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P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,260) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,014,982 4,300,997 739
Proteins 871,448 3,740,022 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000000000011410.00000006658Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process10Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.43250Least InformativeInherited
Biological Process (BP)single-organism cellular process01Least InformativeInherited
Biological Process (BP)biological regulation01Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.29560Least InformativeInherited
Biological Process (BP)macromolecule metabolic process10.000000000000003692Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process10.4218Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.70150Least InformativeInherited
Biological Process (BP)biosynthetic process10.0000000003179Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.00014440.0000000308Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.00000000042580.00000000001065Moderately InformativeDirect
Biological Process (BP)organelle organization0.00000000000018820Moderately InformativeDirect
Biological Process (BP)cellular localization0.00000070830.0003159Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.029320.01846Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.23310.0003954Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0000000014010.4299Moderately InformativeInherited
Biological Process (BP)system development11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0000080420.002829Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.2773Moderately InformativeInherited
Biological Process (BP)ribose phosphate metabolic process0.0082110.00000555Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.0000030250.0096Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process11Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound biosynthetic process0.00000039831Moderately InformativeInherited
Biological Process (BP)cell communication0.0000000043561Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.77731Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of cell communication11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.60470.8003Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.0027350.8525Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.94621Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.0045950.0000009098Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.2191Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00000000000012150.02482Moderately InformativeInherited
Biological Process (BP)signaling01Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative biosynthetic process0.0018140.558Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.00005181Moderately InformativeInherited
Biological Process (BP)single-organism transport11Moderately InformativeInherited
Biological Process (BP)response to stress10.00000001962Moderately InformativeInherited
Biological Process (BP)organic substance transport10.3695Moderately InformativeInherited
Biological Process (BP)movement of cell or subcellular component00InformativeDirect
Biological Process (BP)microtubule-based process0.0000000066740InformativeDirect
Biological Process (BP)nucleoside diphosphate metabolic process0.000000025040.0000000003122InformativeDirect
Biological Process (BP)cell cycle process0.00000000034770InformativeDirect
Biological Process (BP)actin filament-based process0.00000000040580InformativeDirect
Biological Process (BP)intracellular signal transduction00.00004573InformativeDirect
Biological Process (BP)single-organism membrane organization00InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.000013380.0000000003411InformativeDirect
Biological Process (BP)epithelium development00.0000000005086InformativeDirect
Biological Process (BP)organelle assembly0.0000000000037510.00002371InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000073860.0003217InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process0.000003360.00000000001878InformativeDirect
Biological Process (BP)secretion0.017761InformativeInherited
Biological Process (BP)locomotion00.4207InformativeInherited
Biological Process (BP)lipid catabolic process11InformativeInherited
Biological Process (BP)regulation of cellular localization0.035540.0001687InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)generation of neurons0.0000047911InformativeInherited
Biological Process (BP)single-organism intracellular transport0.0011560.001221InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)pigment metabolic process0.6220.9716InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.000031190.01121InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated11InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of gene expression11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)DNA metabolic process0.077040InformativeInherited
Biological Process (BP)regulation of immune response11InformativeInherited
Biological Process (BP)negative regulation of cell communication0.52811InformativeInherited
Biological Process (BP)negative regulation of signaling0.51611InformativeInherited
Biological Process (BP)regulation of defense response10.1142InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.019361InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.59071InformativeInherited
