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CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,810) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 46,892 262,503 39
Proteins 20,552 109,229 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00003971 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4902 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02532 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000001103 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000001148 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.0000001732 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00004755 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0001125 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001539 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.6744 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4108 Moderately Informative Inherited
Biological Process (BP) ion transport 0.09603 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2855 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.631 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4419 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.653 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8291 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.1067 Moderately Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00000000003406 Informative Direct
Biological Process (BP) lipid localization 0.0000002201 Informative Direct
Biological Process (BP) organic acid transport 0.0000004375 Informative Direct
Biological Process (BP) cellular lipid catabolic process 0.000003116 Informative Direct
Biological Process (BP) anion transport 0.0002747 Informative Direct
Biological Process (BP) transmembrane transport 0.1627 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.219 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.002075 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.1458 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.02217 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2941 Informative Inherited
Biological Process (BP) behavior 0.03691 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.8647 Informative Inherited
Biological Process (BP) cellular respiration 0.03446 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.05378 Informative Inherited
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00000000000001783 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.00000000002935 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0.0000000003207 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000001207 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0002176 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0006041 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0006915 Highly Informative Direct
Biological Process (BP) lipid modification 0.000872 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.03285 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.02721 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.124 Highly Informative Inherited
Biological Process (BP) anion transmembrane transport 0.001305 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.006871 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.05515 Informative Inherited
Molecular Function (MF) O-acyltransferase activity 0.000000000000004806 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000000001037 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.9839 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0000003464 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.4535 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1481 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00000001271 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02786 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.7795 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.7891 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.2937 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) microbody 0.000000002244 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00007041 Informative Direct
Cellular Component (CC) outer membrane 0.002437 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003344InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0.00000000000001237Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.00000000546Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.02421Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02536Moderately InformativeInherited
Disease Ontology (DO)liver disease0.002209InformativeInherited
Disease Ontology (DO)primary biliary cirrhosis0.00001056Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.186Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00107Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3104Moderately InformativeInherited
Phenotypic Abnormality (PA)Lethargy0.0004239InformativeDirect
Phenotypic Abnormality (PA)Coma0.0002362Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00506Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.002509InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.2147Least InformativeInherited
Fly Anatomy (FA)adult0.4106Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult thorax0.1487Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1887Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2185Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.002794InformativeInherited
Fly Anatomy (FA)muscle system0.004294InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.1627Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0000009065InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.002405InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.08111InformativeInherited
Enzyme Commission (EC)Lovastatin nonaketide synthase0.000005975Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.00004099Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000000000002868Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processFatty acid metabolism0.00004402InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.0000000006618InformativeDirect
Cellular componentMitochondrion outer membrane0.00005793InformativeDirect
DomainRepeat0.000006744Least InformativeDirect
DomainTransit peptide0.00000000001487Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0.0003198Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.000000004636Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.05087Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.000000000000003398Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0000000000002135Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000007127Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.0000426Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)alkaloid metabolism2.314e-16InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0.000001064InformativeDirect
UniPathway (UP)polyketide biosynthesis0.1394InformativeInherited
UniPathway (UP)L-lysine biosynthesis0.1893InformativeInherited
UniPathway (UP)ergot alkaloid biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerolipid biosynthesis0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000000000004517Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.0000001209Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.00002798Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.00007029Highly InformativeDirect
UniPathway (UP)tyrocidine biosynthesis0.00007029Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]