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DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,009) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 21,869 112,130 55
Proteins 21,798 112,011 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0040611Least InformativeInherited
Biological Process (BP)primary metabolic process0.14550.7872Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000061470Moderately InformativeDirect
Molecular Function (MF)hydrolase activity0.0062660.002055Least InformativeInherited
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0032420.000004644Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.097840.00131Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0005366 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7872 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09794 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3675 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1423 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000000008204 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000004156 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000003128 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.000002086 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000004539 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0004528 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0005097 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0006168 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.9621 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4057 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7462 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.674 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7996 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1062 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9126 Moderately Informative Inherited
Biological Process (BP) response to stress 0.5071 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01288 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.00104 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4467 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3314 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7958 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5476 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.706 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2428 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.002322 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3097 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7969 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.06198 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00509 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8292 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.1722 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.6448 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.01439 Moderately Informative Inherited
Biological Process (BP) lipid catabolic process 0.00000000056 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000000001259 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00000627 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000007927 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00001552 Informative Direct
Biological Process (BP) positive regulation of cell death 0.00005644 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0003753 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0008227 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0009806 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.5655 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.01246 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2683 Informative Inherited
Biological Process (BP) regulation of defense response 0.9251 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.02809 Informative Inherited
Biological Process (BP) cell death 0.1737 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.03115 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.001883 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4544 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1519 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1889 Informative Inherited
Biological Process (BP) response to bacterium 0.2574 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1337 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2288 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.05229 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.266 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4678 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1833 Informative Inherited
Biological Process (BP) regulation of secretion 0.3859 Informative Inherited
Biological Process (BP) regulation of protein localization 0.02495 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.6093 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.00427 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05836 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02589 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2455 Informative Inherited
Biological Process (BP) amine metabolic process 0.03507 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.04106 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.7688 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.002305 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5524 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.1819 Informative Inherited
Biological Process (BP) cell development 0.9802 Informative Inherited
Biological Process (BP) generation of neurons 0.6306 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.8658 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3603 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0783 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.08598 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5881 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.009256 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000000000007239 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0000000000005994 Highly Informative Direct
Biological Process (BP) gene silencing 0.000000000002739 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.00000000001764 Highly Informative Direct
Biological Process (BP) histone modification 0.000000006748 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000267 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000002804 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0000003335 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000001296 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000003261 Highly Informative Direct
Biological Process (BP) aging 0.000006406 Highly Informative Direct
Biological Process (BP) lipid modification 0.00001937 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00007391 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.00009051 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0001354 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.0001781 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001918 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0002391 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0002548 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.0002846 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0003194 Highly Informative Direct
Biological Process (BP) fermentation 0.0003871 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0004012 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0005168 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0008598 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000963 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00678 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01173 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.08935 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.008898 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.009251 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.004116 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.2547 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.002212 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.0375 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.009866 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1923 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.005143 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002212 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002426 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01812 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.001564 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.03467 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.003867 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.008639 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.6297 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.004327 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.04623 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.001917 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.001705 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.00849 Highly Informative Inherited
Molecular Function (MF) binding 0.6759 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.002055 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.000000000005692 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.000001406 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00005621 Moderately Informative Direct
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000002216 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000001167 Informative Direct
Molecular Function (MF) zinc ion binding 0.0003803 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0007549 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.005549 Informative Inherited
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0000000000375 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00000002848 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0001344 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.002165 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000004644 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00131 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6802 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7083 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00001551 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0001379 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.9958 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.03267 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2091 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000005021 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.331 Informative Inherited
Cellular Component (CC) neuron projection 0.2319 Informative Inherited
Cellular Component (CC) cell projection part 0.2448 Informative Inherited
Cellular Component (CC) cell junction 0.3076 Informative Inherited
Cellular Component (CC) nuclear chromosome 0.000000000003381 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000000000442 Highly Informative Direct
Cellular Component (CC) midbody 0.000009793 Highly Informative Direct
Cellular Component (CC) organelle envelope lumen 0.00001438 Highly Informative Direct
Cellular Component (CC) spindle 0.001942 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 0.01044 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.08317 Highly Informative Inherited
Cellular Component (CC) centrosome 0.004892 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005466Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.005235Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.09488Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.005363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.2853InformativeInherited
Mammalian Phenotype (MP)hepatic steatosis0.00006185Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0005015Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.004414Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01667Least InformativeInherited
Worm Phenotype (WP)protein modification variant0.001312InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.000464Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.03084InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000000002698Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.0006494Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.6092Least InformativeInherited
Biological processTranscription regulation0.0002964Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1476Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002687InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.0000000001276Highly InformativeDirect
Cellular componentMitochondrion0.000000000000001298Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001422Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase4.502e-16Least InformativeDirect
Post-translational modificationLyase0.000003036Moderately InformativeDirect
Post-translational modificationRepressor0.000003056Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.000000000006798Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.000001596Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.000006519Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.005234Moderately InformativeInherited
UniPathway (UP)energy metabolism0.2715Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.3799Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.5109Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.5162Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)protein maturation0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis0.0000000006644InformativeDirect
UniPathway (UP)organosulfur metabolism0.000000004481InformativeDirect
UniPathway (UP)alkaloid metabolism0.0001135InformativeDirect
UniPathway (UP)alcohol degradation0.02349InformativeInherited
UniPathway (UP)alcohol biosynthesis0.7756InformativeInherited
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate0Highly InformativeDirect
UniPathway (UP)organosulfur degradation0.000000000004519Highly InformativeDirect
UniPathway (UP)(R,R)-butane-2,3-diol metabolism0.0008728Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.2082Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]