SUPERFAMILY 1.75 HMM library and genome assignments server


DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,007) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,829 112,130 55
Proteins 21,757 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.01979.74e-07Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0017590.346Least InformativeInherited
Biological Process (BP)single-organism cellular process0.32591Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.017580.02762Least InformativeInherited
Biological Process (BP)cellular protein modification process6.551e-052.375e-07Moderately InformativeDirect
Biological Process (BP)organelle organization0.0011849.723e-09Moderately InformativeInherited
Biological Process (BP)chromosome organization6.357e-070InformativeDirect
Biological Process (BP)histone modification0.00070850Highly InformativeDirect
Biological Process (BP)protein deacylation1.722e-130Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0079191.272e-05Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds6.144e-050InformativeDirect
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0042031.34e-05Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.081551.284e-05Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.74e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0001869 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.9949 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.346 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0866 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02762 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.04632 Least Informative Inherited
Biological Process (BP) cellular protein modification process 2.375e-07 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.495e-11 Moderately Informative Direct
Biological Process (BP) organelle organization 9.723e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.841e-08 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 2.589e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0009059 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.012e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.1036 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.4144 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0222 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.03496 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07401 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8133 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2797 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9737 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8153 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3695 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5529 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3853 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.617 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4531 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8857 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3929 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7499 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.6835 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.886 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.08949 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.8009 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7402 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4741 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3283 Moderately Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 4.45e-09 Informative Direct
Biological Process (BP) negative regulation of gene expression 8.616e-10 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008524 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001273 Informative Direct
Biological Process (BP) response to nutrient levels 5.659e-06 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 9.389e-11 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0993 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0136 Informative Inherited
Biological Process (BP) regulation of defense response 0.7176 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1868 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8348 Informative Inherited
Biological Process (BP) regulation of secretion 0.02777 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1527 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09518 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.124 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5708 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08922 Informative Inherited
Biological Process (BP) response to bacterium 0.2426 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.0443 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1372 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2708 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.9076 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.007093 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5066 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1494 Informative Inherited
Biological Process (BP) response to oxidative stress 0.004982 Informative Inherited
Biological Process (BP) regulation of system process 0.04849 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4434 Informative Inherited
Biological Process (BP) regulation of cell development 0.2654 Informative Inherited
Biological Process (BP) generation of neurons 0.693 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04909 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1935 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3958 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07404 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01717 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5184 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6371 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3236 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3626 Informative Inherited
Biological Process (BP) negative regulation of transport 0.05639 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.4067 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4581 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.03763 Informative Inherited
Biological Process (BP) response to hypoxia 1.322e-07 Highly Informative Direct
Biological Process (BP) aging 3.975e-06 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 3.635e-12 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 6.105e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0008645 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 3.061e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.629e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 5.915e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0009958 Highly Informative Direct
Biological Process (BP) gene silencing 4.791e-13 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 9.235e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0002467 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 3.37e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 3.481e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001839 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001538 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 2.118e-08 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 1.678e-11 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 1.487e-05 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 4.538e-05 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0002252 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0003211 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000268 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 5.461e-06 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 7.697e-05 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 7.219e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.3811 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02652 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.002797 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01991 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06656 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001211 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.003042 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001145 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.03596 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.09551 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1063 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001116 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.005665 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.01338 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01738 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.272e-05 Least Informative Direct
Molecular Function (MF) binding 0.5554 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 8.421e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000306 Moderately Informative Direct
Molecular Function (MF) cation binding 1.464e-05 Moderately Informative Direct
Molecular Function (MF) chromatin binding 2.144e-06 Informative Direct
Molecular Function (MF) zinc ion binding 0.0003051 Informative Direct
Molecular Function (MF) electron carrier activity 2.74e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0001153 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 9.802e-10 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 1.034e-06 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 9.43e-12 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) NAD binding 3.135e-11 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001622 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1.34e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.284e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3168 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 9.955e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 4.639e-09 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 8.794e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.8598 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.2046 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4797 Moderately Informative Inherited
Cellular Component (CC) chromosome 9.384e-08 Informative Direct
Cellular Component (CC) mitochondrial matrix 6.833e-05 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3651 Informative Inherited
Cellular Component (CC) neuron projection 0.09214 Informative Inherited
Cellular Component (CC) cell junction 0.3444 Informative Inherited
Cellular Component (CC) chromatin 0.0004465 Highly Informative Direct
Cellular Component (CC) midbody 1.102e-05 Highly Informative Direct
Cellular Component (CC) main axon 7.166e-07 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1.122e-13 Highly Informative Direct
Cellular Component (CC) spindle 0.003711 Highly Informative Inherited
Cellular Component (CC) cell body 0.02567 Highly Informative Inherited
Cellular Component (CC) centrosome 0.002427 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases5.466e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007867Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.04446Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1997Moderately InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.000907InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.008289InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.312InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.4423InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis2.709e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0003539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.003973Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0002573Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases8.198e-08InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0284InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor2.946e-11Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.003952Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.5884Least InformativeInherited
Biological processTranscription regulation0.0001528Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1517Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.00027InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis3.307e-09Highly InformativeDirect
Cellular componentMitochondrion6.436e-16Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase6.664e-16Least InformativeDirect
Post-translational modificationLyase1.851e-06Moderately InformativeDirect
Post-translational modificationRepressor1.907e-06Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism7.21e-12Least InformativeDirect
UniPathway (UP)biopolymer metabolism7.207e-07Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism5.958e-06Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0382Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.3048Moderately InformativeInherited
UniPathway (UP)energy metabolism0.4485Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.4903Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5057Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis1.681e-07InformativeDirect
UniPathway (UP)alkaloid metabolism5.956e-05InformativeDirect
UniPathway (UP)polyol degradation0.005491InformativeInherited
UniPathway (UP)alcohol biosynthesis0.7957InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate9.291e-14Highly InformativeDirect
UniPathway (UP)organosulfur degradation3.177e-10Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.0009693Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.2235Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]