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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,267) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,023,540 6,645,484 739
Proteins 878,716 5,785,563 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases0.5689Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00001366Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.00000000004252InformativeDirect
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000001114Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.000000000001586Highly InformativeDirect
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0.00000000001552Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.0000000002809Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.000000001067Highly InformativeDirect
Enzyme Commission (EC)Phosphate acetyltransferase0.00000005958Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.00000006032Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.0000003757Highly InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase0.00004074Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0006792Highly InformativeDirect
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoest0.9116Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01646Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.7069Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0001155InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.003629Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000000000003537Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00000005679Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.3753Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00006112Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00009484Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0002122Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.004728Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.006596Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.02995Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.1472Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2078Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2389Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.462Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.8047Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8949Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000000000001006InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0000000000001195InformativeDirect
Worm Phenotype (WP)sick0.00000005653InformativeDirect
Worm Phenotype (WP)brood size variant0.0000013InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003751InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0009327InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.01265InformativeInherited
Worm Phenotype (WP)localized movement variant0.02699InformativeInherited
Worm Phenotype (WP)body posture variant0.031InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.09987InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.1023InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.1099InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.3422InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.4849InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.7967InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0.00000002623Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000002878Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.00001815Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.00002331Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00003094Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.0000643Highly InformativeDirect
Worm Phenotype (WP)passage through meiosis defective early emb0.0001155Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0001314Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.000136Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0005341Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0008547Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0009341Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.001143Highly InformativeInherited
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.02911Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0006026InformativeDirect
Yeast Phenotype (YP)mutation frequency0.000001882Highly InformativeDirect
Yeast Phenotype (YP)budding0.7535Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.000001294InformativeDirect
Fly Phenotype (FP)radiation sensitive0.0005612Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.06743Least InformativeInherited
Fly Anatomy (FA)gonad0.00006968Moderately InformativeDirect
Fly Anatomy (FA)germline cyst0.0004118InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.07232Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.3256Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.4469Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.006309Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.02158Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.0002371InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.000001884Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.007054Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.008909Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0000001359Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ line cell0.04327Moderately InformativeInherited
Xenopus ANatomical entity (XAN)oocyte0.0000011Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.0003509Least InformativeDirect
Plant ANatomical entity (PAN)gamete0.00003033InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.007863Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1InformativeInherited
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases9.936e-16Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.000000000003389Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.0000000001645Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0002769Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0005454Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.0008371Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0.8149Highly InformativeInherited
Enzyme Commission (EC)Endodeoxyribonucleases producing 5'-phosphomonoesters0.8348Highly InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 406 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 406 hidden Markov models representing the P-loop containing nucleoside triphosphate hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]