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DHS-like NAD/FAD-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   DHS-like NAD/FAD-binding domain [ 52466]
Superfamily:   DHS-like NAD/FAD-binding domain [ 52467] (6)
Families:   Deoxyhypusine synthase, DHS [ 52468]
  C-terminal domain of the electron transfer flavoprotein alpha subunit [ 52471]
  Pyruvate oxidase and decarboxylase, middle domain [ 52475] (8)
  Transhydrogenase domain III (dIII) [ 52484]
  Sir2 family of transcriptional regulators [ 63984] (7)
  ACDE2-like [ 142130]


Superfamily statistics
Genomes (3,014) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 21,962 119,291 55
Proteins 21,891 119,009 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0022241Least InformativeInherited
Biological Process (BP)primary metabolic process0.11640.9503Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.091340.000284Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000016330Moderately InformativeDirect
Molecular Function (MF)hydrolase activity0.01860.002333Least InformativeInherited
Molecular Function (MF)deacetylase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00075960.000007966Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.000284 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001753 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000000001422 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1227 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9503 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2789 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00001924 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000000291 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000004378 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0003161 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0003315 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.001796 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8607 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7059 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5387 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8945 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.6795 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3125 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8508 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7141 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7278 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2387 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5731 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8092 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001919 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4918 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01232 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4235 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3455 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.002535 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2398 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.005919 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7996 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.1069 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2724 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7544 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4113 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01699 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.001933 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002781 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0.00000000004868 Informative Direct
Biological Process (BP) lipid catabolic process 0.000000001584 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000000069 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00001246 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00002838 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0002254 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000449 Informative Direct
Biological Process (BP) amine metabolic process 0.0004935 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000792 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000942 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0639 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.03434 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.002285 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4775 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3436 Informative Inherited
Biological Process (BP) cell death 0.3801 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.009365 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4078 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07025 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1379 Informative Inherited
Biological Process (BP) response to bacterium 0.2232 Informative Inherited
Biological Process (BP) generation of neurons 0.6932 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.09244 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.09235 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.2305 Informative Inherited
Biological Process (BP) regulation of protein localization 0.02018 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.5739 Informative Inherited
Biological Process (BP) regulation of secretion 0.2861 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01715 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.3434 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.002313 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0584 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2411 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.6219 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.063 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.876 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001506 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.005329 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.009216 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.004754 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.05834 Informative Inherited
Biological Process (BP) regulation of defense response 0.8516 Informative Inherited
Biological Process (BP) cell development 0.7407 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2114 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1569 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.8639 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.153 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01641 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.563 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00000000000005058 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.00000000005278 Highly Informative Direct
Biological Process (BP) gene silencing 0.0000000000585 Highly Informative Direct
Biological Process (BP) negative regulation of reactive oxygen species metabolic process 0.000000000391 Highly Informative Direct
Biological Process (BP) histone modification 0.000000001854 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.00000007889 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0000005029 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0000007134 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0000009885 Highly Informative Direct
Biological Process (BP) aging 0.000003585 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.000009334 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.00001316 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.00001555 Highly Informative Direct
Biological Process (BP) lipid modification 0.00002042 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0001401 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000201 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.000224 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.0002248 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0002509 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0003047 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0003053 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.0003229 Highly Informative Direct
Biological Process (BP) fermentation 0.0003329 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0006483 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.0006543 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0006597 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0007099 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0009494 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.007658 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.02105 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.06476 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.006129 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.008848 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.05122 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.009853 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.1863 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.006848 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.0186 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.2013 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.01141 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.008026 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.004885 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1137 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.003097 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.004863 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.6326 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.007972 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.0825 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.003798 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01152 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.2179 Highly Informative Inherited
Biological Process (BP) protein maturation 0.021 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.002385 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.01012 Highly Informative Inherited
Molecular Function (MF) binding 0.9529 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.002333 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.00000000004371 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000009484 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000032 Moderately Informative Direct
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000006966 Informative Direct
Molecular Function (MF) electron carrier activity 0.0000001697 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0001331 Informative Direct
Molecular Function (MF) zinc ion binding 0.0002738 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.002878 Informative Inherited
Molecular Function (MF) deacetylase activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00000000000009403 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00000001271 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00003923 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.00006181 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.005002 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000007966 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.001378 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7577 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6752 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00001167 Moderately Informative Direct
Cellular Component (CC) cell projection 0.9741 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1498 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000005742 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.3133 Informative Inherited
Cellular Component (CC) neuron projection 0.3195 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.178 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.000000000002567 Highly Informative Direct
Cellular Component (CC) main axon 0.0000004029 Highly Informative Direct
Cellular Component (CC) midbody 0.00001573 Highly Informative Direct
Cellular Component (CC) spindle 0.002668 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.0249 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 0.02251 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.08467 Highly Informative Inherited
Cellular Component (CC) chromatin 0.001435 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.003317Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.000005466Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.02009Moderately InformativeInherited
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.6443Least InformativeInherited
Biological processTranscription regulation0.0002204Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.1582Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processNitrogen fixation0.0002794InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.0000000001325Highly InformativeDirect
Cellular componentMitochondrion0.000000000000001952Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001694Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationLyase0.000001233Moderately InformativeDirect
Post-translational modificationRepressor0.000001398Moderately InformativeDirect
Post-translational modificationDecarboxylase0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DHS-like NAD/FAD-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the DHS-like NAD/FAD-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]