SUPERFAMILY 1.75 HMM library and genome assignments server

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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,267) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,023,540 5,158,641 739
Proteins 878,716 4,487,912 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00.000001653Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.37080Least InformativeInherited
Biological Process (BP)biological regulation0.0000000000000031441Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.30120Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.21140Least InformativeInherited
Biological Process (BP)biosynthetic process10.00008587Least InformativeInherited
Biological Process (BP)multicellular organismal process0.00017991Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00000000000008880.5274Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process10Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process10.00000001441Least InformativeInherited
Biological Process (BP)reproduction0.00017290.0000001401Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.0000000000046840Moderately InformativeDirect
Biological Process (BP)organelle organization0.000000000056360Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0000000000050050.00004591Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process0.00023060.0000001165Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.77830.001029Moderately InformativeInherited
Biological Process (BP)tissue development00.2835Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.013361Moderately InformativeInherited
Biological Process (BP)animal organ development11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0000000000023250.08051Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000016450.00118Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.18920.2975Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.000001660.002613Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.2121Moderately InformativeInherited
Biological Process (BP)cell communication01Moderately InformativeInherited
Biological Process (BP)regulation of cell communication11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.88171Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)cellular localization0.00042150.004139Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.39361Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.43231Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.87551Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.16790.1442Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.12850.4092Moderately InformativeInherited
Biological Process (BP)organic substance transport10.05967Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)single organism signaling0.000000000019021Moderately InformativeInherited
Biological Process (BP)cellular response to stress10Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0030861Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.025821Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)cell differentiation0.30431Moderately InformativeInherited
Biological Process (BP)single-organism transport11Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)movement of cell or subcellular component00InformativeDirect
Biological Process (BP)microtubule-based process0.00000000000020290InformativeDirect
Biological Process (BP)response to wounding00.0003111InformativeDirect
Biological Process (BP)cell cycle process0.00000000017130InformativeDirect
Biological Process (BP)intracellular signal transduction00.0000002212InformativeDirect
Biological Process (BP)single-organism membrane organization0.000000000013570InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.000033250.000000004484InformativeDirect
Biological Process (BP)epithelium development00.0000000005331InformativeDirect
Biological Process (BP)organelle assembly0.00000000038660.00004092InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000044790.00001032InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.0000046180.000000001384InformativeDirect
Biological Process (BP)single-organism cellular localization0.00000000020360.000005302InformativeDirect
Biological Process (BP)vesicle-mediated transport01InformativeInherited
Biological Process (BP)secretion by cell0.00000017310.2458InformativeInherited
Biological Process (BP)locomotion00.5117InformativeInherited
Biological Process (BP)localization of cell0.000000000028451InformativeInherited
Biological Process (BP)intracellular transport0.00000000081720.003353InformativeInherited
Biological Process (BP)regulation of cellular localization0.018610.0000004621InformativeInherited
Biological Process (BP)regulation of protein localization0.99621InformativeInherited
Biological Process (BP)inorganic ion homeostasis0.44950.1461InformativeInherited
Biological Process (BP)cation homeostasis0.43840.07435InformativeInherited
Biological Process (BP)organelle localization0.10620.00000000000008578InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)phosphorylation0.57821InformativeInherited
Biological Process (BP)secondary metabolic process0.0022841InformativeInherited
Biological Process (BP)pigment metabolic process0.51720.998InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of gene expression11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process11InformativeInherited
Biological Process (BP)protein transport10.7717InformativeInherited
Biological Process (BP)negative regulation of cell communication0.60281InformativeInherited
