SUPERFAMILY 1.75 HMM library and genome assignments server

DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,008) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,875 112,130 55
Proteins 21,803 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.18340.04545Least InformativeInherited
Biological Process (BP)protein metabolic process0.019630.000001093Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0016110.2865Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0090640Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.01820.02897Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000066050.0000002237Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.00068020.00000000007994Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.034150.00000000000006308Moderately InformativeInherited
Biological Process (BP)chromosome organization0.00000062120InformativeDirect
Biological Process (BP)protein deacylation0.00000000000017020Highly InformativeDirect
Biological Process (BP)histone modification0.000016780Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0078360.00001216Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000061660InformativeDirect
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0035210.000003635Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.082490.00001961Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000001093 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.9932 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2865 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02897 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.08967 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1975 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04545 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0000002237 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000007994 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00000000000006308 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000004781 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000002016 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000006298 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0004783 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.798 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2843 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9776 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8192 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8188 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3759 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.43 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4864 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3171 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04822 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.05135 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7541 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1043 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4719 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001644 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.04786 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.6414 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.2247 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.02201 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3802 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7016 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4613 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3327 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7233 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3974 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00000000006968 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.00000000116 Informative Direct
Biological Process (BP) response to nutrient levels 0.000007567 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001444 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0002916 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008038 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.01422 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1133 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.6384 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.01119 Informative Inherited
Biological Process (BP) regulation of defense response 0.688 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04946 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08167 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5145 Informative Inherited
Biological Process (BP) regulation of cell development 0.1933 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.006565 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.845 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1261 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1553 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08934 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.0954 Informative Inherited
Biological Process (BP) response to bacterium 0.2454 Informative Inherited
Biological Process (BP) generation of neurons 0.699 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.003221 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05118 Informative Inherited
Biological Process (BP) regulation of protein localization 0.07757 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.02578 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2701 Informative Inherited
Biological Process (BP) regulation of secretion 0.05982 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01835 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1877 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2267 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.006533 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4955 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.00496 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5243 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.267 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0499 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2419 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4707 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.4982 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01391 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.05941 Informative Inherited
Biological Process (BP) protein catabolic process 0.5225 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6514 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.8897 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2685 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4305 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.3462 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.03011 Informative Inherited
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0000000000003231 Highly Informative Direct
Biological Process (BP) gene silencing 0.000000000008719 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.00000000002225 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.00000000002955 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0000000002275 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.00000002084 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0000001747 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000004289 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.000001378 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.000001654 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000003447 Highly Informative Direct
Biological Process (BP) aging 0.000004184 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00001637 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.00003884 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00003956 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.00005421 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.00007531 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00007972 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0.0001217 Highly Informative Direct
Biological Process (BP) negative regulation of protein phosphorylation 0.0001623 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002935 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0003014 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.0003884 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.0006155 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0008753 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1086 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.004179 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.00445 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.3531 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1461 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01142 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002158 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01475 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06619 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.001836 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.003176 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.05822 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001119 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.03753 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.00192 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.002724 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00001216 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.5888 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.00000000009531 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000001028 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00001499 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003052 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0000000009777 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000001787 Informative Direct
Molecular Function (MF) chromatin binding 0.000002438 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.00004444 Informative Direct
Molecular Function (MF) electron carrier activity 0.0001323 Informative Direct
Molecular Function (MF) zinc ion binding 0.0003201 Informative Direct
Molecular Function (MF) nucleotide binding 0.7784 Informative Inherited
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000000009468 Highly Informative Direct
Molecular Function (MF) NAD binding 0.000000000032 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001346 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000003635 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001961 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2785 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000000005846 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000009324 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000112 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2972 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.888 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.00000009207 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.0001601 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3742 Informative Inherited
Cellular Component (CC) neuron projection 0.09093 Informative Inherited
Cellular Component (CC) cell junction 0.3412 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.0000000000001091 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000000000234 Highly Informative Direct
Cellular Component (CC) main axon 0.000000709 Highly Informative Direct
Cellular Component (CC) midbody 0.00001302 Highly Informative Direct
Cellular Component (CC) spindle 0.003884 Highly Informative Inherited
Cellular Component (CC) cell body 0.02565 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.01335 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005466Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007867Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.04446Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1997Moderately InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.000907InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.008289InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.312InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.4423InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis0.00002709Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0003539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.003973Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0002573Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.00000008198InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0284InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000000002946Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.003952Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.5884Least InformativeInherited
Biological processTranscription regulation0.0001528Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1517Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.00027InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.000000003307Highly InformativeDirect
Cellular componentMitochondrion6.436e-16Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase6.664e-16Least InformativeDirect
Post-translational modificationLyase0.000001851Moderately InformativeDirect
Post-translational modificationRepressor0.000001907Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.00000000000721Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.0000007207Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.000005958Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0382Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.3048Moderately InformativeInherited
UniPathway (UP)energy metabolism0.4485Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.4903Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5057Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis0.0000001681InformativeDirect
UniPathway (UP)alkaloid metabolism0.00005956InformativeDirect
UniPathway (UP)polyol degradation0.005491InformativeInherited
UniPathway (UP)alcohol biosynthesis0.7957InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate0.00000000000009291Highly InformativeDirect
UniPathway (UP)organosulfur degradation0.0000000003177Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.0009693Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.2235Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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