SUPERFAMILY 1.75 HMM library and genome assignments server


Nucleotidylyl transferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Families:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)
  Cytidylyltransferase [ 52394]
  Adenylyltransferase [ 52397] (5)
  Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) [ 63976]
  ATP sulfurylase catalytic domain [ 63979]


Superfamily statistics
Genomes (3,211) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 57,456 128,264 81
Proteins 56,688 127,617 81


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00087343.746e-15Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process7.801e-120Least InformativeDirect
Biological Process (BP)biosynthetic process1.586e-110Least InformativeDirect
Biological Process (BP)single-organism metabolic process2.888e-080Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00075480Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0017840Least InformativeInherited
Biological Process (BP)protein metabolic process0.96331.059e-07Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.2728Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process7.469e-060Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process5.313e-101.432e-09Moderately InformativeDirect
Biological Process (BP)gene expression4.902e-050Moderately InformativeDirect
Biological Process (BP)RNA metabolic process4.815e-050Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process3.729e-094.68e-09Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process3.152e-155.924e-07Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.82150.6867Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.64220.1175Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.03760.01685Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.39771Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00066070.7334Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process7.056e-060.8743Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.012261Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.017851Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process1.42e-060.03045Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0039251Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.070671Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.18960Moderately InformativeInherited
Biological Process (BP)translation9.311e-080InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process5.618e-050InformativeDirect
Biological Process (BP)coenzyme biosynthetic process1.357e-066.995e-11InformativeDirect
Biological Process (BP)nucleotide biosynthetic process1.192e-061.773e-14InformativeDirect
Biological Process (BP)ncRNA metabolic process1.101e-080InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00075110.0002017InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.00013197.348e-12InformativeDirect
Biological Process (BP)alcohol metabolic process0.099930.736InformativeInherited
Biological Process (BP)phospholipid metabolic process0.055781.009e-10InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.053880.002571InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.045931.677e-06InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process4.395e-070.003469InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.39131InformativeInherited
Biological Process (BP)vitamin metabolic process0.00016880.1007InformativeInherited
Biological Process (BP)cellular amide metabolic process0.041870.9709InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.60720.9292InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process0.03660.0004979InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.11270.163InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process0.00041262.238e-09Highly InformativeDirect
Biological Process (BP)coenzyme A metabolic process0.00044238.122e-08Highly InformativeDirect
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process1.573e-090Highly InformativeDirect
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process1.573e-091.931e-15Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process5.431e-064.306e-05Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process5.379e-090Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process1.269e-051.484e-08Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process5.139e-146.316e-09Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process1.03e-071.319e-09Highly InformativeDirect
Biological Process (BP)amide biosynthetic process0.034360.03966Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.010175.105e-08Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.10590.4447Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)nucleotide binding0.029050.0495InformativeInherited
Molecular Function (MF)purine ribonucleoside binding0.012440.004486InformativeInherited
Molecular Function (MF)purine ribonucleoside triphosphate binding0.0087970.002963InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)ATP binding0.00017020.0001258Highly InformativeDirect
Molecular Function (MF)adenylyltransferase activity4.541e-101.066e-11Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00044280.00361Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.049730Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 3.746e-15 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 1.059e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2728 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.432e-09 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 4.68e-09 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.924e-07 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6867 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1175 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01685 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.7334 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.8743 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.03045 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6511 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.002312 Moderately Informative Inherited
Biological Process (BP) translation 0 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 1.009e-10 Informative Direct
Biological Process (BP) mitochondrion organization 7.997e-09 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 6.995e-11 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 1.773e-14 Informative Direct
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002017 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0004979 Informative Direct
Biological Process (BP) glycerolipid metabolic process 7.348e-12 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.677e-06 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.736 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.163 Informative Inherited
Biological Process (BP) reproductive structure development 0.03945 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.003469 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.1007 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.9709 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.9292 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.002571 Informative Inherited
Biological Process (BP) purine ribonucleotide biosynthetic process 2.238e-09 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 8.122e-08 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 1.931e-15 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 4.306e-05 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 5.105e-08 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 1.484e-08 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 6.316e-09 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.105e-05 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 1.319e-09 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.004247 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03966 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4447 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.9084 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.0495 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.004486 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.002963 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) RNA binding 0.003793 Informative Inherited
Molecular Function (MF) ATP binding 0.0001258 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 1.066e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00361 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.7232 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0009628 Informative Direct
Cellular Component (CC) plastid 7.04e-08 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Tryptophan--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Isoleucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Leucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0Highly InformativeDirect
Enzyme Commission (EC)Arginine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Glutamate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1.827e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6108Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.007615Moderately InformativeInherited
Phenotypic Abnormality (PA)Increased serum lactate0.0001252Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002319Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.4024Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0112Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.04175Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.1746Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2959Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5054Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb3.354e-07InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0003724InformativeDirect
Worm Phenotype (WP)brood size variant0.0004107InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0193InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03735InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.0003Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0005038Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0005572Highly InformativeDirect
Worm Phenotype (WP)organism oxidative stress response variant0.001512Highly InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.06148Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell size defective0.0004731InformativeDirect
Fly Phenotype (FP)decreased cell size0.0001405Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)eye0Moderately InformativeDirect
Zebrafish Anatomy (ZA)gut0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01124Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.02258Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.09702Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.4179Least InformativeInherited
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0002934Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0.0008758Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1.26e-10Highly InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processProtein biosynthesis0InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processCysteine biosynthesis3.895e-10Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainCoiled coil1.553e-10Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein1Moderately InformativeInherited
Molecular functionRNA-binding1Moderately InformativeInherited
Molecular functiontRNA-binding0InformativeDirect
Molecular functionFMN0.0001447InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)coenzyme A biosynthesis0InformativeDirect
UniPathway (UP)phospholipid metabolism0.001813InformativeInherited
UniPathway (UP)phospholipid biosynthesis0.0001464Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotidylyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]