Biological Process (BP)regulation of immune response11InformativeInherited
Biological Process (BP)negative regulation of signaling0.60281InformativeInherited
Biological Process (BP)regulation of defense response11InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process11InformativeInherited
Biological Process (BP)regulation of cytokine production11InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.033151InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.64441InformativeInherited
Biological Process (BP)actin cytoskeleton organization0.72041InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.065950.0313InformativeInherited
Biological Process (BP)regulation of secretion0.63751InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0038881InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.12580.2543InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)lipid localization10.2669InformativeInherited
Biological Process (BP)anion transport0.0097440.0000000002969InformativeInherited
Biological Process (BP)organic acid transport0.72850.5849InformativeInherited
Biological Process (BP)regulation of catabolic process0.12390.002471InformativeInherited
Biological Process (BP)amine metabolic process11InformativeInherited
Biological Process (BP)regulation of hormone levels0.94251InformativeInherited
Biological Process (BP)response to extracellular stimulus0.13490.1272InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.0084110.0000001637InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis11InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.17320InformativeInherited
Biological Process (BP)alcohol metabolic process0.72611InformativeInherited
Biological Process (BP)cell development0.19680.0009851InformativeInherited
Biological Process (BP)DNA metabolic process0.15020InformativeInherited
Biological Process (BP)mitotic cell cycle11InformativeInherited
Biological Process (BP)metal ion transport0.012531InformativeInherited
Biological Process (BP)transition metal ion transport0.00053620.000158Highly InformativeDirect
Biological Process (BP)cytokinesis0.00000000095960.0007815Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium00.000000003437Highly InformativeDirect
Biological Process (BP)double-strand break repair0.00011070.000008581Highly InformativeDirect
Biological Process (BP)DNA recombination0.0000001390.00000000001095Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity00.000000000001005Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)regulation of cell shape0.000017890.00000008359Highly InformativeDirect
Biological Process (BP)nucleoside triphosphate biosynthetic process0.000000000043650.00000000000003429Highly InformativeDirect
Biological Process (BP)nucleoside biosynthetic process0.00028150.00000002554Highly InformativeDirect
Biological Process (BP)endomembrane system organization00.00001694Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.000024530.000000004311Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.000000000088780.00001607Highly InformativeDirect
Biological Process (BP)deoxyribose phosphate metabolic process0.0000031340.00007299Highly InformativeDirect
Biological Process (BP)cell projection assembly00.0000000000163Highly InformativeDirect
Biological Process (BP)wound healing0.0000000000016780.000000000000003734Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH0.000000033890Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.0003210.0000000001028Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00Highly InformativeDirect
Biological Process (BP)microtubule-based movement0.023280Highly InformativeInherited
Biological Process (BP)cell proliferation0.74961Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0000054311Highly InformativeInherited
Biological Process (BP)pigmentation0.00000001720.00302Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process0.00032090.03099Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.00011490.005583Highly InformativeInherited
Biological Process (BP)plasma membrane bounded cell projection organization0.0018921Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.0055670.04103Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.087180.8334Highly InformativeInherited
Biological Process (BP)negative regulation of cytokine production0.61271Highly InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.041370.5221Highly InformativeInherited
Biological Process (BP)autophagy0.00000016260.003368Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.000034660.002063Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process11Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.043480.005528Highly InformativeInherited
Biological Process (BP)carbohydrate derivative transport10.9441Highly InformativeInherited
Biological Process (BP)amino acid transport0.020130.1421Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.032051Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.21461Highly InformativeInherited
Biological Process (BP)cellular response to extracellular stimulus0.38890.04481Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.73431Highly InformativeInherited
Biological Process (BP)divalent inorganic cation transport0.62191Highly InformativeInherited
Biological Process (BP)pyrimidine nucleoside triphosphate metabolic process0.0027580.00000596Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide biosynthetic process0.008250.0000002619Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.020380.00171Highly InformativeInherited
