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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,258) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,013,221 4,300,997 739
Proteins 869,941 3,740,022 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.13840.1839Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00010291Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000040861Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.9603Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.0000000011040.00000000000035Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0000000073520.00000000002863Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.73141Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.77690.0000008936Moderately InformativeInherited
Biological Process (BP)nervous system development0.00000039791Moderately InformativeInherited
Biological Process (BP)regulation of localization00.01652Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.42031Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.052540.000000000001249Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.99561Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.99051Moderately InformativeInherited
Biological Process (BP)organic substance transport10.02773Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.79521Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.058931Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.20811Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.074091Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0033290.005285Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00051711Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0000000030320.5853Moderately InformativeInherited
Biological Process (BP)tissue development0.82680.9177Moderately InformativeInherited
Biological Process (BP)signal transduction0.0013221Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.55770Moderately InformativeInherited
Biological Process (BP)cellular response to stress10.000000000001082Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.71961Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization00.001198Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.11050.9044Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.000043240InformativeDirect
Biological Process (BP)cellular membrane organization0.0000059850.0000000001271InformativeDirect
Biological Process (BP)cell cycle process0.000021530InformativeDirect
Biological Process (BP)actin filament-based process0.0000000000000420.000000008275InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.0000000017030InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.000000079030InformativeDirect
Biological Process (BP)epithelium development0.00016120.000257InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00InformativeDirect
Biological Process (BP)organelle assembly0.0000062990.00000001712InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)glycosyl compound catabolic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.49370.9582InformativeInherited
Biological Process (BP)proteolysis10.591InformativeInherited
Biological Process (BP)protein catabolic process10.7887InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0000000054291InformativeInherited
Biological Process (BP)generation of neurons0.000010121InformativeInherited
Biological Process (BP)organelle localization0.027110.000000004242InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)regulation of system process0.00033091InformativeInherited
Biological Process (BP)response to light stimulus0.75951InformativeInherited
Biological Process (BP)vesicle-mediated transport00.06573InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.00380.4932InformativeInherited
Biological Process (BP)secondary metabolic process0.70761InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of gene expression0.92981InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.99381InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.9104InformativeInherited
Biological Process (BP)regulation of organelle organization0.0000000039430.008059InformativeInherited
Biological Process (BP)protein transport00.003426InformativeInherited
Biological Process (BP)regulation of growth0.94171InformativeInherited
Biological Process (BP)negative regulation of cell communication0.90621InformativeInherited
Biological Process (BP)negative regulation of signaling0.87281InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.11511InformativeInherited
Biological Process (BP)cytoskeleton organization0.028441InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.55140.0000001439InformativeInherited
Biological Process (BP)sexual reproduction0.45910.7199InformativeInherited
Biological Process (BP)single organism reproductive process0.84520.7182InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.03368InformativeInherited
Biological Process (BP)cation homeostasis0.086390.3712InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.015380.2243InformativeInherited
Biological Process (BP)growth0.00000089360.1446InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.075281InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.2540.5115InformativeInherited
Biological Process (BP)regulation of hormone levels0.12781InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00045831InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching10.6917InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00016380.04596InformativeInherited
Biological Process (BP)intracellular signal transduction00.02503InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0028180InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.79950InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)tissue morphogenesis0.0080231InformativeInherited
Biological Process (BP)double-strand break repair0.000041390.0000002792Highly InformativeDirect
Biological Process (BP)DNA recombination0.00000000039580.00000000007787Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.0000000000000094660.000000000117Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process0.0000000000015590Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process0.00000010510Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.00037930Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000010530.000000000006112Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.00000000000023090.0004857Highly InformativeDirect
Biological Process (BP)regulation of exocytosis00.00000000004982Highly InformativeDirect
Biological Process (BP)cell projection assembly0.00000000065910.000003976Highly InformativeDirect
Biological Process (BP)cell junction organization0.00000000004050.00008708Highly InformativeDirect
Biological Process (BP)cilium organization0.00000090920.000000000006155Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.00000000000065350.00001767Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.00000027990Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.0000067960.000000004582Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process00.000000007128Highly InformativeDirect
Biological Process (BP)nucleus organization0.82130.9499Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.7703Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.065721Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.00034750.2051Highly InformativeInherited
Biological Process (BP)cell fate commitment0.90071Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0024670.003038Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0020210.01096Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.017010.904Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.00013710.1461Highly InformativeInherited
Biological Process (BP)sensory perception10.09573Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.57710.3613Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate metabolic process11Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate metabolic process0.89181Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.0048960.08643Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.54261Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent11Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.98420.00003399Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.030660.00248Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity0.0000017390.6882Highly InformativeInherited
Biological Process (BP)female gamete generation0.00049420.02966Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.38290.06162Highly InformativeInherited
Biological Process (BP)protein methylation0.69160.8135Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00016881Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0036971Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.32011Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.091211Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.88541Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.31530.1319Highly InformativeInherited
Biological Process (BP)meiosis0.0260Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.88671Highly InformativeInherited
Biological Process (BP)protein glycosylation0.016591Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.030090.02235Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.006260.0102Highly InformativeInherited
Biological Process (BP)phagocytosis0.82221Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.25751Least InformativeInherited
Molecular Function (MF)transporter activity0.00028770Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00.05833Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.00000000000097580InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.32850.001275InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.69480.0000000405InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups11InformativeInherited
Molecular Function (MF)purine ribonucleoside binding00.01865InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity0.00000000000011440.3708InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding0.000066720.00000003072Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding0.000000082870.0006204Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0098230.2735Highly InformativeInherited
Cellular Component (CC)membrane00.0000000001176Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.00006054Least InformativeDirect
Cellular Component (CC)protein complex0.8140.3234Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0000043731Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.70050Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0000000000000070740.000000000003957Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)vesicle00.03233Moderately InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.000049661Moderately InformativeInherited
Cellular Component (CC)nuclear part10.6305Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.069781Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0056080.0000006299Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.00008101InformativeDirect
Cellular Component (CC)cell cortex0.000000000000094450.000000000000006075InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00000000000038540.00000000000001473InformativeDirect
Cellular Component (CC)cell junction0.000017670.000000004257InformativeDirect
Cellular Component (CC)secretory granule10.8025InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.73410.9634InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.64311InformativeInherited
Cellular Component (CC)synapse part00.02519InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.43181InformativeInherited
Cellular Component (CC)spindle0.000000000000004270Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.000520Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.00003940.00000000009488Highly InformativeDirect
Cellular Component (CC)midbody0.000000000000002870Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle0.000000024690.00000003148Highly InformativeDirect
Cellular Component (CC)cell division site part0.0000014240.000000000007202Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.000000041110Highly InformativeDirect
Cellular Component (CC)cilium part00.00003415Highly InformativeDirect
Cellular Component (CC)nuclear body0.15250.5808Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.0083870.0005046Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0035360Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)