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DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,010) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,927 112,130 55
Proteins 21,856 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0042941Least InformativeInherited
Biological Process (BP)primary metabolic process0.15040.9927Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000096770Moderately InformativeDirect
Molecular Function (MF)hydrolase activity0.0062430.001424Least InformativeInherited
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.001470.00001631Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.10010.003843Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000000001416 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000004025 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9927 Least Informative Inherited
Biological Process (BP) cellular biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic substance biosynthetic process 0.704 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1086 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.08084 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000633 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00002818 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000009984 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000543 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00001096 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8605 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.8685 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02214 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5099 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8103 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3358 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6726 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9332 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.006299 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7918 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.8003 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8958 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9253 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.002897 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.82 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002495 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.08198 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.003571 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3253 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.002355 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002434 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3123 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5761 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.5754 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.886 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.001474 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2707 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2592 Moderately Informative Inherited
Biological Process (BP) amine metabolic process 0.0002273 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0001648 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00001017 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000000388 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0001213 Informative Direct
Biological Process (BP) lipid catabolic process 0.000000001062 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000007316 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0004292 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000007585 Informative Direct
Biological Process (BP) chromosome organization 0.0000000001209 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.05783 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1397 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5849 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.4591 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.006281 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3714 Informative Inherited
Biological Process (BP) regulation of defense response 0.8675 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.3001 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001685 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.1607 Informative Inherited
Biological Process (BP) cell death 0.3721 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.04517 Informative Inherited
Biological Process (BP) regulation of secretion 0.3884 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01873 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1217 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5491 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1389 Informative Inherited
Biological Process (BP) response to bacterium 0.19 Informative Inherited
Biological Process (BP) generation of neurons 0.7548 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.001789 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.2247 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04216 Informative Inherited
Biological Process (BP) regulation of protein localization 0.04348 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.5405 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.002175 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.09757 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.8533 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.001893 Informative Inherited
Biological Process (BP) response to oxidative stress 0.003812 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5462 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.07688 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0657 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.154 Informative Inherited
Biological Process (BP) cell development 0.6427 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2927 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1439 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.8094 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.217 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.002074 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.009784 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.001927 Informative Inherited
Biological Process (BP) response to hypoxia 0.0000007446 Highly Informative Direct
Biological Process (BP) fermentation 0.0003461 Highly Informative Direct
Biological Process (BP) aging 0.00001488 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0000000000004621 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00008835 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0007315 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000001593 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000000000003705 Highly Informative Direct
Biological Process (BP) gene silencing 0.00000000005969 Highly Informative Direct
Biological Process (BP) histone modification 0.000000003053 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.00002003 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000002698 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0005953 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.0001837 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.0006757 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.00000000007951 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0002039 Highly Informative Direct
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.00001223 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0002665 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0002098 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.0000001688 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.0002764 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0007086 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0006556 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.0002281 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0006271 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.002352 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.008754 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1733 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.06497 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01454 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.01236 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.09521 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.004187 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.5865 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.1923 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.002944 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.01895 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.01433 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.02016 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.01534 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.002993 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.007637 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.1004 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.06217 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.002618 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.005404 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.006566 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.2263 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.01079 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.002298 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.007986 Highly Informative Inherited
Molecular Function (MF) binding 0.9318 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.001424 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.000002395 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000001359 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00006097 Moderately Informative Direct
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.0004058 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000001816 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000006357 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.002144 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.001333 Informative Inherited
Molecular Function (MF) chromatin binding 0.00003222 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0000000001046 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.00003914 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00000006166 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001814 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001631 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.003843 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7567 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.867 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00003397 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2049 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.000001605 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.2927 Informative Inherited
Cellular Component (CC) neuron projection 0.2985 Informative Inherited
Cellular Component (CC) cell projection part 0.2893 Informative Inherited
Cellular Component (CC) cell junction 0.3328 Informative Inherited
Cellular Component (CC) midbody 0.00001471 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.000000000002136 Highly Informative Direct
Cellular Component (CC) spindle 0.001645 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 0.01575 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.07468 Highly Informative Inherited
Cellular Component (CC) centrosome 0.004148 Highly Informative Inherited
Cellular Component (CC) chromatin 0.00128 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005466Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.02424Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1502Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.009155Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.009225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.4357InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis0.0001032Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0007099Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.004184Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01723Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0005309Moderately InformativeDirect
Worm Phenotype (WP)protein modification variant0.001482InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0006159Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.03069InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.000658Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.6208Least InformativeInherited
Biological processTranscription regulation0.0003557Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1503Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002756InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.0000000001294Highly InformativeDirect
Cellular componentMitochondrion0.000000000000001627Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001633Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0.0000009146Moderately InformativeDirect
Post-translational modificationRepressor0.000001215Moderately InformativeDirect
Post-translational modificationDecarboxylase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.00000000001223Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.0000004127Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.000007231Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.005473Moderately InformativeInherited
UniPathway (UP)energy metabolism0.2792Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.416Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5243Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.5447Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis0.0000000007052InformativeDirect
UniPathway (UP)organosulfur metabolism0.000000006964InformativeDirect
UniPathway (UP)alkaloid metabolism0.0004786InformativeDirect
UniPathway (UP)alcohol degradation0.02134InformativeInherited
UniPathway (UP)alcohol biosynthesis0.7692InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate0Highly InformativeDirect
UniPathway (UP)organosulfur degradation0.000000000004698Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.0008312Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.2011Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]