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Cryptochrome/photolyase, N-terminal domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Information |
| Detailed category | DNA replication/repair |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR006050 SSF52425 Protein matches |
| Abstract | DNA photolyases are enzymes that bind to DNA containing pyrimidine dimers:
on absorption of visible light, they catalyse dimer splitting into the
constituent monomers, a process called photoreactivation [ 6325459]. This is a DNA
repair mechanism, repairing mismatched pyrimidine dimers induced by
exposure to ultra-violet light [3000886]. The precise mechanisms involved in
substrate binding, conversion of light energy to the mechanical energy
needed to rupture the cyclobutane ring, and subsequent release of the
product are uncertain [6325459]. Analysis of DNA lyases has revealed the presence
of an intrinsic chromophore, all monomers containing a reduced FAD moiety,
and, in addition, either a reduced pterin or 8-hydroxy-5-diazaflavin as a
second chromophore [3000886, 2110564]. Either chromophore may act as the primary photon
acceptor, peak absorptions occurring in the blue region of the spectrum
and in the UV-B region, at a wavelength around 290nm [2110564]. This domain binds a light harvesting cofactor. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 5 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Cryptochrome/photolyase, N-terminal domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 5 hidden Markov models representing the Cryptochrome/photolyase, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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