SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,218) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 969,475 2,078,183 739
Proteins 832,282 1,810,192 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process5.324e-051Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.08220.2923Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0010751Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.7244Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.237e-092.161e-12Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization4.493e-081.15e-08Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00.0007713Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.69541Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.98871Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.80010.0003071Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.16061Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development6.311e-081Moderately InformativeInherited
Biological Process (BP)multi-organism process0.92880.0782Moderately InformativeInherited
Biological Process (BP)regulation of localization00.01341Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.83551Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.063554.879e-12Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.96991Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)organic substance transport10.09154Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.017121Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0018911Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)tissue development0.89181Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis3.439e-080.8794Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.13811Moderately InformativeInherited
Biological Process (BP)signal transduction0.00084671Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.43770Moderately InformativeInherited
Biological Process (BP)cellular response to stress12.624e-12Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.71871Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.069040.8906Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process2.93e-050InformativeDirect
Biological Process (BP)cell cycle process1.452e-050InformativeDirect
Biological Process (BP)actin filament-based process1.698e-122.832e-07InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process2.575e-090InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction6.259e-080InformativeDirect
Biological Process (BP)organelle assembly3.105e-057.784e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)glycosyl compound catabolic process00InformativeDirect
Biological Process (BP)epithelium development0.00043780.001584InformativeInherited
Biological Process (BP)reproductive structure development10.3964InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.64181InformativeInherited
Biological Process (BP)membrane organization0.01255.686e-05InformativeInherited
Biological Process (BP)proteolysis10.7393InformativeInherited
Biological Process (BP)protein catabolic process10.6988InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)cellular component morphogenesis1.38e-081InformativeInherited
Biological Process (BP)generation of neurons1.005e-051InformativeInherited
Biological Process (BP)organelle localization0.093177.84e-08InformativeInherited
Biological Process (BP)biological adhesion7.594e-071InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)regulation of system process0.00050751InformativeInherited
Biological Process (BP)response to light stimulus0.7111InformativeInherited
Biological Process (BP)vesicle-mediated transport1.61e-150.07541InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.010530.8705InformativeInherited
Biological Process (BP)secondary metabolic process0.66511InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.97731InformativeInherited
Biological Process (BP)positive regulation of gene expression0.92531InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.97011InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.8993InformativeInherited
Biological Process (BP)regulation of organelle organization2.167e-080.005957InformativeInherited
Biological Process (BP)protein transport5.668e-130.03614InformativeInherited
Biological Process (BP)regulation of growth0.92461InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.010270.5697InformativeInherited
Biological Process (BP)cytoskeleton organization0.021371InformativeInherited
Biological Process (BP)cation homeostasis0.13980.2712InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.043710.3049InformativeInherited
Biological Process (BP)growth2.427e-090.5195InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.043091InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.90721InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process11InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.14180.2253InformativeInherited
Biological Process (BP)regulation of hormone levels0.17771InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis4.208e-051InformativeInherited
Biological Process (BP)steroid metabolic process0.63971InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.82640.7566InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00037750.1151InformativeInherited
Biological Process (BP)intracellular signal transduction00.02285InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0034140InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.80930InformativeInherited
Biological Process (BP)tissue morphogenesis0.015931InformativeInherited
Biological Process (BP)double-strand break repair4.691e-055.218e-08Highly InformativeDirect
Biological Process (BP)DNA recombination1.6e-102.78e-11Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity6.167e-151.741e-09Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process2.057e-110Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process9.807e-070Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis6.083e-096.895e-09Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly2.399e-130.0004974Highly InformativeDirect
Biological Process (BP)cell projection assembly2.685e-097.04e-07Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport7.426e-134.649e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH6.381e-070Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process2.416e-051.665e-07Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process06.665e-08Highly InformativeDirect
Biological Process (BP)epithelial cell development0.067948.278e-14Highly InformativeInherited
Biological Process (BP)gonad development0.93451Highly InformativeInherited
Biological Process (BP)development of primary male sexual characteristics0.073961Highly InformativeInherited
Biological Process (BP)nucleus organization0.79640.791Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.7385Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.036741Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.000520.09159Highly InformativeInherited
Biological Process (BP)cell proliferation0.99461Highly InformativeInherited
Biological Process (BP)cell fate commitment0.91231Highly InformativeInherited
Biological Process (BP)establishment of vesicle localization0.00088280.9962Highly InformativeInherited
Biological Process (BP)interaction with symbiont0.085820.009137Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.035261Highly InformativeInherited
Biological Process (BP)sensory perception10.09555Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.58680.3755Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.0070470.1033Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.5531Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent11Highly InformativeInherited
Biological Process (BP)cell junction organization7.93e-110.006702Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity1.983e-060.7181Highly InformativeInherited
Biological Process (BP)protein methylation0.66960.6631Highly InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process11Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.68661Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process0.92880.6648Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.035970.001864Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00017960.9974Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0046831Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.34181Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.075051Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.91551Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.20140.2666Highly InformativeInherited
Biological Process (BP)meiosis0.010320Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.86341Highly InformativeInherited
Biological Process (BP)protein glycosylation0.015971Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.043260.01861Highly InformativeInherited
Biological Process (BP)phagocytosis0.93891Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transporter activity0.00029520Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity1.821e-120InformativeDirect
Molecular Function (MF)purine ribonucleoside binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.27230.0001027InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.98144.146e-07InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.96431InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity1.373e-120.6578InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding1.911e-061.613e-09Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0068880.2364Highly InformativeInherited
Cellular Component (CC)membrane02.177e-05Least InformativeDirect
Cellular Component (CC)protein complex0.90220.2417Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0015721Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.60840Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoplasmic part2.676e-150.001141Least InformativeInherited
Cellular Component (CC)cytoskeleton2.885e-143.789e-08Moderately InformativeDirect
Cellular Component (CC)vesicle00.0006421Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.90691Moderately InformativeInherited
Cellular Component (CC)nuclear part10.5314Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0003089InformativeDirect
Cellular Component (CC)cell cortex5.044e-135.141e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton1.373e-152.939e-13InformativeDirect
Cellular Component (CC)cell-cell junction0.92010.0004797InformativeInherited
Cellular Component (CC)secretory granule10.6643InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.05080.01541InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.73341InformativeInherited
Cellular Component (CC)synapse part00.009541InformativeInherited
Cellular Component (CC)spindle2.676e-152.365e-14Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.0002537.508e-06Highly InformativeDirect
Cellular Component (CC)cilium05.927e-14Highly InformativeDirect
Cellular Component (CC)lateral plasma membrane1.105e-072.401e-11Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.00024730Highly InformativeDirect
Cellular Component (CC)endocytic vesicle7.541e-056.444e-09Highly InformativeDirect
Cellular Component (CC)midbody9.088e-150Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle B7.503e-050.0006544Highly InformativeDirect
Cellular Component (CC)cell division site part2.575e-062.473e-12Highly InformativeDirect
Cellular Component (CC)insulin-responsive compartment9.765e-053.802e-09Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex5.054e-070Highly InformativeDirect
Cellular Component (CC)recycling endosome3.101e-090Highly InformativeDirect
Cellular Component (CC)host cell part0.0014115.584e-05Highly InformativeInherited
Cellular Component (CC)nuclear body0.14460.5888Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.012510.003237Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0095870Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)