SUPERFAMILY 1.75 HMM library and genome assignments server


CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,761) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 45,724 87,136 39
Proteins 19,648 39,404 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle0.014330.05965Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.015692.82e-09Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5744 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0003662 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0003438 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 3.746e-15 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 3.283e-07 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 5.579e-06 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.005369 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6863 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.003492 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.1208 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01358 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05923 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9007 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.03013 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9192 Moderately Informative Inherited
Biological Process (BP) anion transport 4.227e-09 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 3.338e-05 Informative Direct
Biological Process (BP) lipid localization 2.636e-12 Informative Direct
Biological Process (BP) organic acid transport 1.119e-12 Informative Direct
Biological Process (BP) lipid catabolic process 4.015e-05 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.0009728 Informative Direct
Biological Process (BP) cellular amide metabolic process 3.746e-15 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.7327 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.2042 Informative Inherited
Biological Process (BP) transmembrane transport 0.2098 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.006774 Informative Inherited
Biological Process (BP) amino-acid betaine metabolic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) mitochondrial transport 4.715e-05 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.0003749 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 1.042e-06 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.316e-05 Highly Informative Direct
Biological Process (BP) lipid modification 0.0009446 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 2.674e-12 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.008289 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.01956 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.2994 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.03984 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.7366 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) O-acyltransferase activity 2.364e-13 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.599e-09 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.8532 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 2.82e-09 Least Informative Direct
Cellular Component (CC) protein complex 0.9636 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05965 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.000317 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 2.952e-08 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.1136 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5642 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 5.703e-07 Informative Direct
Cellular Component (CC) microbody 3.684e-11 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0001452 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives3.344e-05InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase1.237e-14Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)2.79e-13Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra5.46e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1776Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02529Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02664Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of urogenital tract1.267e-05InformativeDirect
Disease Ontology (DO)liver disease0.002225InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06011Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdomen0.1624Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001098Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.009092Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.186Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0002211InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0005826InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0.01473InformativeInherited
Phenotypic Abnormality (PA)Feeding difficulties in infancy0.0005122Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.1424Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1.031e-06InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.002121InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01748InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.09036InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives3.393e-05Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processVirulence4.087e-12InformativeDirect
Biological processFatty acid metabolism1.952e-06InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism4.701e-16Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome8.913e-11InformativeDirect
Cellular componentMitochondrion outer membrane2.442e-05InformativeDirect
DomainTransit peptide3.412e-12Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLigase3.424e-11Moderately InformativeDirect
Post-translational modificationIsomerase4.103e-05Moderately InformativeDirect
Post-translational modificationLyase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0.0001058InformativeDirect
Post-translational modificationPhosphoprotein9.703e-14Least InformativeDirect
Post-translational modificationAcetylation7.206e-05Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism4.326e-07Least InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism6.63e-12Moderately InformativeDirect
UniPathway (UP)lipid degradation0InformativeDirect
UniPathway (UP)siderophore metabolism1.049e-13InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.003295InformativeInherited
UniPathway (UP)penicillin G biosynthesis0Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0001113Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.000225Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]