Biological Process (BP)primary alcohol metabolic process0.0093980.7727Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.43471Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.083920.09185Highly InformativeInherited
Biological Process (BP)phagocytosis0.38661Highly InformativeInherited
Biological Process (BP)lysosome organization10.000000842Highly InformativeInherited
Biological Process (BP)vesicle organization0.0000000000023490.03094Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.022810.00006826Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.67281Least InformativeInherited
Molecular Function (MF)transporter activity0.00000000000064480Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00.9596Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00.05957Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0000016770.00000000003057InformativeDirect
Molecular Function (MF)P-P-bond-hydrolysis-driven transmembrane transporter activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring sulfur-containing groups00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups11InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances11InformativeInherited
Molecular Function (MF)ATPase activity11InformativeInherited
Molecular Function (MF)active ion transmembrane transporter activity0.42910.04106InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.17068.27e-16InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)ligase activity11InformativeInherited
Molecular Function (MF)kinase activity0.0000000000000099540.4111InformativeInherited
Molecular Function (MF)amine transmembrane transporter activity0.000000047540.0000000001515Highly InformativeDirect
Molecular Function (MF)tubulin binding0.00012940.000000003344Highly InformativeDirect
Molecular Function (MF)phosphotransferase activity, phosphate group as acceptor00Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)ATPase coupled ion transmembrane transporter activity11Highly InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity0.0000000000012690.009113Highly InformativeInherited
Molecular Function (MF)lipid transporter activity0.95020.000003345Highly InformativeInherited
Molecular Function (MF)macromolecule transmembrane transporter activity0.096470.0002327Highly InformativeInherited
Molecular Function (MF)carbohydrate derivative transporter activity11Highly InformativeInherited
Molecular Function (MF)purine nucleoside binding0.001620.000007965Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000074010Least InformativeDirect
Cellular Component (CC)protein complex10Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.00000000018960.008145Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vacuole0.00000058340.0006373Moderately InformativeDirect
Cellular Component (CC)cytoskeleton00.0000000000001001Moderately InformativeDirect
Cellular Component (CC)vesicle00.0000000000004625Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle00.000000419Moderately InformativeDirect
Cellular Component (CC)whole membrane00.000000001754Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane11Moderately InformativeInherited
Cellular Component (CC)membrane protein complex0.99750.4853Moderately InformativeInherited
Cellular Component (CC)nuclear part10.5957Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.00000000000043981Moderately InformativeInherited
Cellular Component (CC)endomembrane system00.2215Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0001057InformativeDirect
Cellular Component (CC)cilium00InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00000021480.000000000000008837InformativeDirect
Cellular Component (CC)extrinsic component of membrane0.0000000034480.000000000004425InformativeDirect
Cellular Component (CC)vacuolar part0.0000074840.0004455InformativeDirect
Cellular Component (CC)cytoplasmic region0.0000000000000089940.000000000000003036InformativeDirect
Cellular Component (CC)side of membrane0.00025630.2478InformativeInherited
Cellular Component (CC)cell surface0.11531InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.10220.00000004879InformativeInherited
Cellular Component (CC)transporter complex0.00015090.01632InformativeInherited
Cellular Component (CC)plasma membrane protein complex0.0012340InformativeInherited
Cellular Component (CC)secretory granule0.86670.4724InformativeInherited
Cellular Component (CC)lytic vacuole0.99670.9916InformativeInherited
Cellular Component (CC)neuron projection11InformativeInherited
Cellular Component (CC)supramolecular polymer0.98031InformativeInherited
Cellular Component (CC)spindle0.00000014250.00000002993Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.0000060220.00000000000005256Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.00000030480.000002138Highly InformativeDirect
Cellular Component (CC)dynein complex0.00077690Highly InformativeDirect
Cellular Component (CC)midbody0.000000000013460Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00020.000000000000003036Highly InformativeDirect
Cellular Component (CC)cell division site part0.00000000000098480.000000000000008837Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.000000064430Highly InformativeDirect
Cellular Component (CC)Golgi subcompartment00.0000002276Highly InformativeDirect
Cellular Component (CC)cell-cell junction0.91550.0009772Highly InformativeInherited
Cellular Component (CC)extrinsic component of organelle membrane0.000042860.009025Highly InformativeInherited
Cellular Component (CC)lysosomal membrane0.000058340.00639Highly InformativeInherited
Cellular Component (CC)photoreceptor cell cilium0.82310Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)