SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,258) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,013,221 4,300,997 739
Proteins 869,941 3,740,022 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.17790.1869Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00018531Least InformativeInherited
Biological Process (BP)multicellular organismal process1.714e-051Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction8.295e-105.661e-13Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization2.805e-086.027e-11Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00.0009261Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.74521Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.68994.927e-07Moderately InformativeInherited
Biological Process (BP)nervous system development2.02e-071Moderately InformativeInherited
Biological Process (BP)regulation of localization00.01104Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.50831Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.042528.593e-13Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)organic substance transport10.03859Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.73061Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.042971Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.18791Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0028620.00482Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00046621Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis1.327e-090.5037Moderately InformativeInherited
Biological Process (BP)tissue development0.88360.9299Moderately InformativeInherited
Biological Process (BP)signal transduction0.0011241Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.55940Moderately InformativeInherited
Biological Process (BP)cellular response to stress11.283e-12Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.94361Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.14390.9001Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process2.536e-050InformativeDirect
Biological Process (BP)cellular membrane organization5.659e-061.61e-10InformativeDirect
Biological Process (BP)cell cycle process1.883e-050InformativeDirect
Biological Process (BP)actin filament-based process3.774e-147.656e-09InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process7.697e-100InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction1.094e-070InformativeDirect
Biological Process (BP)epithelium development0.00016580.0003614InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00InformativeDirect
Biological Process (BP)organelle assembly8.803e-074.541e-09InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.56230.9714InformativeInherited
Biological Process (BP)proteolysis10.6525InformativeInherited
Biological Process (BP)protein catabolic process10.8064InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)cellular component morphogenesis8.751e-101InformativeInherited
Biological Process (BP)regulation of protein localization0.89941InformativeInherited
Biological Process (BP)generation of neurons1.045e-051InformativeInherited
Biological Process (BP)organelle localization0.031364.125e-09InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)regulation of system process0.00038131InformativeInherited
Biological Process (BP)response to light stimulus0.76571InformativeInherited
Biological Process (BP)vesicle-mediated transport1.688e-150.03997InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0049690.496InformativeInherited
Biological Process (BP)secondary metabolic process0.79331InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of gene expression0.94691InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.8063InformativeInherited
Biological Process (BP)regulation of organelle organization1.43e-090.00565InformativeInherited
Biological Process (BP)protein transport00.003588InformativeInherited
Biological Process (BP)regulation of growth0.94291InformativeInherited
Biological Process (BP)negative regulation of immune system process0.99195.296e-05InformativeInherited
Biological Process (BP)negative regulation of cell communication0.94161InformativeInherited
Biological Process (BP)negative regulation of signaling0.89751InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.064421InformativeInherited
Biological Process (BP)cytoskeleton organization0.03771InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.60412.6e-07InformativeInherited
Biological Process (BP)sexual reproduction0.51050.7908InformativeInherited
Biological Process (BP)single organism reproductive process0.84860.7623InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.03744InformativeInherited
Biological Process (BP)cation homeostasis0.091260.2864InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.01550.1891InformativeInherited
Biological Process (BP)growth1.205e-060.2217InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.067641InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.91491InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process11InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.1680.1663InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.14970.2948InformativeInherited
Biological Process (BP)regulation of hormone levels0.12961InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00030611InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching10.6711InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis3.502e-050.03222InformativeInherited
Biological Process (BP)intracellular signal transduction00.0298InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0028490InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.8010InformativeInherited
Biological Process (BP)tissue morphogenesis0.010051InformativeInherited
Biological Process (BP)double-strand break repair4.172e-054.687e-07Highly InformativeDirect
Biological Process (BP)DNA recombination4.983e-101.484e-10Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity3.261e-152.321e-11Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate catabolic process1.161e-060Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process2.821e-130Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate catabolic process8.75e-110Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.00017260Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis2.855e-119.865e-13Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly2.34e-130.0004891Highly InformativeDirect
Biological Process (BP)regulation of exocytosis01.109e-10Highly InformativeDirect
Biological Process (BP)cell projection assembly3.439e-111.249e-06Highly InformativeDirect
Biological Process (BP)cytoskeleton-dependent intracellular transport0.00054220Highly InformativeDirect
Biological Process (BP)cell junction organization3.867e-116.448e-05Highly InformativeDirect
Biological Process (BP)cilium organization1.417e-075.038e-13Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport2.821e-131.455e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis2.828e-070Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process6.858e-064.595e-09Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process02.195e-09Highly InformativeDirect
Biological Process (BP)nucleus organization0.83580.944Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.7886Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.065971Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.00011490.1577Highly InformativeInherited
Biological Process (BP)cell fate commitment0.91741Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0055910.003574Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0046260.01098Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.022230.9353Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.00014220.1583Highly InformativeInherited
Biological Process (BP)sensory perception10.08218Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.57750.3657Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.006810.09064Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.6021Highly InformativeInherited
Biological Process (BP)purine ribonucleoside triphosphate metabolic process0.0020010.003125Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.030780.002484Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity1.753e-060.6886Highly InformativeInherited
Biological Process (BP)female gamete generation0.0004520.03371Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.4080.09037Highly InformativeInherited
Biological Process (BP)protein methylation0.70090.8336Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.8181Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process0.90550.5671Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.039410.002294Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00025011Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0036071Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.37641Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.1241Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.88811Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.31140.1233Highly InformativeInherited
Biological Process (BP)meiosis0.026060Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.89741Highly InformativeInherited
Biological Process (BP)protein glycosylation0.016691Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.041250.0239Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.0046940.008594Highly InformativeInherited
Biological Process (BP)phagocytosis0.85891Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.25781Least InformativeInherited
Molecular Function (MF)transporter activity0.00031050Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity9.964e-130InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.32940.001314InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.69879.694e-09InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups11InformativeInherited
Molecular Function (MF)purine ribonucleoside binding00.01865InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity1.139e-130.3618InformativeInherited
Molecular Function (MF)ligase activity11InformativeInherited
Molecular Function (MF)tubulin binding6.661e-059.412e-08Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding1.01e-070.0007671Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0098620.2737Highly InformativeInherited
Cellular Component (CC)membrane01.735e-13Least InformativeDirect
Cellular Component (CC)cytoplasmic part03.217e-05Least InformativeDirect
Cellular Component (CC)protein complex0.78980.3595Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle4.356e-061Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.64020Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoskeleton6.929e-151.405e-11Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)vesicle00.03277Moderately InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane1.644e-061Moderately InformativeInherited
Cellular Component (CC)nuclear part10.5652Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.069871Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0065471.143e-06Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus06.002e-05InformativeDirect
Cellular Component (CC)cell cortex1.608e-148.984e-15InformativeDirect
Cellular Component (CC)microtubule cytoskeleton3.201e-131.901e-14InformativeDirect
Cellular Component (CC)cell junction2.126e-056.14e-09InformativeDirect
Cellular Component (CC)secretory granule10.8211InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.73970.9616InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.58711InformativeInherited
Cellular Component (CC)synapse part00.02912InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.45711InformativeInherited
Cellular Component (CC)spindle4.186e-150Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.00056020Highly InformativeDirect
Cellular Component (CC)endocytic vesicle3.652e-057.789e-11Highly InformativeDirect
Cellular Component (CC)midbody2.824e-150Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle2.465e-083.12e-08Highly InformativeDirect
Cellular Component (CC)cell division site part1.434e-061.216e-11Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex4.347e-080Highly InformativeDirect
Cellular Component (CC)cilium part03.389e-06Highly InformativeDirect
Cellular Component (CC)nuclear body0.16190.5706Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.0076410.0003865Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0034690Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)