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Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52342]
Superfamily:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52343] (5)
Families:   Reductases [ 52344] (4)
  Aromatic dioxygenase reductase-like [ 52359] (3)
  Dihydroorotate dehydrogenase B, PyrK subunit [ 52362]
  NADPH-cytochrome p450 reductase-like [ 52365] (3)
  Flavohemoglobin, C-terminal domain [ 52370]


Superfamily statistics
Genomes (2,831) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 20,550 97,380 57
Proteins 20,517 97,269 57


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0000000009289 Least Informative Direct
Biological Process (BP) response to stimulus 0.0007494 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6027 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9641 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9344 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3978 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.00003772 Moderately Informative Direct
Biological Process (BP) defense response 0.000009935 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0000001105 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000005712 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000004648 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00002351 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.3499 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7861 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9369 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7763 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01887 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.2878 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2046 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.386 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.001571 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.07069 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.6216 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4883 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3453 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.01178 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.812 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2997 Moderately Informative Inherited
Biological Process (BP) cell communication 0.5172 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7588 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8128 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.07529 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3338 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.919 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01117 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.00003393 Informative Direct
Biological Process (BP) lipid localization 0.0001589 Informative Direct
Biological Process (BP) organic acid transport 0.0002934 Informative Direct
Biological Process (BP) electron transport chain 0.00001327 Informative Direct
Biological Process (BP) secretion by cell 0.00009078 Informative Direct
Biological Process (BP) alcohol metabolic process 0.691 Informative Inherited
Biological Process (BP) regulation of defense response 0.1078 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1017 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001344 Informative Inherited
Biological Process (BP) protein transport 0.1978 Informative Inherited
Biological Process (BP) anion transport 0.1785 Informative Inherited
Biological Process (BP) cation homeostasis 0.00342 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.003922 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.3362 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01906 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1762 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5837 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1864 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.006848 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01642 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.009007 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.1589 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.007161 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3846 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1187 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.05332 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.05332 Informative Inherited
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.001193 Informative Inherited
Biological Process (BP) system process 0.5728 Informative Inherited
Biological Process (BP) behavior 0.3148 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.04926 Informative Inherited
Biological Process (BP) metal ion transport 0.03777 Informative Inherited
Biological Process (BP) transition metal ion transport 0.00006802 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.000002391 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.0000009248 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000004619 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.0000009219 Highly Informative Direct
Biological Process (BP) protein secretion 0.00000008163 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000000003023 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000148 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00001243 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000004118 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.00006325 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.00000000000149 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0004692 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00002803 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.0001558 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) response to ketone 0.004568 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.0398 Highly Informative Inherited
Biological Process (BP) aging 0.01129 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 0.003523 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00008851 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002209 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.00000006409 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000000000000002411 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.00000000000002862 Highly Informative Direct
Molecular Function (MF) iron-sulfur cluster binding 0.00008037 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on iron-sulfur proteins as donors 0.001472 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.02855 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.003956 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.8088 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.7601 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.07004 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8331 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.01923 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.2842 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.001722 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0004559 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00000000001178 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0163 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000000000000101Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.0000000000001728InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.1139InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000006783Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.000278Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.000284Moderately InformativeDirect
Biological processIon transport0.1158Moderately InformativeInherited
Biological processSteroid metabolism0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processLipid biosynthesis0.002334InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processOxygen transport0.00000000000000286Highly InformativeDirect
Biological processLuminescence0.00000000001139Highly InformativeDirect
Biological processSterol biosynthesis0.000000238Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentThylakoid0.0009014InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0.0000285Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionIron-sulfur0Moderately InformativeDirect
Molecular functionCalcium0.0002355Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Molecular functionIron transport0.0001725Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationIon channel0.0182InformativeInherited
Post-translational modificationVoltage-gated channel0.000707Highly InformativeDirect
Post-translational modificationMyristate0.0000003512InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferredoxin reductase-like, C-terminal NADP-linked domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]