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Adenine nucleotide alpha hydrolases-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Adenine nucleotide alpha hydrolases-like [ 52402] (6)
Families:   N-type ATP pyrophosphatases [ 52403] (8)
  PP-loop ATPase [ 82359] (2)
  PAPS reductase-like [ 52410] (2)
  ETFP subunits [ 52432] (2)
  Universal stress protein-like [ 52436] (7)
  ThiI-like [ 142093] (2)


Superfamily statistics
Genomes (3,265) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 57,962 323,433 38
Proteins 54,215 299,279 38


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.68990.03326Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.69740.000000000001751Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.50470Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.7030.000000000000218Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.64640.000000000000003734Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.30341Least InformativeInherited
Biological Process (BP)single-organism cellular process0.65011Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.076620.000001468Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.047070.4025Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.037960.7667Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.00007120.01046Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0013990.0000000001626Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.10351Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.036861Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.072651Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.17410.03252Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0017690.002632Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.000015160.000001539InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.0012370.07541InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.011660.02765InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00020270.01989InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.0013870.05305InformativeInherited
Biological Process (BP)fatty acid catabolic process0.00000002480.000000000157Highly InformativeDirect
Biological Process (BP)NAD metabolic process0.0000023120.0000000285Highly InformativeDirect
Biological Process (BP)lipid modification0.000000020030.000000005681Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.17310.8397Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.0000000017350.000000000000001615InformativeDirect
Molecular Function (MF)ligase activity0.00012210InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.0000001690.0000002812Highly InformativeDirect
Cellular Component (CC)protein complex0.98381Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.4370Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.61251Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.68881Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.011181Moderately InformativeInherited
Cellular Component (CC)mitochondrial protein complex0.0082480.003031Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000001751 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000001468 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000000218 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000000003734 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03326 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.000007339 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000001626 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0007713 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0002328 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.05734 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.4025 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.7667 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.01046 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.002632 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.03252 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.002839 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) lipid catabolic process 0.000001539 Informative Direct
Biological Process (BP) ncRNA processing 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000004026 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.09351 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.07541 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.02765 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01989 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.05305 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.00498 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.006855 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002121 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.1006 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.01622 Informative Inherited
Biological Process (BP) tRNA modification 0 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.000001081 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.000000000157 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.0000000285 Highly Informative Direct
Biological Process (BP) lipid modification 0.000000005681 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0001355 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0.0006448 Highly Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3073 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.8397 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.04788 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00000000000007015 Informative Direct
Molecular Function (MF) electron carrier activity 0.000000000000001615 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.000002812 Informative Direct
Molecular Function (MF) transferase activity, transferring sulfur-containing groups 0.0005057 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.0000002812 Highly Informative Direct
Molecular Function (MF) sulfurtransferase activity 0.000002572 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.003031 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003274Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)tRNA(Ile)-lysidine synthetase0Highly InformativeDirect
Enzyme Commission (EC)tRNA sulfurtransferase0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.0000002237Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRedox-active center0InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionFlavoprotein1Moderately InformativeInherited
Molecular functionFAD0.00005236InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationtRNA-binding0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Adenine nucleotide alpha hydrolases-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Adenine nucleotide alpha hydrolases-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]