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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,265) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,019,610 5,158,641 739
Proteins 875,264 4,487,912 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00.00000001946Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process10Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.20490Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.29230Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0000000000027390.7526Least InformativeInherited
Biological Process (BP)macromolecule metabolic process10.0000000000001947Least InformativeInherited
Biological Process (BP)biological regulation01Least InformativeInherited
Biological Process (BP)primary metabolic process10.4168Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.39470Least InformativeInherited
Biological Process (BP)biosynthetic process10.0000243Least InformativeInherited
Biological Process (BP)reproduction0.000075890.00000002245Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.0000000000073440Moderately InformativeDirect
Biological Process (BP)organelle organization0.00000000025050Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.000000000017490.00007083Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process0.00022050.000005355Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.075070.1713Moderately InformativeInherited
Biological Process (BP)cellular localization0.00006560.01019Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.026251Moderately InformativeInherited
Biological Process (BP)regulation of localization0.000000000030350.1404Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.39Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.000026521Moderately InformativeInherited
Biological Process (BP)system development11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000037380.002709Moderately InformativeInherited
Biological Process (BP)regulation of cell communication11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.8381Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.38581Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.18540.3272Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.69050.001024Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.86621Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.002731Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.49221Moderately InformativeInherited
Biological Process (BP)cell communication01Moderately InformativeInherited
Biological Process (BP)single organism signaling0.0000000000035431Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.00000085430.003004Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.011971Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism transport11Moderately InformativeInherited
Biological Process (BP)cellular response to stress10Moderately InformativeInherited
Biological Process (BP)organic substance transport10.1323Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.11870.6042Moderately InformativeInherited
Biological Process (BP)movement of cell or subcellular component00InformativeDirect
Biological Process (BP)microtubule-based process0.00000000000035830InformativeDirect
Biological Process (BP)nucleoside diphosphate metabolic process0.00000029850.0000001895InformativeDirect
Biological Process (BP)cell cycle process0.0000000000039730InformativeDirect
Biological Process (BP)actin filament-based process0.000000014270InformativeDirect
Biological Process (BP)intracellular signal transduction00.000006674InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.000018580.000000004824InformativeDirect
Biological Process (BP)organelle assembly0.00000000029610.00000681InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000025330.0000114InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.0000032070.000000001433InformativeDirect
Biological Process (BP)secretion by cell0.000000076810.2667InformativeInherited
Biological Process (BP)cellular lipid catabolic process0.9641InformativeInherited
Biological Process (BP)regulation of cellular localization0.024750.000001184InformativeInherited
Biological Process (BP)generation of neurons0.000068461InformativeInherited
Biological Process (BP)single-organism intracellular transport0.00024840.004546InformativeInherited
Biological Process (BP)organelle localization0.097320.0000000000002575InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.050160.08367InformativeInherited
Biological Process (BP)phosphorylation0.50671InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of gene expression11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process11InformativeInherited
Biological Process (BP)membrane organization0.0000003360.007317InformativeInherited
Biological Process (BP)locomotion00.7084InformativeInherited
Biological Process (BP)DNA metabolic process0.13220InformativeInherited
Biological Process (BP)negative regulation of signaling0.56341InformativeInherited
Biological Process (BP)regulation of defense response10.2513InformativeInherited
Biological Process (BP)negative regulation of cell communication0.56341InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle0.99721InformativeInherited
Biological Process (BP)vesicle-mediated transport01InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.025271InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.59891InformativeInherited
Biological Process (BP)cytoskeleton organization0.41121InformativeInherited
Biological Process (BP)regulation of secretion0.5151InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0047391InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)lipid localization10.2799InformativeInherited
Biological Process (BP)anion transport0.0063650.0000000004177InformativeInherited
Biological Process (BP)organic acid transport0.67140.5497InformativeInherited
Biological Process (BP)regulation of catabolic process0.15260.002581InformativeInherited
Biological Process (BP)amine metabolic process11InformativeInherited
Biological Process (BP)regulation of hormone levels0.89431InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.17640InformativeInherited
Biological Process (BP)response to extracellular stimulus0.16110.1409InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.0063910.000008128InformativeInherited
Biological Process (BP)secondary metabolic process0.0033771InformativeInherited
Biological Process (BP)embryo development0.0038851InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.96491InformativeInherited
Biological Process (BP)ion homeostasis0.55020.3541InformativeInherited
Biological Process (BP)pigment metabolic process0.61371InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.10620.1906InformativeInherited
Biological Process (BP)alcohol metabolic process0.7821InformativeInherited
Biological Process (BP)cell development0.041120.00009285InformativeInherited
Biological Process (BP)tissue development00.5399InformativeInherited
Biological Process (BP)mitotic cell cycle11InformativeInherited
Biological Process (BP)intracellular protein transport11InformativeInherited
Biological Process (BP)metal ion transport0.010621InformativeInherited
Biological Process (BP)transition metal ion transport0.00065270.00008557Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium0.00000000000036540.0000006148Highly InformativeDirect
Biological Process (BP)double-strand break repair0.00011130.00000385Highly InformativeDirect
Biological Process (BP)DNA recombination0.00000014670.000000000002617Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity00.00000000001185Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)regulation of cell shape0.000018830.0000004564Highly InformativeDirect
Biological Process (BP)nucleoside triphosphate biosynthetic process0.000000000020540.00000000000001783Highly InformativeDirect
Biological Process (BP)nucleoside biosynthetic process0.00014290.00000001236Highly InformativeDirect
