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Adenine nucleotide alpha hydrolases-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Adenine nucleotide alpha hydrolases-like [ 52402] (6)
Families:   N-type ATP pyrophosphatases [ 52403] (8)
  PP-loop ATPase [ 82359] (2)
  PAPS reductase-like [ 52410] (2)
  ETFP subunits [ 52432] (2)
  Universal stress protein-like [ 52436] (7)
  ThiI-like [ 142093] (2)


Superfamily statistics
Genomes (3,262) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,870 279,809 38
Proteins 54,123 265,904 38


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.69080.03421Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.7060.000000000001471Least InformativeInherited
Biological Process (BP)single-organism cellular process0.62881Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.078320.00000574Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.5130Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.71080.0000000000001732Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.64750.000000000000001945Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.29441Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.050140.3971Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0013950.0000000002001Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.041320.7791Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.000066960.009111Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.10431Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.03891Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.076451Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.17730.02429Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0019160.002835Moderately InformativeInherited
Biological Process (BP)cellular lipid catabolic process0.0000035370.0000002188InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.00051220.000201InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.0013020.06549InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00022010.02015InformativeInherited
Biological Process (BP)fatty acid catabolic process0.000000026610.0000000001903Highly InformativeDirect
Biological Process (BP)NAD metabolic process0.000001940.00000002756Highly InformativeDirect
Biological Process (BP)lipid modification0.000000021530.000000006414Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.16950.8474Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000000017610.000000000000001646InformativeDirect
Molecular Function (MF)ligase activity0.00012110InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.00000017230.0000003325Highly InformativeDirect
Cellular Component (CC)macromolecular complex11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.59911Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.67511Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.41360Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0099661Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.0015720.1819Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000001471 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000574 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000000001732 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000000001945 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03421 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00001767 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000002001 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0002054 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3971 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.05704 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.009111 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.002835 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.7791 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.001398 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.02429 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.002784 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) ncRNA processing 0 Informative Direct
Biological Process (BP) cellular lipid catabolic process 0.0000002188 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0.000201 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000007849 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.08976 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.06549 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.007062 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.005154 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.02015 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0865 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.001343 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.02806 Informative Inherited
Biological Process (BP) tRNA modification 0 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.000003038 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0000000001903 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.00000002756 Highly Informative Direct
Biological Process (BP) lipid modification 0.000000006414 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0001267 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0.0006541 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.8474 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3073 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.04005 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00000000000007237 Informative Direct
Molecular Function (MF) electron carrier activity 0.000000000000001646 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.000002293 Informative Direct
Molecular Function (MF) transferase activity, transferring sulfur-containing groups 0.0005057 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0000003325 Highly Informative Direct
Molecular Function (MF) sulfurtransferase activity 0.000002816 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.1819 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003274Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)tRNA(Ile)-lysidine synthetase0Highly InformativeDirect
Enzyme Commission (EC)tRNA sulfurtransferase0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.0000002237Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.3524Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00107Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.02112Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.5031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.00001426InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mitochondrial metabolism0.00003913InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.002645InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.003673InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.008945InformativeInherited
Phenotypic Abnormality (PA)Abnormality of abdomen morphology0.02125InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.07936InformativeInherited
Phenotypic Abnormality (PA)Vomiting0.000003535Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.00003502Highly InformativeDirect
Phenotypic Abnormality (PA)Coma0.00004342Highly InformativeDirect
Phenotypic Abnormality (PA)Jaundice0.0001305Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatomegaly0.0004675Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.0005887Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.7139Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.01216InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.00000000009057InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0.000000000000001469Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRedox-active center0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionFlavoprotein1Moderately InformativeInherited
Molecular functionFAD0.00005131InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationtRNA-binding0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.0000004534Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.000009987Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)purine base metabolism0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)thiamine metabolism0InformativeDirect
UniPathway (UP)carnitine metabolism0.0000000000000165InformativeDirect
UniPathway (UP)tRNA modification0.00381InformativeInherited
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)purine base biosynthesis0Highly InformativeDirect
UniPathway (UP)5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)urea cycle0.0000002164Highly InformativeDirect
UniPathway (UP)FAD biosynthesis0.00002019Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Adenine nucleotide alpha hydrolases-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Adenine nucleotide alpha hydrolases-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]