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DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,007) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,829 112,130 55
Proteins 21,757 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.019710.0000009113Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0017770.3463Least InformativeInherited
Biological Process (BP)single-organism cellular process0.32611Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.013340.0254Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000044670.0000002348Moderately InformativeDirect
Biological Process (BP)organelle organization0.0010320.000000008156Moderately InformativeInherited
Biological Process (BP)chromosome organization0.00000045840InformativeDirect
Biological Process (BP)histone modification0.00069450Highly InformativeDirect
Biological Process (BP)protein deacylation0.00000000000011490Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0079660.00002036Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000061720InformativeDirect
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.038770.0001533Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.16140.0001257Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000009113 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000206 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3463 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2334 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0254 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.04589 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0000002348 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.00000000003106 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000008156 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000001209 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.00000002578 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000009666 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.01931 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1532 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08359 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.006468 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.03011 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8037 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5225 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9091 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4911 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8178 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3845 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5211 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4016 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4637 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.486 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9557 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.6386 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.04325 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.7915 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7385 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.7993 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3416 Moderately Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.0000000003244 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000000007136 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008467 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001262 Informative Direct
Biological Process (BP) response to nutrient levels 0.00007933 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00000000005358 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.05263 Informative Inherited
Biological Process (BP) regulation of defense response 0.7211 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1768 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1881 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8187 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1485 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09234 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1158 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5597 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08413 Informative Inherited
Biological Process (BP) response to other organism 0.6656 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.02558 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2658 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.9002 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5043 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1572 Informative Inherited
Biological Process (BP) response to oxidative stress 0.004528 Informative Inherited
Biological Process (BP) regulation of system process 0.2115 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.005578 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4356 Informative Inherited
Biological Process (BP) regulation of cell development 0.4458 Informative Inherited
Biological Process (BP) generation of neurons 0.9553 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1978 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08985 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3977 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07113 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.08668 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5183 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6404 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3258 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4965 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3876 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4531 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0368 Informative Inherited
Biological Process (BP) response to hypoxia 0.000000925 Highly Informative Direct
Biological Process (BP) aging 0.00000355 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.000000000003341 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000005716 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0008554 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00002887 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.000001824 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00001789 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0009535 Highly Informative Direct
Biological Process (BP) gene silencing 0.0000000000004146 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.000088 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0001407 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0009892 Highly Informative Direct
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0000000003834 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001725 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001366 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.00000002081 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00000000001352 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00004806 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0002054 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0003179 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000243 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.00001667 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0000004744 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.09475 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.2417 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.0246 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.001731 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01949 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06516 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002971 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.03519 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.001038 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04353 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.005618 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.01357 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01666 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.1114 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00002036 Least Informative Direct
Molecular Function (MF) binding 0.6473 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.00000007126 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0002942 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00001514 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0.000001642 Informative Direct
Molecular Function (MF) zinc ion binding 0.0003125 Informative Direct
Molecular Function (MF) electron carrier activity 0.000002708 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0001119 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.000000001013 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000009718 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000000009229 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00000000003375 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001623 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001533 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001257 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1852 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.00004986 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000000001258 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000009178 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1581 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4466 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000000869 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00006964 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3634 Informative Inherited
Cellular Component (CC) neuron projection 0.2944 Informative Inherited
Cellular Component (CC) cell junction 0.3401 Informative Inherited
Cellular Component (CC) chromatin 0.0004952 Highly Informative Direct
Cellular Component (CC) midbody 0.00000861 Highly Informative Direct
Cellular Component (CC) main axon 0.0000007073 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00000000000008838 Highly Informative Direct
Cellular Component (CC) spindle 0.003645 Highly Informative Inherited
Cellular Component (CC) cell body 0.0213 Highly Informative Inherited
Cellular Component (CC) centrosome 0.002384 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005466Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007711Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.04236Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2039Moderately InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.000883InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.008009InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.304InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.4451InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis0.00002615Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0003448Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.003767Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0002646Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.00000008537InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.02864InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000000002981Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.003981Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.588Least InformativeInherited
Biological processTranscription regulation0.0001459Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1531Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002715InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.00000000333Highly InformativeDirect
Cellular componentMitochondrion6.428e-16Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase6.651e-16Least InformativeDirect
Post-translational modificationRepressor0.000001576Moderately InformativeDirect
Post-translational modificationLyase0.000001645Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)one-carbon metabolism0.00000000001006InformativeDirect
UniPathway (UP)protein maturation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]