SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,218) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 969,475 2,078,183 739
Proteins 832,282 1,810,192 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00014241Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0013091Least InformativeInherited
Biological Process (BP)response to stimulus0.099810.3002Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)developmental process1.489e-141Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.7628Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction8.516e-106.543e-12Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization1.648e-072.961e-08Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.86530.0004024Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.15751Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development6.593e-081Moderately InformativeInherited
Biological Process (BP)multi-organism process0.92440.09398Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.065615.257e-12Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.93011Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.97711Moderately InformativeInherited
Biological Process (BP)organic substance transport10.1319Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.017361Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of localization1.201e-140.0205Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0086021Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)tissue development11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis2.325e-060.9924Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.20591Moderately InformativeInherited
Biological Process (BP)signal transduction0.00048421Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.42280Moderately InformativeInherited
Biological Process (BP)cellular response to stress16.471e-12Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.67631Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization00.001465Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.064720.8862Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process3.266e-050InformativeDirect
Biological Process (BP)cell cycle process1.096e-050InformativeDirect
Biological Process (BP)actin filament-based process1.152e-122.537e-07InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process3.001e-090InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction4.716e-080InformativeDirect
Biological Process (BP)organelle assembly3.175e-057.079e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)glycosyl compound catabolic process00InformativeDirect
Biological Process (BP)epithelium development0.0052290.01883InformativeInherited
Biological Process (BP)reproductive structure development10.4601InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.62881InformativeInherited
Biological Process (BP)cellular component morphogenesis1.489e-081InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)generation of neurons2.067e-051InformativeInherited
Biological Process (BP)organelle localization0.21762.347e-07InformativeInherited
Biological Process (BP)biological adhesion5.015e-051InformativeInherited
Biological Process (BP)response to light stimulus0.70991InformativeInherited
Biological Process (BP)vesicle-mediated transport1.059e-140.1025InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0079720.8664InformativeInherited
Biological Process (BP)secondary metabolic process0.65111InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.97431InformativeInherited
Biological Process (BP)positive regulation of gene expression0.92131InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.96731InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.9871InformativeInherited
Biological Process (BP)regulation of organelle organization2.807e-080.007001InformativeInherited
Biological Process (BP)protein transport4.513e-120.04779InformativeInherited
Biological Process (BP)regulation of growth0.90781InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.010840.6054InformativeInherited
Biological Process (BP)cytoskeleton organization0.040231InformativeInherited
Biological Process (BP)cation homeostasis0.13920.2687InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.043450.3197InformativeInherited
Biological Process (BP)growth2.334e-090.5076InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.020321InformativeInherited
Biological Process (BP)membrane organization0.031180.0001421InformativeInherited
Biological Process (BP)regulation of hormone levels0.18341InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis5.336e-061InformativeInherited
Biological Process (BP)steroid metabolic process0.62771InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.82620.7662InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00033380.1205InformativeInherited
Biological Process (BP)intracellular signal transduction00.02281InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0033730InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.80810InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)tissue morphogenesis0.29631InformativeInherited
Biological Process (BP)double-strand break repair4.654e-054.814e-08Highly InformativeDirect
Biological Process (BP)DNA recombination1.595e-102.092e-11Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity3.14e-151.549e-09Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process2.574e-110Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process1.045e-060Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis6.326e-099.041e-09Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly2.351e-130.0004963Highly InformativeDirect
Biological Process (BP)cell projection assembly3.73e-098.461e-07Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport4.555e-133.861e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH6.333e-070Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process2.477e-051.663e-07Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process06.275e-08Highly InformativeDirect
Biological Process (BP)epithelial cell development0.041471.814e-12Highly InformativeInherited
Biological Process (BP)gonad development0.90181Highly InformativeInherited
Biological Process (BP)development of primary male sexual characteristics0.066421Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.0007420.1021Highly InformativeInherited
Biological Process (BP)cell proliferation0.98281Highly InformativeInherited
Biological Process (BP)cell fate commitment0.88231Highly InformativeInherited
Biological Process (BP)establishment of vesicle localization0.0076491Highly InformativeInherited
Biological Process (BP)interaction with symbiont0.085690.00923Highly InformativeInherited
Biological Process (BP)sensory perception10.09306Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.58620.3712Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate metabolic process11Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate metabolic process0.67591Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.00670.1019Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.54811Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent11Highly InformativeInherited
Biological Process (BP)cell junction organization7.097e-110.006487Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity1.968e-060.7967Highly InformativeInherited
Biological Process (BP)protein methylation0.66910.6629Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00018110.998Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0047561Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.30651Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.050631Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.9171Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.065180.2665Highly InformativeInherited
Biological Process (BP)meiosis0.010590Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.86271Highly InformativeInherited
Biological Process (BP)protein glycosylation0.013961Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.042750.01871Highly InformativeInherited
Biological Process (BP)phagocytosis0.91991Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transporter activity0.00028580Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity1.594e-120InformativeDirect
Molecular Function (MF)purine ribonucleoside binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.27160.0001026InformativeInherited
Molecular Function (MF)cytoskeletal protein binding18.448e-07InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.9671InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity1.302e-120.6436InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding1.896e-068.346e-10Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0068610.2361Highly InformativeInherited
Cellular Component (CC)membrane02.689e-05Least InformativeDirect
Cellular Component (CC)protein complex0.89680.2389Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0016991Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.63140Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoplasmic part2.681e-150.00106Least InformativeInherited
Cellular Component (CC)cytoskeleton2.876e-142.839e-08Moderately InformativeDirect
Cellular Component (CC)vesicle00.0009095Moderately InformativeDirect
Cellular Component (CC)cell projection02.969e-15Moderately InformativeDirect
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.89581Moderately InformativeInherited
Cellular Component (CC)nuclear part10.6497Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0002644InformativeDirect
Cellular Component (CC)cell cortex4.512e-135.145e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton1.372e-152.556e-13InformativeDirect
Cellular Component (CC)cell-cell junction0.92080.0004474InformativeInherited
Cellular Component (CC)secretory granule10.9021InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.047840.01479InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.91661InformativeInherited
Cellular Component (CC)synapse part1.536e-140.03113InformativeInherited
Cellular Component (CC)spindle2.681e-152.498e-14Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.00024577.43e-06Highly InformativeDirect
Cellular Component (CC)cilium06.054e-14Highly InformativeDirect
Cellular Component (CC)lateral plasma membrane1.113e-072.396e-11Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.00011210Highly InformativeDirect
Cellular Component (CC)endocytic vesicle3.398e-052.103e-09Highly InformativeDirect
Cellular Component (CC)midbody7.787e-150Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle B7.434e-050.000655Highly InformativeDirect
Cellular Component (CC)cell division site part2.469e-062.075e-12Highly InformativeDirect
Cellular Component (CC)insulin-responsive compartment2.941e-059.28e-10Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex5.01e-070Highly InformativeDirect
Cellular Component (CC)recycling endosome2.468e-090Highly InformativeDirect
Cellular Component (CC)host cell part0.0014045.581e-05Highly InformativeInherited
Cellular Component (CC)nuclear body0.14430.5737Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.021330.01701Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0096420Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)