SUPERFAMILY 1.75 HMM library and genome assignments server

P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,259) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,015,384 4,300,997 739
Proteins 871,759 3,740,022 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000048360Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000045671Least InformativeInherited
Biological Process (BP)response to stimulus0.19110.1771Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.94191Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0052581Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.8214Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0000000060370.00000000004572Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization0.00000000000014730.00000000000496Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.76480.9927Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of localization00.01522Moderately InformativeInherited
Biological Process (BP)nervous system development0.00000015281Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.65411Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.20351Moderately InformativeInherited
Biological Process (BP)tissue development0.44881Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization00.00102Moderately InformativeInherited
Biological Process (BP)organic substance transport0.93090.00683Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.75941Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.78341Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.052181Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.20071Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)reproductive process0.000060790.06059Moderately InformativeInherited
Biological Process (BP)multi-organism process0.17450.000002562Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.98850.00014Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.005040.004516Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.039080.00000000000213Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.95841Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00057171Moderately InformativeInherited
Biological Process (BP)signal transduction0.00089281Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.57980Moderately InformativeInherited
Biological Process (BP)cellular response to stress10.000000000000003707Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0000000016490.5275Moderately InformativeInherited
Biological Process (BP)cellular component movement0.000015580.00003144InformativeDirect
Biological Process (BP)microtubule-based process0.00015640InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.00018920InformativeDirect
Biological Process (BP)cell cycle process0.000000053330InformativeDirect
Biological Process (BP)actin filament-based process00.000000007022InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)single-organism membrane organization0.000000000049790InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.0000000085640.00000000000004385InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cell division00InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00InformativeDirect
Biological Process (BP)organelle assembly0.0000023380.00000002616InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00InformativeDirect
Biological Process (BP)single-organism cellular localization0.00064480.00002176InformativeDirect
Biological Process (BP)single-organism intracellular transport0.0000000000018850.0000000000001499InformativeDirect
Biological Process (BP)cation homeostasis0.18060.3142InformativeInherited
Biological Process (BP)proteolysis10.6628InformativeInherited
Biological Process (BP)protein catabolic process10.8098InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)regulation of protein localization0.9221InformativeInherited
Biological Process (BP)cell proliferation0.65231InformativeInherited
Biological Process (BP)generation of neurons0.00001011InformativeInherited
Biological Process (BP)organelle localization0.023940.000000001182InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)neurological system process0.57330.9665InformativeInherited
Biological Process (BP)response to light stimulus0.76681InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.002430.5189InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching10.6524InformativeInherited
Biological Process (BP)secondary metabolic process0.58091InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.49570.8574InformativeInherited
Biological Process (BP)cell projection organization00.6686InformativeInherited
Biological Process (BP)regulation of organelle organization0.000000015820.01616InformativeInherited
Biological Process (BP)protein transport0.00000000017290.007925InformativeInherited
Biological Process (BP)regulation of growth0.92531InformativeInherited
Biological Process (BP)negative regulation of immune system process10.04993InformativeInherited
Biological Process (BP)negative regulation of cell communication0.7671InformativeInherited
Biological Process (BP)negative regulation of signaling0.65991InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.074281InformativeInherited
Biological Process (BP)cytoskeleton organization0.10831InformativeInherited
Biological Process (BP)sexual reproduction0.96261InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.11460.00005502InformativeInherited
Biological Process (BP)single organism reproductive process0.45480.6881InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.004851InformativeInherited
Biological Process (BP)growth0.0000012870.2215InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.03760.256InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.048061InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.99371InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.14760.133InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00000031221InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.26210.2335InformativeInherited
Biological Process (BP)regulation of hormone levels0.12941InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00015521InformativeInherited
Biological Process (BP)tissue morphogenesis0.0066881InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.000036830.02312InformativeInherited
Biological Process (BP)intracellular signal transduction00.05324InformativeInherited
Biological Process (BP)organelle fission10InformativeInherited
Biological Process (BP)cytoplasmic transport0.99411InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)epithelium development0.00099390.6357InformativeInherited
Biological Process (BP)vesicle-mediated transport00.007501InformativeInherited
Biological Process (BP)DNA repair0.91170InformativeInherited
Biological Process (BP)mitotic cell cycle11InformativeInherited
Biological Process (BP)cytokinesis0.000000000026760.00001379Highly InformativeDirect
Biological Process (BP)epithelial cell development0.0000085580.000143Highly InformativeDirect
Biological Process (BP)double-strand break repair0.00004270.0000004049Highly InformativeDirect
