SUPERFAMILY 1.75 HMM library and genome assignments server

PreATP-grasp domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PreATP-grasp domain [ 52439]
Superfamily:   PreATP-grasp domain [ 52440] (8)
Families:   BC N-terminal domain-like [ 52441] (6)
  D-Alanine ligase N-terminal domain [ 52452] (2)
  Lysine biosynthesis enzyme LysX, N-terminal domain [ 102284]
  Prokaryotic glutathione synthetase, N-terminal domain [ 52457]
  Eukaryotic glutathione synthetase, substrate-binding domain [ 52460]
  Synapsin domain [ 52463] (2)
  Glutathionylspermidine synthase substrate-binding domain-like [ 142119]
  PurP N-terminal domain-like [ 159526]


Superfamily statistics
Genomes (3,155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 27,228 156,521 37
Proteins 23,772 138,450 34


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000001477 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00001766 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.8254 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3351 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9245 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000000000000007248 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.00000000000011 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000000000002105 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000000003407 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000005536 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000001605 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00005761 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000741 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.5267 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9142 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.7127 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1934 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03601 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.789 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5206 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.2569 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5242 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7765 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.002661 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.09051 Moderately Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.00000000007478 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000000795 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000001205 Informative Direct
Biological Process (BP) hexose metabolic process 0.0000009792 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00001933 Informative Direct
Biological Process (BP) synaptic transmission 0.00002251 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00003005 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0001407 Informative Direct
Biological Process (BP) protein oligomerization 0.001371 Informative Inherited
Biological Process (BP) response to inorganic substance 0.00497 Informative Inherited
Biological Process (BP) secretion by cell 0.001546 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.4287 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.07591 Informative Inherited
Biological Process (BP) peptide metabolic process 0.001628 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.001701 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.07261 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.001437 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1311 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00000000002923 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00000000007464 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0.0000000001128 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.00000001139 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00000014 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.0000001733 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000001739 Highly Informative Direct
Biological Process (BP) signal release 0.000001835 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.000005414 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00001121 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.0001393 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0003876 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0006875 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.001862 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.03443 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.5918 Least Informative Inherited
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000008001 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.2603 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.7869 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00000000003937 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0000000001293 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000935 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0000001892 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00002997 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0001474 Informative Direct
Molecular Function (MF) nucleotide binding 0.1005 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.000000001163 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.000177 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.4478 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.3125 Highly Informative Inherited
Molecular Function (MF) acid-amino acid ligase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000000000001464 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.7907 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.04889 Least Informative Inherited
Cellular Component (CC) membrane 0.2497 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00002494 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2527 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4582 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001909 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001102 Moderately Informative Inherited
Cellular Component (CC) synapse 0.000000001178 Informative Direct
Cellular Component (CC) lipid particle 0.0001528 Informative Direct
Cellular Component (CC) neuron projection 0.6465 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00001332InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000003482Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.000000000003972Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001397Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.00001747Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.08113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1482Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00002548Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0.1835Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperammonemia0.00003018InformativeDirect
Phenotypic Abnormality (PA)Coma0.0002173InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0004168InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.5406Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.03508InformativeInherited
Mammalian Phenotype (MP)abnormal social investigation0.00002748Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aggression-related behavior0.00004583Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.000121Highly InformativeDirect

Document: MP annotation of SCOP domains