SUPERFAMILY 1.75 HMM library and genome assignments server

CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,804) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 46,519 172,334 39
Proteins 20,412 83,900 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity0.0052890Least InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.0000022630InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.028310.2798Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.030060.000000315Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.05809 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000001028 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00001255 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00002746 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00003645 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.02206 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9567 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.6662 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.02091 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.7766 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1099 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.002326 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9226 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.04725 Moderately Informative Inherited
Biological Process (BP) ion transport 0.002833 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.03154 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) organic acid transport 0.000000000003379 Informative Direct
Biological Process (BP) peptide metabolic process 0.000000000004619 Informative Direct
Biological Process (BP) lipid localization 0.00000000001206 Informative Direct
Biological Process (BP) anion transport 0.00000002534 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00000452 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000005319 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.00003745 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00005726 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008937 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.726 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.449 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.5099 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.01218 Informative Inherited
Biological Process (BP) response to nutrient levels 0.001187 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.002069 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.7353 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.7518 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.0000000000015 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000001327 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000007858 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.00001154 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00008874 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.02692 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.03392 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.01118 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0.6217 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.09425 Informative Inherited
Molecular Function (MF) O-acyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00000000002993 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000315 Least Informative Direct
Cellular Component (CC) protein complex 0.9059 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2798 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0000004551 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.8652 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001647 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.9059 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) microbody 0.0000000004935 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.0000011 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000009953 Informative Direct
Cellular Component (CC) lipid particle 0.0001435 Informative Direct
Cellular Component (CC) organelle outer membrane 0.000016 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003344InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0.00000000000001237Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.00000000546Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1804Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02633Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of urogenital tract0.0000121InformativeDirect
Disease Ontology (DO)liver disease0.002298InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05775Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.1611Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001123Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.008893Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.1835Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0002047InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0005658InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0.01427InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.1641Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.000001329InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.002357InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.02188InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.1187InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003857Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.03254Least InformativeInherited
Drugbank ATC_code (DB)other alimentary tract and metabolism products1InformativeInherited
Drugbank ATC_code (DB)levocarnitine0.000000004743Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processVirulence0.0000000000006416InformativeDirect
Biological processFatty acid metabolism0.0000614InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.0000000001123InformativeDirect
Cellular componentMitochondrion outer membrane0.00002766InformativeDirect
DomainTransit peptide0.0000000000004208Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLigase0.00000000004009Moderately InformativeDirect
Post-translational modificationIsomerase0.00006961Moderately InformativeDirect
Post-translational modificationLyase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0.0001323InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000002493Least InformativeDirect
Post-translational modificationAcetylation0.000009308Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.0000000006082Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.0214Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism6.774e-16Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.00003283Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.003823Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0.0000004098InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0006392InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.1598InformativeInherited
UniPathway (UP)glycerolipid biosynthesis0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000000000003122Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.00000006557Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0000001134Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]