Biological Process (BP)cytoskeleton organization0.66211InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.026240.01941InformativeInherited
Biological Process (BP)regulation of secretion0.39561InformativeInherited
Biological Process (BP)coenzyme biosynthetic process11InformativeInherited
Biological Process (BP)lipid localization10.389InformativeInherited
Biological Process (BP)anion transport0.001690.000000139InformativeInherited
Biological Process (BP)organic acid transport0.66650.2684InformativeInherited
Biological Process (BP)nitrogen compound transport10.3284InformativeInherited
Biological Process (BP)amine metabolic process11InformativeInherited
Biological Process (BP)regulation of hormone levels0.76931InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.050380.03682InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00088771InformativeInherited
Biological Process (BP)embryo development0.0057761InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.93921InformativeInherited
Biological Process (BP)ion homeostasis0.44550.1117InformativeInherited
Biological Process (BP)metal ion transport0.0083711InformativeInherited
Biological Process (BP)secondary metabolic process0.0030771InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.45740InformativeInherited
Biological Process (BP)cell development0.062760.0005465InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0000000000031970.8708InformativeInherited
Biological Process (BP)mitotic cell cycle11InformativeInherited
Biological Process (BP)protein targeting11InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.00000000000420.000003205Highly InformativeDirect
Biological Process (BP)DNA recombination0.000000074660.00000000001286Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity00.000000000001201Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)regulation of cell shape0.000000032630.0000002757Highly InformativeDirect
Biological Process (BP)nucleoside triphosphate biosynthetic process0.000000000015710Highly InformativeDirect
Biological Process (BP)pyrimidine nucleoside triphosphate metabolic process0.00040750.0000000769Highly InformativeDirect
Biological Process (BP)endomembrane system organization00.00002605Highly InformativeDirect
Biological Process (BP)endosomal transport00.000000001815Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly0.000000000032320.000004794Highly InformativeDirect
Biological Process (BP)deoxyribose phosphate metabolic process0.00000096930.00002559Highly InformativeDirect
Biological Process (BP)wound healing0.00000000045120.0000000000001067Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.000015210.000002362Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH0.000000012860Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.00011580.000000000005227Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport00Highly InformativeDirect
Biological Process (BP)cell migration0.0005021Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.1230Highly InformativeInherited
Biological Process (BP)cell proliferation0.60211Highly InformativeInherited
Biological Process (BP)vesicle localization0.0012021Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0000086011Highly InformativeInherited
Biological Process (BP)pigmentation0.0000000072930.002798Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.000024290.001411Highly InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-templated11Highly InformativeInherited
Biological Process (BP)cell projection organization00.0349Highly InformativeInherited
Biological Process (BP)cell junction assembly0.0000084210.02339Highly InformativeInherited
Biological Process (BP)establishment of protein localization to membrane0.082310.1954Highly InformativeInherited
Biological Process (BP)vesicle-mediated transport to the plasma membrane0.00035070.1444Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.084460.6424Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process10.5848Highly InformativeInherited
Biological Process (BP)autophagy0.00063770.06721Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.000026410.001578Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process10.89Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.031980.005995Highly InformativeInherited
Biological Process (BP)carbohydrate derivative transport10.734Highly InformativeInherited
Biological Process (BP)amino acid transport0.00000049240.02623Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.030161Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.22281Highly InformativeInherited
Biological Process (BP)cellular response to external stimulus0.017940.001225Highly InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.28970.8405Highly InformativeInherited
Biological Process (BP)transition metal ion transport0.0016390.0004983Highly InformativeInherited
Biological Process (BP)divalent inorganic cation transport0.40621Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside triphosphate metabolic process0.000031320.003495Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide biosynthetic process0.0083780.0000001384Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.022360.002025Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.0092880.001725Highly InformativeInherited
Biological Process (BP)endocytosis11Highly InformativeInherited
Biological Process (BP)lysosome organization10.0000003502Highly InformativeInherited