Biological Process (BP)DNA recombination0.0000000004530.0000000003582Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity00.000000000009011Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate catabolic process00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process00Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate catabolic process00Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.00022670Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000000091580.000000000000147Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.00000000000025190.0005461Highly InformativeDirect
Biological Process (BP)regulation of exocytosis0.000000000000053510.0000000000003378Highly InformativeDirect
Biological Process (BP)cell projection assembly0.000000000025960.000001317Highly InformativeDirect
Biological Process (BP)cell junction organization0.0000000000015030.00004881Highly InformativeDirect
Biological Process (BP)cilium organization0.0000000000069440.000002083Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.000000002070.0002411Highly InformativeDirect
Biological Process (BP)meiotic cell cycle0.00061780Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.0000002950Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process00.000000000000001913Highly InformativeDirect
Biological Process (BP)nucleus organization0.90191Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.8994Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.066911Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0011420.9047Highly InformativeInherited
Biological Process (BP)cell fate commitment0.92651Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0055530.003831Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0045940.01114Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.000000003950.2353Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.00014610.1657Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.52470.2374Highly InformativeInherited
Biological Process (BP)sensory perception10.06245Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.30710.1249Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.0029040.04692Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.020110.009607Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.46241Highly InformativeInherited
Biological Process (BP)plasma membrane organization0.046360.5858Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.53891Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.030910.002516Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.0000018060.6892Highly InformativeInherited
Biological Process (BP)columnar/cuboidal epithelial cell differentiation0.16220.2214Highly InformativeInherited
Biological Process (BP)germ cell development0.16520.000000000002564Highly InformativeInherited
Biological Process (BP)female gamete generation0.00044790.04769Highly InformativeInherited
Biological Process (BP)protein methylation0.70480.6762Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.73651Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process0.90660.5675Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.039340.002302Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00024641Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0037761Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate catabolic process10.0000000003748Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.17141Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.011940.9604Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.91521Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.86371Highly InformativeInherited
Biological Process (BP)nuclear division10.7083Highly InformativeInherited
Biological Process (BP)protein glycosylation0.22531Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.0020110.006984Highly InformativeInherited
Biological Process (BP)phagocytosis0.8191Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.64621Least InformativeInherited
Molecular Function (MF)transporter activity0.00033790Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring sulfur-containing groups00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.0000000000015650InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.98381InformativeInherited
Molecular Function (MF)purine ribonucleoside binding00.01881InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.40380.00134InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.69870.000000009811InformativeInherited
Molecular Function (MF)ligase activity11InformativeInherited
Molecular Function (MF)kinase activity0.0000000000015160.3766InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)tubulin binding0.000074830.00000009843Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding0.000000094780.0008346Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.010150.276Highly InformativeInherited
Cellular Component (CC)membrane00.00000000000007189Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.0000001647Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.43791Least InformativeInherited
Cellular Component (CC)protein complex10.384Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.096840Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000000000028230.00000000006414Moderately InformativeDirect
Cellular Component (CC)cell projection00.00000000000003949Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane11Moderately InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)nuclear part10.01011Moderately InformativeInherited
Cellular Component (CC)vesicle00.02514Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.014061Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.0000000000074960.003938Moderately InformativeInherited
Cellular Component (CC)membrane region11Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.00009518InformativeDirect
Cellular Component (CC)cell cortex0.000000000000049660.00000000000005579InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.000000000000077440InformativeDirect
Cellular Component (CC)cell junction0.000021420.000000006931InformativeDirect
Cellular Component (CC)integral component of membrane11InformativeInherited
Cellular Component (CC)cell surface0.42571InformativeInherited
Cellular Component (CC)transporter complex0.00081630.6098InformativeInherited
Cellular Component (CC)secretory granule0.21450.136InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.57830.7471InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.55161InformativeInherited
Cellular Component (CC)spindle0.00000000000057770.000000002926Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.000036260.0000000001155Highly InformativeDirect
Cellular Component (CC)midbody00Highly InformativeDirect
Cellular Component (CC)intraciliary transport particle0.000000025220.00000001789Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.000070640Highly InformativeDirect
Cellular Component (CC)cell division site part0.0000017320.00000000001463Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.00000081570Highly InformativeDirect
Cellular Component (CC)ciliary part00.000000000007965Highly InformativeDirect
Cellular Component (CC)nuclear body0.17151Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0027630Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)