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Methylglyoxal synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Methylglyoxal synthase-like [ 52334]
Superfamily:   Methylglyoxal synthase-like [ 52335] (3)
Families:   Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain [ 52336]
  Methylglyoxal synthase, MgsA [ 52339]
  Inosicase [ 63971]


Superfamily statistics
Genomes (2,885) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,035 39,356 12
Proteins 6,996 39,108 12


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000004544 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000000000001925 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000000004553 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000003008 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000003353 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00001543 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000004006 Least Informative Direct
Biological Process (BP) primary metabolic process 0.361 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9876 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6237 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000834 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000009323 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000001085 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.2659 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1207 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07801 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1403 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.001009 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.006264 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.119 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.09075 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.1271 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.003972 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.02022 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) central nervous system development 0.0003989 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00000003369 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001282 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0000001533 Informative Direct
Biological Process (BP) circulatory system development 0.000445 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.007593 Informative Inherited
Biological Process (BP) cell development 0.03363 Informative Inherited
Biological Process (BP) generation of neurons 0.03172 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.004114 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001562 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.0000000000001756 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.00001032 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000001666 Highly Informative Direct
Biological Process (BP) neuron development 0.01551 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.005414 Highly Informative Inherited
Molecular Function (MF) binding 0.1482 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.1201 Least Informative Inherited
Molecular Function (MF) transferase activity 0.04429 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.01259 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.1978 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.003084 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001491 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000001256 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0001696 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00006905 Informative Direct
Molecular Function (MF) identical protein binding 0.0002379 Informative Direct
Molecular Function (MF) ATP binding 0.000009558 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.0000000002804 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.0000001683 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.004387 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.000000004493Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)IMP cyclohydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0.000009021Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Methylglyoxal synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Methylglyoxal synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]