SUPERFAMILY 1.73 HMM library and genome assignments server


DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
  3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
  Transhydrogenase domain III (dIII) [ 52484]
  binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode
  Sir2 family of transcriptional regulators [ 63984] (7)
  silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
  ACDE2-like [ 142130]
  Pfam 02552


Superfamily statistics
Genomes (1,173) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 8,927 9,411 50
Proteins 8,913 9,397 50


Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]