SUPERFAMILY 1.75 HMM library and genome assignments server


DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,007) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,832 112,130 55
Proteins 21,760 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.045856.441e-07Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0042830.3183Least InformativeInherited
Biological Process (BP)single-organism cellular process0.19851Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.012760.02135Least InformativeInherited
Biological Process (BP)cellular protein modification process0.00051343.207e-07Moderately InformativeDirect
Biological Process (BP)organelle organization0.0010546.692e-09Moderately InformativeInherited
Biological Process (BP)chromosome organization4.492e-070InformativeDirect
Biological Process (BP)histone modification0.00017250Highly InformativeDirect
Biological Process (BP)protein deacylation3.548e-110Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.018771.6e-05Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds1.219e-050InformativeDirect
Molecular Function (MF)deacetylase activity5.814e-150Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.037910.0001451Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.16050.0001157Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 6.441e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002203 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3183 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2143 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02135 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.08421 Least Informative Inherited
Biological Process (BP) cellular protein modification process 3.207e-07 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.024e-10 Moderately Informative Direct
Biological Process (BP) organelle organization 6.692e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 8.489e-08 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 8.868e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.557e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0164 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1405 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08489 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02765 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7851 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5069 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.893 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4654 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8038 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4623 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5155 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.384 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4413 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4568 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9437 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5832 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8141 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.003258 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.7726 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.9678 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6761 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.7947 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2963 Moderately Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 2.475e-10 Informative Direct
Biological Process (BP) negative regulation of gene expression 5.405e-10 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008509 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.775e-05 Informative Direct
Biological Process (BP) response to nutrient levels 5.478e-05 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 4.086e-11 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of defense response 0.7254 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1746 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8133 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1435 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.08868 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1105 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5397 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08222 Informative Inherited
Biological Process (BP) response to other organism 0.6409 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.02297 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2612 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.8232 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5019 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1646 Informative Inherited
Biological Process (BP) response to oxidative stress 0.004024 Informative Inherited
Biological Process (BP) regulation of system process 0.2011 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00542 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4568 Informative Inherited
Biological Process (BP) regulation of cell development 0.4484 Informative Inherited
Biological Process (BP) generation of neurons 0.9518 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1953 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.09218 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3973 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06374 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.08154 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.4873 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6163 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3028 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4969 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3542 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4134 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0282 Informative Inherited
Biological Process (BP) response to hypoxia 7.385e-07 Highly Informative Direct
Biological Process (BP) aging 3.307e-06 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 1.479e-10 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 3.167e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0008709 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 2.624e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.097e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.646e-05 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000817 Highly Informative Direct
Biological Process (BP) gene silencing 3.756e-13 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 8.1e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 7.181e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0009897 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0008311 Highly Informative Direct
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 3.677e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001599 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001387 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 2.103e-08 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 1.034e-11 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 4.518e-05 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0001946 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0003235 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002331 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0008391 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.039e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.08875 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.2481 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02403 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.0015 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01857 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06362 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002852 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.03078 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04538 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.002893 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.03132 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01551 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.08971 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.6e-05 Least Informative Direct
Molecular Function (MF) binding 0.7774 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 3.459e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0008081 Moderately Informative Direct
Molecular Function (MF) cation binding 3.819e-05 Moderately Informative Direct
Molecular Function (MF) chromatin binding 1.611e-06 Informative Direct
Molecular Function (MF) electron carrier activity 2.503e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 4.534e-05 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1.128e-09 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 7.24e-05 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.009578 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 6.89e-12 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) NAD binding 4.111e-12 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001695 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001451 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001157 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1906 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 4.98e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 1.221e-09 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1.087e-05 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1579 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4664 Moderately Informative Inherited
Cellular Component (CC) chromosome 7.949e-08 Informative Direct
Cellular Component (CC) mitochondrial matrix 6.068e-05 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3589 Informative Inherited
Cellular Component (CC) neuron projection 0.2791 Informative Inherited
Cellular Component (CC) cell-cell junction 0.08745 Informative Inherited
Cellular Component (CC) chromatin 0.000493 Highly Informative Direct
Cellular Component (CC) midbody 8.507e-06 Highly Informative Direct
Cellular Component (CC) main axon 6.882e-07 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 8.425e-14 Highly Informative Direct
Cellular Component (CC) spindle 0.003552 Highly Informative Inherited
Cellular Component (CC) cell body 0.02057 Highly Informative Inherited
Cellular Component (CC) centrosome 0.002379 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases5.466e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007692Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.04093Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01553Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01598Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2036Moderately InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.0008705InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.008303InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.3015InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.4436InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis2.558e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0003464Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.003682Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0002408Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases6.381e-08InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0285InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.992e-11Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.00399Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.588Least InformativeInherited
Biological processTranscription regulation0.0001459Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1531Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002715InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis3.33e-09Highly InformativeDirect
Cellular componentMitochondrion6.428e-16Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase6.651e-16Least InformativeDirect
Post-translational modificationRepressor1.576e-06Moderately InformativeDirect
Post-translational modificationLyase1.645e-06Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism7.28e-12Least InformativeDirect
UniPathway (UP)biopolymer metabolism7.218e-07Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism5.91e-06Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0375Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.3005Moderately InformativeInherited
UniPathway (UP)energy metabolism0.4473Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.4888Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5053Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis1.686e-07InformativeDirect
UniPathway (UP)alkaloid metabolism5.636e-05InformativeDirect
UniPathway (UP)polyol degradation0.005485InformativeInherited
UniPathway (UP)alcohol biosynthesis0.7958InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate9.325e-14Highly InformativeDirect
UniPathway (UP)organosulfur degradation3.179e-10Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.0009673Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.2235Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]