SUPERFAMILY 1.75 HMM library and genome assignments server

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PTS system IIB component-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphotyrosine protein phosphatases I-like [ 52787] (2)
Superfamily:   PTS system IIB component-like [ 52794] (2)
Families:   PTS system, Lactose/Cellobiose specific IIB subunit [ 52795] (2)
  PTS system, Fructose specific IIB subunit-like [ 159584] (2)

Superfamily statistics
Genomes (1,262) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,964 42,025 5
Proteins 8,479 39,331 5

Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism transport00.000001564Moderately InformativeDirect
Biological Process (BP)organic substance transport00.0000000002555Moderately InformativeDirect
Biological Process (BP)phosphoenolpyruvate-dependent sugar phosphotransferase system00Highly InformativeDirect
Molecular Function (MF)transferase activity0.00030990.000002621Least InformativeDirect
Molecular Function (MF)transporter activity0.000000016240.0000000000002247Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000000015440.00000000002295Moderately InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000000000020990.0000000000003571InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism transport 0.000001564 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000000002555 Moderately Informative Direct
Biological Process (BP) phosphoenolpyruvate-dependent sugar phosphotransferase system 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000002621 Least Informative Direct
Molecular Function (MF) transporter activity 0.0000000000002247 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000000002295 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000000003571 Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Protein-N(pi)-phosphohistidine--sugar phosphotrans0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processPhosphotransferase system0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0.00000000000675Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a PTS system IIB component-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the PTS system IIB component-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]