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Adenine nucleotide alpha hydrolases-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Adenine nucleotide alpha hydrolases-like [ 52402] (6)
Families:   N-type ATP pyrophosphatases [ 52403] (8)
  PP-loop ATPase [ 82359] (2)
  PAPS reductase-like [ 52410] (2)
  ETFP subunits [ 52432] (2)
  Universal stress protein-like [ 52436] (7)
  ThiI-like [ 142093] (2)


Superfamily statistics
Genomes (3,258) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,787 279,809 38
Proteins 54,041 265,904 38


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.71790.00000000000005657Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.7230.000000000000007239Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.58570Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.67170Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.12570.009073Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.092760.00005366Least InformativeInherited
Biological Process (BP)primary metabolic process0.67220.01549Least InformativeInherited
Biological Process (BP)single-organism cellular process0.86131Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.032160.2458Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.069471Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0014420.000000000106Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.041180.6951Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.000072110.003358Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.18310.002415Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.11421Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.16441Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0019320.001788Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.000019520.000001443InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.00099320.008876InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.0088050.01947InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.0012730.1842InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00028290.02503InformativeInherited
Biological Process (BP)fatty acid catabolic process0.000000026220.0000000001467Highly InformativeDirect
Biological Process (BP)NAD metabolic process0.0000016420.000000008489Highly InformativeDirect
Biological Process (BP)lipid modification0.000000026220.00000000619Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.19680.8362Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000000017350.000000000000001646InformativeDirect
Molecular Function (MF)ligase activity0.00015270InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.00000020110.0000002707Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.34330Least InformativeInherited
Cellular Component (CC)protein complex0.95981Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.60161Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.66641Least InformativeInherited
Cellular Component (CC)mitochondrial part0.0016690.1801Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0068891Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000005657 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00005366 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000000007239 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.009073 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01549 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.000000000106 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.00003803 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00002386 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.3767 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.1634 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2458 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.6951 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.003358 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.002415 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.001788 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.04259 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.06857 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001449 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.00003547 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) lipid catabolic process 0.000001443 Informative Direct
Biological Process (BP) ncRNA processing 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0002982 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.008876 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.1842 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.00799 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.006221 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.01947 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.02503 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.02321 Informative Inherited
Biological Process (BP) tRNA modification 0 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0000000001467 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.000000008489 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000000619 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0.0002931 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0001234 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.8362 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.31 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.03014 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.000000000000008674 Informative Direct
Molecular Function (MF) electron carrier activity 0.000000000000001646 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.000002455 Informative Direct
Molecular Function (MF) transferase activity, transferring sulfur-containing groups 0.0005246 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0000002707 Highly Informative Direct
Molecular Function (MF) sulfurtransferase activity 0.000003028 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.1801 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003274Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)tRNA(Ile)-lysidine synthetase0Highly InformativeDirect
Enzyme Commission (EC)tRNA sulfurtransferase0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.0000002237Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.3511Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001037Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.02052Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1314Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1926Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.4741Moderately InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.00001492InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.00004332InformativeDirect
Phenotypic Abnormality (PA)Dermatological manifestations of systemic disorders0.000696InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.002908InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.003699InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.008854InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.03644InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.07594InformativeInherited
Phenotypic Abnormality (PA)Hepatic steatosis0.00003056Highly InformativeDirect
Phenotypic Abnormality (PA)Coma0.00004266Highly InformativeDirect
Phenotypic Abnormality (PA)Jaundice0.0001251Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatomegaly0.0004642Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.0005784Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.7139Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.01216InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.00000000008755InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0.000000000000001702Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRedox-active center0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functiontRNA-binding0InformativeDirect
Molecular functionFAD0.0000477InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.000000353Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.000008553Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)purine base metabolism0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)thiamine metabolism0InformativeDirect
UniPathway (UP)carnitine metabolism0.00000000000001733InformativeDirect
UniPathway (UP)tRNA modification0.006274InformativeInherited
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)purine base biosynthesis0Highly InformativeDirect
UniPathway (UP)5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)urea cycle0.0000002213Highly InformativeDirect
UniPathway (UP)FAD biosynthesis0.00002063Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Adenine nucleotide alpha hydrolases-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Adenine nucleotide alpha hydrolases-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]