Biological Process (BP)endomembrane system organization00.000008122Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.000039560.000000001013Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.000000000050040.000011Highly InformativeDirect
Biological Process (BP)deoxyribose phosphate metabolic process0.0000028130.0000676Highly InformativeDirect
Biological Process (BP)cell projection assembly00.00000000002742Highly InformativeDirect
Biological Process (BP)wound healing0.00000000023610.0000000000006157Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH0.00000002360Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00Highly InformativeDirect
Biological Process (BP)plasma membrane bounded cell projection organization0.0018741Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.024590Highly InformativeInherited
Biological Process (BP)autophagy0.00000010130.005293Highly InformativeInherited
Biological Process (BP)cell proliferation0.73921Highly InformativeInherited
Biological Process (BP)vesicle localization0.0013671Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.000014361Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.00011320.005355Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-templated11Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.012120.03879Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process10.5304Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.079250.7909Highly InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.041560.7782Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.000032520.001886Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process10.9731Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.04410.005174Highly InformativeInherited
Biological Process (BP)carbohydrate derivative transport10.967Highly InformativeInherited
Biological Process (BP)amino acid transport0.015550.09944Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.027381Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.20951Highly InformativeInherited
Biological Process (BP)cellular response to extracellular stimulus0.44790.04774Highly InformativeInherited
Biological Process (BP)pigmentation0.000000018030.004775Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.84631Highly InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.34920.9539Highly InformativeInherited
Biological Process (BP)pyrimidine nucleoside triphosphate metabolic process0.0031610.000003937Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process0.00039230.02203Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide biosynthetic process0.0097090.0000002918Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.017750.004135Highly InformativeInherited
Biological Process (BP)primary alcohol metabolic process0.0073940.7572Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.40531Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.029350.0465Highly InformativeInherited
Biological Process (BP)phagocytosis0.36041Highly InformativeInherited
Biological Process (BP)lysosome organization10.0000008977Highly InformativeInherited
Biological Process (BP)vesicle organization0.000000000042640.03631Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0086770.00001793Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.72581Least InformativeInherited
Molecular Function (MF)transporter activity0.000000000000066250Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00.9199Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00.05985Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.00000097360.000000000008451InformativeDirect
Molecular Function (MF)transferase activity, transferring sulfur-containing groups00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)ATPase activity11InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.15340InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups11InformativeInherited
Molecular Function (MF)kinase activity0.000000000000035860.406InformativeInherited
Molecular Function (MF)ligase activity11InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)amine transmembrane transporter activity0.00000005520.0000000002597Highly InformativeDirect
Molecular Function (MF)tubulin binding0.00017610.00000006203Highly InformativeDirect
Molecular Function (MF)phosphotransferase activity, phosphate group as acceptor00Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)ATPase coupled ion transmembrane transporter activity11Highly InformativeInherited
Molecular Function (MF)purine nucleoside binding0.0036960.00001648Highly InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity0.00000000000044670.009535Highly InformativeInherited
Molecular Function (MF)lipid transporter activity0.7830.0000007315Highly InformativeInherited
Molecular Function (MF)macromolecule transmembrane transporter activity0.099080.0003143Highly InformativeInherited
Molecular Function (MF)carbohydrate derivative transporter activity11Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000010810Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)macromolecular complex10Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.00000000025470.05593Least InformativeInherited
Cellular Component (CC)cytoskeleton00.00000000001232Moderately InformativeDirect
Cellular Component (CC)vesicle00.0000000000008799Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle00.00000007443Moderately InformativeDirect
Cellular Component (CC)whole membrane00.000000001184Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)membrane protein complex0.94910.716Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane11Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.0000000000021270.9793Moderately InformativeInherited
Cellular Component (CC)nuclear part10.586Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.00004272InformativeDirect
Cellular Component (CC)cilium00InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.000000640.0000000000005714InformativeDirect
Cellular Component (CC)extrinsic component of membrane0.000000004940.000000000001507InformativeDirect
Cellular Component (CC)vacuolar part0.0000039840.0006131InformativeDirect
Cellular Component (CC)plasma membrane protein complex0.00045940InformativeDirect
Cellular Component (CC)cytoplasmic region0.000000000000034970.000000000000004679InformativeDirect
Cellular Component (CC)cell surface0.059151InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.13640.000007874InformativeInherited
Cellular Component (CC)transporter complex0.000066840.01234InformativeInherited
Cellular Component (CC)secretory granule0.71380.4152InformativeInherited
Cellular Component (CC)lytic vacuole0.99721InformativeInherited
Cellular Component (CC)neuron projection11InformativeInherited
Cellular Component (CC)side of membrane0.00013150.1403InformativeInherited
Cellular Component (CC)supramolecular polymer0.97161InformativeInherited
Cellular Component (CC)spindle0.00000011390.0000001227Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.00000610.0000000000123Highly InformativeDirect
Cellular Component (CC)lateral plasma membrane0.000028740.0002575Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.00000030090.000001488Highly InformativeDirect
Cellular Component (CC)dynein complex0.00061360Highly InformativeDirect
Cellular Component (CC)midbody0.000000000014360Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00024470.000000000000003141Highly InformativeDirect
Cellular Component (CC)cell division site part0.00000000000029630.00000000000002218Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.000000052740Highly InformativeDirect
Cellular Component (CC)Golgi subcompartment00.0000001892Highly InformativeDirect
Cellular Component (CC)cell-cell junction0.9390.002224Highly InformativeInherited
Cellular Component (CC)extrinsic component of organelle membrane0.00004310.003746Highly InformativeInherited
Cellular Component (CC)lysosomal membrane0.00014510.01383Highly InformativeInherited
Cellular Component (CC)photoreceptor cell cilium0.75240Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)