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(Phosphotyrosine protein) phosphatases II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Families:   Dual specificity phosphatase-like [ 52800] (8)
  Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)
  Myotubularin-like phosphatases [ 102422]
  Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [ 117583]
  Mycobacterial PtpB-like [ 142348]


Superfamily statistics
Genomes (1,854) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 28,852 101,343 63
Proteins 25,546 91,386 60


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000002129InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.848Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.3397Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.6755Moderately InformativeInherited
Phenotypic Abnormality (PA)Hemangioma0.01979Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.6568Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.9859Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.9864Least InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.002596InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.05161InformativeInherited
Worm Phenotype (WP)cell component localization variant0.05991InformativeInherited
Worm Phenotype (WP)muscle cell attachment variant0.0003637Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.05948Least InformativeInherited
Fly Anatomy (FA)larva0.2523Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3546Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4799Least InformativeInherited
Fly Anatomy (FA)adult0.5439Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00109Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.005859Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.007942Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02836Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1854Moderately InformativeInherited
Fly Anatomy (FA)head0.3152Moderately InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.005386InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.01072InformativeInherited
Fly Anatomy (FA)adult central nervous system0.02271InformativeInherited
Fly Anatomy (FA)brain0.06527InformativeInherited
Fly Anatomy (FA)nerve0.109InformativeInherited
Fly Anatomy (FA)labral segment0.1243InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.1778InformativeInherited
Fly Anatomy (FA)neuromere0.1791InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.0004429Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.02077Highly InformativeInherited
Fly Anatomy (FA)mushroom body medial lobe0.04614Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0005902Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.03255Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.1193Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0005422Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.001653Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0001031InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0008222InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000006422Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 77 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 77 hidden Markov models representing the (Phosphotyrosine protein) phosphatases II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]