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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,267) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,023,540 6,645,484 739
Proteins 878,716 5,785,563 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases0.5689Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00001366Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.00000000004252InformativeDirect
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000001114Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.000000000001586Highly InformativeDirect
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.00000000001552Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.0000000002809Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.000000001067Highly InformativeDirect
Enzyme Commission (EC)Phosphate acetyltransferase0.00000005958Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.00000006032Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.0000003757Highly InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase0.00004074Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0006792Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.9116Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.3828InformativeInherited
Mode of Inheritance (MI)Somatic mosaicism0.0005223Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01582Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.7057Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0001148InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.003628Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000000001345Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000005933Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00000005089Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0.6002Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)cell cycle variant0.00000008711Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport variant0.0000025Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00001194Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00003198Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00004774Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0002405Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.001419Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.02072Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.03381Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05614Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.1135Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.2315Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2613Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.728Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.9922Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000000000001527InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0000000000003632InformativeDirect
Worm Phenotype (WP)sick0.00000008729InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0000005978InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000001262InformativeDirect
Worm Phenotype (WP)brood size variant0.000001381InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.000102InformativeDirect
Worm Phenotype (WP)vesicle organization variant0.000149InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000455InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0008155InformativeDirect
Worm Phenotype (WP)anesthetic response variant0.004853InformativeInherited
Worm Phenotype (WP)localized movement variant0.02792InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.04205InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.04408InformativeInherited
Worm Phenotype (WP)directionality variant0.05414InformativeInherited
Worm Phenotype (WP)organism ionizing radiation response variant0.06444InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.07807InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.197InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.3651InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.4013InformativeInherited
Worm Phenotype (WP)organism pathogen response variant1InformativeInherited
Worm Phenotype (WP)RNAi response variant0Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.00000000000001253Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00000003498Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000005219Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.00001136Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.00001492Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.0000681Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0001093Highly InformativeDirect
Worm Phenotype (WP)passage through meiosis defective early emb0.0003352Highly InformativeDirect
Worm Phenotype (WP)actin organization biogenesis variant0.000456Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0008613Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.04656Highly InformativeInherited
Worm Phenotype (WP)synaptic transmission variant0.1957Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0006243InformativeDirect
Yeast Phenotype (YP)mutation frequency0.00000182Highly InformativeDirect
Yeast Phenotype (YP)budding0.7542Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.000001148InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.08906Least InformativeInherited
Fly Anatomy (FA)gonad0.0001612Moderately InformativeDirect
Fly Anatomy (FA)germline cyst0.0004731InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.000237Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.007805Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.03844Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0000002624Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.0003553Least InformativeDirect
Plant ANatomical entity (PAN)gamete0.00003081InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.1419Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Isomerases altering macromolecular conformation0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Catalysing the translocation of hydrons0.02209InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Transferring sulfur-containing groups1InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1InformativeInherited
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Adenosinetriphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Enzymes altering polypeptide conformation or assembly0Highly InformativeDirect
Enzyme Commission (EC)Hydron translocation linked to the hydrolysis of a nucleoside triphosphate0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.000000000000001017Highly InformativeDirect
Enzyme Commission (EC)Linked to the hydrolysis of a nucleoside triphosphate0.0000000000000875Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000003968Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.000000000006927Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.000003257Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0005125Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0009981Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.8645Highly InformativeInherited
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.87Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationTransferase0.0000006695Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 512 hidden Markov models representing the P-loop containing nucleoside triphosphate hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]