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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,267) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,023,540 6,645,484 739
Proteins 878,716 5,785,563 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases0.5689Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00001366Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.00000000004252InformativeDirect
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000001114Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.000000000001586Highly InformativeDirect
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.00000000001552Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.0000000002809Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.000000001067Highly InformativeDirect
Enzyme Commission (EC)Phosphate acetyltransferase0.00000005958Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.00000006032Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.0000003757Highly InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase0.00004074Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0006792Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.9116Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01647Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.7069Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0001155InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.00363Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000000000007856Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00000004958Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.3794Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00006647Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00008292Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002425Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.006982Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.03092Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.1012Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.1455Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1977Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2315Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2802Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.3369Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5281Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.0000000000001234InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000000000001287InformativeDirect
Worm Phenotype (WP)sick0.00000005794InformativeDirect
Worm Phenotype (WP)gonad development variant0.000009061InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0002254InformativeDirect
Worm Phenotype (WP)sexually dimorphic behavior variant0.0003178InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0004539InformativeDirect
Worm Phenotype (WP)copulation variant0.0006679InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.008508InformativeInherited
Worm Phenotype (WP)localized movement variant0.02608InformativeInherited
Worm Phenotype (WP)body posture variant0.02803InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.09623InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.09628InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.09663InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.3516InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.445InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.4694InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0.00000003019Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000003336Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.00001748Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.00002222Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0000293Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.0000599Highly InformativeDirect
Worm Phenotype (WP)passage through meiosis defective early emb0.0001121Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0001266Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0001481Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0005862Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000822Highly InformativeDirect
Worm Phenotype (WP)axon branching variant0.0009035Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0009035Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.0009479Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.00112Highly InformativeInherited
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.02781Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0006243InformativeDirect
Yeast Phenotype (YP)mutation frequency0.00000182Highly InformativeDirect
Yeast Phenotype (YP)budding0.7542Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.000001534InformativeDirect
Fly Phenotype (FP)radiation sensitive0.0006018Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.06292Least InformativeInherited
Fly Anatomy (FA)gonad0.000086Moderately InformativeDirect
Fly Anatomy (FA)germline cyst0.0005873InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.09345Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.3736Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5076Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.00644Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.02853Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.0003433InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.00000269Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.0007962Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.00251Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.008382Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0000001264Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ line cell0.04058Moderately InformativeInherited
Xenopus ANatomical entity (XAN)oocyte0.000001109Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.0003553Least InformativeDirect
Plant ANatomical entity (PAN)gamete0.00003081InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.004729Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Translocases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Transferring sulfur-containing groups1InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1InformativeInherited
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Hydron translocation linked to the hydrolysis of a nucleoside triphosphate0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.000000000000001006Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000003166Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.0000000001122Highly InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.0000000001488Highly InformativeDirect
Enzyme Commission (EC)Linked to the hydrolysis of a nucleoside triphosphate0.000003158Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0002539Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0005016Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.0007737Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.8144Highly InformativeInherited
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.8237Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors1Highly InformativeInherited
Enzyme Commission (EC)Linked to the hydrolysis of a nucleoside triphosphate1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 512 hidden Markov models representing the P-loop containing nucleoside triphosphate hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]