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Arginase/deacetylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Arginase/deacetylase [ 52767]
Superfamily:   Arginase/deacetylase [ 52768] (2)
Families:   Arginase-like amidino hydrolases [ 52769] (4)
  Histone deacetylase, HDAC [ 52773] (3)


Superfamily statistics
Genomes (2,302) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,963 67,757 30
Proteins 10,616 66,757 30


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0.8808Moderately InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4674Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.4179Moderately InformativeInherited
Disease Ontology (DO)lymphoma0.002083InformativeInherited
Disease Ontology (DO)Hodgkin's lymphoma0.0001651Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.08527Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2211Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.03353Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.03517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.03999Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.2124Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palm0.0005016InformativeDirect
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.002907InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1011InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.0001817Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.0005622Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4916Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2582Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0845InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0005524Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006036Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0687Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0000000006418Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0000002997Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.02509Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1867Moderately InformativeInherited
Worm Phenotype (WP)protein modification variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000000008256InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00000001015InformativeDirect
Worm Phenotype (WP)vulva development variant0.000216InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0000000003699Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0000000226Highly InformativeDirect
Worm Phenotype (WP)organism UV hypersensitive0.000001348Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)neuron0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)trunk0InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)vasculature0InformativeDirect
Zebrafish Anatomy (ZA)blood vessel0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Arginase/deacetylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Arginase/deacetylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]