDirect
Biological Process (BP)regulation of proton transport1.159e-117.495e-10Highly InformativeDirect
Biological Process (BP)monoamine transport5.27e-118.76e-10Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport1.687e-076.732e-06Highly InformativeDirect
Biological Process (BP)adult behavior2.998e-090.0001743Highly InformativeDirect
Biological Process (BP)regulation of protein stability5.537e-091.298e-06Highly InformativeDirect
Biological Process (BP)regulation of transporter activity1.962e-094.055e-06Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species7.677e-061.884e-10Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport1.235e-075.595e-05Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process2.41e-051.588e-08Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process7.927e-081.197e-10Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide2.063e-088.345e-09Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process2.456e-064.915e-05Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process6.832e-074.817e-06Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process1.05e-083.707e-09Highly InformativeDirect
Biological Process (BP)vitamin B6 metabolic process0.0004241.901e-05Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.0001240.0001302Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process4.844e-114.993e-10Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.00074080Highly InformativeDirect
Biological Process (BP)regulation of membrane potential1.392e-050.005453Highly InformativeInherited
Biological Process (BP)regulation of binding5.076e-070.001078Highly InformativeInherited
Biological Process (BP)cellular modified amino acid biosynthetic process0.015020.1655Highly InformativeInherited
Biological Process (BP)locomotory behavior1.782e-070.001709Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.0020090.0002711Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.65581Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.83341Moderately InformativeInherited
Molecular Function (MF)lyase activity0.0013920.002147Moderately InformativeInherited
Molecular Function (MF)peptidase activity1.623e-081.202e-09InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity9.622e-052.342e-08InformativeDirect
Molecular Function (MF)transaminase activity6.705e-051.577e-07Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity9.846e-120Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge1.989e-050.01037Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 8.811e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.521e-11 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.473e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.687e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.944e-15 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.205e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001446 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.4166 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01232 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00534 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9192 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9738 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02566 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.01057 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.05895 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.004934 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.06166 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.007662 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0001494 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 1.091e-14 Informative Direct
Biological Process (BP) response to oxidative stress 2.971e-14 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 3.657e-10 Informative Direct
Biological Process (BP) response to inorganic substance 2.104e-08 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 3.77e-15 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 4.446e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.19e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.1101 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.147 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.08962 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.04343 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.1882 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.008822 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01491 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.03976 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.06003 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.01498 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.385 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.849 Informative Inherited
Biological Process (BP) single-organism behavior 0.1212 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.02412 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.9512 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.005843 Informative Inherited
Biological Process (BP) synaptic transmission 0.1824 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0001039 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide metabolic process 4.66e-08 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 0.0002711 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 3.184e-07 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 7.691e-05 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 8.46e-13 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 2.015e-10 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0008618 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 1.783e-10 Highly Informative Direct
Biological Process (BP) regulation of proton transport 7.495e-10 Highly Informative Direct
Biological Process (BP) monoamine transport 8.76e-10 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 6.732e-06 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001743 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.298e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.055e-06 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 1.884e-10 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 5.595e-05 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 1.588e-08 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 1.197e-10 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 8.345e-09 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 4.915e-05 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 4.817e-06 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 3.707e-09 Highly Informative Direct
Biological Process (BP) vitamin B6 metabolic process 1.901e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001302 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 1.002e-08 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 4.993e-10 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 6.059e-05 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.005453 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001078 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.03979 Highly Informative Inherited
Biological Process (BP) guanosine-containing compound metabolic process 0.007635 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.1655 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.001709 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.002147 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 1.202e-09 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0004358 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.118e-06 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 2.342e-08 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.00336 Informative Inherited
Molecular Function (MF) exopeptidase activity 1.657e-06 Highly Informative Direct
Molecular Function (MF) transaminase activity 1.577e-07 Highly Informative Direct
Molecular Function (MF) antioxidant activity 1.167e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 1.931e-09 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0003566 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01037 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.9975Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.2799Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.8592Moderately InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases7.861e-09InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0.165InformativeInherited
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)locomotion variant0.0001427Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to enzymatic treatment5.15e-05Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)male fertile0.000383Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.23Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.8528Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1.755e-05InformativeDirect
Enzyme Commission (EC)Omega peptidases0.1288InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.1414InformativeInherited
Enzyme Commission (EC)Hexosyltransferases1InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.001899Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.136Highly InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis2.37e-16Highly InformativeDirect
Biological processFolate biosynthesis6.026e-07Highly InformativeDirect
Biological processFertilization1.192e-05Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionPyridoxal phosphate0Highly InformativeDirect
Post-translational modificationTransferase0.03277Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationProtease0.01283Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease1.411e-14InformativeDirect
Post-translational modificationCarboxypeptidase0.0003445Highly InformativeDirect
Post-translational modificationOxidation8.928e-05Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism4.356e-10Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis3.318e-14InformativeDirect
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class I glutamine amidotransferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Class I glutamine amidotransferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]