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Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52342]
Superfamily:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52343] (5)
Families:   Reductases [ 52344] (4)
  Aromatic dioxygenase reductase-like [ 52359] (3)
  Dihydroorotate dehydrogenase B, PyrK subunit [ 52362]
  NADPH-cytochrome p450 reductase-like [ 52365] (3)
  Flavohemoglobin, C-terminal domain [ 52370]

 Superfamily statistics
Genomes (2,175) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 17,014 36,647 57
Proteins 16,993 36,625 57

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0009855 Least Informative Direct
Biological Process (BP) response to stimulus 1.515e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9632 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3332 Least Informative Inherited
Biological Process (BP) developmental process 0.06743 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.719 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3417 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8812 Least Informative Inherited
Biological Process (BP) multi-organism process 5.793e-11 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 1.158e-14 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.663e-08 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.483e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.649e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.34 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1548 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.0155 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2578 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.563 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.2925 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7651 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03672 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5943 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1405 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001702 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) system process 0.7428 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.08969 Moderately Informative Inherited
Biological Process (BP) ion transport 0.08422 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.003908 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1293 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.76 Moderately Informative Inherited
Biological Process (BP) blood circulation 0.0004243 Informative Direct
Biological Process (BP) response to organic nitrogen 0.000264 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0008055 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000663 Informative Direct
Biological Process (BP) response to cytokine stimulus 3.778e-05 Informative Direct
Biological Process (BP) regulation of ion transport 0.00039 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0002463 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.1375 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.08622 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4004 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4093 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) metal ion transport 0.1997 Informative Inherited
Biological Process (BP) transmembrane transport 0.06892 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) steroid metabolic process 0.002873 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2356 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.08439 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.2136 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.01335 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.3206 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.001701 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.09868 Informative Inherited
Biological Process (BP) sexual reproduction 0.3562 Informative Inherited
Biological Process (BP) reproductive system development 0.004393 Informative Inherited
Biological Process (BP) transition metal ion transport 4.582e-05 Highly Informative Direct
Biological Process (BP) arginine metabolic process 1.127e-06 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0005341 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 1.86e-05 Highly Informative Direct
Biological Process (BP) cellular iron ion homeostasis 3.753e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.46e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 6.795e-13 Highly Informative Direct
Biological Process (BP) sterol metabolic process 9.107e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.819e-05 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 2.156e-10 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001165 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 1.236e-05 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0002643 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.507e-05 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.01498 Highly Informative Inherited
Biological Process (BP) gonad development 0.01948 Highly Informative Inherited
Biological Process (BP) aging 0.01828 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01582 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.0157 Highly Informative Inherited
Molecular Function (MF) binding 0.6563 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0009455 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 1.979e-05 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1.307e-05 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 3.396e-08 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01759 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.465 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.1987 Highly Informative Inherited
Cellular Component (CC) membrane 7.909e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 4.602e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3295 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1.454e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0001602 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.08349 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04166 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01834 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.4885 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0165 Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.08434 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors1.01e-14Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions1.728e-13InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.1139InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase1.117e-12Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)6.783e-10Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor4.206e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.07256Least InformativeInherited
Disease Ontology (DO)nervous system disease0.6514Least InformativeInherited
Disease Ontology (DO)lung disease0.001307Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02346Moderately InformativeInherited
Disease Ontology (DO)brain disease0.1459Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2224Moderately InformativeInherited
Disease Ontology (DO)malaria2.474e-05InformativeDirect
Disease Ontology (DO)allergic rhinitis2.474e-05InformativeDirect
Disease Ontology (DO)migraine0.0008685InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.0615InformativeInherited
Disease Ontology (DO)thyroid gland disease0.1023InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction4.877e-07Highly InformativeDirect
Disease Ontology (DO)hypothyroidism3.967e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00996Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1485Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.338Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4063Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4582Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.0006102Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.001521Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.001581Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.01756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.02168Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.02534Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.04437Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.05181Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0608Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.06358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.07079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1681Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1938Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.469Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology2.665e-05InformativeDirect
Mammalian Phenotype (MP)pathological neovascularization0.000124InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001688InformativeDirect
Mammalian Phenotype (MP)abnormal artery morphology0.0002759InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.0003406InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0005096InformativeDirect
Mammalian Phenotype (MP)abnormal circulating amino acid level0.001405InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001496InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.001921InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.003131InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003163InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.004359InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.004654InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.005316InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.007307InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.008616InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.01261InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01282InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02292InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.03265InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03304InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.0399InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.05187InformativeInherited
Mammalian Phenotype (MP)seizures0.05262InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.07509InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.07768InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.07993InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.09572InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2359InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy1.178e-09Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level7.878e-09Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis1.793e-08Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure1.014e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis1.72e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.665e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level7.681e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis9.669e-07Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis9.669e-07Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia3.493e-06Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion3.493e-06Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis5.394e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level6.156e-06Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion9.85e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount1.103e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level1.844e-05Highly InformativeDirect
Mammalian Phenotype (MP)hypertension2.027e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level2.4e-05Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis2.829e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mineral density4.147e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number4.147e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level4.455e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function5.306e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure6.714e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001169Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0001177Highly InformativeDirect
Mammalian Phenotype (MP)decreased cardiac muscle contractility0.000151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0002361Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0003611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0003733Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0003867Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004045Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0005694Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coronary artery morphology0.0006297Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0007289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.03686Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.05035Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.1146Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors1.576e-14InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors6.068e-09InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions1.93e-13Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.2945Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.0002032Moderately InformativeDirect
Biological processLipid metabolism0.006805Moderately InformativeInherited
Biological processIon transport0.1047Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.0004016InformativeDirect
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processOxygen transport2.729e-15Highly InformativeDirect
Biological processThyroid hormones biosynthesis5.216e-14Highly InformativeDirect
Biological processLuminescence8.932e-12Highly InformativeDirect
Biological processCholesterol biosynthesis2.376e-11Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentThylakoid0.0006874InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionCalcium6.856e-07Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Molecular functionFMN0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Molecular functionIron transport0.0005484Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMyristate1.146e-07InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism6.123e-15Least InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation5.231e-05Moderately InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)hormone metabolism2.424e-09InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis2.169e-07InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)vanillyl-alcohol degradation1.587e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferredoxin reductase-like, C-terminal NADP-linked domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.