SUPERFAMILY 1.75 HMM library and genome assignments server

Nucleotidylyl transferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Families:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)
  Cytidylyltransferase [ 52394]
  Adenylyltransferase [ 52397] (5)
  Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) [ 63976]
  ATP sulfurylase catalytic domain [ 63979]


Superfamily statistics
Genomes (3,253) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 58,623 283,155 81
Proteins 57,744 282,172 81


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00021960Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.00000000000018640Least InformativeDirect
Biological Process (BP)biosynthetic process0.0000000000000063590Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000016660Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000035090.00000000005994Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00019480Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00049630Least InformativeDirect
Biological Process (BP)protein metabolic process0.92340.0000000002349Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.04106Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00000031980Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00000000024190.00000006867Moderately InformativeDirect
Biological Process (BP)gene expression0.0000066730Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.000003640Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.0000000049060.0000004357Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process00.00000009208Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000001040.0002854Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.0040621Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.66330.4185Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.087290.06781Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0010291Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.43221Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00000047670.983Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0061851Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.23661Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00000011140.07683Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.1110Moderately InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.000089510InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.0000003990.0000000004897InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.0000000025240InformativeDirect
Biological Process (BP)ncRNA metabolic process0.000000000074230InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.00018880.00000000002079InformativeDirect
Biological Process (BP)phospholipid metabolic process0.066910.0000000002001InformativeInherited
Biological Process (BP)alcohol metabolic process0.18030.9162InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.00039670.001024InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.030720.002923InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.019470.000002081InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.000003120.008831InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.27050.7752InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.42431InformativeInherited
Biological Process (BP)amide biosynthetic process0.030040.01847InformativeInherited
Biological Process (BP)vitamin metabolic process0.000090440.08895InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.58340.9655InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process0.014110.0006021InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.25730.5114InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.00012160.0000002173Highly InformativeDirect
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process0.000000000055890Highly InformativeDirect
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.000000000055890.000000000000007248Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00000047760.000005811Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.00000067640Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.000017590.0000000247Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.00000000000015540.00000001132Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process0.0000016420.000000009872Highly InformativeDirect
Molecular Function (MF)binding0.95741Least InformativeInherited
Molecular Function (MF)transferase activity0.00015570.7741Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.032730.02859Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.012510.0102Moderately InformativeInherited
Molecular Function (MF)anion binding0.049970.135Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)ligase activity00InformativeDirect
Molecular Function (MF)nucleotide binding0.0096440.003461InformativeInherited
Molecular Function (MF)purine ribonucleoside binding0.0031460.00009023InformativeInherited
Molecular Function (MF)purine ribonucleoside triphosphate binding0.0020930.00005027InformativeInherited
Molecular Function (MF)ATP binding0.000018240.000000542Highly InformativeDirect
Molecular Function (MF)adenylyltransferase activity0.0000000000098720.0000000000001722Highly InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.0000000000074830.007825Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0005070.0001269Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000000002349 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000005994 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.04106 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000006867 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000004357 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000009208 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0002854 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.07683 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02699 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.06781 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.983 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.4185 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000000002001 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000000213 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0000000004897 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0 Informative Direct
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0006021 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000002079 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000002081 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.9655 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.1267 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.9162 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.5114 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.001024 Informative Inherited
Biological Process (BP) immune response 0.9812 Informative Inherited
Biological Process (BP) response to cytokine 0.2608 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.008831 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.01847 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.08895 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.7752 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.002923 Informative Inherited
Biological Process (BP) coenzyme A metabolic process 0.0000002173 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0.000000000000007248 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000005811 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0000000247 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0.00000001132 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0001678 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0.000000009872 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.01001 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5383 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7741 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.135 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0102 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.02859 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00009023 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00005027 Informative Direct
Molecular Function (MF) nucleotide binding 0.003461 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) RNA binding 0.008 Informative Inherited
Molecular Function (MF) ATP binding 0.000000542 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 0.0000000000001722 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.007825 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001269 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000007093 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.3488 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.00001339 Informative Direct
Cellular Component (CC) plastid 0.00001243 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Tryptophan--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Isoleucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Leucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0Highly InformativeDirect
Enzyme Commission (EC)Arginine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Glutamate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0.00000001827Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6045Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.007498Moderately InformativeInherited
Phenotypic Abnormality (PA)Increased serum lactate0.0001366Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002319Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.4024Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0112Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.04175Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.1746Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2959Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5054Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.0000003354InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0003724InformativeDirect
Worm Phenotype (WP)brood size variant0.0004107InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0193InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03735InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.0003Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0005038Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0005572Highly InformativeDirect
Worm Phenotype (WP)organism oxidative stress response variant0.001512Highly InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.06148Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell size0.0001168Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)gut0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01124Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.02258Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.09702Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.4179Least InformativeInherited
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0002934Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0.0008758Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0.00000000007129Highly InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.04653Least InformativeInherited
Drugbank ATC_code (DB)psychoanaleptics0.1762Moderately InformativeInherited
Drugbank ATC_code (DB)other antidepressants0.0002651InformativeDirect
Drugbank ATC_code (DB)tryptophan0.000059Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processProtein biosynthesis0InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processCysteine biosynthesis0.00000000035Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainCoiled coil0.0000000003331Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionFlavoprotein1Moderately InformativeInherited
Molecular functionRNA-binding1Moderately InformativeInherited
Molecular functiontRNA-binding0InformativeDirect
Molecular functionFMN0.00003273InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.9014Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.000002431Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.007377Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis0.0398Moderately InformativeInherited
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0.0000000008373InformativeDirect
UniPathway (UP)phospholipid metabolism0.05402InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)(R)-pantothenate biosynthesis0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)FAD biosynthesis0Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerophospholipid biosynthesis0.00000000347Highly InformativeDirect
UniPathway (UP)phosphatidylethanolamine biosynthesis0.00009489Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.0001772Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0005048Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotidylyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]