Biological Process (BP)vesicle organization0.00000000072460.2546Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.83821Least InformativeInherited
Molecular Function (MF)transporter activity0.00000000000095330Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding00Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00.06143Moderately InformativeInherited
Molecular Function (MF)protein binding0.08781Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00.8721Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding11Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.00000053050.00000000001364InformativeDirect
Molecular Function (MF)transferase activity, transferring sulfur-containing groups00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity00InformativeDirect
Molecular Function (MF)ribonucleoside binding00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.27520.0000000000008586InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups11InformativeInherited
Molecular Function (MF)purine nucleoside binding00.01291InformativeInherited
Molecular Function (MF)kinase activity0.000000000000019220.397InformativeInherited
Molecular Function (MF)ligase activity11InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)DNA binding0.78131InformativeInherited
Molecular Function (MF)single-stranded DNA binding0.00099880Highly InformativeDirect
Molecular Function (MF)amine transmembrane transporter activity0.000053140.00006281Highly InformativeDirect
Molecular Function (MF)tubulin binding0.00065510.00000009806Highly InformativeDirect
Molecular Function (MF)phosphotransferase activity, phosphate group as acceptor00Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0000000000010230.006969Highly InformativeInherited
Molecular Function (MF)lipid transporter activity0.73280.000000261Highly InformativeInherited
Molecular Function (MF)macromolecule transmembrane transporter activity0.090240.0001225Highly InformativeInherited
Molecular Function (MF)carbohydrate derivative transporter activity11Highly InformativeInherited
Cellular Component (CC)membrane00.000000000000008925Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00010030Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)protein complex10Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.00000000012010.04203Least InformativeInherited
Cellular Component (CC)vacuole0.00000040530.0003864Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0000000000019230.00000000009749Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.000000001210.00000000002802Moderately InformativeDirect
Cellular Component (CC)vesicle00.000000000003607Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)whole membrane0.000000000000040290.000000009228Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane11Moderately InformativeInherited
Cellular Component (CC)membrane protein complex11Moderately InformativeInherited
Cellular Component (CC)nuclear part10.1833Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.000000042621Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0002592InformativeDirect
Cellular Component (CC)cilium00InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0000011240.0000000000002724InformativeDirect
Cellular Component (CC)extrinsic component of membrane0.00000000020090.0000000000001934InformativeDirect
Cellular Component (CC)cell junction0.00000036330.00000001363InformativeDirect
Cellular Component (CC)site of polarized growth0.00000000010090.000001358InformativeDirect
Cellular Component (CC)vacuolar part0.0000030180.0003586InformativeDirect
Cellular Component (CC)cell projection part00InformativeDirect
Cellular Component (CC)cytoplasmic region0.00000000000024680.000000000009761InformativeDirect
Cellular Component (CC)side of membrane0.043150.8263InformativeInherited
Cellular Component (CC)cell surface0.095121InformativeInherited
Cellular Component (CC)organelle subcompartment00.001471InformativeInherited
Cellular Component (CC)transporter complex0.0057670.4993InformativeInherited
Cellular Component (CC)plasma membrane protein complex0.18920.0000000000002623InformativeInherited
Cellular Component (CC)secretory vesicle11InformativeInherited
Cellular Component (CC)lytic vacuole0.8070.891InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.62451InformativeInherited
Cellular Component (CC)spindle0.000000061780.00000001114Highly InformativeDirect
Cellular Component (CC)lateral plasma membrane0.000010890.00003414Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.0000048350.000005189Highly InformativeDirect
Cellular Component (CC)dynein complex0.0004390Highly InformativeDirect
Cellular Component (CC)midbody0.000000000044660Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00033340.000000000000003057Highly InformativeDirect
Cellular Component (CC)cell division site0.00000000000035320.0000000001048Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.00017210Highly InformativeDirect
Cellular Component (CC)endoplasmic reticulum subcompartment0.0048460.00004369Highly InformativeInherited
Cellular Component (CC)cell-cell junction10.001264Highly InformativeInherited
Cellular Component (CC)extrinsic component of organelle membrane0.000043050.002686Highly InformativeInherited
Cellular Component (CC)lytic vacuole membrane0.045890.5445Highly InformativeInherited
Cellular Component (CC)polymeric cytoskeletal fiber0.0061340.7616Highly InformativeInherited
Cellular Component (CC)rough endoplasmic reticulum0.29030.4953Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)