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CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,810) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 46,892 262,503 39
Proteins 20,552 109,229 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00004636 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5888 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8523 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01427 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.0001449 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.0000003205 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00002973 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000001626 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000002682 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0002501 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000001171 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000268 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0862 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4958 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.7393 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.002234 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5882 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7657 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.808 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5594 Moderately Informative Inherited
Biological Process (BP) ion transport 0.151 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.07528 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0005415 Informative Direct
Biological Process (BP) lipid localization 0.0000005734 Informative Direct
Biological Process (BP) organic acid transport 0.0000009283 Informative Direct
Biological Process (BP) lipid catabolic process 0.00000442 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00000000003998 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000000005629 Informative Direct
Biological Process (BP) transmembrane transport 0.2224 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.005516 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.3233 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01378 Informative Inherited
Biological Process (BP) behavior 0.06849 Informative Inherited
Biological Process (BP) intracellular transport 0.9266 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.263 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.001144 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.8979 Informative Inherited
Biological Process (BP) cellular respiration 0.03084 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.05167 Informative Inherited
Biological Process (BP) citrate metabolic process 0.0000000006498 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0008218 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.00008354 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.00000000007192 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.0003186 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000001162 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00000000000001763 Highly Informative Direct
Biological Process (BP) organic acid transmembrane transport 0.0000133 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.002093 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.04739 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1443 Highly Informative Inherited
Biological Process (BP) anion transmembrane transport 0.001888 Highly Informative Inherited
Biological Process (BP) aerobic respiration 0.006948 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) ligase activity 0.1601 Informative Inherited
Molecular Function (MF) O-acyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.0000000002695 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.2419 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000009385 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4261 Least Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.0004816 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.8695 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.8753 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.352 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0001379 Informative Direct
Cellular Component (CC) microbody 0.0000000002193 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct
Cellular Component (CC) outer membrane 0.003426 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003344InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0.00000000000001237Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.00000000546Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processFatty acid metabolism0.00004157InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.0000000009181InformativeDirect
Cellular componentMitochondrion outer membrane0.00006554InformativeDirect
DomainRepeat0.00000008558Least InformativeDirect
DomainTransit peptide0.00000000007929Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationIsomerase0.0001734Moderately InformativeDirect
Post-translational modificationLyase1Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0.0004199Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]