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CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,805) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 46,485 172,334 39
Proteins 20,398 83,900 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000001219 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000776 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1626 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8682 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000001231 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000006518 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00003866 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00006741 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0001039 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.2247 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06662 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.427 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.09937 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8127 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.01396 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7764 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.521 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3584 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.001102 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4681 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3321 Moderately Informative Inherited
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000000000277 Informative Direct
Biological Process (BP) lipid localization 0.0000001605 Informative Direct
Biological Process (BP) organic acid transport 0.0000003653 Informative Direct
Biological Process (BP) lipid catabolic process 0.0000179 Informative Direct
Biological Process (BP) anion transport 0.0001466 Informative Direct
Biological Process (BP) transmembrane transport 0.09117 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1241 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.1298 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.04552 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1977 Informative Inherited
Biological Process (BP) behavior 0.03313 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.9058 Informative Inherited
Biological Process (BP) cellular respiration 0.03944 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.06439 Informative Inherited
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00000000000009745 Highly Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000000000002503 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000000000273 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0.0000000002444 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0001477 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.000389 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0006914 Highly Informative Direct
Biological Process (BP) lipid modification 0.0008267 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.02797 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.01618 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1119 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.006248 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.09265 Informative Inherited
Molecular Function (MF) O-acyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.0000000006304 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.7892 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000002302 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1158 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00000000731 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.6822 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1333 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01928 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.6553 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) microbody 0.000000001214 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00003827 Informative Direct
Cellular Component (CC) lipid particle 0.0001101 Informative Direct
Cellular Component (CC) outer membrane 0.001481 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.0008411 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003344InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0.00000000000001237Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.00000000546Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09117Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0244Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02489Moderately InformativeInherited
Disease Ontology (DO)liver disease0.002191InformativeInherited
Disease Ontology (DO)primary biliary cirrhosis0.00001088Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.188Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001037Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2817Moderately InformativeInherited
Phenotypic Abnormality (PA)Lethargy0.0004191InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.0005606InformativeDirect
Phenotypic Abnormality (PA)Coma0.0002322Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0006417Least InformativeDirect
Worm Phenotype (WP)fat content variant0.00002349InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.1706Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.000001141InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.002543InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.08469InformativeInherited
Enzyme Commission (EC)Lovastatin nonaketide synthase0.000006242Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.00004411Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.000000000000297Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processFatty acid metabolism0.00004617InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.0000000003713InformativeDirect
Cellular componentMitochondrion outer membrane0.00005678InformativeDirect
DomainRepeat0.000177Least InformativeDirect
DomainTransit peptide0.00000000001095Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationIsomerase0.000000003221Moderately InformativeDirect
Post-translational modificationLyase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0.0002319InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0002192Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.000000000428Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.01537Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism9.126e-16Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.0000436Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0002017Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0.0000005344InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0007485InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.1489InformativeInherited
UniPathway (UP)glycerolipid biosynthesis0Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.000000000000002713Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.00000005586Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.00002801Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.00007031Highly InformativeDirect
UniPathway (UP)tyrocidine biosynthesis0.00007031Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]