SUPERFAMILY 1.75 HMM library and genome assignments server


DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (2,999) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,694 0 55
Proteins 21,625 0 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.04656.668e-07Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0043290.3229Least InformativeInherited
Biological Process (BP)single-organism cellular process0.19711Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.008750.01438Least InformativeInherited
Biological Process (BP)cellular protein modification process0.00037013.57e-07Moderately InformativeDirect
Biological Process (BP)organelle organization0.0010512.997e-09Moderately InformativeInherited
Biological Process (BP)chromosome organization3.045e-070InformativeDirect
Biological Process (BP)protein deacylation2.365e-110Highly InformativeDirect
Biological Process (BP)histone modification0.00017810Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.018881.597e-05Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds1.196e-050InformativeDirect
Molecular Function (MF)deacetylase activity3.246e-150Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.02460.0002455Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.15650.0001253Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 6.668e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002267 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3229 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2345 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01438 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.08738 Least Informative Inherited
Biological Process (BP) cellular protein modification process 3.57e-07 Moderately Informative Direct
Biological Process (BP) organelle organization 2.997e-09 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 1.945e-10 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 8.572e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.029e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.466e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0183 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1507 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08466 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.03061 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7657 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5171 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9021 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4739 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.814 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4665 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5189 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3896 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4517 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4735 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.952 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5797 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8213 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.003913 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.7855 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6729 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.401 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2954 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 5.554e-11 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 3.285e-10 Informative Direct
Biological Process (BP) response to nutrient levels 5.933e-05 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.75e-05 Informative Direct
Biological Process (BP) lipid catabolic process 0.000839 Informative Direct
Biological Process (BP) regulation of response to stress 0.07355 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0538 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.185 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1831 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.81 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.143 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09012 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1143 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.0839 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5446 Informative Inherited
Biological Process (BP) response to other organism 0.6378 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.02241 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2542 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.8122 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5028 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.3647 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1634 Informative Inherited
Biological Process (BP) response to oxidative stress 0.004097 Informative Inherited
Biological Process (BP) regulation of system process 0.206 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.005154 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4665 Informative Inherited
Biological Process (BP) regulation of cell development 0.4501 Informative Inherited
Biological Process (BP) generation of neurons 0.9583 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1975 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.09139 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3941 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06459 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.08341 Informative Inherited
Biological Process (BP) protein catabolic process 0.4776 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6218 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3053 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4882 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3517 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.411 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02747 Informative Inherited
Biological Process (BP) protein deacylation 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 1.397e-11 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 1.548e-10 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 2.925e-10 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 2.359e-08 Highly Informative Direct
Biological Process (BP) response to hypoxia 6.492e-07 Highly Informative Direct
Biological Process (BP) regulation of autophagy 2.044e-06 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 3.04e-06 Highly Informative Direct
Biological Process (BP) aging 3.493e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.419e-05 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 1.953e-05 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 2.821e-05 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 4.764e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 6.372e-05 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 8.08e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0001415 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001526 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0001867 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002201 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0003046 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0007058 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0007858 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0008308 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0008647 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.08792 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.2527 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.025 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.00147 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01916 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.06618 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002837 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.03008 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04545 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001028 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.002846 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.03148 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01599 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.08685 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.597e-05 Least Informative Direct
Molecular Function (MF) binding 0.8109 Least Informative Inherited
Molecular Function (MF) lyase activity 3.572e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 3.718e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0008102 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1.166e-09 Informative Direct
Molecular Function (MF) chromatin binding 1.67e-06 Informative Direct
Molecular Function (MF) electron carrier activity 2.685e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 4.312e-05 Informative Direct
Molecular Function (MF) sulfur compound binding 7.832e-05 Informative Direct
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.01003 Informative Inherited
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) NAD binding 3.945e-12 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 7.402e-12 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.001692 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002455 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001253 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1765 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 1.035e-09 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1.123e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 5.048e-05 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.151 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4711 Moderately Informative Inherited
Cellular Component (CC) chromosome 8.369e-08 Informative Direct
Cellular Component (CC) mitochondrial matrix 5.876e-05 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3709 Informative Inherited
Cellular Component (CC) neuron projection 0.2843 Informative Inherited
Cellular Component (CC) cell-cell junction 0.08973 Informative Inherited
Cellular Component (CC) nuclear chromosome part 1.08e-13 Highly Informative Direct
Cellular Component (CC) main axon 7.275e-07 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 5.381e-06 Highly Informative Direct
Cellular Component (CC) midbody 6.901e-06 Highly Informative Direct
Cellular Component (CC) chromatin 0.0005011 Highly Informative Direct
Cellular Component (CC) spindle 0.003725 Highly Informative Inherited
Cellular Component (CC) cell body 0.01851 Highly Informative Inherited
Cellular Component (CC) centrosome 0.002531 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases5.466e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.007756Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.04036Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0687Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.07386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2003Moderately InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.0008879InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.008618InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.2302InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0003517Highly InformativeDirect
Mammalian Phenotype (MP)hepatic steatosis0.0006303Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0002438Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases6.508e-08InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.02851InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor3.017e-11Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.003958Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.642Least InformativeInherited
Biological processTranscription regulation0.0001325Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1487Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002681InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis3.272e-09Highly InformativeDirect
Cellular componentMitochondrion6.421e-16Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase8.838e-16Least InformativeDirect
Post-translational modificationRepressor1.497e-06Moderately InformativeDirect
Post-translational modificationLyase3.218e-06Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism7.227e-12Least InformativeDirect
UniPathway (UP)biopolymer metabolism7.524e-07Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism6.019e-06Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.03772Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.3013Moderately InformativeInherited
UniPathway (UP)energy metabolism0.4471Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.49Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5058Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis1.703e-07InformativeDirect
UniPathway (UP)alkaloid metabolism5.674e-05InformativeDirect
UniPathway (UP)polyol degradation0.007302InformativeInherited
UniPathway (UP)alcohol biosynthesis0.8047InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate9.41e-14Highly InformativeDirect
UniPathway (UP)organosulfur degradation3.202e-10Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.001027Highly InformativeInherited
UniPathway (UP)polyol biosynthesis0.2252Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]